Lagovirus

VIRION

Non-enveloped, capsid of about 35 nm in diameter, with T=3 icosahedral symmetry. The capsid is composed of 180 capsid proteins. T=1 particles composed of 60 capsid proteins, about in diameter 15nm are also observed. Genomic or subgenomic RNA are encapsidated in different particles.

GENOME

Monopartite, linear ssRNA(+) genome of 7.3 to 8.3 kb. The 5’-terminus is linked to a VPg protein and the 3’-terminus has a poly(A) tract.

GENE EXPRESSION

The virion RNA is infectious and serves as both genome and viral messenger RNA. Cleavage of ORF1 polyprotein by the virus-encoded 3C-like cysteine proteinase yields the non-structural proteins and the capsid protein. ORF2 encodes a small structural protein VP2 which is expressed through RNA termination-reinitiation.

REPLICATION

CYTOPLASMIC

  1. Attachement to host receptors mediates endocytosis of the virus into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. VPg is removed from the viral RNA, which is then translated into a processed ORF1 polyprotein to yield the replication proteins.
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Subgenomic RNA translation gives rise to the capsid protein and VP2.
  7. Assembly of new virus particles and release by cell lysis.

Host-virus interaction

Apoptosis modulation

Rabbit hemorrhagic disease virus induces host cell apoptosis .

Matching UniProtKB/Swiss-Prot entries

10 entries grouped by strain (browse by keywords)

All proteins are shown (view only 7 complete proteome entries)

2 entries

Rabbit hemorrhagic disease virus (strain Rabbit/Germany/FRG/1989) (Ra/LV/RHDV/GH/1989/GE) (RHDV-FRG) reference strain

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POLG_RHDVFGenome polyprotein (p254)
VP2_RHDVFProtein VP2 (Minor capsid protein)

2 entries

Rabbit hemorrhagic disease virus (strain AST89) (Ra/LV/RHDV/AST89/1989/SP) (RHDV-AST89)

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POLG_RHDVAGenome polyprotein (p254)
VP2_RHDVAProtein VP2 (Minor capsid protein)

2 entries

Rabbit hemorrhagic disease virus (strain V-351) (Ra/LV/RHDV/V351/1991/CK) (RHDV-V351)

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POLG_RHDV3Genome polyprotein (p254)
VP2_RHDV3Protein VP2 (Minor capsid protein)

1 entry

European brown hare syndrome virus (strain GD) (Ha/LV/EBHSV/GD/1989/FR) (EBHSV-GD)


POLG_EBHSGGenome polyprotein (p254)

1 entry

Rabbit calicivirus (Ra/LV/RHDV/RCV/1995/IT) (RHDV)


CAPSD_RHDVRSubgenomic capsid protein VP60

1 entry

Rabbit hemorrhagic disease virus (strain BS89) (Ra/LV/RHDV/BS89/1989/IT) (RHDV-BS89)


POLG_RHDVBGenome polyprotein (p254)

1 entry

Rabbit hemorrhagic disease virus (strain SD) (Ra/LV/RHDV/SD/1989/FR) (RHDV-SD)


POLG_RHDVSGenome polyprotein (p254)