Suipoxvirus

VIRION

Enveloped, brick-shaped about 300×250x200nm. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).

GENOME

Linear, dsDNA genome of 175kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.
Swinepox virus strain Nebraska 17077-99 genome at Poxvirus Bioinformatics Ressource center

GENE EXPRESSION

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core into the host cytoplasm.
  3. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
  4. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
  5. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
  6. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
  7. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
  8. IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).

Host-virus interaction

Adaptive immune response inhibition

The poxviral E3 ubiquitin-protein ligase LAP promotes ubiquitination and subsequent degradation of host MHC-I and CD4 molecules.

Matching UniProtKB/Swiss-Prot entries

28 entries grouped by strain (browse by keywords)

All proteins are shown (view only 2 complete proteome entries)

2 entries

Swinepox virus (strain Swine/Nebraska/17077-99/1999) (SWPV) reference strain

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D3_SWPV127 kDa core protein
PAP1_SWPV1Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large ...

26 entries

Swinepox virus (strain Kasza) (SWPV)

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D13_SWPVKScaffold protein D13 ortholog (62 kDa protein) (Rifampicin resistance protein)
DUT_SWPVKDeoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
F9_SWPVKF9 protein homolog (Protein C19)
K3_SWPVKProtein K3 homolog
KITH_SWPVKThymidine kinase (EC 2.7.1.21)
LAP_SWPVKE3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) ...
MCES_SWPVKmRNA-capping enzyme small subunit (mRNA (guanine-N(7)-)-methyltransferase) (EC ...
RIR2_SWPVKRibonucleoside-diphosphate reductase small chain (EC 1.17.4.1) (Ribonucleotide ...
SPI1_SWPVKProbable serine proteinase inhibitor 1 (Serp-1) (Serpin-1)
VC01_SWPVKPutative Ig-like domain-containing protein C1
VC02_SWPVKUncharacterized protein C2
VC03_SWPVKG-protein coupled receptor homolog C3
VC04_SWPVKProtein C4
VC05_SWPVKUncharacterized protein C5
VC06_SWPVKUncharacterized protein C6
VC09_SWPVKUncharacterized protein C9
VC10_SWPVKUncharacterized protein C10
VC12_SWPVKUncharacterized protein C12
VC13_SWPVKProtein C13
VC15_SWPVKUncharacterized protein C15
VC16_SWPVKUncharacterized protein C16
VC17_SWPVKUncharacterized protein C17
VC18_SWPVKUncharacterized protein C18
VHR2_SWPVKProbable host range protein 2
VK02_SWPVKG-protein coupled receptor homolog K2
VPK2_SWPVKSerine/threonine-protein kinase 2 (EC 2.7.11.1)