Lambda-like viruses

Molecular biology

VIRION


Nonenveloped, head-tail structure. The head is about 60 nm in diameter and consists of 72 capsomers. Tails are flexible with one short fiber and four long fibers.

GENOME

Linear, dsDNA genome of about 48 kb, containing about 70 genes.

GENE EXPRESSION

REPLICATION

CYTOPLASMIC

  1. Adsorption: the phage attaches to target cell trhough its tail fibers.
  2. Viral lysozyme degrades cell wall locally
  3. Injection: viral DNA is injected in host cell periplasm
  4. DNA genome is circularized or integrated into host chromosome
  5. Transcription and traduction of early genes
  6. Replication of genomic DNA
  7. Transcription and traduction of late genes
  8. Assembly of new virions in host cell cytoplasm
  9. Mature virions are released from the cell by lysis
DB LINKS Nucleotide DB: NCBI
Protein DB: UniProtKB
TAXONOMY Group I: dsDNA viruses
Order: Caudovirales
Family: Siphoviridae
Genus: Lambda-like virus
SPECIES
Type: Enterobacteria phage λ (λ)
Main: Vibrio phage 149 (phi149)
REFERENCE STRAIN Enterobacteria phage λ
Sequence | Genome | Proteome
HOST Bacteria.

Epidemiology

GEOGRAPHY Worldwide
TRANSMISSION Passive diffusion through medium
ANTIVIRAL DRUGS None

Matching UniProtKB/Swiss-Prot entries

157 entries grouped by strain

All proteins are shown (view only 62 complete proteome entries)

62 entries

Enterobacteria phage lambda (Bacteriophage lambda) reference strain

Select_all Deselect_all  
BOR_LAMBDLipoprotein bor
EA10_LAMBDProtein ea10
EA22_LAMBDProtein ea22
EA31_LAMBDProtein ea31
EA47_LAMBDProtein ea47
EA59_LAMBDProtein ea59
EA85_LAMBDProtein ea8.5
ENPP_LAMBDEndopeptidase (EC 3.4.-.-) (Lysis protein Rz)
EXO_LAMBDExonuclease (EC 3.1.11.3)

pdb 1AVQ  3SLP  3SM4 

HEAD_LAMBDMajor head protein (Major coat protein) (gpE)
LYS_LAMBDLysozyme (EC 3.2.1.17) (Endolysin) (Lysis protein) (Muramidase)

pdb 1AM7  1D9U  3D3D 

NINB_LAMBDProtein ninB

pdb 1PC6 

NIND_LAMBDProtein ninD
NINE_LAMBDProtein ninE (Nin60)
NINF_LAMBDProtein ninF
NING_LAMBDProtein ninG
NINH_LAMBDProtein ninH
PORTL_LAMBDPortal protein B (GpB) (Minor capsid protein B)
PP_LAMBDSerine/threonine-protein phosphatase (EC 3.1.3.16)

pdb 1G5B 

RCRO_LAMBDRegulatory protein cro

pdb 1COP  1D1L  1D1M  1ORC  2A63  2ECS  2ORC  2OVG  3ORC  4CRO  5CRO  6CRO 

REGN_LAMBDAntitermination protein N (Nucleocapsid protein) (Regulatory protein N) (PN)

pdb 1QFQ 

REGQ_LAMBDAntitermination protein Q
REXA_LAMBDProtein rexA
REXB_LAMBDProtein rexB
RPC1_LAMBDRepressor protein CI

pdb 1F39  1GFX  1J5G  1KCA  1LLI  1LMB  1LRP  1LWQ  1RIO  3BDN  3KZ3 

RPC2_LAMBDRegulatory protein CII

pdb 1XWR  1ZPQ  1ZS4 

RPC3_LAMBDRegulatory protein CIII
RZ1_LAMBDOuter membrane lipoprotein Rz1
SIEB_LAMBDSuperinfection exclusion protein B
STF_LAMBDSide tail fiber protein
TERL_LAMBDLarge terminase protein (DNA-packaging protein A) (GpA) (Terminase large ...
TERS_LAMBDTerminase small subunit (DNA-packaging protein Nu1)

pdb 1J9I 

TFA_LAMBDTail fiber assembly protein
VBET_LAMBDRecombination protein bet
VCAC_LAMBDMinor capsid protein C (EC 3.4.21.-) (Putative peptidase GPC) (GPC)
VCAD_LAMBDHead decoration protein (Major capsid protein D) (gpD)

pdb 1C5E  1TCZ  1VD0 

VCF2_LAMBDTail attachment protein (Minor capsid protein FII)

pdb 1K0H  2KX4 

VGAM_LAMBDHost-nuclease inhibitor protein gam

pdb 2UUZ  2UV1 

VHSJ_LAMBDHost specificity protein J
VHTJ_LAMBDHead-to-tail joining protein W (gpW)

pdb 1HYW 

VINT_LAMBDIntegrase

pdb 1AE9  1KJK  1M97  1P7D  1Z19  1Z1B  1Z1G  2OXO  2WCC 

VKIL_LAMBDProtein kil
VLOM_LAMBDOuter membrane protein lom (ORF 206A)
VLYS_LAMBDHolin (gpS protein)
VMTG_LAMBDMinor tail protein G
VMTH_LAMBDTail tape measure protein H (Minor tail protein H)
VMTL_LAMBDMinor tail protein L
VMTM_LAMBDMinor tail protein M
VMTT_LAMBDMinor tail protein T
VMTU_LAMBDMinor tail protein U

pdb 1Z1Z  3FZ2  3FZB 

VMTV_LAMBDMajor tail protein V

pdb 2K4Q  2L04 

VMTZ_LAMBDMinor tail protein Z (GpZ)
VPF1_LAMBDDNA-packaging protein FI
VRAL_LAMBDRestriction inhibitor protein ral (Antirestriction protein)
VREN_LAMBDProtein ren
VRPO_LAMBDReplication protein O
VRPP_LAMBDReplication protein P
VTAI_LAMBDTail assembly protein I
VTAK_LAMBDProbable endopeptidase (EC 3.4.-.-) (Tail assembly protein K)
VXIS_LAMBDExcisionase

pdb 1LX8  1RH6  2IEF  2OG0 

Y290_LAMBDUncharacterized nin region protein ORF290
Y64_LAMBDPutative uncharacterized protein ORF64

17 entries

Enterobacteria phage P21 (Bacteriophage 21) (Bacteriophage P21)

Select_all Deselect_all  
ENPP_BPP21Endopeptidase (EC 3.4.-.-) (Lysis protein Rz)
HEAD_BPP21Major head protein (Head protein gp7)
LYS_BPP21Lysozyme (EC 3.2.1.17) (Endolysin) (Lysis protein) (Muramidase)

pdb 3HDE  3HDF 

NINB_BPP21Protein ninB
NINE_BPP21Protein ninE
NINF_BPP21Protein ninF
NING_BPP21Protein ninG
PORTL_BPP21Portal protein (Head protein Gp4)
TERL_BPP21Large terminase protein (DNA-packaging protein Gp2) (Terminase large subunit)
TERS_BPP21Terminase small subunit (Gp1)
VG03_BPP21Head-stabilizing protein (Head protein gp3)
VG05_BPP21Head-tail preconnector protein GP5 (EC 3.4.21.-) (Putative peptidase GP5)
VINT_BPP21Integrase
VLYS_BPP21Lysis protein S
VSHP_BPP21Head decoration protein (Head protein GPshp)

pdb 1TD0  1TD3  1TD4 

VXIS_BPP21Excisionase
YG78_BPP21Uncharacterized 13.5 kDa protein in GP7-GP8 intergenic region

15 entries

Bacillus phage phi105 (Bacteriophage phi-105)

Select_all Deselect_all  
IMMF_BPPH1ImmF control region 10 kDa protein
RPC_BPPH1Immunity repressor protein
VLYS_BPPH1Probable holin (Lysis protein)
YIM2_BPPH1Uncharacterized immunity region protein 2
YIM3_BPPH1Uncharacterized immunity region protein 3
YIM4_BPPH1Putative uncharacterized immunity region protein 4
YIM5_BPPH1Uncharacterized immunity region protein 5
YIM6_BPPH1Putative uncharacterized immunity region protein 6
YIM8_BPPH1Putative uncharacterized immunity region protein 8
YIM9_BPPH1Putative uncharacterized immunity region protein 9
YIMA_BPPH1Putative uncharacterized immunity region protein 10
YIMB_BPPH1Putative uncharacterized immunity region protein 11
YIMC_BPPH1Uncharacterized immunity region protein 12
YIMD_BPPH1Uncharacterized immunity region protein 13
YIME_BPPH1Uncharacterized immunity region protein 14

11 entries

Enterobacteria phage phi80 (Bacteriophage phi-80)

Select_all Deselect_all  
COR_BPPH8Adsorption-inhibiting cor protein
HEAD_BPPH8Major head protein (GP5) (GPE) (Major coat protein)
REGN_BPPH8Probable regulatory protein N
RPC1_BPPH8Repressor protein CI
RPC2_BPPH8Regulatory protein CII
VG14_BPPH8Replication protein 14
VG15_BPPH8Replication protein 15
VG30_BPPH8Gene 30 protein
VG40_BPPH8Protein 40A
VINT_BPPH8Integrase
VXIS_BPPH8Excisionase

9 entries

Bacillus phage SPP1 (Bacteriophage SPP1)

Select_all Deselect_all  
GP171_BPSPPMajor tail protein 17.1
GP18_BPSPPTail tape measure protein gp18
GP7_BPSPPMinor head structural component GP7
PORTL_BPSPPPortal protein (GP6) (Portal vertex protein)

pdb 2JES 

TERL_BPSPPLarge terminase protein (DNA-packaging protein G2P) (Terminase large subunit)

pdb 2WBN  2WC9 

TERS_BPSPPTerminase small subunit (G1P)
YOR3_BPSPPUncharacterized 8.5 kDa protein in GP2-GP6 intergenic region (ORF 3)
YOR4_BPSPPUncharacterized 10.2 kDa protein in GP2-GP6 intergenic region (ORF 4)
YOR5_BPSPPUncharacterized 10.3 kDa protein in GP2-GP6 intergenic region (ORF 5)

9 entries

Enterobacteria phage HK022 (Bacteriophage HK022)

Select_all Deselect_all  
RCRO_BPHK08.4 kDa cro protein
REGQ_BPHK0Antitermination protein
RPC1_BPHK026 kDa repressor protein (Regulatory protein CI)
RPC3_BPHK0Regulatory protein CIII
VINT_BPHK0Integrase
VKIL_BPHK0Protein kil
VNUN_BPHK0Transcription termination factor nun

pdb 1E4Z  1HJI 

VXIS_BPHK0Excisionase

pdb 1PM6 

YO48_BPHK0Uncharacterized 5.8 kDa protein (ORF48)

8 entries

Enterobacteria phage H19B (Bacteriophage H19B)

Select_all Deselect_all  
LYS_BPH19Lysozyme (EC 3.2.1.17) (Endolysin) (Lysis protein) (Muramidase)
NINE_BPH19Protein ninE
NINF_BPH19Protein ninF
NING_BPH19Protein ninG
NINH_BPH19Protein ninH
REGQ_BPH19Antitermination protein Q
STXA_BPH19Shiga-like toxin 1 subunit A (SLT-1 A subunit) (SLT-1a) (SLT-Ia) (EC 3.2.2.22) ...
STXB_BPH19Shiga-like toxin 1 subunit B (SLT-1 B subunit) (SLT-1b) (SLT-Ib) (Verocytotoxin ...

pdb 1BOS  1C48  1C4Q  1CQF  1CZG  1CZW  1D1I  1D1K  1QNU  2XSC  4ULL 

7 entries

Enterobacteria phage 82 (Bacteriophage 82)

Select_all Deselect_all  
NINE_BP82Protein ninE
REGQ_BP82Antitermination protein Q
RUSA_BP82Crossover junction endodeoxyribonuclease rusA (EC 3.1.22.4) (Holliday junction ...
YBCN_BP82Uncharacterized protein in rusA 5'region (ORF151)
YBCO_BP82Uncharacterized protein ybcO
YLCG_BP82Uncharacterized protein in rusA 3'region (ORF45)
YLCH_BP82Uncharacterized 3.7 kDa protein in rusA 5'region (ORF33)

5 entries

Bacteriophage 434

Select_all Deselect_all  
RCRO_BP434Regulatory protein cro (Antirepressor)

pdb 1ZUG  2CRO  3CRO 

REXA_BP434Protein rexA
RPC2_BP434Regulatory protein CII
VINT_BP434Integrase
VXIS_BP434Excisionase

4 entries

Enterobacteria phage HK97 (Bacteriophage HK97)

Select_all Deselect_all  
COAT_BPHK7Major capsid protein (Gp5) (Head protein)

pdb 1IF0  1OHG  2FRP  2FS3  2FSY  2FT1  2FTE  2GP1  3DDX  3E8K  3QPR 

PORTL_BPHK7Portal protein (GP3)
RUSA_BPHK7Crossover junction endodeoxyribonuclease rusA (EC 3.1.22.4) (Gp67) (Holliday ...
VP4_BPHK7Putative prohead protease (GP4)

2 entries

Bacillus phage phi3T (Bacteriophage phi-3T)

Select_all Deselect_all  
MTBP_BPPHTModification methylase Phi3TI (M.Phi3TI) (EC 2.1.1.37) (Cytosine-specific ...
TYSY_BPPHTThymidylate synthase (TS) (TSase) (EC 2.1.1.45)

2 entries

Corynephage beta

Select_all Deselect_all  
DTXH_CORBEDiphtheria toxin homolog CRM228
DTX_CORBEDiphtheria toxin (DT) (NAD(+)--diphthamide ADP-ribosyltransferase) (EC 2.4.2.36)

pdb 1DDT  1DTP  1F0L  1MDT  1SGK  1TOX  1XDT 

2 entries

Enterobacteria phage PA-2 (Bacteriophage PA-2)

Select_all Deselect_all  
LYS_BPPA2Lysozyme (EC 3.2.1.17) (Endolysin) (Lysis protein) (Muramidase)
PORI_BPPA2Outer membrane porin protein LC

1 entry

Bacillus phage SP02 (Bacteriophage SP02)


DPOL_BPSP2DNA polymerase (EC 2.7.7.7)

1 entry

Bacillus phage SPR (Bacteriophage SPR)


MTBS_BPSPRModification methylase SPRI (M.SPRI) (EC 2.1.1.37) (Cytosine-specific ...

1 entry

Bacillus phage rho11s (Bacteriophage rho-11s)


MTBR_BPRH1Modification methylase Rho11sI (M.Rho11sI) (EC 2.1.1.37) (Bsu P11s) ...

1 entry

Corynephage omega


DTX_COROMDiphtheria toxin (DT) (NAD(+)--diphthamide ADP-ribosyltransferase) (EC 2.4.2.36)
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