Muvirus

VIRION

Non-enveloped, head-tail structure. The icosahedral head is about 54 nm with a knob-like neck. The tails is contractile, has a baseplate and 6 short fibers.

GENOME

Linear, dsDNA genome of about 40 kb, encoding for 56 proteins. 50-150 bp and about 2 Kb of bacterial DNA are respectively covalently linked at the left and the right end of Mu genome. The presence of these pieces of bacterial DNA is due to the headful packaging mechanism.

GENE EXPRESSION

Genes are transcribed by operons.

REPLICATION

CYTOPLASMIC

  1. Adsorption: the phage attaches to the target cell lipopolysaccharides (LPS) through its tail fibers. Two types of fibers are encoded by the phage to allow receptor tropism switching.
  2. Ejection of the viral DNA into host cell cytoplasm by contraction of the tail sheath.
  3. Viral DNA ends are protected from degradation by host nucleases.
  4. ?Transcription and translation of early genes?
  5. Circularization and supercoiling of the viral DNA.
  6. Integration of viral DNA into the host chromosome.
  7. Replicative transposition gives rise to 50-100 new copies of the viral genome in the host chromosome.
  8. Transcription and translation of late genes.
  9. Assembly of an empty procapsid.
  10. Momylation of viral DNA (modification of adenines) makes the packaged viral DNA resistant to host restriction enzymes.
  11. Viral tail fibers assembly and viral tail assembly.
  12. Mature virions are released from the cell by lysis.

Matching UniProtKB/Swiss-Prot entries

64 entries grouped by strain (browse by keywords)

55 entries

Escherichia phage Mu (Bacteriophage Mu) reference strain

Select_all Deselect_all  
ACTC_BPMULate transcription activator C (C) (Gene product 21) (gp21) (Protein C)
BP44_BPMUBaseplate hub protein gp44 (43 kDa tail protein) (Gene product 44) (gp44) (Gene ...
BP45_BPMUBaseplate puncturing device gp45 (Gene product 45) (gp45) (Gene product Q) (gpQ)
BP46_BPMUBaseplate protein gp46 (Gene product 46) (gp46) (Gene product V) (gpV)
BP47_BPMUBaseplate protein gp47 (Gene product 47) (gp47) (Gene product W) (gpW)
BP48_BPMUBaseplate protein gp48 (Gene product 48) (gp48) (Gene product R) (gpR)
CAPSD_BPMUMajor capsid protein (Gene product 34) (gp34) (Gene product T) (gpT) (Major ...
CIRCN_BPMUDNA circularization protein N (64 kDa virion protein) (Gene product 43) (gp43) ...
COM_BPMUTranslational activator com (Gene product 54) (gp54) (Gene product com) (gpCom)
ENLYS_BPMUEndolysin (EC 3.2.1.17) (Gene product 22) (gp22) (Lysis protein) (Lysozyme) ...
GAM_BPMUPutative DNA ends protecting protein gam (Gene product 10) (gp10)
GEMA_BPMUGemA protein (Gene product 16) (gp16)
GIN_BPMUSerine recombinase gin (EC 3.1.22.-) (EC 6.5.1.-) (G-segment invertase) (Gin) ...
GP11_BPMUUncharacterized protein gp11 (Gene product 11) (gp11)
GP12_BPMUUncharacterized protein gp12 (E13) (Gene product 12) (gp12)
GP13_BPMUUncharacterized protein gp13 (E14) (Gene product 13) (gp13)
GP14_BPMUUncharacterized protein gp14 (E15) (Gene product 14) (gp14)
GP15_BPMUUncharacterized protein gp15 (Gene product 15) (gp15)
GP18_BPMUUncharacterized protein gp18 (E18) (E18 protein) (Gene product 18)
GP19_BPMUUncharacterized protein gp19 (E19 protein) (Gene product 19) (gp19)
GP24_BPMUUncharacterized protein gp24 (Gene product 24) (gp24)
GP25_BPMUUncharacterized protein gp25 (Gene product 25) (gp25)
GP26_BPMUUncharacterized protein gp26 (Gene product 26) (gp26)
GP35_BPMUUncharacterized protein gp35 (Gene product 35) (gp35)
GP38_BPMUPutative sheath terminator protein (Gene product 38) (gp38)
GP6_BPMUUncharacterized protein gp6 (E5) (Gene product 6) (gp6)
GP7_BPMUUncharacterized protein gp7 (E6) (Gene product 7) (gp7)
GP8_BPMUUncharacterized protein gp8 (E7) (Gene product 8) (gp8)
GP9_BPMUUncharacterized protein gp9 (E8) (Gene product 9) (gp9)
GPF_BPMUPutative capsid assembly protein F (Gene product 30) (gp30) (Gene product F) ...
GPG_BPMUPutative capsid assembly protein G (Gene product G) (gpG)
GPJ_BPMUGene product J (gpJ) (Gene product 36) (gp36)
KIL_BPMUProtein kil (Gene product 5) (gp5) (Protein cim)
MOM_BPMUAdenine modification enzyme mom (Adenine acetyltransferase) (EC 2.3.1.-) (Gene ...
MOR_BPMUMiddle operon regulator (Mor) (GemB) (Gene product 17) (gp17)
NER_BPMUNegative regulator of transcription (Ner) (Gene product 2) (gp2)
PORTL_BPMUPortal protein (Gene product 29) (gp29) (Gene product H) (gpH) (Head-tail ...
PRO_BPMUProtease I (Gene product 32) (gp32) (Gene product I) (gpI)
REPC_BPMURepressor protein c (Repc) (CI) (Gene product 1) (gp1) (Mu repressor) (MuR)
S1_BPMUTail fiber protein S (Gene product 49) (gp49) (Gene product S) (gpS)
S2_BPMUTail fiber protein S' (Gene product S') (gpS')
SPAN1_BPMUProbable spanin, inner membrane subunit (i-spanin) (gene product 23) (gp23)
TAPFS_BPMUProbable tail assembly protein FS-gp41
TAP_BPMUProbable tail assembly protein gp41 (Gene product 41) (gp41) (Tail assembly ...
TARGB_BPMUATP-dependent target DNA activator B (EC 3.6.1.3) (Gene product 04) (gp04) ...
TERL_BPMUProbable terminase, large subunit gp28 (EC 3.1.-.-) (Gene product 28) (gp28) ...
TERS_BPMUProbable terminase, small subunit gp27 (Gene product 27) (gp27) (Gene product ...
TMP_BPMUProbable tape measure protein (TMP) (Gene product 42) (gp42) (Gene product Y) ...
TNPA_BPMUDDE-recombinase A (EC 3.1.22.-) (EC 6.5.1.-) (DDE-transposase A) (Gene product ...
TRP_BPMUProbable tail terminator protein (TrP) (Gene product 37) (gp37) (Gene product ...
TSP_BPMUTail sheath protein (TSP) (Gene product 39) (gp39) (Gene product L) (gpL)
TUBE_BPMUTail tube protein (TTP) (Gene product 40) (gp40) (Gene product M) (gpM)
U1_BPMUTail fiber assembly protein U (Gene product 50) (gp50) (Gene product U) (gpU)
U2_BPMUTail fiber assembly protein U' (Gene product U') (gpU')
VG20_BPMUUncharacterized protein gp20 (Gene product 20) (gp20)

9 entries

Escherichia phage D108 (Bacteriophage D108)

Select_all Deselect_all  
COM_BPD10Translational activator com (Gene product com) (gpCom)
E15_BPD10Uncharacterized protein gp14 (E15) (Gene product 14) (gp14)
GEMA_BPD10GemA protein (Gene product 16) (gp16)
GES_BPD10D108-specific protein (12 kDa protein)
GIN_BPD10Serine recombinase gin (EC 3.1.22.-) (EC 6.5.1.-) (G-segment invertase) (Gin)
MOM_BPD10Adenine modification enzyme mom (Adenine acetyltransferase) (EC 2.3.1.-) (Gene ...
NER_BPD10Negative regulator of transcription (Ner)
REPC_BPD10Repressor c protein (Repc) (CI)
TARGB_BPD10ATP-dependent target DNA activator B (EC 3.6.1.3) (Gene product B) (gpB) (MuB)