Lyssavirus

VIRION

Enveloped, bullet shaped. 180 nm long and 75 nm wide.

GENOME

Negative-stranded RNA linear genome, about 11 kb in size. Encodes for 5 proteins, plus 4 by alternative initiation.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Attachment of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.

Host-virus interaction

Inhibition of host Interferon induction

Rabies nucleoprotein plays a role in inhibition of RIG-I antiviral signaling
Rabies phosphoprotein may inhibit IRF-3 phosphorylation

Inhibition of host type I interferon signaling

Rabies phosphoprotein may inhibit STAT-I antiviral pathway signaling by preventing nuclear localization of STAT dimers upon activation.

Inhibition of T-cell response

Rabies nucleoprotein may act as a superantigen by inhibiting Vbeta T-Cell repertoire

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Matching UniProtKB/Swiss-Prot entries

108 entries grouped by strain (browse by keywords)

All proteins are shown (view only 83 complete proteome entries)

5 entries

Australian bat lyssavirus (isolate Bat/AUS/1996) (ABLV) reference strain

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L_ABLVBLarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_ABLVBMatrix protein (Phosphoprotein M2)
NCAP_ABLVBNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_ABLVBPhosphoprotein (Protein P) (Protein M1)
VGLG_ABLVBGlycoprotein G

5 entries

European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) (EBLV1) reference strain

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L_EBLV1RNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_EBLV1Matrix protein
NCAP_EBLV1Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_EBLV1Phosphoprotein (Protein P) (Protein M1)
VGLG_EBLV1Glycoprotein G

5 entries

European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2) reference strain

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L_EBLV2RNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_EBLV2Matrix protein
NCAP_EBLV2Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_EBLV2Phosphoprotein (Protein P) (Protein M1)
VGLG_EBLV2Glycoprotein G

5 entries

Mokola virus (MOKV) reference strain

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L_MOKVLarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_MOKVMatrix protein (Phosphoprotein M2)
NCAP_MOKVNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_MOKVPhosphoprotein (Protein P) (Protein M1)
VGLG_MOKVGlycoprotein G

5 entries

Rabies virus (strain Pasteur vaccins / PV) (RABV) reference strain

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L_RABVPLarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_RABVPMatrix protein (Phosphoprotein M2)
NCAP_RABVPNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVPPhosphoprotein (Protein P) (Protein M1)
VGLG_RABVPGlycoprotein G

6 entries

Rabies virus (strain PM1503/AVO1) (RABV)

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C_RABVAPutative uncharacterized protein C
L_RABVALarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_RABVAMatrix protein (Phosphoprotein M2)
NCAP_RABVANucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVAPhosphoprotein (Protein P) (Protein M1)
VGLG_RABVAGlycoprotein G

5 entries

Australian bat lyssavirus (isolate Human/AUS/1998) (ABLV)

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L_ABLVHLarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_ABLVHMatrix protein (Phosphoprotein M2)
NCAP_ABLVHNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_ABLVHPhosphoprotein (Protein P) (Protein M1)
VGLG_ABLVHGlycoprotein G

5 entries

Rabies virus (strain China/DRV) (RABV)

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L_RABVDLarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_RABVDMatrix protein (Phosphoprotein M2)
NCAP_RABVDNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVDPhosphoprotein (Protein P) (Protein M1)
VGLG_RABVDGlycoprotein G

5 entries

Rabies virus (strain China/MRV) (RABV)

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L_RABVRLarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_RABVRMatrix protein (Phosphoprotein M2)
NCAP_RABVRNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVRPhosphoprotein (Protein P) (Protein M1)
VGLG_RABVRGlycoprotein G

5 entries

Rabies virus (strain ERA) (RABV)

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L_RABVELarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_RABVEMatrix protein (Phosphoprotein M2)
NCAP_RABVENucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVEPhosphoprotein (Protein P) (Protein M1)
VGLG_RABVEGlycoprotein G

5 entries

Rabies virus (strain HEP-Flury) (RABV)

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L_RABVHLarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_RABVHMatrix protein (Phosphoprotein M2)
NCAP_RABVHNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVHPhosphoprotein (Protein P) (Protein M1)
VGLG_RABVHGlycoprotein G

5 entries

Rabies virus (strain India) (RABV)

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L_RABVILarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_RABVIMatrix protein (Phosphoprotein M2)
NCAP_RABVINucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVIPhosphoprotein (Protein P) (Protein M1)
VGLG_RABVIGlycoprotein G

5 entries

Rabies virus (strain Nishigahara RCEH) (RABV)

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L_RABVNLarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_RABVNMatrix protein (Phosphoprotein M2)
NCAP_RABVNNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVNPhosphoprotein (Protein P) (Protein M1)
VGLG_RABVNGlycoprotein G

5 entries

Rabies virus (strain SAD B19) (RABV)

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L_RABVSLarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_RABVSMatrix protein (Phosphoprotein M2)
NCAP_RABVSNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVSPhosphoprotein (Protein P) (Protein M1)
VGLG_RABVSGlycoprotein G

5 entries

Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)

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L_RABVBLarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_RABVBMatrix protein (Phosphoprotein M2)
NCAP_RABVBNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVBPhosphoprotein (Protein P) (Protein M1)
VGLG_RABVBGlycoprotein G

4 entries

Aravan virus (ARAV)

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MATRX_ARAVMatrix protein (Phosphoprotein M2)
NCAP_ARAVNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_ARAVPhosphoprotein (Protein P) (Protein M1)
VGLG_ARAVGlycoprotein G

4 entries

Irkut virus (IRKV)

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MATRX_IRKVMatrix protein (Phosphoprotein M2)
NCAP_IRKVNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_IRKVPhosphoprotein (Protein P) (Protein M1)
VGLG_IRKVGlycoprotein G

4 entries

Khujand virus (KHUV)

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MATRX_KHUVMatrix protein (Phosphoprotein M2)
NCAP_KHUVNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_KHUVPhosphoprotein (Protein P) (Protein M1)
VGLG_KHUVGlycoprotein G

4 entries

Lagos bat virus (LBV)

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MATRX_LBVMatrix protein
NCAP_LBVNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_LBVPhosphoprotein (Protein P) (Protein M1)
VGLG_LBVGlycoprotein G

4 entries

Rabies virus (strain CVS-11) (RABV)

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MATRX_RABVCMatrix protein (Phosphoprotein M2)
NCAP_RABVCNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVCPhosphoprotein (Protein P) (Protein M1)
VGLG_RABVCGlycoprotein G

4 entries

West Caucasian bat virus (WCBV)

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MATRX_WCBVMatrix protein (Phosphoprotein M2)
NCAP_WCBVNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_WCBVPhosphoprotein (Protein P) (Protein M1)
VGLG_WCBVGlycoprotein G

3 entries

Duvenhage virus (DUVV)

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NCAP_DUVVNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_DUVVPhosphoprotein (Protein P) (Protein M1)
VGLG_DUVVGlycoprotein G

1 entry

Rabies virus (isolate Fox/Ontario/1991) (RABV)


NCAP_RABVFNucleoprotein (NP) (Nucleocapsid protein) (Protein N)

1 entry

Rabies virus (isolate Human/Algeria/1991) (RABV)


VGLG_RABVTGlycoprotein G

1 entry

Rabies virus (isolate Skunk/Ontario/1991) (RABV)


NCAP_RABVUNucleoprotein (NP) (Nucleocapsid protein) (Protein N)

1 entry

Rabies virus (strain PM) (RABV)


PHOSP_RABVMPhosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain Vnukovo-32) (RABV)


VGLG_RABVVGlycoprotein G