Enveloped, brick-shaped , 300×270x200nm. The surface membrane displays surface tubules or surface filaments. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).


Linear, dsDNA genome of about 154kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.
Sheeppox virus strain A genome at
Poxvirus Bioinformatics Ressource center




  1. Attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core into the host cytoplasm.
  3. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
  4. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
  5. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
  6. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
  7. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
  8. IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).

Host-virus interaction

Apoptosis modulation

Capripoxvirus SPI-2 inhibits the proteolytic activity of interleukin 1- converting enzyme (ICE) and ICE-like enzymes.

Matching UniProtKB/Swiss-Prot entries

14 entries grouped by strain (browse by keywords)

All proteins are shown (view only 4 complete proteome entries)

8 entries

Sheeppox virus (strain KS-1) (SPPV) (Capripoxvirus (strain KS-1))

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A28_SHEVKEnvelope protein A28 homolog (Protein HM3)
J1_SHEVKProtein J1 homolog (Protein F7)
KITH_SHEVKThymidine kinase (EC
VFUS_SHEVKPutative fusion protein (Protein HM2)
VHR2_SHEVKProbable host range protein 2
VQ3L_SHEVKG-protein coupled receptor homolog Q2/3L
VT3C_SHEVKT3C protein
VT4_SHEVKT4 protein

4 entries

Lumpy skin disease virus (LSDV)

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A28_LSDVEnvelope protein A28 homolog (Protein LSDV118)
LAP_LSDVE3 ubiquitin-protein ligase LAP (EC (Leukemia associated protein) ...
PAP1_LSDVPoly(A) polymerase catalytic subunit (EC (Poly(A) polymerase large ...
VHR2_LSDVProbable host range protein 2

2 entries

Sheeppox virus (strain InS-1) (SPPV) (Capripoxvirus (strain InS-1))

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B14_SHEVNProtein B14 homolog (Protein T3A)
VT4_SHEVNT4 protein