Varicellovirus

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embedded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 125 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5’ leader sequence of 30-300 bp (not translated), a 3’ non-translated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter.

Transcription occurs in three steps: immediate-early, early and late. The immediate-early genes are transcribed immediately after infection and ensure the transcription of early genes, which encode the proteins necessary for the viral replication. The late genes mostly encode structural proteins.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Innate immune response inhibition

Varicella virus inhibits the cascade leading to production of interferon-beta by targeting host IRF3 protein. Several viral proteins including ORF61, ORF47 and IE62 prevent IRF3 activation and subsequent induction of IFN-beta expression .

Adaptive immune response inhibition

Infected cells show a decrease in MHC class I peptide presentation at the cell surface. Although the mechanism is not fully understood, the ORF66 participates in this process .

Autophagy modulation

Varicella virus does not seem to modulate autophagy that occur in infected cells .

Host shut-off

Varicella-zoster virus IE63 protein represses the basal transcription machinery by disorganizing the pre-initiation complex.

Cell-cycle modulation

The HHV-1 UL24 homolog may inhibit the host cell cycle at the G2/M transition since UL24 from alpha-, beta-, and gammaherpesvirus all inhibit host cell cycle through inactivation of the cyclinB/cdc2 complex .

Apoptosis modulation

The viral protein ORF12 protein triggers phosphorylation of host ERK1/2 and inhibits apoptosis. In neurons, ORF63 also participates in the inhibition of apoptosis .

Host splicing inhibition

VZV IE4 is an alternative splicing regulator of host mRNA. It may act by binding with SR proteins .

Matching UniProtKB/Swiss-Prot entries

364 entries grouped by strain (browse by keywords)

All proteins are shown (view only 238 complete proteome entries)

75 entries

Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) reference strain

Select_all Deselect_all  
AN_EHV1BAlkaline nuclease (EC 3.1.-.-)
CEP1_EHV1BCytoplasmic envelopment protein 1
CEP2_EHV1BCytoplasmic envelopment protein 2
CEP3_EHV1BCytoplasmic envelopment protein 3
CVC1_EHV1BCapsid vertex component 1
CVC2_EHV1BCapsid vertex component 2
DNBI_EHV1BMajor DNA-binding protein
DPOL_EHV1BDNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)
DUT_EHV1BDeoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
EV45_EHV1BEnvelope protein UL45 homolog
GB_EHV1BEnvelope glycoprotein B (gB)
GC_EHV1BEnvelope glycoprotein C (gC) (Glycoprotein 13)
GD_EHV1BEnvelope glycoprotein D (gD) (Glycoprotein 17/18)
GE_EHV1BEnvelope glycoprotein E (gE)
GG_EHV1BEnvelope glycoprotein G (gG)
GH_EHV1BEnvelope glycoprotein H (gH)
GI_EHV1BEnvelope glycoprotein I
GK_EHV1BEnvelope glycoprotein K (Syncytial protein)
GL_EHV1BEnvelope glycoprotein L (gL)
GM_EHV1BEnvelope glycoprotein M (gM)
GN_EHV1BEnvelope glycoprotein N
GP2_EHV1BGlycoprotein gp2 (Glycoprotein X) (GpX)
HELI_EHV1BDNA replication helicase (EC 3.6.4.-)
HEPA_EHV1BDNA helicase/primase complex-associated protein (HEPA) (Primase-associated ...
ICP0_EHV1BE3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (RING-type E3 ubiquitin ...
ICP22_EHV1BTranscriptional regulator ICP22 homolog (IR4 protein) (Immediate-early protein ...
ICP27_EHV1BmRNA export factor ICP27 homolog (Transcriptional regulator IE63 homolog)
ICP4_EHV1BMajor viral transcription factor (155 kDa immediate-early protein)
ITP_EHV1BInner tegument protein
KITH_EHV1BThymidine kinase (EC 2.7.1.21)
LTP_EHV1BLarge tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MB43_EHV1BMembrane protein UL43 homolog (Membrane protein ORF17)
MCP_EHV1BMajor capsid protein (MCP)
NEC1_EHV1BNuclear egress protein 1
NEC2_EHV1BNuclear egress protein 2
NP03_EHV1BNuclear phosphoprotein UL3 homolog (ORF60 protein)
NP04_EHV1BNuclear protein UL4 homolog
OBP_EHV1BReplication origin-binding protein (OriBP) (OBP)
PAP_EHV1BDNA polymerase processivity factor (DNA-binding gene 18 protein) (Polymerase ...
PORTL_EHV1BPortal protein
PRIM_EHV1BDNA primase (EC 2.7.7.-)
RIR1_EHV1BRibonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) ...
RIR2_EHV1BRibonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) ...
SCAF_EHV1BCapsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) ...
SCP_EHV1BSmall capsomere-interacting protein
SHUT_EHV1BVirion host shutoff protein (Vhs) (EC 3.1.27.-)
TEG1_EHV1BTegument protein UL46 homolog (Tegument protein VP11/12 homolog)
TEG3_EHV1BTegument protein UL14 homolog
TEG4_EHV1BTegument protein UL21 homolog
TEG5_EHV1BTegument protein UL47 homolog (GP10)
TEG6_EHV1BTegument protein UL55 homolog
TEG7_EHV1BTegument protein UL51 homolog
TRM1_EHV1BTripartite terminase subunit 1
TRM2_EHV1BTripartite terminase subunit 2
TRM3_EHV1BTripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRX1_EHV1BTriplex capsid protein 1
TRX2_EHV1BTriplex capsid protein 2
UL13_EHV1BSerine/threonine-protein kinase UL13 homolog (EC 2.7.11.1)
UL20_EHV1BProtein UL20 homolog
UL24_EHV1BProtein UL24 homolog
UL32_EHV1BPackaging protein UL32 homolog
UNG_EHV1BUracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
US02_EHV1BGene 68 protein
US03_EHV1BSerine/threonine-protein kinase US3 homolog (EC 2.7.11.1)
US10_EHV1BVirion protein US10 homolog (Gene 66 protein)
US9_EHV1BEnvelope protein US9 homolog (Envelope protein 76) (ORF76 protein)
VG01_EHV1BUncharacterized gene 1 protein
VG02_EHV1BUncharacterized gene 2 protein
VG03_EHV1BGene 3 protein
VG34_EHV1BGene 34 protein
VG59_EHV1BUncharacterized gene 59 protein
VG67_EHV1BUncharacterized gene 67 protein (IR6 protein)
VG75_EHV1BUncharacterized gene 75 protein
VP16_EHV1BTegument protein VP16 homolog (Alpha trans-inducing protein) (Alpha-TIF)
VP22_EHV1BTegument protein VP22 (Gene 11 protein)

69 entries

Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain

Select_all Deselect_all  
AN_VZVDAlkaline nuclease (EC 3.1.-.-)
CEP1_VZVDCytoplasmic envelopment protein 1
CEP2_VZVDCytoplasmic envelopment protein 2
CEP3_VZVDCytoplasmic envelopment protein 3
CVC1_VZVDCapsid vertex component 1
CVC2_VZVDCapsid vertex component 2
DNBI_VZVDMajor DNA-binding protein
DPOL_VZVDDNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)
DUT_VZVDDeoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
GB_VZVDEnvelope glycoprotein B (gB)
GC_VZVDEnvelope glycoprotein C (gC) (Glycoprotein V) (gpV)
GE_VZVDEnvelope glycoprotein E (gE)
GH_VZVDEnvelope glycoprotein H (gH)
GI_VZVDEnvelope glycoprotein I (gI) (Glycoprotein IV) (GPIV)
GK_VZVDEnvelope glycoprotein K (Syncytial protein)
GL_VZVDEnvelope glycoprotein L (gL)
GM_VZVDEnvelope glycoprotein M (gM)
GN_VZVDEnvelope glycoprotein N
HELI_VZVDDNA replication helicase (EC 3.6.4.-)
HEPA_VZVDDNA helicase/primase complex-associated protein (HEPA) (Primase-associated ...
ICP22_VZVDTranscriptional regulator ICP22 homolog (Immediate-early protein 63) (IE63) ...
ICP27_VZVDmRNA export factor ICP27 homolog (Immediate-early protein 4) (IE4) ...
ICP4_VZVDMajor viral transcription factor ICP4 homolog (Immediate-early protein 62) ...
IE61_VZVDE3 ubiquitin-protein ligase IE61 (EC 2.3.2.27) (Immediate-early protein 61) ...
ITP_VZVDInner tegument protein
KITH_VZVDThymidine kinase (EC 2.7.1.21)
LTP_VZVDLarge tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MB43_VZVDMembrane protein UL43 homolog (Membrane protein ORF15)
MCP_VZVDMajor capsid protein (MCP)
NEC1_VZVDNuclear egress protein 1
NEC2_VZVDNuclear egress protein 2
NP03_VZVDNuclear phosphoprotein UL3 homolog (ORF58 protein)
NP04_VZVDNuclear protein UL4 homolog (ORF56 protein)
OBP_VZVDReplication origin-binding protein (OBP) (OriBP)
ORF0_VZVDMembrane protein 0 (Membrane ORF0 protein) (ORF S/L)
ORF1_VZVDStructural protein 1 (Structural ORF1 protein)
ORF2_VZVDMembrane protein 2 (Membrane ORF2 protein)
ORF32_VZVDPhosphoprotein 32 (ORF32 Phosphoprotein)
ORF57_VZVDUncharacterized protein 57 (Uncharacterized ORF57 protein)
PAP_VZVDDNA polymerase processivity factor (DNA-binding gene 16 protein) (Polymerase ...
PORTL_VZVDPortal protein
PRIM_VZVDDNA primase (EC 2.7.7.-)
RIR1_VZVDRibonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) ...
RIR2_VZVDRibonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) ...
SCAF_VZVDCapsid scaffolding protein (Protease precursor) (pPR)
SCP_VZVDSmall capsomere-interacting protein
SHUT_VZVDVirion host shutoff protein (Vhs) (EC 3.1.27.-)
TEG1_VZVDTegument protein UL46 homolog (Tegument protein VP11/12 homolog)
TEG3_VZVDTegument protein UL14 homolog
TEG4_VZVDTegument protein UL21 homolog
TEG5_VZVDTegument protein UL47 homolog
TEG6_VZVDTegument protein UL55 homolog
TEG7_VZVDTegument protein UL51 homolog (ORF7 protein)
TRM1_VZVDTripartite terminase subunit 1
TRM2_VZVDTripartite terminase subunit 2
TRM3_VZVDTripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRX1_VZVDTriplex capsid protein 1
TRX2_VZVDTriplex capsid protein 2
TYSY_VZVDThymidylate synthase (TS) (TSase) (EC 2.1.1.45)
UL13_VZVDSerine/threonine-protein kinase UL13 homolog (Protein kinase ORF47) (EC ...
UL20_VZVDProtein UL20 homolog (Gene 39 membrane protein)
UL24_VZVDProtein UL24 homolog
UL32_VZVDPackaging protein UL32
UNG_VZVDUracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
US03_VZVDSerine/threonine-protein kinase US3 homolog (Protein kinase ORF66) (EC 2.7.11.1)
US10_VZVDVirion protein US10 homolog (Genes 64/69 protein)
US9_VZVDEnvelope protein US9 (Envelope protein 65) (ORF65 protein)
VP16_VZVDTegument protein VP16 homolog (Alpha trans-inducing protein) (Alpha-TIF) (ORF10 ...
VP22_VZVDTegument protein VP22 (ORF9 protein) (Tegument protein 9)

46 entries

Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3) reference strain


ORF0_VZVOMembrane protein 0 (Membrane ORF0 protein) (ORF S/L)

47 entries

Equine herpesvirus 1 (strain V592) (EHV-1) (Equine abortion virus)

Select_all Deselect_all  
AN_EHV1VAlkaline nuclease (EC 3.1.-.-)
CEP1_EHV1VCytoplasmic envelopment protein 1
CEP2_EHV1VCytoplasmic envelopment protein 2
CEP3_EHV1VCytoplasmic envelopment protein 3
CVC2_EHV1VCapsid vertex component 2
DNBI_EHV1VMajor DNA-binding protein
DPOL_EHV1VDNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)
GB_EHV1VEnvelope glycoprotein B (gB)
GG_EHV1VEnvelope glycoprotein G (gG)
GL_EHV1VEnvelope glycoprotein L (gL)
GN_EHV1VEnvelope glycoprotein N
GP2_EHV1VGlycoprotein gp2 (Glycoprotein X) (GpX)
HELI_EHV1VDNA replication helicase (EC 3.6.4.-)
HEPA_EHV1VDNA helicase/primase complex-associated protein (HEPA) (Primase-associated ...
ICP0_EHV1VE3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Infected cell protein 0) ...
ICP4_EHV1VMajor viral transcription factor ICP4 homolog (155 kDa immediate-early protein)
ITP_EHV1VInner tegument protein
MB43_EHV1VMembrane protein UL43 homolog (Membrane protein ORF17)
MCP_EHV1VMajor capsid protein (MCP)
NEC2_EHV1VNuclear egress protein 2
NP03_EHV1VNuclear phosphoprotein UL3 homolog (ORF60 protein)
NP04_EHV1VNuclear protein UL4 homolog
OBP_EHV1VReplication origin-binding protein (OBP) (OriBP)
PAP_EHV1VDNA polymerase processivity factor (Polymerase accessory protein) (PAP)
PORTL_EHV1VPortal protein
PRIM_EHV1VDNA primase (EC 2.7.7.-)
SCAF_EHV1VCapsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR)
SCP_EHV1VSmall capsomere-interacting protein
SHUT_EHV1VVirion host shutoff protein (Vhs) (EC 3.1.27.-)
TEG1_EHV1VTegument protein UL46 homolog (Tegument protein VP11/12 homolog)
TEG3_EHV1VTegument protein UL14 homolog
TEG4_EHV1VTegument protein UL21 homolog
TEG5_EHV1VTegument protein UL47 homolog (GP10)
TRM1_EHV1VTripartite terminase subunit 1
TRM3_EHV1VTripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRX1_EHV1VTriplex capsid protein 1
UL13_EHV1VSerine/threonine-protein kinase UL13 homolog (EC 2.7.11.1)
UL20_EHV1VProtein UL20 homolog
UL24_EHV1VProtein UL24 homolog
UNG_EHV1VUracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
US03_EHV1VSerine/threonine-protein kinase US3 homolog (EC 2.7.11.1)
US10_EHV1VVirion protein US10 homolog (Gene 66 protein)
US9_EHV1VEnvelope protein US9 homolog (Envelope protein 76) (ORF76 protein)
VG01_EHV1VUncharacterized gene 1 protein
VG03_EHV1VGene 3 protein
VG59_EHV1VUncharacterized gene 59 protein
VG75_EHV1VUncharacterized gene 75 protein

46 entries

Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)

Select_all Deselect_all  
AN_VZVOAlkaline nuclease (EC 3.1.-.-)
CEP3_VZVOCytoplasmic envelopment protein 3
DNBI_VZVOMajor DNA-binding protein
DPOL_VZVODNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)
DUT_VZVODeoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
GB_VZVOEnvelope glycoprotein B (gB)
GE_VZVOEnvelope glycoprotein E (gE)
GH_VZVOEnvelope glycoprotein H (gH)
GI_VZVOEnvelope glycoprotein I (gI) (Glycoprotein IV) (GPIV)
GK_VZVOEnvelope glycoprotein K (Syncytial protein)
GL_VZVOEnvelope glycoprotein L (gL)
GM_VZVOEnvelope glycoprotein M (gM)
GN_VZVOEnvelope glycoprotein N
HELI_VZVODNA replication helicase (EC 3.6.4.-)
HEPA_VZVODNA helicase/primase complex-associated protein (HEPA) (Primase-associated ...
ICP22_VZVOTranscriptional regulator ICP22 homolog (Immediate-early protein 63) (IE63) ...
ICP27_VZVOmRNA export factor ICP27 homolog (Immediate-early protein 4) (IE4)
ICP4_VZVOMajor viral transcription factor ICP4 homolog (Immediate-early protein 62) ...
KITH_VZVOThymidine kinase (EC 2.7.1.21)
LTP_VZVOLarge tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MB43_VZVOMembrane protein UL43 homolog (Membrane protein ORF15)
NP03_VZVONuclear phosphoprotein UL3 homolog (ORF58 protein)
NP04_VZVONuclear protein UL4 homolog (ORF56 protein)
OBP_VZVOReplication origin-binding protein (OBP) (OriBP)
ORF1_VZVOStructural protein 1 (Structural ORF1 protein)
ORF2_VZVOMembrane protein 2 (Membrane ORF2 protein)
ORF32_VZVOPhosphoprotein 32 (ORF32 Phosphoprotein)
ORF57_VZVOUncharacterized protein 57 (Uncharacterized ORF57 protein)
PAP_VZVODNA polymerase processivity factor (DNA-binding gene 16 protein) (Polymerase ...
PRIM_VZVODNA primase (EC 2.7.7.-)
RIR1_VZVORibonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) ...
RIR2_VZVORibonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) ...
TEG1_VZVOTegument protein UL46 homolog (Tegument protein VP11/12 homolog)
TEG3_VZVOTegument protein UL14 homolog
TEG4_VZVOTegument protein UL21 homolog
TEG5_VZVOTegument protein UL47 homolog
TEG6_VZVOTegument protein UL55 homolog
TEG7_VZVOTegument protein UL51 homolog (ORF7 protein)
TYSY_VZVOThymidylate synthase (TS) (TSase) (EC 2.1.1.45)
UL13_VZVOSerine/threonine-protein kinase UL13 homolog (Protein kinase ORF47) (EC ...
UL24_VZVOProtein UL24 homolog
UNG_VZVOUracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
US9_VZVOEnvelope protein US9 (Envelope protein 65) (ORF65 protein)
VP16_VZVOTegument protein VP16 homolog (Alpha trans-inducing protein) (Alpha-TIF) (ORF10 ...
VP22_VZVOTegument protein VP22 (ORF9 protein) (Tegument protein 9)

19 entries

Suid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain Kaplan))

Select_all Deselect_all  
DUT_SUHVKDeoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
GH_SUHVKEnvelope glycoprotein H (gH)
GK_SUHVKEnvelope glycoprotein K (Syncytial protein)
GL_SUHVKEnvelope glycoprotein L (gL)
GM_SUHVKEnvelope glycoprotein M (gM)
GN_SUHVKEnvelope glycoprotein N
ICP22_SUHVKTranscriptional regulator ICP22 homolog (Immediate-early protein RSP40)
ICP27_SUHVKmRNA export factor ICP27 homolog (Protein UL54)
ICP4_SUHVKMajor viral transcription factor ICP4 homolog
KR1_SUHVKSerine/threonine-protein kinase (EC 2.7.11.1)
PAP_SUHVKDNA polymerase processivity factor (Polymerase accessory protein) (PAP) (UL42 ...
PRIM_SUHVKDNA primase (EC 2.7.7.-)
RIR1_SUHVKRibonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) ...
RIR2_SUHVKRibonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) ...
SCAF_SUHVKCapsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) ...
SHUT_SUHVKVirion host shutoff protein (Vhs) (EC 3.1.27.-)
TEG7_SUHVKTegument protein UL51
UNG_SUHVKUracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
VNUA_SUHVKProbable nuclear antigen

17 entries

Equine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus)

Select_all Deselect_all  
DUT_EHV4Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
EV45_EHV4Envelope protein UL45 homolog
GB_EHV4Envelope glycoprotein B (gB)
GC_EHV4Envelope glycoprotein C (Glycoprotein 13)
GG_EHV4Envelope glycoprotein G (gG)
GH_EHV4Envelope glycoprotein H (gH)
KITH_EHV4Thymidine kinase (EC 2.7.1.21)
RIR1_EHV4Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) ...
RIR2_EHV4Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) ...
TEG1_EHV4Tegument protein UL46 homolog (Tegument protein VP11/12 homolog)
TEG5_EHV4Tegument protein UL47 homolog (GP10)
TEG7_EHV4Tegument protein UL51 homolog
UL24_EHV4Protein UL24 homolog
US10_EHV4Virion protein US10 homolog (ORF3)
US9_EHV4Envelope protein US9 homolog (Envelope protein 76) (ORF76 protein)
VP16_EHV4Tegument protein VP16 homolog (Alpha trans-inducing protein) (Alpha-TIF)
VP22_EHV4Tegument protein VP22 (Gene 11 protein)

14 entries

Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)

Select_all Deselect_all  
GB_BHV1CEnvelope glycoprotein B (gB)
GC_BHV1CEnvelope glycoprotein C homolog (Glycoprotein GIII)
GD_BHV1CEnvelope glycoprotein D (gD) (Glycoprotein IV)
GH_BHV1CEnvelope glycoprotein H (gH)
GM_BHV1CEnvelope glycoprotein M (gM)
GN_BHV1CEnvelope glycoprotein N
HEPA_BHV1CDNA helicase/primase complex-associated protein (HEPA) (Primase-associated ...
OBP_BHV1CReplication origin-binding protein (OriBP) (OBP)
RIR1_BHV1CRibonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) ...
RIR2_BHV1CRibonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) ...
SCAF_BHV1CCapsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR)
TEG5_BHV1CTegument protein UL47
UNG_BHV1CUracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
VP22_BHV1CTegument protein VP22

14 entries

Equine herpesvirus 1 (strain Kentucky A) (EHV-1) (Equine abortion virus)

Select_all Deselect_all  
GD_EHV1KEnvelope glycoprotein D (gD) (Glycoprotein 17/18)
GG_EHV1KEnvelope glycoprotein G (gG)
GK_EHV1KEnvelope glycoprotein K (Syncytial protein)
GP2_EHV1KGlycoprotein gp2 (Glycoprotein X) (GpX)
ICP22_EHV1KTranscriptional regulator ICP22 homolog (IR4 protein) (Immediate-early protein ...
ICP27_EHV1KmRNA export factor ICP27 homolog (Transcriptional regulator IE63 homolog)
ICP4_EHV1KMajor viral transcription factor (155 kDa immediate-early protein)
KR1_EHV1KSerine/threonine-protein kinase (EC 2.7.11.1)
TEG6_EHV1KTegument protein UL55 homolog
US02_EHV1KUS1 protein
US10_EHV1KVirion protein US10 homolog (Gene 66 protein) (IR5 protein) (ORF S2-1)
US9_EHV1KEnvelope protein US9 homolog (Envelope protein 76) (ORF76 protein)
VG03_EHV1KGene 3 protein (ORF L1)
VG67_EHV1KUncharacterized gene 67 protein (IR6 protein)

8 entries

Bovine herpesvirus 1.2 (strain ST) (BoHV-1) (Infectious bovine rhinotracheitis virus)

Select_all Deselect_all  
GD_BHV1SEnvelope glycoprotein D (gD) (Glycoprotein IV)
GE_BHV1SEnvelope glycoprotein E (gE)
GI_BHV1SEnvelope glycoprotein I (gI)
US02_BHV1SProtein US2 homolog
US03_BHV1SSerine/threonine-protein kinase US3 homolog (EC 2.7.11.1)
US9_BHV1SEnvelope protein US9
VGLX_BHV1SGlycoprotein GX
YOR1_BHV1SUncharacterized 16.1 kDa protein (ORF1)

8 entries

Suid herpesvirus 1 (strain Indiana-Funkhauser / Becker) (SuHV-1) (Pseudorabies virus (strain Indiana-Funkhauser / Becker))

Select_all Deselect_all  
DNBI_SUHVFMajor DNA-binding protein
GB_SUHVFEnvelope glycoprotein B (gB)
GC_SUHVFEnvelope glycoprotein C homolog (Glycoprotein GIII)
GL_SUHVFEnvelope glycoprotein L (gL)
ICP0_SUHVFE3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Early protein 0) (EP0) ...
ICP4_SUHVFMajor viral transcription factor ICP4 homolog
TRM1_SUHVFTripartite terminase subunit 1
UNG_SUHVFUracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)

8 entries

Suid herpesvirus 1 (strain NIA-3) (SuHV-1) (Pseudorabies virus (strain NIA-3))

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GH_SUHVNEnvelope glycoprotein H (gH)
KITH_SUHVNThymidine kinase (EC 2.7.1.21)
TEG3_SUHVNTegument protein UL14
TEG4_SUHVNTegument protein UL21
UL13_SUHVNSerine/threonine-protein kinase UL13 (EC 2.7.11.1)
UL20_SUHVNProtein UL20
US02_SUHVNProtein US2 homolog (28 kDa protein)
US03_SUHVNSerine/threonine-protein kinase US3 homolog (EC 2.7.11.1)

6 entries

Equine herpesvirus 1 (strain Kentucky D) (EHV-1) (Equine abortion virus)

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EV45_EHV1DEnvelope protein UL45 homolog
GB_EHV1DEnvelope glycoprotein B (gB)
GC_EHV1DEnvelope glycoprotein C (gC) (Glycoprotein 13)
GD_EHV1DEnvelope glycoprotein D (gD) (Glycoprotein 17/18)
GE_EHV1DEnvelope glycoprotein E (gE)
GI_EHV1DEnvelope glycoprotein I (gI)

6 entries

Suid herpesvirus 1 (strain Rice) (SuHV-1) (Pseudorabies virus (strain Rice))

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GD_SUHVREnvelope glycoprotein D (gD) (Protein gp50)
GE_SUHVREnvelope glycoprotein E (gE)
GG_SUHVREnvelope glycoprotein G (gG)
GH_SUHVREnvelope glycoprotein H (gH)
GI_SUHVREnvelope glycoprotein I (Glycoprotein GP63)
US9_SUHVREnvelope protein US9 homolog (11 kDa protein)

5 entries

Equine herpesvirus 1 (strain AB1) (EHV-1) (Equine abortion virus)

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GB_EHV1AEnvelope glycoprotein B (gB)
GD_EHV1AEnvelope glycoprotein D (gD) (Glycoprotein 17/18)
GE_EHV1AEnvelope glycoprotein E (gE)
GI_EHV1AEnvelope glycoprotein I
UL32_EHV1APackaging protein UL32 homolog (Glycoprotein 300) (GP300)

5 entries

Equine herpesvirus 1 (strain HVS25A) (EHV-1) (Equine abortion virus)

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GB_EHV1Envelope glycoprotein B (gB)
GH_EHV1Envelope glycoprotein H (gH)
KITH_EHV1Thymidine kinase (EC 2.7.1.21)
TRM1_EHV1Tripartite terminase subunit 1
UL24_EHV1Protein UL24 homolog

4 entries

Bovine herpesvirus 1.1 (strain P8-2) (BoHV-1) (Infectious bovine rhinotracheitis virus)

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GB_BHV1PEnvelope glycoprotein B (gB)
GD_BHV1PEnvelope glycoprotein D (gD) (Glycoprotein IV)
TEG5_BHV1PTegument protein UL47
VP16_BHV1PTegument protein VP16 homolog (Alpha trans-inducing protein) (Alpha-TIF)

4 entries

Cercopithecine herpesvirus 9 (strain DHV) (CeHV-9) (Simian varicella virus)

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GE_CHV9DEnvelope glycoprotein E (Membrane glycoprotein 2) (gE)
GI_CHV9DEnvelope glycoprotein I (Membrane glycoprotein 1)
US03_CHV9DSerine/threonine-protein kinase US3 homolog (EC 2.7.11.1)
US9_CHV9DEnvelope protein US9 homolog (Envelope protein 65) (ORF65 protein)

2 entries

Feline herpesvirus 1 (FeHV-1) (Feline viral rhinotracheitis virus)

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GH_FHV1Envelope glycoprotein H (gH)
KITH_FHV1Thymidine kinase (EC 2.7.1.21)

1 entry

Bovine herpesvirus 1 (strain 6660) (BoHV-1) (Infectious bovine rhinotracheitis virus)


KITH_BHV16Thymidine kinase (EC 2.7.1.21)

1 entry

Bovine herpesvirus 1.1 (strain Jura) (BoHV-1) (Infectious bovine rhinotracheitis virus)


ICP0_BHV1JE3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (IER 2.9/ER2.6) (P135 protein) ...

1 entry

Bovine herpesvirus 1.2 (strain K22) (BoHV-1) (Infectious bovine rhinotracheitis virus)


ICP0_BHV1KE3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (IER 2.9/ER2.6) (P135 protein) ...

1 entry

Bovine herpesvirus 1.2 (strain Q3932) (BoHV-1) (Infectious bovine rhinotracheitis virus)


KITH_BHV1QThymidine kinase (EC 2.7.1.21)

1 entry

Bovine herpesvirus 5 (strain N569) (BoHV-5) (Bovine encephalitis herpesvirus)


KITH_BHV5Thymidine kinase (EC 2.7.1.21)

1 entry

Equine herpesvirus 1 (strain HH1) (EHV-1) (Equine abortion virus)


VG01_EHV1HUncharacterized gene 1 protein

1 entry

Suid herpesvirus 1 (strain Indiana S) (SuHV-1) (Pseudorabies virus (strain Indiana S))


MCP_SUHVSMajor capsid protein (MCP)