Enveloped, bullet shaped. 180 nm long and 75 nm wide.


Negative-stranded RNA linear genome, about 11 kb in size. Encodes for 5 proteins, plus 4 by alternative initiation.


The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.



  1. Attachment of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.

Host-virus interaction

Inhibition of host Interferon induction

Rabies nucleoprotein plays a role in inhibition of RIG-I antiviral signaling
Rabies phosphoprotein may inhibit IRF-3 phosphorylation

Inhibition of host type I interferon signaling

Rabies phosphoprotein may inhibit STAT-I antiviral pathway signaling by preventing nuclear localization of STAT dimers upon activation.

Inhibition of T-cell response

Rabies nucleoprotein may act as a superantigen by inhibiting Vbeta T-Cell repertoire


Matching UniProtKB/Swiss-Prot entries

108 entries grouped by strain (browse by keywords)

All proteins are shown (view only 83 complete proteome entries)

5 entries

Australian bat lyssavirus (isolate Bat/AUS/1996) (ABLV) reference strain

Select_all Deselect_all  
L_ABLVBLarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_ABLVBMatrix protein (Phosphoprotein M2)
NCAP_ABLVBNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_ABLVBPhosphoprotein (Protein P) (Protein M1)

5 entries

European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) (EBLV1) reference strain

Select_all Deselect_all  
L_EBLV1RNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_EBLV1Matrix protein
NCAP_EBLV1Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_EBLV1Phosphoprotein (Protein P) (Protein M1)

5 entries

European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2) reference strain

Select_all Deselect_all  
L_EBLV2RNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_EBLV2Matrix protein
NCAP_EBLV2Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_EBLV2Phosphoprotein (Protein P) (Protein M1)

5 entries

Mokola virus (MOKV) reference strain

Select_all Deselect_all  
L_MOKVLarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_MOKVMatrix protein (Phosphoprotein M2)
NCAP_MOKVNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_MOKVPhosphoprotein (Protein P) (Protein M1)

5 entries

Rabies virus (strain Pasteur vaccins / PV) (RABV) reference strain

Select_all Deselect_all  
L_RABVPLarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_RABVPMatrix protein (Phosphoprotein M2)
NCAP_RABVPNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVPPhosphoprotein (Protein P) (Protein M1)

6 entries

Rabies virus (strain PM1503/AVO1) (RABV)

Select_all Deselect_all  
C_RABVAPutative uncharacterized protein C
L_RABVALarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_RABVAMatrix protein (Phosphoprotein M2)
NCAP_RABVANucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVAPhosphoprotein (Protein P) (Protein M1)

5 entries

Australian bat lyssavirus (isolate Human/AUS/1998) (ABLV)

Select_all Deselect_all  
L_ABLVHLarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_ABLVHMatrix protein (Phosphoprotein M2)
NCAP_ABLVHNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_ABLVHPhosphoprotein (Protein P) (Protein M1)

5 entries

Rabies virus (strain China/DRV) (RABV)

Select_all Deselect_all  
L_RABVDLarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_RABVDMatrix protein (Phosphoprotein M2)
NCAP_RABVDNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVDPhosphoprotein (Protein P) (Protein M1)

5 entries

Rabies virus (strain China/MRV) (RABV)

Select_all Deselect_all  
L_RABVRLarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_RABVRMatrix protein (Phosphoprotein M2)
NCAP_RABVRNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVRPhosphoprotein (Protein P) (Protein M1)

5 entries

Rabies virus (strain ERA) (RABV)

Select_all Deselect_all  
L_RABVELarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_RABVEMatrix protein (Phosphoprotein M2)
NCAP_RABVENucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVEPhosphoprotein (Protein P) (Protein M1)

5 entries

Rabies virus (strain HEP-Flury) (RABV)

Select_all Deselect_all  
L_RABVHLarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_RABVHMatrix protein (Phosphoprotein M2)
NCAP_RABVHNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVHPhosphoprotein (Protein P) (Protein M1)

5 entries

Rabies virus (strain India) (RABV)

Select_all Deselect_all  
L_RABVILarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_RABVIMatrix protein (Phosphoprotein M2)
NCAP_RABVINucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVIPhosphoprotein (Protein P) (Protein M1)

5 entries

Rabies virus (strain Nishigahara RCEH) (RABV)

Select_all Deselect_all  
L_RABVNLarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_RABVNMatrix protein (Phosphoprotein M2)
NCAP_RABVNNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVNPhosphoprotein (Protein P) (Protein M1)

5 entries

Rabies virus (strain SAD B19) (RABV)

Select_all Deselect_all  
L_RABVSLarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_RABVSMatrix protein (Phosphoprotein M2)
NCAP_RABVSNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVSPhosphoprotein (Protein P) (Protein M1)

5 entries

Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)

Select_all Deselect_all  
L_RABVBLarge structural protein (Protein L) (Replicase) (Transcriptase)
MATRX_RABVBMatrix protein (Phosphoprotein M2)
NCAP_RABVBNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVBPhosphoprotein (Protein P) (Protein M1)

4 entries

Aravan virus (ARAV)

Select_all Deselect_all  
MATRX_ARAVMatrix protein (Phosphoprotein M2)
NCAP_ARAVNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_ARAVPhosphoprotein (Protein P) (Protein M1)

4 entries

Irkut virus (IRKV)

Select_all Deselect_all  
MATRX_IRKVMatrix protein (Phosphoprotein M2)
NCAP_IRKVNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_IRKVPhosphoprotein (Protein P) (Protein M1)

4 entries

Khujand virus (KHUV)

Select_all Deselect_all  
MATRX_KHUVMatrix protein (Phosphoprotein M2)
NCAP_KHUVNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_KHUVPhosphoprotein (Protein P) (Protein M1)

4 entries

Lagos bat virus (LBV)

Select_all Deselect_all  
MATRX_LBVMatrix protein
NCAP_LBVNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_LBVPhosphoprotein (Protein P) (Protein M1)

4 entries

Rabies virus (strain CVS-11) (RABV)

Select_all Deselect_all  
MATRX_RABVCMatrix protein (Phosphoprotein M2)
NCAP_RABVCNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVCPhosphoprotein (Protein P) (Protein M1)

4 entries

West Caucasian bat virus (WCBV)

Select_all Deselect_all  
MATRX_WCBVMatrix protein (Phosphoprotein M2)
NCAP_WCBVNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_WCBVPhosphoprotein (Protein P) (Protein M1)

3 entries

Duvenhage virus (DUVV)

Select_all Deselect_all  
NCAP_DUVVNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_DUVVPhosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (isolate Fox/Ontario/1991) (RABV)

NCAP_RABVFNucleoprotein (NP) (Nucleocapsid protein) (Protein N)

1 entry

Rabies virus (isolate Human/Algeria/1991) (RABV)


1 entry

Rabies virus (isolate Skunk/Ontario/1991) (RABV)

NCAP_RABVUNucleoprotein (NP) (Nucleocapsid protein) (Protein N)

1 entry

Rabies virus (strain PM) (RABV)

PHOSP_RABVMPhosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain Vnukovo-32) (RABV)