Comovirus

VIRION

Non-enveloped, 28-30 nm in diameter, T=pseudo3 icosahedral capsid. The capsid is composed of 60 CPS (whih one jelly rolls domain) and 60 CPL proteins (with two jell rolls domains). Genomic RNAs are encapsidated separately into two different types of particle of similar size.

GENOME

Segmented, bipartite linear ssRNA(+) genome composed of RNA-1=6-8 kb and RNA-2=4-7 kb. Each genomic segment has a VPg linked to its 5’ end and a 3’ poly(A) tract.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and mRNA.
RNA-1 and RNA-2 are translated into two polyproteins, which are then processed into functional proteins. RNA-1 encodes proteins necessary for replication, while RNA2 encodes two capsid proteins and product(s) involved in cell-to-cell movement.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. Synthesis and proteolytic cleavage of the replicase polyprotein RNA-1.
  4. Replication occurs in viral factories made of membrane vesicles derived from the ER. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Assembly of new virus particles.
  7. Movement protein allows cell-to-cell movement.

Matching UniProtKB/Swiss-Prot entries

9 entries grouped by strain (browse by keywords)

All proteins are shown (view only 8 complete proteome entries)

2 entries

Cowpea mosaic virus (strain SB) (CPMV) reference strain

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POL1_CPMVSRNA1 polyprotein (Genome polyprotein B) (P1)
POL2_CPMVSRNA2 polyprotein (Genome polyprotein M) (P2)

2 entries

Bean-pod mottle virus (strain Kentucky G7) (BPMV)

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POL1_BPMVRNA1 polyprotein (Genome polyprotein B) (P1)
POL2_BPMVRNA2 polyprotein (Genome polyprotein M) (P2)

2 entries

Cowpea severe mosaic virus (strain DG) (CPSMV)

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POL1_CPSMVRNA1 polyprotein (Genome polyprotein B) (P1)
POL2_CPSMVRNA2 polyprotein (Genome polyprotein M) (P2)

2 entries

Red clover mottle virus (RCMV)

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POL1_RCMVRNA1 polyprotein (Genome polyprotein B) (P1)
POL2_RCMVRNA2 polyprotein (Genome polyprotein M) (P2)

1 entry

Andean potato mottle virus (APMV)


POL2_APMVRNA2 polyprotein (Genome polyprotein M) (P2)