Iltovirus

VIRION

Enveloped, spherical to pleomorphic, 120-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embeded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 150 kb. The genome contains terminal and internal reiterated sequences. The genome sequence is repeated at one end. Each virion contains multiple isomeric forms of the genome

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5’ leader sequence of 30-300 bp (not translated), a 3’ nontranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.

There are three types of genes: immediate-early, early and late. The immediate-early genes are transcribed immediately after infection and ensure the transcription of early genes, which encode the proteins necessary for the viral replication. The late genes mostly encode structural proteins. Standing apart are genes expressed during latency.

The viral proteins VHS and ICP27 are involved in shut-off of host protein translation in order to ensure the selective expression of viral proteins versus cellular proteins.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral gB, gC, gD and gH proteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Cell-cycle modulation

The conserved UL24 family of human alpha, beta and gamma herpesviruses induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex. Iltoviruses encode an UL24 homolog that should fullfill this role.

Host splicing inhibition

PsHV-1 UL54 is an alternative splicing regulator of host mRNA.

Matching UniProtKB/Swiss-Prot entries

78 entries grouped by strain (browse by keywords)

All proteins are shown (view only 71 complete proteome entries)

71 entries

Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus) reference strain

Select_all Deselect_all  
AN_PSHV1Alkaline nuclease (EC 3.1.-.-)
ATI2_PSHV1Alpha trans-inducing factor (Tegument protein UL46) (Tegument protein VP11/12)
DEN_PSHV1Deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
DNBI_PSHV1Major DNA-binding protein (Infected cell protein 8) (ICP-8 protein)
DPOL_PSHV1DNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)
DUT_PSHV1Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
EV45_PSHV1Envelope protein UL45
GB_PSHV1Envelope glycoprotein B (gB)
GC_PSHV1Envelope glycoprotein C
GD_PSHV1Envelope glycoprotein D (gD)
GE_PSHV1Envelope glycoprotein E (gE)
GG_PSHV1Glycoprotein G
GH_PSHV1Envelope glycoprotein H (gH)
GI_PSHV1Envelope glycoprotein I
GK_PSHV1Envelope glycoprotein K (Syncytial protein)
GL_PSHV1Envelope glycoprotein L
GM_PSHV1Envelope glycoprotein M
GN_PSHV1Envelope glycoprotein N (Protein UL49.5) (Protein UL49A)
HELI_PSHV1DNA replication helicase (EC 3.6.4.-)
HEPA_PSHV1DNA helicase/primase complex-associated protein (HEPA) (Primase-associated ...
ICP27_PSHV1mRNA export factor (Immediate-early protein IE63) (Infected cell protein 27) ...
ICP4_PSHV1Major viral transcription factor ICP4 homolog
KITH_PSHV1Thymidine kinase (EC 2.7.1.21)
MCP_PSHV1Major capsid protein (MCP) (Capsid protein VP5)
NP04_PSHV1Nuclear protein UL4
OBP_PSHV1Replication origin-binding protein (OBP) (OriBP)
ORF2_PSHV1Uncharacterized protein sORF2
ORF3_PSHV1Uncharacterized protein sORF3/4
ORFA_PSHV1Uncharacterized protein ORFA
ORFB_PSHV1Uncharacterized protein ORFB
ORFC_PSHV1Uncharacterized protein ORFC
ORFD_PSHV1Uncharacterized protein ORFD
ORFE_PSHV1Uncharacterized protein ORFE
PAP_PSHV1DNA polymerase processivity factor (DNA-binding protein UL42) (Polymerase ...
PORTL_PSHV1Portal protein UL6
PRIM_PSHV1DNA primase (EC 2.7.7.-)
PRTP_PSHV1Processing and transport protein (Infected cell protein 18.5) (ICP18.5 protein)
RIR1_PSHV1Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) ...
RIR2_PSHV1Ribonucleoside-diphosphate reductase small chain (EC 1.17.4.1) (Ribonucleotide ...
SCAF_PSHV1Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR)
SHUT_PSHV1Virion host shutoff protein (Vhs) (EC 3.1.27.-)
TEG2_PSHV1Tegument protein UL11
TEG3_PSHV1Tegument protein UL14
TEG5_PSHV1Tegument protein UL47 homolog
TEG7_PSHV1Tegument protein UL51
TERL_PSHV1Large terminase protein (DNA-packaging protein UL15) (Terminase large subunit)
TG21_PSHV1Tegument protein UL21
UL01_PSHV1Uncharacterized protein UL-1
UL03_PSHV1Uncharacterized protein UL3
UL07_PSHV1Virion egress protein UL7
UL13_PSHV1Serine/threonine-protein kinase UL13 (EC 2.7.11.1)
UL15B_PSHV1Large terminase protein homolog UL15b
UL16_PSHV1Capsid-binding protein UL16
UL17_PSHV1Virion-packaging protein UL17
UL20_PSHV1Protein UL20
UL24_PSHV1Protein UL24
UL25_PSHV1Virion-packaging protein UL25
UL31_PSHV1Virion egress protein UL31
UL32_PSHV1Packaging protein UL32
UL33_PSHV1Protein UL33
UL34_PSHV1Virion egress protein UL34 (Primary envelopment factor UL34)
UL37_PSHV1Capsid assembly protein UL37
UL43_PSHV1Membrane protein UL43
UNG_PSHV1Uracil-DNA glycosylase (UDG) (EC 3.2.2.27)
US02_PSHV1Uncharacterized protein US2
US03_PSHV1Protein kinase US3 homolog (EC 2.7.11.1)
US10_PSHV1Virion protein US10 homolog
VP19_PSHV1Triplex capsid protein VP19C (Virion protein UL38)
VP22_PSHV1Tegument protein VP22
VP23_PSHV1Triplex capsid protein VP23
VP26_PSHV1Capsid protein VP26 homolog

5 entries

Infectious laryngotracheitis virus (strain Thorne V882) (ILTV) (Gallid herpesvirus 1)

Select_all Deselect_all  
GB_ILTVTEnvelope glycoprotein B (gB)
KITH_ILTVTThymidine kinase (EC 2.7.1.21)
SCAF_ILTVTCapsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR)
UL24_ILTVTProtein UL24 homolog (ORF 3)
UL25_ILTVTVirion-packaging protein UL25 homolog (ORF 2)

1 entry

Infectious laryngotracheitis virus (strain 632) (ILTV) (Gallid herpesvirus 1)


GB_ILTV6Envelope glycoprotein B (gB)

1 entry

Infectious laryngotracheitis virus (strain SA-2) (ILTV) (Gallid herpesvirus 1)


GB_ILTVSEnvelope glycoprotein B (gB)