Gammaherpesvirinae

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter,T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embeded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 180 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5’ leader sequence of 30-300 bp (not translated), a 3’ nontranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Adaptive immune response inhibition

Gamma-herpesviruses have evolved different strategies to inhibit the host adaptive immune response. For example, the EHV-2 viral interleukin-10 homolog down-regulates the expression of the TAP1 gene (transporter associated with antigen processing), thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.

Apoptosis modulation

Apoptosis is very often modulated (and usually inhibited) by gamma-herpesviruses. For example, Epstein-Barr, HHV-8 or AlHV-1 all possess a viral homologue of the Bcl-2 oncogene that is able to protect cells from induced apoptosis.

Autophagy modulation

Several gamma-herpesviruses are able to inhibit host autophagy process, via interaction of vBcl-2 and vFLIP with host Beclin 1 and Atg3 respectively, that impact two stages of autophagy.

Cell-cycle modulation

The UL24 protein that is present in all herpesvirus subfamilies (alpha, beta and gamma-herpesviruses) induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex .

Innate immune response inhibition

Herpes viruses inhibit the cascade leading to production of interferon-beta by mainly targeting the host IRF3 protein. EBV inhibits the cascade leading to production of interferon-beta by targeting host IRF3 protein with the BGLF4 protein kinase that directly interacts with and inhibits host IRF3. BRLF1 expression also decreases induction of IFN-beta, and reduces expression of IRF3 and IRF7.

Host splicing inhibition

Modulates the host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing .

Matching UniProtKB/Swiss-Prot entries

520 entries grouped by strain (browse by keywords)

All proteins are shown (view only 498 complete proteome entries)

85 entries

Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

Select_all Deselect_all  
AN_HHV8PShutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
ARBH_HHV8PApoptosis regulator Bcl-2 homolog
CEP1_HHV8PCytoplasmic envelopment protein 1
CEP2_HHV8PCytoplasmic envelopment protein 2
CEP3_HHV8PCytoplasmic envelopment protein 3
CVC1_HHV8PCapsid vertex component 1
CVC2_HHV8PCapsid vertex component 2
DNBI_HHV8PMajor DNA-binding protein
DPOL_HHV8PDNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)
DUT_HHV8PDeoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
DYR_HHV8PPutative Dihydrofolate reductase (EC 1.5.1.3)
GB_HHV8PEnvelope glycoprotein B (gB)
GH_HHV8PEnvelope glycoprotein H (gH)
GL_HHV8PEnvelope glycoprotein L (gL)
GM_HHV8PEnvelope glycoprotein M (gM)
GN_HHV8PEnvelope glycoprotein N
HELI_HHV8PDNA replication helicase (EC 3.6.4.-)
HEPA_HHV8PDNA helicase/primase complex-associated protein (HEPA) (Primase-associated ...
ICP27_HHV8PmRNA export factor ICP27 homolog (EB2 protein homolog)
ITP_HHV8PInner tegument protein
K12_HHV8PProtein K12
K15_HHV8PProtein K15
K1_HHV8PProtein K1
K42_HHV8PProtein K4.2
K6_HHV8PProtein K6
K7_HHV8PProtein K7
K81_HHV8PProtein K8.1
KBZIP_HHV8PE3 SUMO-protein ligase K-bZIP (EC 6.3.2.-)
KITH_HHV8PThymidine kinase (EC 2.7.1.21)
LTP_HHV8PLarge tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MCP_HHV8PMajor capsid protein (MCP)
MIR1_HHV8PE3 ubiquitin-protein ligase MIR1 (EC 2.3.2.27) (IE1B protein) (Modulator of ...
MIR2_HHV8PE3 ubiquitin-protein ligase MIR2 (EC 2.3.2.27) (IE1A protein) (Modulator of ...
NEC1_HHV8PNuclear egress protein 1
NEC2_HHV8PNuclear egress protein 2
ORF10_HHV8PProtein ORF10
ORF11_HHV8PProtein ORF11
ORF23_HHV8PProtein ORF23
ORF24_HHV8PProtein ORF24
ORF27_HHV8PProtein ORF27
ORF28_HHV8PProtein ORF28
ORF30_HHV8PProtein ORF30
ORF35_HHV8PProtein ORF35
ORF36_HHV8PProtein ORF36 (EC 2.7.-.-)
ORF45_HHV8PProtein ORF45
ORF48_HHV8PTegument protein ORF48
ORF49_HHV8PProtein ORF49
ORF4_HHV8PComplement control protein (KCP)
ORF50_HHV8PPutative transcription activator ORF50
ORF52_HHV8PTegument protein ORF52
ORF58_HHV8PProtein ORF58
ORF73_HHV8PProtein ORF73
ORF75_HHV8PProtein ORF75
OX2V_HHV8POX-2 membrane glycoprotein homolog (Viral OX2) (vOX2)
PAP_HHV8PDNA polymerase processivity factor
PORTL_HHV8PPortal protein
PRIM_HHV8PDNA primase (EC 2.7.7.-)
RIR1_HHV8PRibonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) ...
RIR2_HHV8PRibonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) ...
SCAF_HHV8PCapsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR)
SCP_HHV8PSmall capsomere-interacting protein
TEG7_HHV8PTegument protein ORF55
TRM1_HHV8PTripartite terminase subunit 1
TRM2_HHV8PTripartite terminase subunit 2
TRM3_HHV8PTripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRX1_HHV8PTriplex capsid protein 1
TRX2_HHV8PTriplex capsid protein 2
TYSY_HHV8PThymidylate synthase (TS) (TSase) (EC 2.1.1.45)
UL24_HHV8PProtein UL24 homolog
UL32_HHV8PPackaging protein UL32 homolog
UL49_HHV8PProtein ORF66
UL79_HHV8PProtein UL79 homolog
UL92_HHV8PProtein ORF31
UL95_HHV8PProtein UL95 homolog
UNG_HHV8PUracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
VCCL3_HHV8PProtein vCCL3
VCYCL_HHV8Pviral cyclin homolog (v-cyclin)
VFLIP_HHV8PViral FLICE protein (vFLIP)
VGPCR_HHV8Pviral G-protein coupled receptor (vGPCR) (Protein ORF74)
VIL6_HHV8PViral interleukin-6 homolog (vIL-6)
VIRF1_HHV8PVIRF-1
VIRF2_HHV8PViral IRF2-like protein (vIRF-2)
VIRF3_HHV8PViral IRF3-like protein (VIRF-3)
VIRF4_HHV8PViral IRF4-like protein (vIRF-4)
VMI2_HHV8PViral macrophage inflammatory protein 2 (Viral macrophage inflammatory protein ...

79 entries

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Select_all Deselect_all  
AN_EBVB9Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
BALF1_EBVB9Apoptosis regulator BALF1
BARF1_EBVB9Secreted protein BARF1 (33 kDa early protein) (p33)
BDLF2_EBVB9Protein BDLF2
BDLF3_EBVB9Glycoprotein BDLF3
BFRF2_EBVB9Uncharacterized protein BFRF2
BHLF1_EBVB9Uncharacterized protein BHLF1
BILF1_EBVB9G-protein coupled receptor BILF1
BILF2_EBVB9Glycoprotein BILF2
BKRF4_EBVB9Tegument protein BKRF4
BLLF2_EBVB9Uncharacterized protein BLLF2
BLRF2_EBVB9Tegument protein BLRF2
BMRF2_EBVB9Protein BMRF2
BNL2A_EBVB9Protein BNLF2a
BNL2B_EBVB9Uncharacterized protein BNLF2b
BRRF1_EBVB9Transcriptional activator BRRF1
BRRF2_EBVB9Tegument protein BRRF2
BTRF1_EBVB9Uncharacterized protein BTRF1
BZLF1_EBVB9Trans-activator protein BZLF1 (EB1) (Zebra)
CEP1_EBVB9Cytoplasmic envelopment protein 1
CEP2_EBVB9Cytoplasmic envelopment protein 2
CEP3_EBVB9Cytoplasmic envelopment protein 3
CVC1_EBVB9Capsid vertex component 1
CVC2_EBVB9Capsid vertex component 2
DNBI_EBVB9Major DNA-binding protein
DPOL_EBVB9DNA polymerase catalytic subunit (EC 2.7.7.7)
DUT_EBVB9Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
EAD_EBVB9DNA polymerase processivity factor BMRF1 (Early antigen protein D) (EA-D) ...
EAR_EBVB9Apoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)
EBNA1_EBVB9Epstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1)
EBNA2_EBVB9Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)
EBNA3_EBVB9Epstein-Barr nuclear antigen 3 (EBNA-3) (EBV nuclear antigen 3) (Epstein-Barr ...
EBNA4_EBVB9Epstein-Barr nuclear antigen 4 (EBNA-4) (EBV nuclear antigen 4) (Epstein-Barr ...
EBNA5_EBVB9Epstein-Barr nuclear antigen leader protein (EBNA-LP) (EBV nuclear antigen ...
EBNA6_EBVB9Epstein-Barr nuclear antigen 6 (EBNA-6) (EBV nuclear antigen 6) (Epstein-Barr ...
GB_EBVB9Envelope glycoprotein B (gB)
GH_EBVB9Envelope glycoprotein H (gH)
GL_EBVB9Envelope glycoprotein L (gL)
GM_EBVB9Envelope glycoprotein M (gM)
GN_EBVB9Envelope glycoprotein N
GP350_EBVB9Envelope glycoprotein GP350 (Membrane antigen) (MA)
GP42_EBVB9Glycoprotein 42 (gp42)
HELI_EBVB9DNA replication helicase (EC 3.6.4.-)
ICP27_EBVB9mRNA export factor ICP27 homolog (Mta) (ORF57 protein homolog) (Protein SM)
IL10H_EBVB9Viral interleukin-10 homolog (vIL-10) (20 kDa protein) (Protein BCRF1)
ITP_EBVB9Inner tegument protein
KITH_EBVB9Thymidine kinase (EC 2.7.1.21)
KR2_EBVB9Serine/threonine-protein kinase BGLF4 (EC 2.7.11.1)
LF1_EBVB9Uncharacterized LF1 protein
LF2_EBVB9Protein LF2
LF3_EBVB9Uncharacterized protein LF3
LMP1_EBVB9Latent membrane protein 1 (LMP-1) (Protein p63)
LMP2_EBVB9Latent membrane protein 2 (Terminal protein)
LTP_EBVB9Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MCP_EBVB9Major capsid protein (MCP)
MTP_EBVB9Major tegument protein (MTP) (Protein p140)
NEC1_EBVB9Nuclear egress protein 1
NEC2_EBVB9Nuclear egress protein 2
PORTL_EBVB9Portal protein
PRIM_EBVB9DNA primase (EC 2.7.7.-)
RIR1_EBVB9Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) ...
RIR2_EBVB9Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) ...
RPMS1_EBVB9Uncharacterized protein RPMS1
RTA_EBVB9Replication and transcription activator (Rta) (Immediate-early protein Rta)
SCAF_EBVB9Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) ...
SCP_EBVB9Small capsomere-interacting protein
TEG7_EBVB9Tegument protein UL51 homolog
TRM1_EBVB9Tripartite terminase subunit 1
TRM3_EBVB9Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRX1_EBVB9Triplex capsid protein 1
TRX2_EBVB9Triplex capsid protein 2
UL24_EBVB9Protein UL24 homolog
UL32_EBVB9Packaging protein UL32 homolog
UL87_EBVB9TBP-like protein BcRF1
UL92_EBVB9Uncharacterized protein BDLF4
UL95_EBVB9Protein BGLF3
UNG_EBVB9Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
YBL2_EBVB9Uncharacterized protein BBLF2
YEC4_EBVB9Uncharacterized protein EC-RF4

75 entries

Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Select_all Deselect_all  
AN_SHV21Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
BRLF1_SHV21Putative transcription activator BRLF1 homolog (Transcription activator EDRF1)
CCPH_SHV21Complement control protein homolog (CCPH)
CD59_SHV21Surface glycoprotein CD59 homolog
CEP1_SHV21Cytoplasmic envelopment protein 1
CEP2_SHV21Cytoplasmic envelopment protein 2
CEP3_SHV21Cytoplasmic envelopment protein 3
CGH2_SHV21Cyclin homolog (V-cyclin)
CVC1_SHV21Capsid vertex component 1
CVC2_SHV21Capsid vertex component 2
DNBI_SHV21Major DNA-binding protein
DPOL_SHV21DNA polymerase catalytic subunit (EC 2.7.7.7)
DUT_SHV21Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
DYR_SHV21Viral dihydrofolate reductase (vDHFR) (EC 1.5.1.3)
GB_SHV21Envelope glycoprotein B (gB)
GCVK_SHV21Probable ganciclovir kinase (EC 2.7.1.-)
GH_SHV21Envelope glycoprotein H (gH)
GL_SHV21Envelope glycoprotein L (gL)
GM_SHV21Envelope glycoprotein M (gM)
GN_SHV21Envelope glycoprotein N
HELI_SHV21DNA replication helicase (EC 3.6.4.-)
ICP22_SHV21Transcriptional regulator ICP22 homolog (Immediate-early protein)
ICP27_SHV21mRNA export factor ICP27 homolog (52 kDa immediate-early phosphoprotein) (EB2 ...
IL17_SHV21Viral interleukin-17 (vIL-17) (Immediate early gene 13 protein)
ITP_SHV21Inner tegument protein
KITH_SHV21Thymidine kinase (EC 2.7.1.21)
LTP_SHV21Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MCP_SHV21Major capsid protein (MCP)
NEC1_SHV21Nuclear egress protein 1
NEC2_SHV21Nuclear egress protein 2
PORTL_SHV21Portal protein
PRIM_SHV21DNA primase (EC 2.7.7.-)
RIR1_SHV21Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) ...
RIR2_SHV21Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) ...
SCAF_SHV21Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR)
SCP_SHV21Small capsomere-interacting protein
TEG7_SHV21Gene 55 protein
TRM1_SHV21Tripartite terminase subunit 1
TRM3_SHV21Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRX1_SHV21Triplex capsid protein 1
TRX2_SHV21Triplex capsid protein 2
TSTP_SHV21Transforming protein STP
TYSY_SHV21Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
UL24_SHV21Protein UL24 homolog
UL32_SHV21Packaging protein UL32
UL49_SHV21Uncharacterized gene 66 protein
UL79_SHV21Gene 18 protein
UL87_SHV21Gene 24 protein
UL91_SHV21Uncharacterized gene 30 protein
UL92_SHV21Gene 31 protein
UL95_SHV21Gene 34 protein
UL96_SHV21Gene 35 protein
UNG_SHV21Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
VG05_SHV21Uncharacterized gene 5 protein
VG10_SHV21Uncharacterized gene 10 protein
VG11_SHV21Uncharacterized gene 11 protein
VG12_SHV21Uncharacterized gene 12 protein
VG16_SHV21Bcl-2-like gene 16 protein
VG23_SHV21Uncharacterized gene 23 protein
VG27_SHV21Uncharacterized gene 27 protein
VG28_SHV21Uncharacterized gene 28 protein
VG40_SHV21Uncharacterized gene 40 protein
VG41_SHV21Uncharacterized gene 41 protein
VG45_SHV21Uncharacterized gene 45 protein
VG48_SHV21Uncharacterized gene 48 protein
VG49_SHV21Uncharacterized gene 49 protein
VG51_SHV21Gene 51 glycoprotein
VG52_SHV21Uncharacterized gene 52 protein
VG58_SHV21Gene 58 protein
VG59_SHV21Gene 59 protein
VG71_SHV21Uncharacterized gene 71 protein
VG74_SHV21G-protein coupled receptor homolog ECRF3
VIEG_SHV21Immediate-early protein IE-G
VP03_SHV21Probable membrane antigen 3 (Tegument protein)
VP75_SHV21Probable membrane antigen 75 (Tegument protein)

74 entries

Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

Select_all Deselect_all  
AN_EHV2Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
BRLF1_EHV2Putative transcription activator BRLF1 homolog
CEP1_EHV2Cytoplasmic envelopment protein 1
CEP2_EHV2Cytoplasmic envelopment protein 2
CEP3_EHV2Cytoplasmic envelopment protein 3
CFLA_EHV2Viral CASP8 and FADD-like apoptosis regulator (v-CFLAR) (Viral FLICE-inhibitory ...
CVC1_EHV2Capsid vertex component 1
CVC2_EHV2Capsid vertex component 2
DNBI_EHV2Major DNA-binding protein
DPOL_EHV2DNA polymerase catalytic subunit (EC 2.7.7.7)
DUT_EHV2Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
GB_EHV2Envelope glycoprotein B (gB)
GH_EHV2Envelope glycoprotein H (gH)
GL_EHV2Envelope glycoprotein L (gL)
GM_EHV2Envelope glycoprotein M (gM)
GN_EHV2Envelope glycoprotein N
HELI_EHV2DNA replication helicase (EC 3.6.4.-)
HEPA_EHV2DNA helicase/primase complex-associated protein (HEPA) (Primase-associated ...
IE63_EHV2Immediate-early phosphoprotein 57
IL10H_EHV2Viral interleukin-10 homolog (vIL-10)
ITP_EHV2Inner tegument protein
KITH_EHV2Thymidine kinase (EC 2.7.1.21)
LTP_EHV2Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MCP_EHV2Major capsid protein (MCP)
NEC1_EHV2Nuclear egress protein 1
NEC2_EHV2Nuclear egress protein 2
PORTL_EHV2Portal protein
PRIM_EHV2DNA primase (EC 2.7.7.-)
RIR1_EHV2Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) ...
RIR2_EHV2Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) ...
SCAF_EHV2Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR)
SCP_EHV2Small capsomere-interacting protein
TEG7_EHV2Tegument protein UL51 homolog
TRM1_EHV2Tripartite terminase subunit 1
TRM2_EHV2Tripartite terminase subunit 2
TRM3_EHV2Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRX1_EHV2Triplex capsid protein 1
TRX2_EHV2Triplex capsid protein 2
TYSY_EHV2Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
UL24_EHV2Protein UL24 homolog
UL32_EHV2Packaging protein UL32 homolog
UL49_EHV2Uncharacterized gene 66 protein
UL79_EHV2Gene 18 protein
UL87_EHV2Gene 24 protein
UL91_EHV2Uncharacterized gene 30 protein
UL92_EHV2Gene 31 protein
UL95_EHV2Gene 34 protein
UL96_EHV2Gene 35 protein
UNG_EHV2Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
VCLAP_EHV2CARD domain-containing protein E10
VG10_EHV2Uncharacterized gene 10 protein
VG11_EHV2Uncharacterized gene 11 protein
VG12_EHV2Protein E6A
VG13_EHV2Protein E6C
VG23_EHV2Uncharacterized gene 23 protein
VG27_EHV2Uncharacterized gene 27 protein
VG28_EHV2Uncharacterized gene 28 protein
VG36_EHV2Probable inactive protein kinase 38
VG45_EHV2Uncharacterized gene 45 protein
VG48_EHV2Tegument protein G48
VG49_EHV2Uncharacterized gene 49 protein
VG51_EHV2Putative C-type lectin protein 51
VG52_EHV2Gene 52 protein
VG58_EHV2Gene 58 protein
VG59_EHV2DNA polymerase processivity factor
VG74_EHV2G-protein coupled receptor 74
VG75_EHV2Probable membrane antigen 75 (Tegument protein)
VGE1_EHV2G-protein coupled receptor E1
VGE2_EHV2Uncharacterized gene E2 protein
VGE3_EHV2SUSHI domain-containing protein E3
VGE4_EHV2Uncharacterized gene E4 protein
VGE6_EHV2G-protein coupled receptor E6
VGE9_EHV2Uncharacterized gene E9 protein
VP03_EHV2Probable membrane antigen 3 (Tegument protein)

70 entries

Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

Select_all Deselect_all  
AN_ALHV1Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
BRLF1_ALHV1Putative transcription activator BRLF1 homolog
CEP1_ALHV1Cytoplasmic envelopment protein 1
CEP2_ALHV1Cytoplasmic envelopment protein 2
CEP3_ALHV1Cytoplasmic envelopment protein 3
CVC1_ALHV1Capsid vertex component 1
CVC2_ALHV1Capsid vertex component 2
DNBI_ALHV1Major DNA-binding protein
DPOL_ALHV1DNA polymerase catalytic subunit (EC 2.7.7.7)
DUT_ALHV1Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
GB_ALHV1Envelope glycoprotein B (gB)
GH_ALHV1Envelope glycoprotein H (gH)
GL_ALHV1Envelope glycoprotein L (gL)
GM_ALHV1Envelope glycoprotein M (gM)
GN_ALHV1Envelope glycoprotein N
HELI_ALHV1DNA replication helicase (EC 3.6.4.-)
IE63_ALHV1Immediate-early phosphoprotein 57
ITP_ALHV1Inner tegument protein
KITH_ALHV1Thymidine kinase (EC 2.7.1.21)
LTP_ALHV1Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MCP_ALHV1Major capsid protein (MCP)
NEC1_ALHV1Nuclear egress protein 1
NEC2_ALHV1Nuclear egress protein 2
PORTL_ALHV1Portal protein
PRIM_ALHV1DNA primase (EC 2.7.7.-)
RIR1_ALHV1Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) ...
RIR2_ALHV1Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) ...
SCAF_ALHV1Capsid scaffolding protein (Capsid protein 17) (Protease precursor) (pPR)
SCP_ALHV1Small capsomere-interacting protein
SEMA_ALHV1Semaphorin-like protein A3
TEG7_ALHV1Tegument protein UL51 homolog (Uncharacterized gene 55 protein)
TRM1_ALHV1Tripartite terminase subunit 1
TRM2_ALHV1Tripartite terminase subunit 2
TRM3_ALHV1Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRX1_ALHV1Triplex capsid protein 1
TRX2_ALHV1Triplex capsid protein 2
UL24_ALHV1Protein UL24 homolog
UL32_ALHV1Packaging protein UL32 homolog
UL49_ALHV1Uncharacterized gene 66 protein
UL79_ALHV1Gene 18 protein
UL87_ALHV1Uncharacterized gene 24 protein
UL91_ALHV1Uncharacterized gene 30 protein
UL92_ALHV1Gene 31 protein
UL95_ALHV1Gene 34 protein
UL96_ALHV1Gene 35 protein
UNG_ALHV1Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
VG10_ALHV1Uncharacterized gene 10 protein
VG11_ALHV1Uncharacterized gene 11 protein
VG23_ALHV1Uncharacterized gene 23 protein
VG27_ALHV1Uncharacterized gene 27 protein
VG36_ALHV1Putative tyrosine kinase 36 (EC 2.7.10.2)
VG40_ALHV1Uncharacterized gene 40 protein
VG41_ALHV1Uncharacterized gene 41 protein
VG45_ALHV1Uncharacterized gene 45 protein
VG48_ALHV1Uncharacterized gene 48 protein
VG52_ALHV1Uncharacterized gene 52 protein
VG58_ALHV1Gene 58 protein
VG59_ALHV1DNA polymerase processivity factor
VG73_ALHV1Uncharacterized gene 73 protein
VGA10_ALHV1Uncharacterized gene A10 protein
VGA1_ALHV1Uncharacterized gene A1 protein
VGA2_ALHV1Uncharacterized protein A2
VGA4_ALHV1Uncharacterized gene A4 protein
VGA5_ALHV1G-protein coupled receptor A5
VGA6_ALHV1Uncharacterized gene A6 protein
VGA7_ALHV1Putative C-type lectin protein A7
VGA8_ALHV1Uncharacterized gene A8 protein
VGA9_ALHV1Putative apoptosis regulator A9
VP03_ALHV1Probable tegument protein antigen 3
VP75_ALHV1Probable membrane antigen 75 (Tegument protein)

56 entries

Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain

Select_all Deselect_all  
AN_EBVA8Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
BARF1_EBVA8Secreted protein BARF1 (33 kDa early protein) (p33)
BDLF2_EBVA8Protein BDLF2
BKRF4_EBVA8Tegument protein BKRF4
BLLF2_EBVA8Uncharacterized protein BLLF2
BLRF2_EBVA8Tegument protein BLRF2
BMRF2_EBVA8Protein BMRF2
BNL2A_EBVA8Protein BNLF2a
BNL2B_EBVA8Uncharacterized protein BNLF2b
BRRF1_EBVA8Transcriptional activator BRRF1
BRRF2_EBVA8Tegument protein BRRF2
BTRF1_EBVA8Uncharacterized protein BTRF1
BZLF1_EBVA8Trans-activator protein BZLF1 (EB1) (Zebra)
CEP1_EBVA8Cytoplasmic envelopment protein 1
CEP2_EBVA8Cytoplasmic envelopment protein 2
CEP3_EBVA8Cytoplasmic envelopment protein 3
CVC2_EBVA8Capsid vertex component 2
DNBI_EBVA8Major DNA-binding protein
DPOL_EBVA8DNA polymerase catalytic subunit (EC 2.7.7.7)
DUT_EBVA8Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
EAD_EBVA8DNA polymerase processivity factor BMRF1 (Early antigen protein D) (EA-D) ...
EAR_EBVA8Apoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)
EBNA1_EBVA8Epstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1)
EBNA2_EBVA8Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)
EBNA3_EBVA8Epstein-Barr nuclear antigen 3 (EBNA-3) (EBV nuclear antigen 3) (Epstein-Barr ...
EBNA4_EBVA8Epstein-Barr nuclear antigen 4 (EBNA-4) (EBV nuclear antigen 4) (Epstein-Barr ...
EBNA5_EBVA8Epstein-Barr nuclear antigen leader protein (EBNA-LP) (EBV nuclear antigen ...
EBNA6_EBVA8Epstein-Barr nuclear antigen 6 (EBNA-6) (EBV nuclear antigen 6) (Epstein-Barr ...
GB_EBVA8Envelope glycoprotein B (gB)
GH_EBVA8Envelope glycoprotein H (gH)
GL_EBVA8Envelope glycoprotein L (gL)
GM_EBVA8Envelope glycoprotein M (gM)
GN_EBVA8Envelope glycoprotein N
GP350_EBVA8Envelope glycoprotein GP350 (Membrane antigen) (MA)
GP42_EBVA8Glycoprotein 42 (gp42)
ICP27_EBVA8mRNA export factor ICP27 homolog (Mta) (ORF57 protein homolog) (Protein SM)
IL10H_EBVA8Viral interleukin-10 homolog (vIL-10) (20 kDa protein) (Protein BCRF1)
ITP_EBVA8Inner tegument protein
KITH_EBVA8Thymidine kinase (EC 2.7.1.21)
KR2_EBVA8Serine/threonine-protein kinase BGLF4 (EC 2.7.11.1)
LF1_EBVA8Uncharacterized LF1 protein
LF2_EBVA8Protein LF2
LMP1_EBVA8Latent membrane protein 1 (LMP-1) (Protein p63)
LMP2_EBVA8Latent membrane protein 2 (Terminal protein)
LTP_EBVA8Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MCP_EBVA8Major capsid protein (MCP)
MTP_EBVA8Major tegument protein (MTP) (Protein p140)
NEC1_EBVA8Nuclear egress protein 1
PORTL_EBVA8Portal protein
RIR1_EBVA8Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) ...
RIR2_EBVA8Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) ...
RTA_EBVA8Replication and transcription activator (Rta) (Immediate-early protein Rta)
SCAF_EBVA8Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) ...
TEG7_EBVA8Tegument protein UL51 homolog
TRM3_EBVA8Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
UL92_EBVA8Uncharacterized protein BDLF4

56 entries

Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Select_all Deselect_all  
AN_EBVGShutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
BALF1_EBVGApoptosis regulator BALF1
BARF1_EBVGSecreted protein BARF1 (33 kDa early protein) (p33)
BDLF2_EBVGProtein BDLF2
BKRF4_EBVGTegument protein BKRF4
BLLF2_EBVGUncharacterized protein BLLF2
BLRF2_EBVGTegument protein BLRF2
BMRF2_EBVGProtein BMRF2
BNL2A_EBVGProtein BNLF2a
BNL2B_EBVGUncharacterized protein BNLF2b
BRRF1_EBVGTranscriptional activator BRRF1
BRRF2_EBVGTegument protein BRRF2
BTRF1_EBVGUncharacterized protein BTRF1
BZLF1_EBVGTrans-activator protein BZLF1 (EB1) (Zebra)
CEP1_EBVGCytoplasmic envelopment protein 1
CEP2_EBVGCytoplasmic envelopment protein 2
CVC2_EBVGCapsid vertex component 2
DNBI_EBVGMajor DNA-binding protein
DPOL_EBVGDNA polymerase catalytic subunit (EC 2.7.7.7)
DUT_EBVGDeoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
EAD_EBVGDNA polymerase processivity factor BMRF1 (Early antigen protein D) (EA-D) ...
EAR_EBVGApoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)
EBNA1_EBVGEpstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1)
EBNA2_EBVGEpstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)
EBNA3_EBVGEpstein-Barr nuclear antigen 3 (EBNA-3) (EBV nuclear antigen 3) (Epstein-Barr ...
EBNA4_EBVGEpstein-Barr nuclear antigen 4 (EBNA-4) (EBV nuclear antigen 4) (Epstein-Barr ...
EBNA5_EBVGEpstein-Barr nuclear antigen leader protein (EBNA-LP) (EBV nuclear antigen ...
EBNA6_EBVGEpstein-Barr nuclear antigen 6 (EBNA-6) (EBV nuclear antigen 6) (Epstein-Barr ...
GB_EBVGEnvelope glycoprotein B (gB)
GH_EBVGEnvelope glycoprotein H (gH)
GL_EBVGEnvelope glycoprotein L (gL)
GM_EBVGEnvelope glycoprotein M (gM)
GN_EBVGEnvelope glycoprotein N
GP350_EBVGEnvelope glycoprotein GP350 (Membrane antigen) (MA)
GP42_EBVGGlycoprotein 42 (gp42)
ICP27_EBVGmRNA export factor ICP27 homolog (Mta) (ORF57 protein homolog) (Protein SM)
IL10H_EBVGViral interleukin-10 homolog (vIL-10) (20 kDa protein) (Protein BCRF1)
ITP_EBVGInner tegument protein
KITH_EBVGThymidine kinase (EC 2.7.1.21)
KR2_EBVGSerine/threonine-protein kinase BGLF4 (EC 2.7.11.1)
LF1_EBVGUncharacterized LF1 protein
LF2_EBVGProtein LF2
LF3_EBVGUncharacterized protein LF3
LMP1_EBVGLatent membrane protein 1 (LMP-1) (Protein p63)
LMP2_EBVGLatent membrane protein 2 (Terminal protein)
LTP_EBVGLarge tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MCP_EBVGMajor capsid protein (MCP)
MTP_EBVGMajor tegument protein (MTP) (Protein p140)
PORTL_EBVGPortal protein
RIR1_EBVGRibonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) ...
RIR2_EBVGRibonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) ...
RPMS1_EBVGUncharacterized protein RPMS1
RTA_EBVGReplication and transcription activator (Rta) (Immediate-early protein Rta)
SCAF_EBVGCapsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) ...
TEG7_EBVGTegument protein UL51 homolog
TRM3_EBVGTripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)

6 entries

Saimiriine herpesvirus 2 (strain 488) (SaHV-2) (Herpesvirus saimiri)

Select_all Deselect_all  
DYR_SHV2CViral dihydrofolate reductase (vDHFR) (EC 1.5.1.3)
IL17_SHV2CViral interleukin-17 (vIL-17) (Immediate early gene 13 protein)
STP_SHV2CSaimiri transformation-associated protein (Collagen-like protein) (stpC)
TIP_SHV2CTyrosine-protein kinase-interacting protein (Tip)
YDH3_SHV2CUncharacterized 9.5 kDa protein in DHFR 3'region (ORF3)
YDH4_SHV2CUncharacterized 9.9 kDa protein in DHFR 3'region (ORF4)

3 entries

Bovine herpesvirus 4 (strain DN-599) (BoHV-4) (Movar virus)

Select_all Deselect_all  
BRLF1_BHV4DPutative transcription activator BRLF1 homolog
GCNT3_BHV4DBeta-1,3-galactosyl-O-glycosyl-glycoprotein ...
VIE1_BHV4DProbable E3 ubiquitin-protein ligase IE1 (EC 2.3.2.27) (32.7 kDa immediate ...

3 entries

Saimiriine herpesvirus 2 (strain 484-77) (SaHV-2) (Herpesvirus saimiri)

Select_all Deselect_all  
DYR_SHV24Viral dihydrofolate reductase (vDHFR) (EC 1.5.1.3)
STP_SHV24Saimiri transformation-associated protein (Collagen-like protein) (stpC)
TIP_SHV24Tyrosine-protein kinase-interacting protein (Tip)

2 entries

Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68)

Select_all Deselect_all  
LTP_MHV68Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MIR1_MHV68E3 ubiquitin-protein ligase MIR1 (EC 2.3.2.27) (MK3) (Modulator of immune ...

1 entry

Alcelaphine herpesvirus 1 (strain WC11) (AlHV-1) (Malignant catarrhal fever virus)


KITH_AHV1WThymidine kinase (EC 2.7.1.21)

1 entry

Ateline herpesvirus 3 (AtHV-3) (Herpesvirus ateles)


TIO_ATHV3Protein tio

1 entry

Bovine herpesvirus 4 (BoHV-4) (Movar virus)


GCNT3_BHV4Beta-1,3-galactosyl-O-glycosyl-glycoprotein ...

1 entry

Bovine herpesvirus 4 (strain LVR140) (BoHV-4) (Movar virus)


GCNT3_BHV4LBeta-1,3-galactosyl-O-glycosyl-glycoprotein ...

1 entry

Bovine herpesvirus 4 (strain V. test) (BoHV-4) (Movar virus)


GCNT3_BHV4VBeta-1,3-galactosyl-O-glycosyl-glycoprotein ...

1 entry

Epstein-Barr virus (strain Cao) (HHV-4) (Human herpesvirus 4)


LMP1_EBVCLatent membrane protein 1 (LMP-1) (Protein p63)

1 entry

Epstein-Barr virus (strain P3HR-1) (HHV-4) (Human herpesvirus 4)


VGP3_EBVP3Envelope glycoprotein GP340 (Membrane antigen) (MA)

1 entry

Epstein-Barr virus (strain Raji) (HHV-4) (Human herpesvirus 4)


LMP1_EBVRLatent membrane protein 1 (LMP-1) (Protein p63)

1 entry

Equine herpesvirus 2 (strain T400/3) (EHV-2)


IL10H_EHV2TViral interleukin-10 homolog (vIL-10)

1 entry

Herpesvirus ateles


TYSY_HSVATThymidylate synthase (TS) (TSase) (EC 2.1.1.45)

1 entry

Saimiriine herpesvirus 2 (strain 484) (SaHV-2) (Herpesvirus saimiri)


TIP_SHV48Tyrosine protein kinase-interacting protein (Tip) (TipC484)