Marburgvirus

Molecular biology

Filamentous, greatly variable up to 1400 nm in length. Diameter is about 80nm.

GENOME

Negative-stranded RNA linear genome, about 19 kb in size. Encodes for seven proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Attachment to host receptors through GP glycoprotein mediates is endocytosed into vesicles in the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane, buds via the host ESCRT complexes from the plasma membrane, releasing the virion.

Host-virus interaction

Inhibition of host interferon signaling

Vp40 protein prevents interferon signaling by preventing the tyrosine phosphorylation of JAK1 and subsequent phosphorylation of STAT1 and STAT2. .

Matching UniProtKB/Swiss-Prot entries

35 entries grouped by strain (browse by keywords)

7 entries

Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980)) reference strain

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L_MABVMRNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
NCAP_MABVMNucleoprotein (Nucleocapsid protein) (Protein N)
VGP_MABVMEnvelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein)
VP24_MABVMMembrane-associated protein VP24
VP30_MABVMMinor nucleoprotein VP30 (Transcription activator VP30)
VP35_MABVMPolymerase cofactor VP35
VP40_MABVMMatrix protein VP40 (Membrane-associated protein VP40)

7 entries

Lake Victoria marburgvirus (strain Angola/2005) (MARV)

Select_all Deselect_all  
L_MABVARNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
NCAP_MABVANucleoprotein (Nucleocapsid protein)
VGP_MABVAEnvelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein)
VP24_MABVAMembrane-associated protein VP24
VP30_MABVAMinor nucleoprotein VP30 (Transcription activator VP30)
VP35_MABVAPolymerase cofactor VP35
VP40_MABVAMatrix protein VP40 (Membrane-associated protein VP40)

7 entries

Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975))

Select_all Deselect_all  
L_MABVORNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
NCAP_MABVONucleoprotein (Nucleocapsid protein)
VGP_MABVOEnvelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein)
VP24_MABVOMembrane-associated protein VP24
VP30_MABVOMinor nucleoprotein VP30 (Transcription activator VP30)
VP35_MABVOPolymerase cofactor VP35
VP40_MABVOMatrix protein VP40 (Membrane-associated protein VP40)

7 entries

Lake Victoria marburgvirus (strain Popp-67) (MARV) (Marburg virus (strain West Germany/Popp/1967))

Select_all Deselect_all  
L_MABVPRNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
NCAP_MABVPNucleoprotein (Nucleocapsid protein) (Protein N)
VGP_MABVPEnvelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein)
VP24_MABVPMembrane-associated protein VP24
VP30_MABVPMinor nucleoprotein VP30 (Transcription activator VP30)
VP35_MABVPPolymerase cofactor VP35
VP40_MABVPMatrix protein VP40 (Membrane-associated protein VP40)

7 entries

Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987))

Select_all Deselect_all  
L_MABVRRNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
NCAP_MABVRNucleoprotein (Nucleocapsid protein)
VGP_MABVREnvelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein)
VP24_MABVRMembrane-associated protein VP24
VP30_MABVRMinor nucleoprotein VP30 (Transcription activator VP30)
VP35_MABVRPolymerase cofactor VP35
VP40_MABVRMatrix protein VP40 (Membrane-associated protein VP40)