Vesivirus

VIRION

Non-enveloped, capsid of about 38-40 nm in diameter, with T=3 icosahedral symmetry. The capsid is composed of 180 VP1 proteins. Small empty virions are about 23nm in diameter, and would be of T=1 icosahedral symmetry, composed of 60 VP1 proteins.

GENOME

Monopartite, linear ssRNA(+) genome of 7.3 to 8.3 kb. The 5’-terminus is linked to a VPg protein and the 3’-terminus has a poly(A) tract.

GENE EXPRESSION

The virion RNA is infectious and serves as both genome and viral messenger RNA. Cleavage of ORF1 polyprotein by the virus-encoded 3C-like cysteine proteinase yields the mature nonstructural proteins. Subgenomic RNA encodes for ORF2 capsid protein and ORF3 minor structural protein. ORF2 encodes a capsid precursor protein that is proteolytically processed by the viral proteinase to yield the mature capsid protein. ORF3 encodes a small structural protein VP2 which is expressed through RNA termination-reinitiation.

REPLICATION

CYTOPLASMIC

  1. Attachement to host receptors mediates endocytosis of the virus into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. VPg is removed from the viral RNA, which is then translated into a processed ORF1 polyprotein to yield the replication proteins.
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Subgenomic RNA translation gives rise to the capsid protein and VP2.
  7. Assembly of new virus particles and release by cell lysis.

Host-virus interaction

Host gene expression shutoff by virus

Feline calicivirus mediates host translation shutoff by cleaving PABP1 .

Matching UniProtKB/Swiss-Prot entries

23 entries grouped by strain (browse by keywords)

All proteins are shown (view only 18 complete proteome entries)

3 entries

Feline calicivirus (strain Cat/United States/Urbana/1960) (FCV) reference strain

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CAPSD_FCVURCapsid protein (Coat protein) (CP)
POLG_FCVURGenome polyprotein
VP2_FCVURProtein VP2 (Minor capsid protein)

3 entries

Vesicular exanthema of swine virus serotype A48 (isolate Swine/United States/A48/1948) (VESV) reference strain

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CAPSD_VESVACapsid protein (CP) (Coat protein) (VP1)
POLG_VESVAGenome polyprotein
VP2_VESVAProtein VP2 (Minor capsid protein)

3 entries

Canine calicivirus (strain 48) (CaCV)

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CAPSD_CACV4Capsid protein (Coat protein) (CP) (VP1)
POLG_CACV4Genome polyprotein
VP2_CACV4Protein VP2 (Minor capsid protein)

3 entries

Feline calicivirus (strain CFI/68 FIV) (FCV)

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CAPSD_FCVC6Capsid protein (Coat protein) (CP) (VP1)
POLG_FCVC6Genome polyprotein
VP2_FCVC6Protein VP2 (Minor capsid protein)

3 entries

Feline calicivirus (strain F9) (FCV)

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CAPSD_FCVF9Capsid protein (Coat protein) (CP) (VP1)
POLG_FCVF9Genome polyprotein
VP2_FCVF9Protein VP2 (Minor capsid protein)

3 entries

Feline calicivirus (strain Japanese F4) (FCV)

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CAPSD_FCVF4Capsid protein (Coat protein) (CP) (VP1)
POLG_FCVF4Genome polyprotein
VP2_FCVF4Protein VP2 (Minor capsid protein)

3 entries

San Miguel sea lion virus serotype 1 (SMSV-1) (SMSV serotype 1)

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CAPSD_SMSV1Capsid protein (Coat protein) (CP) (VP1)
POLG_SMSV1Genome polyprotein
VP2_SMSV1Protein VP2 (Minor capsid protein)

2 entries

San Miguel sea lion virus serotype 4 (SMSV-4) (SMSV serotype 4)

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CAPSD_SMSV4Capsid protein (Coat protein) (CP) (VP1)
VP2_SMSV4Protein VP2 (Minor capsid protein)