Birnaviridae

VIRION

Non enveloped, single-shelled T=13 icosahedral symmetry capsid of about 70 nm in diameter, composed of 260 trimers of VP2 that form spikes projecting radially from the capsid. The peptides derived from pre-VP2 C-terminal cleavages remain associated within virion. VP3 forms a ribonucleoprotein complex with the genomic RNA. Minor amounts of VP1 are also incorporated in the virion.

GENOME

Segmented linear dsRNA genome: 2 segments (A,B) encode for 5-6 proteins. VP1 is found in a free form and covalently attached at the 5’ genomic RNA end (VPg). Segments size is about 2.3-3 kb. Genome total size is about 6 kb.

GENE EXPRESSION

Genomic segment A encodes for a structural polyprotein which is matured in cis by VP4. It also encodes an alternative ORF translated possibly by leaky scanning (VP5).
Genomic segment B encodes for VP1.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the cytoplasm.
  2. Transcription of the dsRNA genome by viral polymerase occurs inside the virion, so that dsRNA is never exposed to the cytoplasm. This plus-strand transcript is used as template for translation.
  3. (+)RNAs are encapsidated in virion particle, inside which they are transcribed to give RNA (-) molecules with which they become base-paired to produce dsRNA genomes.
  4. Mature virions are released by budding.

Host-virus interaction

Host transcription modulation

NF-kappaB 21272652 19576240

Apoptosis modulation

21304825

18471101

21304825

20131002

Matching UniProtKB/Swiss-Prot entries

32 entries grouped by strain (browse by keywords)

All proteins are shown (view only 17 complete proteome entries)

3 entries

Avian infectious bursal disease virus (isolate Chicken/UK/UK661/1989) (IBDV) (Gumboro disease virus) reference strain

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POLS_IBDVUStructural polyprotein (PP)
RDRP_IBDVURNA-directed RNA polymerase (RDRP) (EC 2.7.7.48) (Protein VP1)
VP5_IBDVUProtein VP5

3 entries

Blotched snakehead virus (BSNV) (Channa lucius virus) reference strain

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POLS_BSNVStructural polyprotein (PP)
RDRP_BSNVRNA-directed RNA polymerase (RDRP) (EC 2.7.7.48) (Protein VP1)
VP5_BSNVProtein VP5

3 entries

Drosophila x virus (isolate Chung/1996) (DXV) reference strain

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POLS_DXV96Structural polyprotein (PP)
RDRP_DXV96RNA-directed RNA polymerase (RDRP) (EC 2.7.7.48) (Protein VP1)
VP5_DXV96Protein VP5

3 entries

Infectious pancreatic necrosis virus (strain Jasper) (IPNV) reference strain

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POLS_IPNVJStructural polyprotein (PP)
RDRP_IPNVJRNA-directed RNA polymerase (RDRP) (EC 2.7.7.48) (Protein VP1)
VP5_IPNVJProtein VP5

3 entries

Avian infectious bursal disease virus (strain Chicken/Cuba/Soroa/1998) (IBDV) (Gumboro disease virus)

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POLS_IBDVBStructural polyprotein (PP)
RDRP_IBDVBRNA-directed RNA polymerase (RDRP) (EC 2.7.7.48) (Protein VP1)
VP5_IBDVBProtein VP5

3 entries

Infectious pancreatic necrosis virus (strain Sp) (IPNV)

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POLS_IPNVSStructural polyprotein (PP)
RDRP_IPNVSRNA-directed RNA polymerase (RDRP) (EC 2.7.7.48) (Protein VP1)
VP5_IPNVSProtein VP5

2 entries

Avian infectious bursal disease virus (IBDV) (Gumboro disease virus)

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POLS_IBDVStructural polyprotein (PP)
RDRP_IBDVRNA-directed RNA polymerase (RDRP) (EC 2.7.7.48) (Protein VP1)

2 entries

Avian infectious bursal disease virus (strain 52/70) (IBDV) (Gumboro disease virus)

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POLS_IBDV5Structural polyprotein (PP)
VP5_IBDV5Protein VP5

2 entries

Avian infectious bursal disease virus (strain Australian 002-73) (IBDV) (Gumboro disease virus)

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POLS_IBDVAStructural polyprotein (PP)
RDRP_IBDVARNA-directed RNA polymerase (RDRP) (EC 2.7.7.48) (Protein VP1)

2 entries

Avian infectious bursal disease virus (strain Cu-1) (IBDV) (Gumboro disease virus)

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POLS_IBDVCStructural polyprotein (PP)
VP5_IBDVCProtein VP5

2 entries

Avian infectious bursal disease virus (strain STC) (IBDV) (Gumboro disease virus)

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POLS_IBDVSStructural polyprotein (PP)
VP5_IBDVSProtein VP5

2 entries

Infectious pancreatic necrosis virus (strain N1) (IPNV)

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POLS_IPNVNStructural polyprotein (PP)
VP5_IPNVNProtein VP5

1 entry

Avian infectious bursal disease virus (strain E) (IBDV) (Gumboro disease virus)


POLS_IBDVEStructural polyprotein (PP)

1 entry

Avian infectious bursal disease virus (strain OH) (IBDV) (Gumboro disease virus)


POLS_IBDVOStructural polyprotein (PP)