Non-enveloped. Small, icosahedral, about 60 nm in size. A single molecule of circular dsDNA is contained within the T=7 icosahedral capsid, which is composed of 72 pentamers.


Circular dsDNA, about 8 kb in size, associated with cellular histones.
On rare non-specific recombination, the viral genome can be integrated in host chromosome. This inactivates the integrated virus but can gives the host cell a replicative advantage sometimes leading to malignant tumours.


Only one strand of the genome is transcribed and yield two classes of proteins expressed by alternative splicing:
a) Early Proteins: non-structural regulatory proteins (E1-E7).
b) Late Proteins: the structural proteins L1 and L2.



Replication is divided in two distinct steps that are linked to the differentiation state of the host epithelial cell:

a) The plasmid replication takes place in the basal squamous epithelial cells. It corresponds to viral DNA replication in synchrony with the host cell chromosome in order to ensures an average of one viral genome per basal cell.

  1. Attachment of the viral proteins to host receptors mediates endocytosis into vesicles in the basal squamous epithelial cell.
  2. Transport to the nucleus and uncoating of the viral DNA.
  3. Early-region transcription and translation of the early proteins.
  4. Steady-state viral DNA nuclear replication. Requires the origin of DNA replication in cis and the viral E1 and E2 proteins in trans.
b) The vegetative replication, which occurs in differentiated keratinocytes. In these cells, which no longer undergo cellular DNA synthesis, there is a burst of viral DNA synthesis with active production of virions.
  1. Vegetative viral DNA synthesis.
  2. Transcription of the late region.
  3. Capsid proteins L1 and L2 synthesis.
  4. Nuclear capsid assembly and release of viruses.

Matching UniProtKB/Swiss-Prot entries

128 entries grouped by strain (browse by keywords)

All proteins are shown (view only 127 complete proteome entries)

8 entries

Human papillomavirus type 47 reference strain

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VE1_HPV47Replication protein E1 (EC (ATP-dependent helicase E1)
VE2_HPV47Regulatory protein E2
VE4_HPV47Protein E4
VE6_HPV47Protein E6
VE7_HPV47Protein E7
VE8E2_HPV47Protein E8^E2C
VL1_HPV47Major capsid protein L1
VL2_HPV47Minor capsid protein L2

8 entries

Human papillomavirus type 5 reference strain

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VE1_HPV05Replication protein E1 (EC (ATP-dependent helicase E1)
VE2_HPV05Regulatory protein E2
VE4_HPV05Protein E4
VE6_HPV05Protein E6
VE7_HPV05Protein E7
VE8E2_HPV05Protein E8^E2C
VL1_HPV05Major capsid protein L1
VL2_HPV05Minor capsid protein L2

6 entries

Human papillomavirus type 12 reference strain

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VE1_HPV12Replication protein E1 (EC (ATP-dependent helicase E1)
VE2_HPV12Regulatory protein E2
VE6_HPV12Protein E6
VE7_HPV12Protein E7
VL1_HPV12Major capsid protein L1
VL2_HPV12Minor capsid protein L2

6 entries

Human papillomavirus type 25 reference strain

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VE1_HPV25Replication protein E1 (EC (ATP-dependent helicase E1)
VE2_HPV25Regulatory protein E2
VE6_HPV25Protein E6
VE7_HPV25Protein E7
VL1_HPV25Major capsid protein L1
VL2_HPV25Minor capsid protein L2

6 entries

Human papillomavirus type 38 reference strain

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VE1_HPV38Replication protein E1 (EC (ATP-dependent helicase E1)
VE2_HPV38Regulatory protein E2
VE6_HPV38Protein E6
VE7_HPV38Protein E7
VL1_HPV38Major capsid protein L1
VL2_HPV38Minor capsid protein L2

6 entries

Human papillomavirus type 49 reference strain

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VE1_HPV49Replication protein E1 (EC (ATP-dependent helicase E1)
VE2_HPV49Regulatory protein E2
VE6_HPV49Protein E6
VE7_HPV49Protein E7
VL1_HPV49Major capsid protein L1
VL2_HPV49Minor capsid protein L2

6 entries

Human papillomavirus type 9 reference strain

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VE1_HPV09Replication protein E1 (EC (ATP-dependent helicase E1)
VE2_HPV09Regulatory protein E2
VE6_HPV09Protein E6
VE7_HPV09Protein E7
VL1_HPV09Major capsid protein L1
VL2_HPV09Minor capsid protein L2

1 entry

Human papillomavirus type RTRX7 reference strain

VE1_HPVR7Replication protein E1 (EC (ATP-dependent helicase E1)

9 entries

Human papillomavirus type 5b

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VE1_HPV5BReplication protein E1 (EC (ATP-dependent helicase E1)
VE2_HPV5BRegulatory protein E2
VE4_HPV5BProtein E4
VE5_HPV5BProbable protein E5
VE6_HPV5BProtein E6
VE7_HPV5BProtein E7
VL1_HPV5BMajor capsid protein L1
VL2_HPV5BMinor capsid protein L2
VL3_HPV5BProbable protein L3

8 entries

Human papillomavirus type 8

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VE1_HPV08Replication protein E1 (EC (ATP-dependent helicase E1)
VE2_HPV08Regulatory protein E2
VE4_HPV08Protein E4
VE6_HPV08Protein E6
VE7_HPV08Protein E7
VE8E2_HPV08Protein E8^E2C
VL1_HPV08Major capsid protein L1
VL2_HPV08Minor capsid protein L2

6 entries

Human papillomavirus type 15

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VE1_HPV15Replication protein E1 (EC (ATP-dependent helicase E1)
VE2_HPV15Regulatory protein E2
VE6_HPV15Protein E6
VE7_HPV15Protein E7
VL1_HPV15Major capsid protein L1
VL2_HPV15Minor capsid protein L2

6 entries

Human papillomavirus type 17

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VE1_HPV17Replication protein E1 (EC (ATP-dependent helicase E1)
VE2_HPV17Regulatory protein E2
VE6_HPV17Protein E6
VE7_HPV17Protein E7
VL1_HPV17Major capsid protein L1
VL2_HPV17Minor capsid protein L2

6 entries

Human papillomavirus type 19

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VE1_HPV19Replication protein E1 (EC (ATP-dependent helicase E1)
VE2_HPV19Regulatory protein E2
VE6_HPV19Protein E6
VE7_HPV19Protein E7
VL1_HPV19Major capsid protein L1
VL2_HPV19Minor capsid protein L2

6 entries

Human papillomavirus type 20

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VE1_HPV20Replication protein E1 (EC (ATP-dependent helicase E1)
VE2_HPV20Regulatory protein E2
VE6_HPV20Protein E6
VE7_HPV20Protein E7
VL1_HPV20Major capsid protein L1
VL2_HPV20Minor capsid protein L2

6 entries

Human papillomavirus type 21

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VE1_HPV21Replication protein E1 (EC (ATP-dependent helicase E1)
VE2_HPV21Regulatory protein E2
VE6_HPV21Protein E6
VE7_HPV21Protein E7
VL1_HPV21Major capsid protein L1
VL2_HPV21Minor capsid protein L2

6 entries

Human papillomavirus type 22

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VE1_HPV22Replication protein E1 (EC (ATP-dependent helicase E1)
VE2_HPV22Regulatory protein E2
VE6_HPV22Protein E6
VE7_HPV22Protein E7
VL1_HPV22Major capsid protein L1
VL2_HPV22Minor capsid protein L2

6 entries

Human papillomavirus type 23

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VE1_HPV23Replication protein E1 (EC (ATP-dependent helicase E1)
VE2_HPV23Regulatory protein E2
VE6_HPV23Protein E6
VE7_HPV23Protein E7
VL1_HPV23Major capsid protein L1
VL2_HPV23Minor capsid protein L2

6 entries

Human papillomavirus type 24

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VE1_HPV24Replication protein E1 (EC (ATP-dependent helicase E1)
VE2_HPV24Regulatory protein E2
VE6_HPV24Protein E6
VE7_HPV24Protein E7
VL1_HPV24Major capsid protein L1
VL2_HPV24Minor capsid protein L2

6 entries

Human papillomavirus type 36

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VE1_HPV36Replication protein E1 (EC (ATP-dependent helicase E1)
VE2_HPV36Regulatory protein E2
VE6_HPV36Protein E6
VE7_HPV36Protein E7
VL1_HPV36Major capsid protein L1
VL2_HPV36Minor capsid protein L2

5 entries

Human papillomavirus type 14

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VE1_HPV14Replication protein E1 (EC (ATP-dependent helicase E1)
VE2_HPV14Regulatory protein E2
VE6_HPV14Protein E6
VL1_HPV14Major capsid protein L1
VL2_HPV14Minor capsid protein L2

5 entries

Human papillomavirus type 37

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VE1_HPV37Replication protein E1 (EC (ATP-dependent helicase E1)
VE2_HPV37Regulatory protein E2
VE7_HPV37Protein E7
VL1_HPV37Major capsid protein L1
VL2_HPV37Minor capsid protein L2