Mardivirus (taxid:180252)

VIRION

image

Enveloped, spherical to pleomorphic, 120-200 nm in diameter T=16 icosahedral symmetry. The capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embedded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 175 kbp. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' nontranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.

There are three types of genes: immediate-early, early and late. The immediate-early genes are transcribed immediately after infection and ensure the transcription of early genes, which encode the proteins necessary for the viral replication. The late genes mostly encode structural proteins. Standing apart are genes expressed during latency.

ENZYMES

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral gB, gC, gD and gH proteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Cell-cycle modulation

The conserved UL24 family of human alpha, beta and gamma herpesviruses induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex. Marek disease virus encodes an UL24 homolog that should fullfill this role.

Apoptosis modulation

MEQ antagonizes apoptosis possibly through regulation of its downstream target genes involved in apoptotic and/or anti-apoptotic pathways.

Host splicing inhibition

GaHV-2 MDV068 is an alternative splicing regulator of host mRNA.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

115 entries grouped by strain

90 entries

Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1) reference strain

Select_allDeselect_all
MEQ_GAHVM Oncoprotein MEQ (MEQ)
SCAF_GAHVM Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Virion structural ...
GB_GAHVM Envelope glycoprotein B (gB)
LTP_GAHVM Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
GC_GAHVM Envelope glycoprotein C homolog (A antigen) (Glycoprotein A) (GA) (Secretory glycoprotein GP57-65)
GE_GAHVM Envelope glycoprotein E (gE)
IL8H_GAHVM Viral interleukin-8 homolog (vIL8)
ICP27_GAHVM mRNA export factor ICP27 homolog (Transcriptional regulator IE63 homolog)
GN_GAHVM Envelope glycoprotein N
RIR2_GAHVM Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
RIR1_GAHVM Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
CEP3_GAHVM Cytoplasmic envelopment protein 3
GL_GAHVM Envelope glycoprotein L (gL)
GI_GAHVM Envelope glycoprotein I
GD_GAHVM Envelope glycoprotein D (gD)
US03_GAHVM Protein kinase US3 homolog (EC 2.7.11.1)
GK_GAHVM Envelope glycoprotein K
TEG5_GAHVM Tegument protein UL47 homolog
DPOL_GAHVM DNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)
GH_GAHVM Envelope glycoprotein H (gH)
UL13_GAHVM Serine/threonine-protein kinase UL13 homolog (EC 2.7.11.1)
GM_GAHVM Envelope glycoprotein M (gM)
EV45_GAHVM Envelope protein UL45 homolog
US10_GAHVM Virion protein US10 homolog
ICP22_GAHVM Transcriptional regulator ICP22 homolog (Immediate early ICP22-like protein)
PP38_GAHVM Phosphoprotein pp38
VP16_GAHVM Tegument protein VP16 homolog (Alpha trans-inducing protein) (Alpha-TIF) (ORF10 protein) (Tegument ...
TEG1_GAHVM Tegument protein UL46 homolog (Tegument protein VP11/12 homolog)
PAP_GAHVM DNA polymerase processivity factor (DNA-binding protein UL42) (Polymerase accessory protein) (PAP)
TRM1_GAHVM Tripartite terminase subunit 1
UL20_GAHVM Protein UL20 homolog
VLIP_GAHVM Virulence factor MDV010 (Viral lipase homolog) (vLIP)
ICP4_GAHVM Major viral transcription factor ICP4 homolog (Immediate-early protein IE175)
PRIM_GAHVM DNA primase (EC 2.7.7.-)
TEG7_GAHVM Tegument protein UL51 homolog
DUT_GAHVM Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
VP22_GAHVM Tegument protein VP22
MB43_GAHVM Membrane protein UL43 homolog
SHUT_GAHVM Virion host shutoff protein (Vhs) (EC 3.1.27.-)
TRX1_GAHVM Triplex capsid protein 1
ITP_GAHVM Inner tegument protein
SCP_GAHVM Small capsomere-interacting protein
NEC2_GAHVM Nuclear egress protein 2
TRM2_GAHVM Tripartite terminase subunit 2
UL32_GAHVM Packaging protein UL32 homolog
NEC1_GAHVM Nuclear egress protein 1
DNBI_GAHVM Major DNA-binding protein
CVC2_GAHVM Capsid vertex component 2
UL24_GAHVM Protein UL24 homolog
KITH_GAHVM Thymidine kinase (EC 2.7.1.21)
TG21_GAHVM Tegument protein UL21 homolog
MCP_GAHVM Major capsid protein (MCP)
TRX2_GAHVM Triplex capsid protein 2
CVC1_GAHVM Capsid vertex component 1
CEP2_GAHVM Cytoplasmic envelopment protein 2
TRM3_GAHVM Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TEG3_GAHVM Tegument protein UL14 homolog
AN_GAHVM Alkaline nuclease (EC 3.1.-.-)
OBP_GAHVM Replication origin-binding protein (OBP) (OriBP)
HEPA_GAHVM DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
CEP1_GAHVM Cytoplasmic envelopment protein 1
PORTL_GAHVM Portal protein
HELI_GAHVM DNA replication helicase (EC 3.6.4.-)
UNG_GAHVM Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
VG87_GAHVM Uncharacterized gene 87 protein
VG07_GAHVM Uncharacterized gene 7 protein
TEG6_GAHVM Tegument protein UL55 homolog
VG69_GAHVM Uncharacterized gene 69 protein
UL4_GAHVM Nuclear protein UL4 homolog
NP03_GAHVM Nuclear phosphoprotein UL3 homolog
PP24_GAHVM Phosphoprotein pp24
VG06B_GAHVM Uncharacterized gene 6b protein
VG01_GAHVM Uncharacterized gene 1 protein
VG02_GAHVM Uncharacterized gene 2 protein
VG06A_GAHVM Uncharacterized gene 6a protein
VG86_GAHVM Uncharacterized gene 86 protein
VG85_GAHVM Uncharacterized gene 85 protein
VG82_GAHVM Uncharacterized gene 82 protein
VG83_GAHVM Uncharacterized gene 83 protein
VG04_GAHVM Uncharacterized gene 4 protein
VG81_GAHVM Uncharacterized gene 81 protein
VG97_GAHVM Uncharacterized gene 97 protein
VG93_GAHVM Uncharacterized gene 93 protein
US02_GAHVM Protein US2 homolog
VG90_GAHVM Uncharacterized gene 90 protein
VG72_GAHVM Uncharacterized gene 72 protein
VG71_GAHVM Uncharacterized gene 71 protein
VG12_GAHVM Uncharacterized gene 12 protein
VG11_GAHVM Uncharacterized gene 11 protein
VG09_GAHVM Uncharacterized gene 9 protein

12 entries

Gallid herpesvirus 2 (strain GA) (GaHV-2) (Marek's disease herpesvirus type 1)

Select_allDeselect_all
US03_GAHVG Serine/threonine-protein kinase US3 homolog (EC 2.7.11.1)
GC_GAHVG Envelope glycoprotein C homolog (A antigen) (Glycoprotein A) (GA) (Secretory glycoprotein GP57-65)
GL_GAHVG Envelope glycoprotein L (gL)
ICP4_GAHVG Major viral transcription factor ICP4 homolog (Immediate-early protein IE175)
VP38_GAHVG 38 kDa phosphoprotein (Phosphoprotein pp38)
US10_GAHVG Virion protein US10 homolog
U1053_GAHVG Uncharacterized 40.6 kDa protein
US384_GAHVG Uncharacterized 14.2 kDa protein
US420_GAHVG Uncharacterized 15.5 kDa protein
US426_GAHVG Uncharacterized 15.7 kDa protein
US441_GAHVG Uncharacterized 16.7 kDa protein
US453_GAHVG Uncharacterized 16.6 kDa protein

4 entries

Gallid herpesvirus 2 (strain RB-1b) (GaHV-2) (Marek's disease herpesvirus type 1)

Select_allDeselect_all
GB_GAHVR Envelope glycoprotein B (gB)
GC_GAHVR Envelope glycoprotein C homolog (A antigen) (Glycoprotein A) (GA) (Secretory glycoprotein GP57-65)
GH_GAHVR Envelope glycoprotein H (gH)
KITH_GAHVR Thymidine kinase (EC 2.7.1.21)

2 entries

Gallid herpesvirus 2 (strain bc-1) (GaHV-2) (Marek's disease herpesvirus type 1)

Select_allDeselect_all
GC_GAHVB Envelope glycoprotein C homolog (A antigen) (Glycoprotein A) (GA) (Secretory glycoprotein GP57-65)
EV45_GAHVB Envelope protein UL45 homolog

2 entries

Meleagrid herpesvirus 1 (MeHV-1) (Turkey herpesvirus)

Select_allDeselect_all
GH_MEHV1 Envelope glycoprotein H (gH)
KITH_MEHV1 Thymidine kinase (EC 2.7.1.21)

2 entries

Meleagrid herpesvirus 1 (strain FC126) (MeHV-1) (Turkey herpesvirus)

Select_allDeselect_all
KITH_MEHVF Thymidine kinase (EC 2.7.1.21)
GC_MEHVF Envelope glycoprotein C homolog (A antigen) (Glycoprotein A)

2 entries

Meleagrid herpesvirus 1 (strain H2) (MeHV-1) (Turkey herpesvirus)

Select_allDeselect_all
GC_MEHVH Envelope glycoprotein C homolog (A antigen) (Glycoprotein A)
EV45_MEHVH Envelope protein UL45 homolog (23.5 kDa protein)

1 entry

Gallid herpesvirus 2 (strain MD11/75C/R2) (GaHV-2) (Marek's disease herpesvirus type 1)

VP38_GAHVN 38 kDa phosphoprotein (Phosphoprotein pp38)
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Falconid herpesvirus 1 taxid:1510155

Protein ModelArchive
Alpha trans-inducing protein (Alpha-TIF) ma-jd-viral-06949
Capsid portal protein ma-jd-viral-59317
Capsid scaffolding protein (Protease precursor) (pPR) ma-jd-viral-12503
Capsid triplex subunit 1 ma-jd-viral-09132
Capsid triplex subunit 2 ma-jd-viral-04804
Cytoplasmic envelopment protein 3 ma-jd-viral-45136
DNA packaging protein UL33 ma-jd-viral-66368
DNA packaging tegument protein UL17 ma-jd-viral-02150
DNA packaging tegument protein UL25 ma-jd-viral-01766
DNA packaging terminase subunit 1 ma-jd-viral-06526
DNA packaging terminase subunit 2 ma-jd-viral-61476
DNA polymerase (EC 2.7.7.7) ma-jd-viral-17292
DNA polymerase processivity factor (Polymerase accessory protein) ma-jd-viral-21512
Deoxyribonuclease ma-jd-viral-08434
Deoxyuridine triphosphatase ma-jd-viral-12826
Envelope glycoprotein B ma-jd-viral-31215
Envelope glycoprotein C ma-jd-viral-01818
Envelope glycoprotein D ma-jd-viral-07537
Envelope glycoprotein E ma-jd-viral-00325
Envelope glycoprotein H ma-jd-viral-16904
Envelope glycoprotein I ma-jd-viral-06369
Envelope glycoprotein K ma-jd-viral-49394
Envelope glycoprotein L ma-jd-viral-09082
Envelope glycoprotein M ma-jd-viral-37838
Envelope glycoprotein N ma-jd-viral-37023
Envelope protein UL20 ma-jd-viral-36662
Envelope protein UL43 ma-jd-viral-52488
Helicase-primase helicase subunit ma-jd-viral-37547
Helicase-primase primase subunit ma-jd-viral-33304
Helicase-primase subunit ma-jd-viral-17225
Lipase ma-jd-viral-13825
Major capsid protein ma-jd-viral-63110
Membrane protein UL45 ma-jd-viral-16444
Membrane protein UL56 ma-jd-viral-52169
Membrane protein US9 ma-jd-viral-62652
Membrane protein V1 ma-jd-viral-36614
Multifunctional expression regulator ma-jd-viral-15583
Myristylated tegument protein CIRC ma-jd-viral-66924
Nuclear egress lamina protein ma-jd-viral-10244
Nuclear egress membrane protein ma-jd-viral-12390
Nuclear protein UL24 ma-jd-viral-12179
Nuclear protein UL3 ma-jd-viral-12085
Nuclear protein UL4 ma-jd-viral-10059
Nuclear protein UL55 ma-jd-viral-10296
Packaging protein UL32 ma-jd-viral-40947
Protein LORF3 ma-jd-viral-57074
Protein LORF4 ma-jd-viral-61013
Protein LORF5 ma-jd-viral-43646
Protein SORF3 ma-jd-viral-59859
Regulatory protein ICP22 ma-jd-viral-01867
Regulatory protein ICP22 ma-jd-viral-01877
Replication origin-binding protein (OriBP) ma-jd-viral-01505
Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase large... ma-jd-viral-14203
Secreted protein ma-jd-viral-53016
Secreted protein ma-jd-viral-43272
Secreted protein ma-jd-viral-43273
Serine/threonine protein kinase US3 ma-jd-viral-24961
Single-stranded DNA-binding protein ma-jd-viral-35421
Small capsomere-interacting protein ma-jd-viral-33056
Tegument protein UL14 ma-jd-viral-14655
Tegument protein UL16 ma-jd-viral-02649
Tegument protein UL21 ma-jd-viral-55971
Tegument protein UL37 ma-jd-viral-14873
Tegument protein UL47 ma-jd-viral-02007
Tegument protein UL51 ma-jd-viral-08902
Tegument protein UL7 ma-jd-viral-14052
Tegument protein VP11/12 ma-jd-viral-08947
Tegument protein VP22 ma-jd-viral-07436
Tegument serine/threonine protein kinase ma-jd-viral-24667
Thymidine kinase ma-jd-viral-05902
Transmembrane protein ma-jd-viral-50642
Uncharacterized protein ma-jd-viral-08286
Uncharacterized protein ma-jd-viral-34878
Uncharacterized protein ma-jd-viral-34187
Uncharacterized protein ma-jd-viral-49639
Uncharacterized protein ma-jd-viral-46527
Uncharacterized protein ma-jd-viral-46529
Uncharacterized protein ma-jd-viral-48866
Uncharacterized protein ma-jd-viral-49064
Uncharacterized protein ma-jd-viral-49067
Uncharacterized protein ma-jd-viral-46708
Uncharacterized protein ma-jd-viral-46710
Uncharacterized protein ma-jd-viral-52544
Uncharacterized protein ma-jd-viral-52545
Uncharacterized protein ma-jd-viral-41854
Uncharacterized protein ma-jd-viral-41855
Uncharacterized protein ma-jd-viral-39542
Uncharacterized protein ma-jd-viral-39543
Uncharacterized protein ma-jd-viral-44447
Uncharacterized protein ma-jd-viral-44470
Uncharacterized protein ma-jd-viral-42252
Uncharacterized protein ma-jd-viral-37758
Uncharacterized protein ma-jd-viral-37760
Uncharacterized protein ma-jd-viral-36029
Uncharacterized protein ma-jd-viral-36031
Uncharacterized protein ma-jd-viral-36629
Uncharacterized protein ma-jd-viral-36631
Uncharacterized protein ma-jd-viral-41249
Uncharacterized protein ma-jd-viral-41250
Uncharacterized protein ma-jd-viral-63517
Uncharacterized protein ma-jd-viral-63758
Uncharacterized protein ma-jd-viral-64991
Uncharacterized protein ma-jd-viral-64992
Uncharacterized protein ma-jd-viral-67529
Uncharacterized protein ma-jd-viral-67531
Uncharacterized protein ma-jd-viral-62290
Uncharacterized protein ma-jd-viral-62292
Uncharacterized protein ma-jd-viral-55566
Uncharacterized protein ma-jd-viral-55567
Uncharacterized protein ma-jd-viral-57850
Uncharacterized protein ma-jd-viral-57853
Uncharacterized protein ma-jd-viral-55652
Uncharacterized protein ma-jd-viral-57943
Uncharacterized protein ma-jd-viral-57945
Uncharacterized protein ma-jd-viral-58404
Uncharacterized protein ma-jd-viral-63255
Uncharacterized protein ma-jd-viral-63256
Uncharacterized protein ma-jd-viral-56955
Uncharacterized protein ma-jd-viral-56957
Uncharacterized protein ma-jd-viral-59760
Uncharacterized protein ma-jd-viral-59762
Uracil-DNA glycosylase ma-jd-viral-07800
Virion host shutoff protein ma-jd-viral-22431
Virion protein US10 ma-jd-viral-60843
Virion protein US10 ma-jd-viral-60844
Virion protein US2 ma-jd-viral-21065
ribonucleoside-diphosphate reductase (EC 1.17.4.1) ma-jd-viral-05489

Gallid alphaherpesvirus 2 taxid:10390

Protein ModelArchive
Alpha trans-inducing protein (Alpha-TIF) ma-jd-viral-06945
Capsid protein (Capsid triplex subunit 2) (UL18) ma-jd-viral-04826
Capsid protein (UL38) ma-jd-viral-09148
Capsid protein, DNA packaging/cleavage (UL7) (Tegument protein UL7) ma-jd-viral-14063
Capsid scaffold protein (UL26.5) (Major scaffold capsid protein) ma-jd-viral-38657
Capsid scaffolding protein (Protease precursor) (pPR) ma-jd-viral-12477
Capsid/tegument associated phosphoprotein (US10) (Virion protein) ma-jd-viral-16121
Cell fusion protein (Envelope transmembrane protein) (UL45) ma-jd-viral-16448
Cytoplasmic envelopment protein 3 ma-jd-viral-31685
DNA cleavage/packaging protein (DNA packaging protein) (DNA packaging terminase subunit 2)... ma-jd-viral-61504
DNA cleavage/packaging protein (DNA packaging protein) (UL33) ma-jd-viral-66375
DNA helicase-primase associated protein (UL5) (Helicase-primase helicase subunit)... ma-jd-viral-37560
DNA helicase-primase associated protein (UL8) (Helicase-primase subunit) ma-jd-viral-17243
DNA packaging protein (UL25) (DNA packing protein) (HSV-1 UL25-like protein) ma-jd-viral-01789
DNA packaging protein/terminase (DNA packaging terminase subunit 1) (DNA packing protein)... ma-jd-viral-06520
DNA polymerase (EC 2.7.7.7) ma-jd-viral-17286
DNA polymerase processivity factor (Polymerase accessory protein) ma-jd-viral-21516
DNase (Deoxyribonuclease) (UL12) ma-jd-viral-08441
Envelope glycoprotein C homolog (A antigen) (Glycoprotein A) ma-jd-viral-01805
Envelope glycoprotein E ma-jd-viral-00327
Envelope glycoprotein I ma-jd-viral-06391
Envelope glycoprotein K ma-jd-viral-49402
Envelope protein (Envelope/tegument protein) (UL49.5) ma-jd-viral-37020
Glycoprotein B (UL27) (Virion membrane glycoprotein B) ma-jd-viral-31201
Glycoprotein H (UL22) ma-jd-viral-16902
Glycoprotein L ma-jd-viral-09079
Glycoprotein L ma-jd-viral-09079
Glycoprotein L ma-jd-viral-09079
Glycoprotein L ma-jd-viral-09079
Glycoprotein L ma-jd-viral-09079
Glycoprotein L (UL1) (Virion surface glycoprotein L) ma-jd-viral-09079
Glycoprotein M (UL10) (Virion membrane glycoprotein M) ma-jd-viral-37831
Growth hormone-binding protein (Homologous to FPV ORF4) (SORF2) ma-jd-viral-65800
Helicase/primase complex (UL52) ma-jd-viral-33327
LORF10 (Myristylated tegument protein CIRC) ma-jd-viral-16095
LORF11 ma-jd-viral-43649
LORF12 ma-jd-viral-57769
LORF2 (Lipase) (V-lipase) ma-jd-viral-13813
LORF4 ma-jd-viral-55780
LORF4 ma-jd-viral-55781
LORF9 (Protein LORF4) ma-jd-viral-61016
MEQ ma-jd-viral-37260
MEQ ma-jd-viral-37261
Major capsid protein (UL19) ma-jd-viral-63087
Nuclear protein UL3 ma-jd-viral-12078
Packaging protein UL32 ma-jd-viral-40963
Pp24 (Protein pp24) (R-LORF14) (RLORF14) ma-jd-viral-60083
Pp38 (R-LORF14a) ma-jd-viral-56207
Probable membrane protein (UL43) ma-jd-viral-02346
Protein MDV012 ma-jd-viral-57073
Replication origin-binding protein (OriBP) ma-jd-viral-01486
Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase large... ma-jd-viral-14208
SORF3 (RAF kinase-like protein) ma-jd-viral-59865
SORF4 ma-jd-viral-44748
Single-stranded DNA binding protein (SsDNA binding protein) (UL29) ma-jd-viral-35432
Small capsomere-interacting protein ma-jd-viral-33040
Tegument phosphoprotein VP11/12 (UL46) (VP11/12 tegument phosphoprotein) ma-jd-viral-08939
Tegument protein (UL17) ma-jd-viral-02139
Tegument protein (UL21) ma-jd-viral-55963
Tegument protein VP22 ma-jd-viral-07433
UL13 (Serine/threonine protein kinase) ma-jd-viral-24658
UL14 (Minor tegument protein) (Tegument protein UL14) ma-jd-viral-14656
UL16 (Tegument protein) ma-jd-viral-02673
UL2 (Uracil-DNA glycosylase) ma-jd-viral-07704
UL20 (HSV-1 UL20-like protein) (Membrane protein) (Transmembrane protein) ma-jd-viral-36655
UL23 (Thymidine kinase) ma-jd-viral-05910
UL24 (Membrane protein) (Nonglycosylated membrane-associated protein) (Nuclear protein... ma-jd-viral-12146
UL3.5 (Protein V57) (Tegument protein, virus egress) ma-jd-viral-45599
UL31 (Nuclear egress lamina protein) (Nuclear phosphoprotein) ma-jd-viral-10259
UL34 (Membrane associated phosphoprotein) (Membrane phosphoprotein) (Nuclear egress membrane... ma-jd-viral-12388
UL37 ma-jd-viral-14884
UL4 (Nuclear protein) (Nuclear protein UL4) ma-jd-viral-10057
UL50 (dUTPase) ma-jd-viral-12848
UL51 (Virion phosphoprotein) ma-jd-viral-08912
UL54 (ICP27) ma-jd-viral-15582
UL55 (Nuclear matrix-associated protein) (Nuclear protein UL55) (Putative nuclear... ma-jd-viral-10292
UL6 ma-jd-viral-59336
US1 (ICP22) (Regulatory protein) ma-jd-viral-41056
US2 (US2 protein) (Virion protein US2) ma-jd-viral-21066
VIL8 (Interleukin-8) (Interleukine-8) (R-LORF2) (RLORF2) (VIL-8) ma-jd-viral-16814
VIL8 (Interleukin-8) (Interleukine-8) (R-LORF2) (RLORF2) (VIL-8) ma-jd-viral-16815
Virion host shutoff protein ma-jd-viral-22428
non-specific serine/threonine protein kinase (EC 2.7.11.1) ma-jd-viral-24925
ribonucleoside-diphosphate reductase (EC 1.17.4.1) ma-jd-viral-05505

Gallid alphaherpesvirus 3 taxid:35250

Protein ModelArchive
Alpha trans-inducing protein (Alpha-TIF) ma-jd-viral-06943
Capsid scaffolding protein (Protease precursor) (pPR) ma-jd-viral-12468
DNA polymerase (EC 2.7.7.7) ma-jd-viral-17328
DNA polymerase processivity factor (Polymerase accessory protein) ma-jd-viral-21534
Envelope glycoprotein C homolog (A antigen) (Glycoprotein A) ma-jd-viral-01802
Envelope glycoprotein I ma-jd-viral-06392
Envelope glycoprotein K ma-jd-viral-49388
Glycoprotein B (Major DNA-binding protein-like protein) ma-jd-viral-31222
Glycoprotein D ma-jd-viral-07524
Glycoprotein M (UL10 protein) ma-jd-viral-37849
LORF4 protein ma-jd-viral-38801
LORF5 protein (ORF996 protein) ma-jd-viral-43648
ORF437 protein ma-jd-viral-57071
Packaging protein UL32 ma-jd-viral-40967
Pp24 ma-jd-viral-35229
Pp38 protein ma-jd-viral-57881
Replication origin-binding protein (OriBP) ma-jd-viral-01494
Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase large... ma-jd-viral-14219
SORF2 protein ma-jd-viral-45501
SORF4 protein ma-jd-viral-59864
Small capsomere-interacting protein ma-jd-viral-33066
Tegument protein UL47 ma-jd-viral-02024
Tegument protein VP22 ma-jd-viral-07435
Thymidine kinase (UL23-like protein) ma-jd-viral-05920
UL1 protein (UL1-like protein) ma-jd-viral-09080
UL11 protein (UL11-like protein) ma-jd-viral-31681
UL12 protein (UL12-like protein) ma-jd-viral-08442
UL13 protein (UL13-like protein) ma-jd-viral-24674
UL14 protein (UL14-like protein) ma-jd-viral-14658
UL15 protein ma-jd-viral-06501
UL16 protein (UL16-like protein) ma-jd-viral-02669
UL17 protein (UL17-like protein) ma-jd-viral-02152
UL18 protein (UL18-like protein) ma-jd-viral-04825
UL19 protein ma-jd-viral-63100
UL2 protein (Uracil-DNA glycosylase) ma-jd-viral-07731
UL20 protein (UL20-like protein) ma-jd-viral-36652
UL21 protein (UL21-like protein) ma-jd-viral-55970
UL24 protein (UL24-like protein) ma-jd-viral-12147
UL25 protein ma-jd-viral-01723
UL26.5 protein ma-jd-viral-38658
UL28 protein ma-jd-viral-61533
UL29 protein ma-jd-viral-35418
UL3 protein (UL3-like protein) ma-jd-viral-12098
UL3.5 protein ma-jd-viral-43939
UL31 protein ma-jd-viral-10248
UL33 protein ma-jd-viral-66385
UL34 protein ma-jd-viral-12385
UL37 protein ma-jd-viral-14885
UL38 protein ma-jd-viral-09139
UL4 protein (UL4-like protein) ma-jd-viral-10060
UL43 protein ma-jd-viral-02344
UL45 protein ma-jd-viral-16443
UL46 protein ma-jd-viral-08942
UL49.5 protein ma-jd-viral-37024
UL5 protein ma-jd-viral-37531
UL50 protein ma-jd-viral-12842
UL51 protein ma-jd-viral-08915
UL52 protein ma-jd-viral-33294
UL54 protein ma-jd-viral-15569
UL55 protein ma-jd-viral-10302
UL7 protein (UL7-like protein) ma-jd-viral-14053
UL8 protein (UL8-like protein) ma-jd-viral-17224
US1 protein ma-jd-viral-41057
US10 protein ma-jd-viral-16120
US2 protein ma-jd-viral-21062
US3 protein ma-jd-viral-24922
V-lipase ma-jd-viral-13820
Virion host shutoff protein ma-jd-viral-22422
ribonucleoside-diphosphate reductase (EC 1.17.4.1) ma-jd-viral-05474

Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) taxid:10389

Protein ModelArchive
Alkaline nuclease (EC 3.1.-.-) ma-jd-viral-08441
Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Virion structural protein... ma-jd-viral-12477
Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Virion structural protein... ma-jd-viral-38657
Capsid vertex component 1 ma-jd-viral-02139
Capsid vertex component 2 ma-jd-viral-01789
Cytoplasmic envelopment protein 1 ma-jd-viral-14063
Cytoplasmic envelopment protein 2 ma-jd-viral-02673
Cytoplasmic envelopment protein 3 ma-jd-viral-31685
DNA helicase/primase complex-associated protein (HEPA) (Primase-associated... ma-jd-viral-17243
DNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4) ma-jd-viral-17286
DNA polymerase processivity factor (DNA-binding protein UL42) (Polymerase accessory protein)... ma-jd-viral-21516
DNA primase (EC 2.7.7.-) ma-jd-viral-33327
DNA replication helicase (EC 3.6.4.-) ma-jd-viral-37560
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP... ma-jd-viral-12848
Envelope glycoprotein B (gB) ma-jd-viral-31201
Envelope glycoprotein C homolog (A antigen) (Glycoprotein A) (GA) (Secretory glycoprotein... ma-jd-viral-01805
Envelope glycoprotein E (gE) ma-jd-viral-00327
Envelope glycoprotein H (gH) ma-jd-viral-16902
Envelope glycoprotein I ma-jd-viral-06391
Envelope glycoprotein K ma-jd-viral-49402
Envelope glycoprotein L (gL) ma-jd-viral-09079
Envelope glycoprotein M (gM) ma-jd-viral-37831
Envelope glycoprotein N ma-jd-viral-37020
Envelope protein UL45 homolog ma-jd-viral-16448
Inner tegument protein ma-jd-viral-14884
Major DNA-binding protein ma-jd-viral-35432
Major capsid protein (MCP) ma-jd-viral-63087
Membrane protein UL43 homolog ma-jd-viral-02346
Nuclear egress protein 1 ma-jd-viral-10259
Nuclear egress protein 2 ma-jd-viral-12388
Nuclear protein UL4 homolog ma-jd-viral-10057
Oncoprotein MEQ (MEQ) ma-jd-viral-37260
Oncoprotein MEQ (MEQ) ma-jd-viral-37261
Packaging protein UL32 homolog ma-jd-viral-40963
Phosphoprotein pp24 ma-jd-viral-60083
Phosphoprotein pp38 ma-jd-viral-56207
Portal protein ma-jd-viral-59336
Protein UL20 homolog ma-jd-viral-36655
Protein UL24 homolog ma-jd-viral-12146
Protein US2 homolog ma-jd-viral-21066
Protein kinase US3 homolog (EC 2.7.11.1) ma-jd-viral-24925
Replication origin-binding protein (OBP) (OriBP) ma-jd-viral-01486
Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase large... ma-jd-viral-14208
Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small... ma-jd-viral-05505
Serine/threonine-protein kinase UL13 homolog (EC 2.7.11.1) ma-jd-viral-24658
Small capsomere-interacting protein ma-jd-viral-33040
Tegument protein UL14 homolog ma-jd-viral-14656
Tegument protein UL21 homolog ma-jd-viral-55963
Tegument protein UL46 homolog (Tegument protein VP11/12 homolog) ma-jd-viral-08939
Tegument protein UL47 homolog ma-jd-viral-02023
Tegument protein UL51 homolog ma-jd-viral-08912
Tegument protein UL55 homolog ma-jd-viral-10292
Tegument protein VP16 homolog (Alpha trans-inducing protein) (Alpha-TIF) (ORF10 protein) (Tegument protein... ma-jd-viral-06945
Tegument protein VP22 ma-jd-viral-07433
Thymidine kinase (EC 2.7.1.21) ma-jd-viral-05910
Transcriptional regulator ICP22 homolog (Immediate early ICP22-like protein) ma-jd-viral-41056
Tripartite terminase subunit 1 ma-jd-viral-61504
Tripartite terminase subunit 2 ma-jd-viral-66375
Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit) ma-jd-viral-06520
Triplex capsid protein 1 ma-jd-viral-09148
Triplex capsid protein 2 ma-jd-viral-04826
Uncharacterized gene 69 protein ma-jd-viral-61016
Uncharacterized gene 71 protein ma-jd-viral-16095
Uncharacterized gene 72 protein ma-jd-viral-43649
Uncharacterized gene 87 protein ma-jd-viral-65800
Uncharacterized gene 90 protein ma-jd-viral-59865
Uncharacterized gene 93 protein ma-jd-viral-44748
Uncharacterized gene 97 protein ma-jd-viral-65799
Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG) ma-jd-viral-07704
Viral interleukin-8 homolog (vIL8) ma-jd-viral-16814
Viral interleukin-8 homolog (vIL8) ma-jd-viral-16815
Virion host shutoff protein (Vhs) (EC 3.1.27.-) ma-jd-viral-22428
Virion protein US10 homolog ma-jd-viral-16121
Virulence factor MDV010 (Viral lipase homolog) (vLIP) ma-jd-viral-13813
mRNA export factor ICP27 homolog (Transcriptional regulator IE63 homolog) ma-jd-viral-15582

Gallid herpesvirus 2 (strain GA) taxid:10388

Protein ModelArchive
Envelope glycoprotein L (gL) ma-jd-viral-09079
Virion protein US10 homolog ma-jd-viral-16121

Gallid herpesvirus 2 (strain RB-1b) taxid:33707

Protein ModelArchive
Envelope glycoprotein B (gB) ma-jd-viral-31201

Meleagrid herpesvirus 1 taxid:37108

Protein ModelArchive
Alpha trans-inducing protein (Alpha-TIF) ma-jd-viral-06963
Capsid scaffolding protein (Protease precursor) (pPR) ma-jd-viral-12505
DNA polymerase (EC 2.7.7.7) ma-jd-viral-17331
DNA polymerase processivity factor (Polymerase accessory protein) ma-jd-viral-21526
Envelope glycoprotein C homolog (A antigen) (Glycoprotein A) ma-jd-viral-01810
Envelope glycoprotein E ma-jd-viral-00332
Envelope glycoprotein E ma-jd-viral-64171
Envelope glycoprotein I ma-jd-viral-06393
Envelope glycoprotein K ma-jd-viral-49376
LORF3 ma-jd-viral-61014
LORF4 (Similar to VZV orf2, EHV-4 gene 3) ma-jd-viral-16094
LORF5 ma-jd-viral-61015
LORF6 ma-jd-viral-43647
Lipase ma-jd-viral-13824
MDV-1 LORF4 pp38-like protein (Pp38 homologue) ma-jd-viral-62071
MDV1 SORF3 ma-jd-viral-59863
Packaging protein UL32 ma-jd-viral-40981
Replication origin-binding protein (OriBP) ma-jd-viral-01488
Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase large... ma-jd-viral-14212
Tegument protein UL47 ma-jd-viral-02025
Tegument protein VP22 ma-jd-viral-07434
Thymidine kinase (EC 2.7.1.21) ma-jd-viral-05929
UL10 virion membrane glycoprotein M ma-jd-viral-37844
UL11 myristylated tegument protein ma-jd-viral-31684
UL12 DNase ma-jd-viral-08447
UL13 serine/threonine protein kinase ma-jd-viral-24654
UL14 minor tegument protein ma-jd-viral-14657
UL15 DNA packaging protein (Terminase) ma-jd-viral-06548
UL16 tegument protein ma-jd-viral-02644
UL17 tegument protein ma-jd-viral-02135
UL18 capsid protein ma-jd-viral-04815
UL19 major capsid protein ma-jd-viral-63095
UL2 uracil-DNA glycosylase ma-jd-viral-07759
UL20 membrane protein ma-jd-viral-36671
UL22 envelope glycoprotein H ma-jd-viral-16918
UL23 thymidine kinase ma-jd-viral-05929
UL24 ma-jd-viral-12145
UL25 DNA packaging protein ma-jd-viral-01770
UL26.5 minor capsid scaffold protein ma-jd-viral-38660
UL27 virion membrane glycoprotein B ma-jd-viral-31254
UL28 DNA packaging protein (UL28 processing and transport protein) ma-jd-viral-61512
UL29 single stranded DNA binding protein ma-jd-viral-35433
UL3 nuclear phosphoprotein ma-jd-viral-12080
UL31 nuclear phosphoprotein ma-jd-viral-10247
UL33 ma-jd-viral-66367
UL34 membrane phosphoprotein ma-jd-viral-12384
UL37 tegument protein ma-jd-viral-14876
UL38 capsid protein ma-jd-viral-09134
UL4 nuclear protein ma-jd-viral-10058
UL43 ma-jd-viral-02345
UL45 envelope/membrane protein, cell fusion (UL45 tegument protein) ma-jd-viral-16447
UL46 tegument phosphoprotein (UL46 tegument protein) ma-jd-viral-08938
UL49.5 envelope/tegument protein (UL49.5 glycoprotein gN) ma-jd-viral-37019
UL5 DNA helicase-primase associated protein ma-jd-viral-37542
UL50 dUTPase ma-jd-viral-12824
UL51 virion phosphoprotein ma-jd-viral-08905
UL52 DNA helicase-primase associated protein (UL52 DNA helicase/primase complex... ma-jd-viral-33296
UL54 post-translational gene regulation protein ma-jd-viral-15561
UL55 ma-jd-viral-10309
UL6 minor capsid protein ma-jd-viral-59262
UL7 ma-jd-viral-14077
UL8 DNA helicase-primase associated protein ma-jd-viral-17226
US1 ICP22 regulatory protein (US1 immediate early phosphoprotein, ICP22like... ma-jd-viral-38385
US10 ma-jd-viral-16119
US2 ma-jd-viral-21061
Uncharacterized protein HVT070 ma-jd-viral-62358
VNr-13 long isoform ma-jd-viral-15603
VNr-13 long isoform ma-jd-viral-15606
Virion host shutoff protein ma-jd-viral-22417
non-specific serine/threonine protein kinase (EC 2.7.11.1) ma-jd-viral-24926
ribonucleoside-diphosphate reductase (EC 1.17.4.1) ma-jd-viral-05491

anatid alphaherpesvirus 1 taxid:104388

Protein ModelArchive
Alpha trans-inducing protein (Alpha-TIF) ma-jd-viral-06953
Capsid protein (UL38) ma-jd-viral-09140
Capsid scaffolding protein (Protease precursor) (pPR) ma-jd-viral-12513
Capsid triplex subunit 2 (UL18) (UL18-like protein) ma-jd-viral-04801
DNA polymerase (EC 2.7.7.7) ma-jd-viral-17295
DNA polymerase processivity factor (Polymerase accessory protein) ma-jd-viral-21511
Deoxyuridine triphosphatase (UL50) (dUTPase) ma-jd-viral-12830
Envelope glycoprotein (Envelope protein) (GN) (Glycoprotein N) (UL49.5) ma-jd-viral-37021
Envelope glycoprotein E ma-jd-viral-64108
Envelope glycoprotein I ma-jd-viral-06389
Envelope glycoprotein K ma-jd-viral-49389
Envelope protein (UL43) ma-jd-viral-02380
GB (Glycoprotein B) (UL27) ma-jd-viral-31197
GC (Glycoprotein C) (UL44) ma-jd-viral-01812
GH (Glycoprotein H) (UL22) ma-jd-viral-16903
Glycoprotein D (GD protein) (US6) ma-jd-viral-07542
Glycoprotein G (US4) ma-jd-viral-64380
Glycoprotein J (US5) ma-jd-viral-39452
Helicase-primase primase subunit (UL52) ma-jd-viral-33293
Helicase-primase subunit (UL8) ma-jd-viral-17235
LORF-2 (LORF2) ma-jd-viral-13814
LORF11 ma-jd-viral-57070
LORF3 ma-jd-viral-35860
LORF4 (LORF9) ma-jd-viral-61018
MCP (Major capsid protein) (UL19) ma-jd-viral-63079
Minor capsid protein (UL6) ma-jd-viral-59283
Nuclear protein (UL55) ma-jd-viral-10304
Packaging protein UL32 ma-jd-viral-40951
Phosphoprotein (UL3) ma-jd-viral-12088
Replication origin-binding protein (OriBP) ma-jd-viral-01501
Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase large... ma-jd-viral-14207
SORF-3 (SORF3) ma-jd-viral-59861
Small capsomere-interacting protein ma-jd-viral-33045
Tegument protein (UL46) ma-jd-viral-08948
Tegument protein UL47 ma-jd-viral-02010
Tegument protein VP22 ma-jd-viral-07431
Thymidine kinase (UL23) ma-jd-viral-05914
UL1 ma-jd-viral-09084
UL10 ma-jd-viral-37904
UL11 ma-jd-viral-31683
UL12 ma-jd-viral-08444
UL13 ma-jd-viral-24661
UL14 ma-jd-viral-14630
UL15 ma-jd-viral-06519
UL16 (UL16-like) ma-jd-viral-02674
UL17 (UL17-like protein) ma-jd-viral-02134
UL17.5 ma-jd-viral-29365
UL2 ma-jd-viral-49855
UL20 (UL20-like) ma-jd-viral-36668
UL21 (UL21-like) ma-jd-viral-55953
UL25 ma-jd-viral-01756
UL26.5 ma-jd-viral-38659
UL28 (UL28-like) ma-jd-viral-61486
UL29 (UL29-like) ma-jd-viral-35442
UL3.5 ma-jd-viral-30632
UL31 ma-jd-viral-10255
UL33 (UL33-like) ma-jd-viral-66366
UL34 ma-jd-viral-12419
UL37 ma-jd-viral-14878
UL4 ma-jd-viral-10051
UL44.5 ma-jd-viral-08287
UL45 ma-jd-viral-16446
UL5 ma-jd-viral-37574
UL51 (Tugment protein) ma-jd-viral-08900
UL54 ma-jd-viral-15573
UL7 ma-jd-viral-14072
US1 (US1_1) ma-jd-viral-01880
US1 (US1_1) ma-jd-viral-01884
US10 ma-jd-viral-16122
Virion host shutoff protein ma-jd-viral-22416
non-specific serine/threonine protein kinase (EC 2.7.11.1) ma-jd-viral-24949
ribonucleoside-diphosphate reductase (EC 1.17.4.1) ma-jd-viral-05466
uL24 (UL24-like) ma-jd-viral-12159
uS2 ma-jd-viral-21069