Cytomegalovirus

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embedded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 200 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5’ leader sequence of 30-300 bp (not translated), a 3’ untranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. Certain proteins are downregulated translationaly by a leaky scanning from an upstream ORF.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachement of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Entry into host cell is still unclear and may depend on the host cell type, i.e. endocytosis versus fusion at the plasma membrane.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Adaptive immune response inhibition

Many HCMV proteins are dedicated to interfere with the host adaptive immune system. HCMV US11 reverse the translocation of human class I heavy chains from the host endoplasmic reticulum (ER) back to the cytosol which ultimately results in their degradation by the proteasome. US2 destroys two components of the MHC class II pathway, HLA-DR-alpha and DM-alpha, preventing recognition by CD4+ T cells. US3 prevents forward transport and maturation of all major histocompatibility complex (MHC) class I molecules by trapping them in the ER. HCMV US6 inhibits expression of MHC class I on the cell surface through TAP (specific transporters associated with antigen presentation) by blocking translocation of peptides from the proteasome into the ER for loading onto MHC class I.

Apoptosis modulation

Viral inhibitor of caspase-8-induced apoptosis (from gene UL36) plays a role in the inhibition of apoptosis by interacting with the pro-domain of pro-caspase-8/CASP8 and thus preventing its activation . Another viral protein vMIA inhibits BAX- but not BAK- mediated apoptosis.

Autophagy modulation

The human cytomegalovirus protein TRS1 inhibits host autophagy process via its interaction with Beclin 1 .

Cell-cycle modulation

The conserved UL24 family of human alpha, beta and gamma herpesviruses induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex. HCMV encodes an UL24 homolog that should fullfill this role .

Innate immune response inhibition

HCMV inhibits the cascade leading to production of interferon-beta by targeting host IRF3 protein with the viral pp65 protein .
NK cells are a component of the innate immune system which play an important role in the early control of viral infections and also help to drive subsequent adaptive immunity. Several HCMV proteins are involved in the inhibition of NK-cells cytotoxicity including UL16 or UL142 that retain NKGCD2 ligands inside the cell to prevent their cell surface expression .

Host splicing inhibition

HCMV UL69 modulates the host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing .

Matching UniProtKB/Swiss-Prot entries

403 entries grouped by strain (browse by keywords)

All proteins are shown (view only 369 complete proteome entries)

193 entries

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Select_all Deselect_all  
AN_HCMVAAlkaline nuclease (EC 3.1.-.-)
CEP1_HCMVACytoplasmic envelopment protein 1
CEP2_HCMVACytoplasmic envelopment protein 2
CEP3_HCMVACytoplasmic envelopment protein 3
CVC1_HCMVACapsid vertex component 1
CVC2_HCMVACapsid vertex component 2
DNBI_HCMVAMajor DNA-binding protein
DPOL_HCMVADNA polymerase catalytic subunit (EC 2.7.7.7)
DUT_HCMVADeoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
EP84_HCMVAEarly phosphoprotein p84
GB_HCMVAEnvelope glycoprotein B (gB)
GH_HCMVAEnvelope glycoprotein H (gH)
GL_HCMVAEnvelope glycoprotein L (gL)
GM_HCMVAEnvelope glycoprotein M (gM)
GN_HCMVAEnvelope glycoprotein N
GO_HCMVAGlycoprotein O (gO)
HELI_HCMVADNA replication helicase (EC 3.6.4.-)
HEPA_HCMVADNA helicase/primase complex-associated protein (HEPA) (Primase-associated ...
ICP27_HCMVAmRNA export factor ICP27 homolog
IL10H_HCMVAViral interleukin-10 homolog (cmvIL-10) (vIL-10)
IR01_HCMVAUncharacterized protein HKLF1 (IRL1) (TRL1)
IR02_HCMVAUncharacterized protein IRL2 (TRL2)
IR03_HCMVAUncharacterized protein IRL3 (TRL3)
IR04_HCMVAUncharacterized protein IRL4 (TRL4)
IR05_HCMVAUncharacterized protein IRL5 (TRL5)
IR06_HCMVAUncharacterized protein IRL6 (TRL6)
IR07_HCMVAUncharacterized protein IRL7 (TRL7)
IR08_HCMVAUncharacterized protein IRL8 (TRL8)
IR09_HCMVAUncharacterized protein IRL9 (TRL9)
IR10_HCMVAProtein IRL10 (TRL10)
IR11_HCMVAViral Fc-gamma receptor-like protein IR11 (gp34)
IR12_HCMVAUncharacterized protein IRL12 (TRL12)
IR13_HCMVAUncharacterized protein IRL13 (TRL13)
IR14_HCMVAUncharacterized protein IRL14
IRS1_HCMVAProtein IRS1 (HQRF1)
ITP_HCMVAInner tegument protein
J1I_HCMVAUncharacterized protein HKRFX (J1I)
J1L_HCMVAUncharacterized protein J1L
J1S_HCMVAUncharacterized protein J1S
LTP_HCMVALarge tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MCP_HCMVAMajor capsid protein (MCP)
NEC1_HCMVANuclear egress protein 1
NEC2_HCMVANuclear egress protein 2
PORTL_HCMVAPortal protein
PP150_HCMVALarge structural phosphoprotein (150 kDa matrix phosphoprotein) (150 kDa ...
PP65_HCMVA65 kDa phosphoprotein (pp65) (65 kDa matrix phosphoprotein) (Phosphoprotein ...
PP71_HCMVAProtein pp71 (pp71) (71 kDa upper matrix phosphoprotein) (Phosphoprotein UL82) ...
PP85_HCMVAPhosphoprotein 85 (pp85) (Phosphoprotein UL25)
PRIM_HCMVADNA primase (EC 2.7.7.-)
RIR1_HCMVARibonucleoside-diphosphate reductase large subunit-like protein
SCAF_HCMVACapsid scaffolding protein (Protease precursor) (pPR)
SCP_HCMVASmall capsomere-interacting protein
TEG7_HCMVATegument protein UL51 homolog
TR14_HCMVAProtein TRL14
TRM1_HCMVATripartite terminase subunit 1
TRM2_HCMVATripartite terminase subunit 2
TRM3_HCMVATripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRS1_HCMVAProtein HHLF1
TRX1_HCMVATriplex capsid protein 1
TRX2_HCMVATriplex capsid protein 2
UL01_HCMVAGlycoprotein UL1
UL02_HCMVAUncharacterized protein UL2
UL03_HCMVAUncharacterized protein UL3
UL04_HCMVAEarly glycoprotein GP48
UL05_HCMVAProtein UL5
UL06_HCMVAUncharacterized protein UL6
UL07_HCMVACEACAM1-like protein UL7
UL08_HCMVAUncharacterized protein UL8
UL09_HCMVAUncharacterized protein UL9
UL101_HCMVAUncharacterized protein UL101
UL106_HCMVAUncharacterized protein UL106
UL107_HCMVAUncharacterized protein UL107
UL108_HCMVAUncharacterized protein UL108
UL109_HCMVAUncharacterized protein UL109
UL10_HCMVAUncharacterized protein UL10
UL110_HCMVAUncharacterized protein UL110
UL116_HCMVAUncharacterized protein UL116
UL117_HCMVAProtein UL117
UL119_HCMVAViral Fc-gamma receptor-like protein UL119 (gp68)
UL11P_HCMVAProtein UL11
UL120_HCMVAUncharacterized protein UL120
UL121_HCMVAMembrane protein UL121
UL124_HCMVAUncharacterized protein UL124
UL125_HCMVAUncharacterized protein UL125
UL126_HCMVAUncharacterized protein UL126
UL127_HCMVAUncharacterized protein UL127
UL128_HCMVAUncharacterized protein UL128
UL129_HCMVAUncharacterized protein UL129
UL12_HCMVAUncharacterized protein UL12
UL130_HCMVAUncharacterized protein UL130
UL131_HCMVAUncharacterized protein UL131
UL132_HCMVAEnvelope glycoprotein UL132 (L3)
UL13_HCMVAUncharacterized protein UL13
UL14_HCMVAUncharacterized protein UL14
UL15A_HCMVAUncharacterized protein UL15A
UL16P_HCMVAProtein UL16
UL17_HCMVAUncharacterized protein UL17
UL18_HCMVAGlycoprotein UL18
UL19_HCMVAUncharacterized protein UL19
UL20_HCMVAUncharacterized protein UL20
UL21A_HCMVAUncharacterized protein UL21A
UL21_HCMVAUncharacterized protein UL21
UL22A_HCMVAGlycoprotein UL22A
UL23_HCMVATegument protein UL23
UL26_HCMVATegument protein UL26
UL27_HCMVAProtein UL27
UL28_HCMVAUncharacterized protein UL28
UL29_HCMVAUncharacterized protein UL29
UL30_HCMVAUncharacterized protein UL30
UL31_HCMVAUncharacterized protein UL31
UL33_HCMVAG-protein coupled receptor homolog UL33 (vGPCR UL33)
UL34_HCMVATranscriptional regulator UL34
UL35_HCMVAProtein UL35
UL36_HCMVAUncharacterized protein UL36
UL38_HCMVAApoptosis inhibitor UL38
UL39_HCMVAUncharacterized protein UL39
UL40_HCMVAProtein UL40
UL41A_HCMVAProtein UL41A
UL41_HCMVAUncharacterized protein UL41
UL42_HCMVAUncharacterized protein UL42
UL43_HCMVATegument protein UL43
UL49_HCMVAUncharacterized protein UL49 (Protein HFLF5)
UL52_HCMVAPackaging protein UL32 homolog (Protein HFRF1)
UL58_HCMVAUncharacterized protein UL58
UL59_HCMVAUncharacterized protein UL59
UL60_HCMVAUncharacterized protein UL60
UL61_HCMVAUncharacterized protein UL61
UL62_HCMVAUncharacterized protein UL62
UL63_HCMVAUncharacterized protein UL63
UL64_HCMVAUncharacterized protein UL64
UL65_HCMVAUncharacterized protein UL65
UL66_HCMVAUncharacterized protein UL66
UL67_HCMVAUncharacterized protein UL67
UL68_HCMVAUncharacterized protein UL68
UL76_HCMVAProtein UL76
UL78_HCMVAUncharacterized protein UL78
UL79_HCMVAProtein UL79
UL81_HCMVAUncharacterized protein UL81
UL84_HCMVAProtein UL84
UL87_HCMVAProtein UL87
UL88_HCMVAProtein UL88
UL90_HCMVAUncharacterized protein UL90
UL91_HCMVAProtein UL91
UL92_HCMVAProtein UL92
UL95_HCMVAProtein UL95
UL96_HCMVAProtein UL96
UL97_HCMVASerine/threonine protein kinase UL97 (EC 2.7.1.-) (Ganciclovir kinase) (HSRF3 ...
UNG_HCMVAUracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
US01_HCMVAUncharacterized protein HQLF3
US02_HCMVAUnique short US2 glycoprotein (Protein HQLF2) (gpUS2)
US03_HCMVAMembrane glycoprotein US3 (Glycoprotein E) (Protein HQLF1) (gpUS3 IE)
US04_HCMVAUncharacterized protein US4
US05_HCMVAUncharacterized protein US5
US06_HCMVAUnique short US6 glycoprotein (Protein HXLF6) (gpUS6)
US07_HCMVAUnique short US7 glycoprotein (Protein HXLF5) (gpUS7)
US08_HCMVAUnique short US8 glycoprotein (Protein HXLF4) (gpUS8)
US09_HCMVAUnique short US9 glycoprotein (Protein HXLF3) (gpUS9)
US10_HCMVAUnique short US10 glycoprotein (Protein HXLF2) (gpUS10)
US11_HCMVAUnique short US11 glycoprotein (Protein HXLF1) (gpUS11)
US12_HCMVAUncharacterized protein HVLF6
US13_HCMVAUncharacterized protein HVLF5
US14_HCMVAUncharacterized protein HVLF4
US15_HCMVAUncharacterized protein HVLF3
US16_HCMVAUncharacterized protein HVLF2
US17_HCMVAUncharacterized protein HVLF1
US18_HCMVATransmembrane protein US18
US19_HCMVATransmembrane protein HWLF4
US20_HCMVATransmembrane protein HWLF3
US21_HCMVAUncharacterized protein HWLF2
US22_HCMVAEarly nuclear protein HWLF1 (Tegument protein US22)
US23_HCMVATegument protein US23 (Protein HHLF7)
US24_HCMVATegument protein US24 (Protein HHLF6)
US25_HCMVAUncharacterized protein US25
US26_HCMVAUncharacterized protein HHLF5
US27_HCMVAG-protein coupled receptor homolog US27 (HHRF2)
US28_HCMVAG-protein coupled receptor homolog US28 (HHRF3)
US29_HCMVAUncharacterized protein HHRF4
US30_HCMVAUncharacterized protein HHRF5
US31_HCMVAUncharacterized protein HHRF6
US32_HCMVAUncharacterized protein HHRF7
US33_HCMVAUncharacterized protein HHLF3
US34A_HCMVAUncharacterized protein US34A
US34_HCMVAProtein US34
US35_HCMVAUncharacterized protein HHLF2
US36_HCMVAUncharacterized protein US36
VGLI_HCMVAUL37 immediate early glycoprotein
VIE1_HCMVA55 kDa immediate-early protein 1 (IE1)
VIE2_HCMVAViral transcription factor IE2 (IE2) (Protein UL122)
VP22_HCMVAProtein UL24
VPAP_HCMVADNA polymerase processivity factor (Polymerase accessory protein) (PAP) ...

166 entries

Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Select_all Deselect_all  
AN_HCMVMAlkaline nuclease (EC 3.1.-.-)
CEP1_HCMVMCytoplasmic envelopment protein 1
CEP2_HCMVMCytoplasmic envelopment protein 2
CEP3_HCMVMCytoplasmic envelopment protein 3 (28 kDa structural phosphoprotein) (pp28)
CVC1_HCMVMCapsid vertex component 1
CVC2_HCMVMCapsid vertex component 2
CXCL1_HCMVMChemokine vCXCL1
DNBI_HCMVMMajor DNA-binding protein
DPOL_HCMVMDNA polymerase catalytic subunit (EC 2.7.7.7)
DUT_HCMVMDeoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
EP84_HCMVMEarly phosphoprotein p84
GB_HCMVMEnvelope glycoprotein B (gB)
GH_HCMVMEnvelope glycoprotein H (gH)
GL_HCMVMEnvelope glycoprotein L (gL)
GM_HCMVMEnvelope glycoprotein M (gM)
GN_HCMVMEnvelope glycoprotein N
GO_HCMVMEnvelope glycoprotein O
HELI_HCMVMDNA replication helicase (EC 3.6.4.-)
HEPA_HCMVMDNA helicase/primase complex-associated protein (HEPA) (Primase-associated ...
ICP27_HCMVMmRNA export factor ICP27 homolog
IL10H_HCMVMViral interleukin-10 homolog (cmvIL-10) (vIL-10)
IR01_HCMVMUncharacterized protein HKLF1 (IRL1) (TRL1)
IR06_HCMVMUncharacterized protein IRL6 (TRL6)
IR10_HCMVMProtein IRL10 (TRL10)
IRS1_HCMVMProtein IRS1
ITP_HCMVMInner tegument protein
LTP_HCMVMLarge tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MCP_HCMVMMajor capsid protein (MCP)
NEC1_HCMVMNuclear egress protein 1
NEC2_HCMVMNuclear egress protein 2
PORTL_HCMVMPortal protein
PP150_HCMVMTegument protein pp150
PP65_HCMVM65 kDa phosphoprotein (pp65) (65 kDa matrix phosphoprotein) (Phosphoprotein ...
PP71_HCMVMProtein pp71
PP85_HCMVMPhosphoprotein 85 (pp85) (Phosphoprotein UL25)
PRIM_HCMVMDNA primase (EC 2.7.7.-)
RIR1_HCMVMRibonucleoside-diphosphate reductase large subunit-like protein
RL11_HCMVMMembrane glycoprotein RL11
RL12_HCMVMUncharacterized protein RL12
RL13_HCMVMMembrane protein RL13
RL5A_HCMVMProtein RL5A
RL8A_HCMVMProtein RL8A
RL9A_HCMVMProtein RL9A
SCAF_HCMVMCapsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR)
SCP_HCMVMSmall capsomere-interacting protein
TEG7_HCMVMTegument protein UL51 homolog
TRM1_HCMVMTripartite terminase subunit 1
TRM2_HCMVMTripartite terminase subunit 2
TRM3_HCMVMTripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRS1_HCMVMProtein TRS1
TRX1_HCMVMTriplex capsid protein 1
TRX2_HCMVMTriplex capsid protein 2
U131A_HCMVMProtein UL131A
U147A_HCMVMUncharacterized protein UL147A
U148A_HCMVMProtein UL148A
U148B_HCMVMProtein UL148B
U148C_HCMVMProtein UL148C
U148D_HCMVMProtein UL148D
U150A_HCMVMUncharacterized protein UL150A
UL01_HCMVMGlycoprotein UL1
UL02_HCMVMUncharacterized protein UL2
UL04_HCMVMEnvelope glycoprotein UL4
UL05_HCMVMProtein UL5
UL06_HCMVMUncharacterized protein UL6
UL07_HCMVMCEACAM1-like protein UL7
UL09_HCMVMMembrane glycoprotein UL9
UL10_HCMVMUncharacterized protein UL10
UL116_HCMVMUncharacterized protein UL116
UL117_HCMVMProtein UL117 (pUL117)
UL119_HCMVMViral Fc-gamma receptor-like protein UL119 (gp68)
UL11P_HCMVMProtein UL11
UL120_HCMVMMembrane protein UL120
UL121_HCMVMMembrane protein UL121
UL124_HCMVMUncharacterized protein UL124
UL130_HCMVMEnvelope glycoprotein UL130
UL132_HCMVMEnvelope glycoprotein UL132
UL133_HCMVMProtein UL133
UL135_HCMVMProtein UL135
UL136_HCMVMProtein UL136
UL138_HCMVMProtein UL138
UL139_HCMVMMembrane glycoprotein UL139
UL13_HCMVMUncharacterized protein UL13
UL140_HCMVMProtein UL140
UL141_HCMVMProtein UL141
UL142_HCMVMMembrane glycoprotein UL142
UL144_HCMVMMembrane glycoprotein UL144 (TNF alpha-like receptor UL144) (UL144 protein)
UL145_HCMVMProtein UL145
UL147_HCMVMPutative viral CXC chemokine 2 (vCXCL2)
UL148_HCMVMMembrane protein UL148
UL14_HCMVMUncharacterized protein UL14
UL150_HCMVMUncharacterized protein UL150
UL15A_HCMVMUncharacterized protein UL15A
UL16P_HCMVMProtein UL16
UL17_HCMVMProtein UL17
UL18_HCMVMMembrane glycoprotein UL18
UL19_HCMVMUncharacterized protein UL19
UL20_HCMVMMembrane protein UL20
UL21A_HCMVMUncharacterized protein UL21A
UL22A_HCMVMGlycoprotein UL22A
UL23_HCMVMTegument protein UL23
UL26_HCMVMTegument protein UL26
UL27_HCMVMProtein UL27
UL298_HCMVMProtein UL29/28
UL30_HCMVMUncharacterized protein UL30
UL31_HCMVMUncharacterized protein UL31
UL33_HCMVMG-protein coupled receptor homolog UL33
UL34_HCMVMTranscriptional regulator UL34
UL35_HCMVMTegument protein UL35
UL38_HCMVMApoptosis inhibitor UL38
UL40_HCMVMProtein UL40
UL41A_HCMVMProtein UL41A
UL42_HCMVMProtein UL42
UL43_HCMVMTegument protein UL43
UL49_HCMVMProtein UL49
UL52_HCMVMPackaging protein UL32 homolog
UL74A_HCMVMUncharacterized protein UL74A
UL76_HCMVMProtein UL76
UL78_HCMVMProtein UL78
UL79_HCMVMProtein UL79
UL84_HCMVMProtein UL84
UL87_HCMVMUncharacterized protein UL87
UL88_HCMVMProtein UL88
UL91_HCMVMProtein UL91
UL92_HCMVMUncharacterized protein UL92
UL95_HCMVMProtein UL95
UL96_HCMVMProtein UL96
UL97_HCMVMSerine/threonine protein kinase UL97 (EC 2.7.1.-)
UNG_HCMVMUracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
US01_HCMVMProtein US1
US02_HCMVMUnique short US2 glycoprotein (Protein HQLF2) (gpUS2)
US03_HCMVMMembrane glycoprotein US3
US06_HCMVMUnique short US6 glycoprotein
US07_HCMVMMembrane glycoprotein US7
US08_HCMVMMembrane glycoprotein US8
US09_HCMVMMembrane glycoprotein US9
US10_HCMVMMembrane glycoprotein US10
US11_HCMVMMembrane glycoprotein US11
US12_HCMVMUncharacterized protein US12
US13_HCMVMMembrane protein US13
US14_HCMVMMembrane protein US14
US15_HCMVMMembrane protein US15
US16_HCMVMProtein US16
US17_HCMVMProtein US17
US18_HCMVMTransmembrane protein US18
US19_HCMVMTransmembrane protein US19
US20_HCMVMMembrane protein US20
US21_HCMVMMembrane protein US21
US22_HCMVMTegument protein US22
US23_HCMVMProtein US23
US24_HCMVMTegument protein US24
US26_HCMVMProtein US26
US27_HCMVMEnvelope glycoprotein US27
US28_HCMVMEnvelope protein US28
US29_HCMVMUncharacterized protein US29
US30_HCMVMUncharacterized protein US30
US31_HCMVMUncharacterized protein US31
US32_HCMVMProtein US32
US33A_HCMVMUncharacterized protein US33A
US34A_HCMVMUncharacterized protein US34A
US34_HCMVMProtein US34
VGLI_HCMVMUL37 immediate early glycoprotein
VICA_HCMVMViral inhibitor of caspase-8-induced apoptosis (vICA)
VIE1_HCMVM55 kDa immediate-early protein 1
VIE2_HCMVMViral transcription factor IE2 (IE2) (Protein UL122)
VP22_HCMVMTegument protein UL24
VPAP_HCMVMDNA polymerase processivity factor (Polymerase accessory protein) (PAP) ...

193 entries

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)

Select_all Deselect_all  
UL298_HCMVAProtein UL29/UL28
YHL4_HCMVAUncharacterized protein HHLF4
YHR1_HCMVAUncharacterized protein HHRF1

27 entries

Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Select_all Deselect_all  
GB_HCMVTEnvelope glycoprotein B (gB)
GH_HCMVTEnvelope glycoprotein H (gH)
IE247_HCMVT45 kDa immediate-early protein 2 (IE2)
LTP_HCMVTLarge tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
PP65_HCMVT65 kDa phosphoprotein (pp65) (64 kDa matrix phosphoprotein) (pp64) (GP64) ...
PRIM_HCMVTDNA primase (EC 2.7.7.-)
UL04_HCMVTEarly glycoprotein GP48
UL132_HCMVTEnvelope glycoprotein UL132 (L3)
UL135_HCMVTProtein UL135
UL136_HCMVTProtein UL136
UL147_HCMVTPutative viral CXC chemokine 2 (vCXCL2)
UL17_HCMVTProtein UL17
UL34_HCMVTTranscriptional regulator UL34
UL84_HCMVTUL84 protein
UL95_HCMVTProtein UL95
UL97_HCMVTSerine/threonine protein kinase UL97 (EC 2.7.1.-) (Ganciclovir kinase)
US02_HCMVTUnique short US2 glycoprotein (HQLF2) (gpUS2)
US03_HCMVTMembrane glycoprotein US3
US06_HCMVTUnique short US6 glycoprotein (HXLF6) (gpUS6)
US11_HCMVTUnique short US11 glycoprotein (HXLF1) (gpUS11)
US18_HCMVTTransmembrane protein HWLF5
US19_HCMVTTransmembrane protein HWLF4
US20_HCMVTTransmembrane protein HWLF3
US28_HCMVTG-protein coupled receptor homolog US28 (HHRF3)
VIE1_HCMVT55 kDa immediate-early protein 1 (IE1)
VIE2_HCMVTViral transcription factor IE2 (IE2) (Protein UL122)
VIE3_HCMVT30 kDa immediate-early protein 2 (IE2)

2 entries

Human cytomegalovirus (strain Toledo) (HHV-5) (Human herpesvirus 5)

Select_all Deselect_all  
UL144_HCMVOMembrane glycoprotein UL144 (TNF alpha-like receptor UL144) (UL144 protein)
US05_HCMVOUncharacterized protein US5

2 entries

Rhesus cytomegalovirus (strain 68-1) (RhCMV)

Select_all Deselect_all  
DPOL_RHCM6DNA polymerase catalytic subunit (EC 2.7.7.7)
GB_RHCM6Envelope glycoprotein B (gB)

2 entries

Simian cytomegalovirus (strain Colburn)

Select_all Deselect_all  
DNBI_SCMVCMajor DNA-binding protein
SCAF_SCMVCCapsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR)

1 entry

Human cytomegalovirus (HHV-5) (Human herpesvirus 5)


TEGU_HCMVTegument protein (67 kDa phosphorylated protein)

1 entry

Human cytomegalovirus (strain 1042) (HHV-5) (Human herpesvirus 5)


GL_HCMV2Envelope glycoprotein L (gL)

1 entry

Human cytomegalovirus (strain 119) (HHV-5) (Human herpesvirus 5)


GL_HCMV1Envelope glycoprotein L (gL)

1 entry

Human cytomegalovirus (strain 2387) (HHV-5) (Human herpesvirus 5)


GL_HCMV3Envelope glycoprotein L (gL)

1 entry

Human cytomegalovirus (strain 4654) (HHV-5) (Human herpesvirus 5)


GL_HCMV4Envelope glycoprotein L (gL)

1 entry

Human cytomegalovirus (strain 5035) (HHV-5) (Human herpesvirus 5)


GL_HCMV5Envelope glycoprotein L (gL)

1 entry

Human cytomegalovirus (strain 5040) (HHV-5) (Human herpesvirus 5)


GL_HCMV6Envelope glycoprotein L (gL)

1 entry

Human cytomegalovirus (strain 5160) (HHV-5) (Human herpesvirus 5)


GL_HCMV7Envelope glycoprotein L (gL)

1 entry

Human cytomegalovirus (strain 5508) (HHV-5) (Human herpesvirus 5)


GL_HCMV8Envelope glycoprotein L (gL)

1 entry

Human cytomegalovirus (strain Eisenhardt) (HHV-5) (Human herpesvirus 5)


V30K_HCMVE30 kDa major early protein

1 entry

Human cytomegalovirus (strain PT) (HHV-5) (Human herpesvirus 5)


GL_HCMVPEnvelope glycoprotein L (gL)