Flaviviridae

VIRION

Enveloped, spherical, about 50 nm in diameter. The surface proteins are arranged in an icosahedral-like symmetry.
Source: Zhang et al

GENOME

Monopartite, linear, ssRNA(+) genome of about 9.7-12 kb. The genome 3’ terminus is not polyadenylated but forms a loop structure. The 5’ end has a methylated nucleotide cap (to allow translation) or a genome-linked protein (VPg).

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and the viral messenger RNA. The whole genome is translated into a polyprotein, which is processed co- and post-translationally by host and viral proteases.

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral envelope protein E to host receptors mediates internalization into the host cell by clathrin-mediated endocytosis.
  2. Fusion of virus membrane with host endosomal membrane. RNA genome is released into the cytoplasm.
  3. The positive-sense genomic ssRNA is translated into a polyprotein, which is cleaved into all structural and non structural proteins (to yield the replication proteins).
  4. Replication takes place at the surface of endoplasmic reticulum in cytoplasmic viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Virus assembly occurs at the endoplasmic reticulum and seems to be facilitated by the viral ionic channel p7. The virion buds via the host ESCRT complexes at the endoplasmic reticulum, is transported to the Golgi apparatus, and then exits the cell via the secretory pathway.

Host-virus interaction

Adaptive immune response inhibition

Dengue NS1 protein inhibits host complement by binding C4 and reducing C4b deposition and C3 convertase activity. Through this mechanism, NS1 protects DENV from complement-dependent neutralization in solution. .

Apoptosis modulation

Flaviviruses NS3 induces apoptosis through host caspases activation .

Autophagy modulation

Flaviviruses NS4A and NS4B induces autophagy signaling .

Cell-cycle modulation

Hepatitis C virus induces down-regulation of the retinoblastoma tumor suppressor and G1/S host cell cycle checkpoint dysregulation .

Innate immune response inhibition

Hepatitis C virus inhibits the interferon signaling pathway by blocking the IFN receptors , STAT1 and TYK2 , whilst Dengue virus blocks STAT2
Hepatitis C virus inhibits the host IFN-mediated response by blocking host MAVS , TRAFs and TBK1-IKBKE-DDX3 complex , whilst pestiviruses N(pro) blocks host IRF-3 .

Host gene expression shutoff by virus

Hepatitis C virus activates PKR about 12h p.i. to shutoff host translation through the PKR-mediated phosphorylation of the eIF2alpha initiation factor .

Matching UniProtKB/Swiss-Prot entries

82 entries grouped by strain (browse by keywords)

All proteins are shown (view only 81 complete proteome entries)

2 entries

Hepatitis C virus genotype 1a (isolate H) (HCV) reference strain

Select_all Deselect_all  
F_HCVHF protein (Alternate reading frame protein/F-protein) (ARFP/F) (Frameshifted ...
POLG_HCVHGenome polyprotein

1 entry

Bovine viral diarrhea virus (isolate NADL) (BVDV) (Mucosal disease virus) reference strain


POLG_BVDVNGenome polyprotein

1 entry

Dengue virus type 1 (strain Nauru/West Pac/1974) (DENV-1) reference strain


POLG_DEN1WGenome polyprotein

1 entry

Yellow fever virus (strain 17D vaccine) (YFV) reference strain


POLG_YEFV1Genome polyprotein

2 entries

Hepatitis C virus genotype 1a (isolate 1) (HCV)

Select_all Deselect_all  
F_HCV1F protein (Alternate reading frame protein/F-protein) (ARFP/F) (Frameshifted ...
POLG_HCV1Genome polyprotein

1 entry

Bovine viral diarrhea virus (strain CP7) (BVDV) (Mucosal disease virus)

1 entry

Bovine viral diarrhea virus (strain SD-1) (BVDV) (Mucosal disease virus)


POLG_BVDVSGenome polyprotein

1 entry

Classical swine fever virus (strain Alfort) (CSFV) (Hog cholera virus)


POLG_CSFVAGenome polyprotein

1 entry

Classical swine fever virus (strain Brescia) (CSFV) (Hog cholera virus)


POLG_CSFVBGenome polyprotein

1 entry

Dengue virus type 1 (strain Brazil/97-11/1997) (DENV-1)


POLG_DEN1BGenome polyprotein

1 entry

Dengue virus type 1 (strain Singapore/S275/1990) (DENV-1)


POLG_DEN1SGenome polyprotein

1 entry

Dengue virus type 2 (isolate Thailand/0168/1979) (DENV-2)


POLG_DEN28Genome polyprotein

1 entry

Dengue virus type 2 (strain 16681-PDK53) (DENV-2)


POLG_DEN27Genome polyprotein

1 entry

Dengue virus type 2 (strain Jamaica/1409/1983) (DENV-2)


POLG_DEN2JGenome polyprotein

1 entry

Dengue virus type 2 (strain Peru/IQT2913/1996) (DENV-2)


POLG_DEN2QGenome polyprotein

1 entry

Dengue virus type 2 (strain Puerto Rico/PR159-S1/1969) (DENV-2)

1 entry

Dengue virus type 2 (strain Thailand/16681/1984) (DENV-2)


POLG_DEN26Genome polyprotein

1 entry

Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)


POLG_DEN2NGenome polyprotein

1 entry

Dengue virus type 3 (strain China/80-2/1980) (DENV-3)


POLG_DEN3CGenome polyprotein

1 entry

Dengue virus type 3 (strain Martinique/1243/1999) (DENV-3)


POLG_DEN3MGenome polyprotein

1 entry

Dengue virus type 3 (strain Philippines/H87/1956) (DENV-3)


POLG_DEN3PGenome polyprotein

1 entry

Dengue virus type 3 (strain Singapore/8120/1995) (DENV-3)


POLG_DEN3IGenome polyprotein

1 entry

Dengue virus type 3 (strain Sri Lanka/1266/2000) (DENV-3)


POLG_DEN3SGenome polyprotein

1 entry

Dengue virus type 4 (strain Dominica/814669/1981) (DENV-4)


POLG_DEN4DGenome polyprotein

1 entry

Dengue virus type 4 (strain Philippines/H241/1956) (DENV-4)


POLG_DEN4PGenome polyprotein

1 entry

Dengue virus type 4 (strain Singapore/8976/1995) (DENV-4)


POLG_DEN4SGenome polyprotein

1 entry

Dengue virus type 4 (strain Thailand/0348/1991) (DENV-4)

1 entry

Dengue virus type 4 (strain Thailand/0476/1997) (DENV-4)


POLG_DEN4HGenome polyprotein

1 entry

Hepatitis C virus genotype 1b (isolate BK) (HCV)

1 entry

Hepatitis C virus genotype 1b (isolate Con1) (HCV)

1 entry

Hepatitis C virus genotype 1b (isolate HC-J1) (HCV)


POLG_HCVJ1Genome polyprotein

1 entry

Hepatitis C virus genotype 1b (isolate HC-JT) (HCV)


POLG_HCVJTGenome polyprotein

1 entry

Hepatitis C virus genotype 1b (isolate HCR6) (HCV)


POLG_HCVR6Genome polyprotein

1 entry

Hepatitis C virus genotype 1b (isolate Japanese) (HCV)

1 entry

Hepatitis C virus genotype 1b (isolate Taiwan) (HCV)


POLG_HCVTWGenome polyprotein

1 entry

Hepatitis C virus genotype 1b (strain HC-J4) (HCV)

1 entry

Hepatitis C virus genotype 1c (isolate HC-G9) (HCV)


POLG_HCVH9Genome polyprotein

1 entry

Hepatitis C virus genotype 1c (isolate India) (HCV)


POLG_HCVINGenome polyprotein

1 entry

Hepatitis C virus genotype 2a (isolate HC-J6) (HCV)


POLG_HCVJ6Genome polyprotein

1 entry

Hepatitis C virus genotype 2a (isolate JFH-1) (HCV)

1 entry

Hepatitis C virus genotype 2b (isolate HC-J8) (HCV)


POLG_HCVJ8Genome polyprotein

1 entry

Hepatitis C virus genotype 2b (isolate JPUT971017) (HCV)


POLG_HCVJPGenome polyprotein

1 entry

Hepatitis C virus genotype 2c (isolate BEBE1) (HCV)


POLG_HCVBBGenome polyprotein

1 entry

Hepatitis C virus genotype 2k (isolate VAT96) (HCV)


POLG_HCVVAGenome polyprotein

1 entry

Hepatitis C virus genotype 3a (isolate NZL1) (HCV)


POLG_HCVNZGenome polyprotein

1 entry

Hepatitis C virus genotype 3a (isolate k3a) (HCV)


POLG_HCVK3Genome polyprotein

1 entry

Hepatitis C virus genotype 3b (isolate Tr-Kj) (HCV)


POLG_HCVTRGenome polyprotein

1 entry

Hepatitis C virus genotype 3k (isolate JK049) (HCV)


POLG_HCVJKGenome polyprotein

1 entry

Hepatitis C virus genotype 4a (isolate ED43) (HCV)


POLG_HCVEDGenome polyprotein

1 entry

Hepatitis C virus genotype 5a (isolate EUH1480) (HCV)


POLG_HCVEVGenome polyprotein

1 entry

Hepatitis C virus genotype 5a (isolate SA13) (HCV)


POLG_HCVSAGenome polyprotein

1 entry

Hepatitis C virus genotype 6a (isolate 6a33) (HCV)


POLG_HCV6AGenome polyprotein

1 entry

Hepatitis C virus genotype 6a (isolate EUHK2) (HCV)


POLG_HCVEUGenome polyprotein

1 entry

Hepatitis C virus genotype 6b (isolate Th580) (HCV)


POLG_HCVT5Genome polyprotein

1 entry

Hepatitis C virus genotype 6d (isolate VN235) (HCV)


POLG_HCVVNGenome polyprotein

1 entry

Hepatitis C virus genotype 6g (isolate JK046) (HCV)


POLG_HCVJLGenome polyprotein

1 entry

Hepatitis C virus genotype 6h (isolate VN004) (HCV)


POLG_HCVVPGenome polyprotein

1 entry

Hepatitis C virus genotype 6k (isolate VN405) (HCV)


POLG_HCVVOGenome polyprotein

1 entry

Hepatitis GB virus B (GBV-B) (GB virus B)


POLG_GBVBGenome polyprotein

1 entry

Japanese encephalitis virus (strain Jaoars982)


POLG_JAEVJGenome polyprotein

1 entry

Japanese encephalitis virus (strain SA(v))


POLG_JAEV5Genome polyprotein

1 entry

Japanese encephalitis virus (strain SA-14)


POLG_JAEV1Genome polyprotein

1 entry

Kunjin virus (strain MRM61C)


POLG_KUNJMGenome polyprotein

1 entry

Langat virus (strain TP21)


POLG_LANVTGenome polyprotein

1 entry

Louping ill virus (Li)


POLG_LIVGenome polyprotein

1 entry

Mosquito cell fusing agent (CFA flavivirus)


POLG_MCFAGenome polyprotein

1 entry

Murray valley encephalitis virus (strain MVE-1-51) (MVEV)


POLG_MVEV5Genome polyprotein

1 entry

Tick-borne encephalitis virus (strain Hypr) (TBEV)


POLG_TBEVHGenome polyprotein

1 entry

Tick-borne encephalitis virus European subtype (strain Neudoerfl) (NEUV) (Neudoerfl virus)


POLG_TBEVWGenome polyprotein

1 entry

Tick-borne encephalitis virus Far Eastern subtype (strain Sofjin) (SOFV) (Sofjin virus)


POLG_TBEVSGenome polyprotein

1 entry

Tick-borne powassan virus (strain LB) (POWV) (Powassan virus)


POLG_POWVLGenome polyprotein

1 entry

West Nile virus (WNV)


POLG_WNVGenome polyprotein

1 entry

Yellow fever virus (isolate Angola/14FA/1971) (YFV)


POLG_YEFVNGenome polyprotein

1 entry

Yellow fever virus (isolate Ethiopia/Couma/1961) (YFV)


POLG_YEFVEGenome polyprotein

1 entry

Yellow fever virus (isolate Ivory Coast/1999) (YFV)


POLG_YEFVCGenome polyprotein

1 entry

Yellow fever virus (isolate Ivory Coast/85-82H/1982) (YFV)


POLG_YEFVIGenome polyprotein

1 entry

Yellow fever virus (isolate Uganda/A7094A4/1948) (YFV)


POLG_YEFVUGenome polyprotein

1 entry

Yellow fever virus (strain French neurotropic vaccine FNV) (YFV)


POLG_YEFVFGenome polyprotein

1 entry

Yellow fever virus (strain Ghana/Asibi/1927) (YFV)


POLG_YEFVAGenome polyprotein

1 entry

Yellow fever virus (strain Trinidad/TRINID79A/1979) (YFV)


POLG_YEFVTGenome polyprotein