Aviadenovirus

VIRION

Non-enveloped capsid with a pseudo T=25 icosahedral symmetry. The capsid diameter is about 90 nm. The capsid shell consists of 720 hexon subunits arranged as 240 trimers and 12 vertex penton capsomers each with a fiber protruding from the surface.

GENOME

Non-segmented, linear double-stranded DNA of 35-36kb encoding about 40 proteins. The genome has terminally redundant sequences which have inverted terminal repetitions (ITR). The terminal protein (TP) is covalently attached to each end of the genome.

GENE EXPRESSION

Transcription is nuclear, in two phases; early (replication), late (virion assembly). All genes are transcribed by host RNA pol II except virus-associated (VA) gene(s) of some fowl adenoviruses transcribed by RNA pol III. Genes transcribed by RNA pol II give rise to multiple mRNA that are produced by alternative splicing and use of different poly(A) sites.

REPLICATION

NUCLEUS

  1. Attachment of the viral fiber glycoproteins to host receptors mediates endocytosis of the virus into the host cell and fiber shedding.
  2. Disruption of the endosome by lytic protein VI releases the viral capsid in the cytosol.
  3. Viral penetration into host nucleus.
  4. Transcription of early genes (E genes) by host RNA pol II, replication of the DNA genome by DNA strand displacement in the nucleus.
  5. Transcription of late genes (L genes) by host RNA pol II, mostly encoding for structural proteins.
  6. Assembly of new virions in the nucleus.
  7. Virions are released by lysis of the cell.

Matching UniProtKB/Swiss-Prot entries

42 entries grouped by strain (browse by keywords)

All proteins are shown (view only 38 complete proteome entries)

38 entries

Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

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CAP3_ADEG1Pre-capsid vertex protein (Capsid vertex-specific component IIIa) (CVSC) ...
CAP6_ADEG1Pre-protein VI (pVI)
CAP8_ADEG1Pre-hexon-linking protein (Pre-protein VIII) (pVIII)
CAPSH_ADEG1Hexon protein (CP-H) (Protein II)
CAPSP_ADEG1Penton protein (CP-P) (Penton base protein) (Protein III)
DNB2_ADEG1Early E2A DNA-binding protein
DPOL_ADEG1DNA polymerase (EC 2.7.7.7)
DUT_ADEG1Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
GAM1_ADEG1Protein GAM-1 (Gallus-anti morte protein) (Gam1)
L2MU_ADEG1Late L2 mu core protein (Protein X) (pX) (pMu)
NP_ADEG1Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII)
PKG1_ADEG1Packaging protein 1 (Packaging protein IVa2)
PKG3_ADEG1Packaging protein 3 (L1-52/55 kDa protein) (Packaging protein 52K)
PRO_ADEG1Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus ...
SHUT_ADEG1Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) ...
SPIK1_ADEG1Fiber protein 1
SPIK2_ADEG1Fiber protein 2
TERM_ADEG1DNA terminal protein (Bellett protein) (pTP protein)
YO10_ADEG1Putative Ig-like domain-containing protein ORF10
YO11_ADEG1Uncharacterized protein ORF11
YO12_ADEG1Uncharacterized protein ORF12
YO13_ADEG1Uncharacterized protein ORF13
YO14_ADEG1Uncharacterized protein ORF14
YO15_ADEG1Uncharacterized protein ORF15
YO16_ADEG1Uncharacterized protein ORF16
YO17_ADEG1Uncharacterized protein ORF17
YO18_ADEG1Uncharacterized protein ORF18
YO19_ADEG1Uncharacterized protein ORF19
YO20_ADEG1Uncharacterized protein ORF20
YO21_ADEG1Uncharacterized protein ORF21
YO22_ADEG1Uncharacterized protein ORF22
YO2_ADEG1Uncharacterized protein ORF2
YO3_ADEG1Uncharacterized protein ORF3
YO4_ADEG1Uncharacterized protein ORF4
YO5_ADEG1Uncharacterized protein ORF5
YO6_ADEG1Uncharacterized protein ORF6
YO7_ADEG1Uncharacterized protein ORF7
YO9_ADEG1Uncharacterized protein ORF9

2 entries

Avian adenovirus 8 (strain ATCC A-2A) (FAdV-8) (Fowl adenovirus 8)

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DUT_ADEG8Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
PRO_ADEG8Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus ...

2 entries

Fowl adenovirus C serotype 10 (strain SA2) (FAdV-10) (Fowl adenovirus 10)

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CAPSP_ADEGXPenton protein (CP-P) (Penton base protein) (Protein III)
SHUT_ADEGXShutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) ...