Superantigen (kw:KW-0766)
Super Antigens (SAgs) are molecule able to activate non specific immune repertoire, by bridging together T-cell receptors with non-specific partners.Initially this cause lymphocyte activation but then result in clonal deletion and anergy, leading to immune tolerance.
Some viruses would encode superantigens that may help them survive against host innate immunity.
B T Huber, P N Hsu, N Sutkowski
Microbiol Rev September 1996; 60: 473?482
Epstein-Barr virus would transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen, thereby gaining the advantages of immune escape
N Sutkowski, B Conrad, D A Thorley-Lawson, B T Huber
Immunity October 2001; 15: 579?589
H Acha-Orbea, H R MacDonald
Annu. Rev. Immunol. 1995; 13: 459-486
M Lafon, A Galelli
Springer Semin. Immunopathol. 1996; 17: 307-318
Eric M Leroy, Pierre Becquart, Nadia Wauquier, Sylvain Baize
J. Virol. April 2011; 85: 4041-4042
Albert K Tai, Miao Lin, Francesca Chang, Gang Chen, Francis Hsiao, Natalie Sutkowski, Brigitte T Huber
J. Immunol. September 1, 2006; 177: 3178-3184
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)31 entries grouped by strain
1 entry
Australian bat lyssavirus (isolate Bat/AUS/1996) (ABLV) reference strain
1 entry
European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) (EBLV1) reference strain
1 entry
Maize mosaic virus (isolate Maize/United States/Reed/2005) (MMV) reference strain
1 entry
Mokola virus (MOKV) reference strain
1 entry
Mouse mammary tumor virus (strain BR6) (MMTV) reference strain
1 entry
Mouse mammary tumor virus (strain C3H) (MMTV) reference strain
1 entry
Rabies virus (strain Pasteur vaccins / PV) (RABV) reference strain
1 entry
Rice yellow stunt virus (RYSV) (Rice transitory yellowing virus) reference strain
1 entry
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) reference strain
1 entry
Taro vein chlorosis virus (TAVCV) reference strain
1 entry
West Caucasian bat virus (WCBV) reference strain
3 entries
Mouse mammary tumor virus (strain GR) (MMTV)
1 entry
Aravan virus (ARAV)
1 entry
Australian bat lyssavirus (isolate Human/AUS/1998) (ABLV)
1 entry
Duvenhage virus (DUVV)
1 entry
Irkut virus (IRKV)
1 entry
Khujand virus (KHUV)
1 entry
Rabies virus (isolate Fox/Ontario/1991) (RABV)
1 entry
Rabies virus (isolate Skunk/Ontario/1991) (RABV)
1 entry
Rabies virus (strain CVS-11) (RABV)
1 entry
Rabies virus (strain China/DRV) (RABV)
1 entry
Rabies virus (strain China/MRV) (RABV)
1 entry
Rabies virus (strain ERA) (RABV)
1 entry
Rabies virus (strain HEP-Flury) (RABV)
1 entry
Rabies virus (strain India) (RABV)
1 entry
Rabies virus (strain Nishigahara RCEH) (RABV)
1 entry
Rabies virus (strain PM1503/AVO1) (RABV)
1 entry
Rabies virus (strain SAD B19) (RABV)
1 entry