Molecular biology


Enveloped, bullet shaped.


Negative-stranded RNA linear genome,about 13.2 kb in size. Encodes for 8 proteins.


The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.



  1. Attachement of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription , viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.

Matching UniProtKB/Swiss-Prot entries

9 entries grouped by strain (browse by keywords)

9 entries

Tibrogargan virus (strain CS132) (TIBV) reference strain

Select_all Deselect_all  
L_TIBVCRNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_TIBVCMatrix protein
NCAP_TIBVCNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_TIBVCPhosphoprotein (P protein)
U1_TIBVCProtein U1
U2_TIBVCProtein U2
U3_TIBVCProtein U3
U4_TIBVCUncharacterized protein U4