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Orthobunyavirus

Molecular biology

VIRION

Enveloped, spherical. Diameter from 80 to 120nm.

GENOME

Segmented Negative-stranded RNA linear genome, L segment is about 6.9kb, M segment about 4.5kb and S segment about 1kb.
Encodes for six proteins.

GENE EXPRESSION

Transcription starts by viral RNA dependent RNA polymerase (L) binding to a promoter on each encapsidated segment, and is terminated by a strong hairpin sequence at the end of each gene. mRNAs are capped by L protein during synthesis, but are not polyadenylated.

S segment encodes for NSs protein by leaky scanning. M segment encodes for a polyprotein which is cleaved by host protease into Gn, NSm and Gc proteins.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host receptors though Gn-Gc glycoprotein dimer, and is endocytosed into vesicles in the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid segments are released in the cytoplasm.
  3. Transcription, viral mRNAs are capped in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsids migrate under the plasma membrane and buds, releasing the virion.

Host-virus interaction

Inhibition of host transcription initiation

The Bunyamwera virus (BUNV) NSs protein plays a role in the inhibition of host RNA polymerase II

Matching UniProtKB/Swiss-Prot entries

26 entries grouped by strain (browse by keywords)

All proteins are shown (view only 8 complete proteome entries)

4 entries

Bunyamwera virus (BUNV) reference strain

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GP_BUNYWEnvelope glycoprotein (GP) (M polyprotein)
L_BUNYWRNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural ...
NCAP_BUNYWNucleoprotein (Nucleocapsid protein) (Protein N)
NSS_BUNYWNon-structural protein NS-S

4 entries

Bunyavirus La Crosse (isolate Human/United States/L78/1978) reference strain

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GP_BUNL8Envelope glycoprotein (GP) (M polyprotein)
L_BUNL8RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural ...
NCAP_BUNL8Nucleoprotein (Nucleocapsid protein) (Protein N)
NSS_BUNL8Non-structural protein NS-S

4 entries

Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)

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GP_SBVBHEnvelope glycoprotein (GP) (M polyprotein)
L_SBVBHRNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural ...
NCAP_SBVBHNucleoprotein (Nucleocapsid protein) (Protein N)
NSS_SBVBHNon-structural protein NS-S

3 entries

Bunyavirus germiston

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GP_BUNGEEnvelope glycoprotein (GP) (M polyprotein)
NCAP_BUNGENucleoprotein (Nucleocapsid protein) (Protein N)
NSS_BUNGENon-structural protein NS-S

3 entries

Bunyavirus snowshoe hare

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GP_BUNSHEnvelope glycoprotein (GP) (M polyprotein)
NCAP_BUNSHNucleoprotein (Nucleocapsid protein) (Protein N)
NSS_BUNSHNon-structural protein NS-S

3 entries

Maguari virus

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NCAP_MAGVNucleoprotein (Nucleocapsid protein) (Protein N)
NSS_MAGVNon-structural protein NS-S
Y9KD_MAGVPutative uncharacterized 9.3 kDa protein

2 entries

Aino virus

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NCAP_AINOVNucleoprotein (Nucleocapsid protein) (Protein N)
NSS_AINOVNon-structural protein NS-S

2 entries

Bunyavirus La Crosse

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NCAP_BUNLCNucleoprotein (Nucleocapsid protein) (Protein N)
NSS_BUNLCNon-structural protein NS-S

1 entry

Bunyavirus La Crosse (isolate Aedes triseriatus/United States/L74/1974)


GP_BUNL7Envelope glycoprotein (GP) (M polyprotein)