Macavirus

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embeded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 180 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5’ leader sequence of 30-300 bp (not translated), a 3’ nontranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Apoptosis modulation

Alcelaphine herpesvirus 1 encodes a bcl-2 homologue that may inhibit host apoptosis.

Host splicing inhibition

Modulates the viral and host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing.

Matching UniProtKB/Swiss-Prot entries

71 entries grouped by strain (browse by keywords)

All proteins are shown (view only 70 complete proteome entries)

70 entries

Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

Select_all Deselect_all  
AN_ALHV1Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
BRLF1_ALHV1Putative transcription activator BRLF1 homolog
CEP1_ALHV1Cytoplasmic envelopment protein 1
CEP2_ALHV1Cytoplasmic envelopment protein 2
CEP3_ALHV1Cytoplasmic envelopment protein 3
CVC1_ALHV1Capsid vertex component 1
CVC2_ALHV1Capsid vertex component 2
DNBI_ALHV1Major DNA-binding protein
DPOL_ALHV1DNA polymerase catalytic subunit (EC 2.7.7.7)
DUT_ALHV1Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
GB_ALHV1Envelope glycoprotein B (gB)
GH_ALHV1Envelope glycoprotein H (gH)
GL_ALHV1Envelope glycoprotein L (gL)
GM_ALHV1Envelope glycoprotein M (gM)
GN_ALHV1Envelope glycoprotein N
HELI_ALHV1DNA replication helicase (EC 3.6.4.-)
IE63_ALHV1Immediate-early phosphoprotein 57
ITP_ALHV1Inner tegument protein
KITH_ALHV1Thymidine kinase (EC 2.7.1.21)
LTP_ALHV1Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
MCP_ALHV1Major capsid protein (MCP)
NEC1_ALHV1Nuclear egress protein 1
NEC2_ALHV1Nuclear egress protein 2
PORTL_ALHV1Portal protein
PRIM_ALHV1DNA primase (EC 2.7.7.-)
RIR1_ALHV1Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) ...
RIR2_ALHV1Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) ...
SCAF_ALHV1Capsid scaffolding protein (Capsid protein 17) (Protease precursor) (pPR)
SCP_ALHV1Small capsomere-interacting protein
SEMA_ALHV1Semaphorin-like protein A3
TEG7_ALHV1Tegument protein UL51 homolog (Uncharacterized gene 55 protein)
TRM1_ALHV1Tripartite terminase subunit 1
TRM2_ALHV1Tripartite terminase subunit 2
TRM3_ALHV1Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRX1_ALHV1Triplex capsid protein 1
TRX2_ALHV1Triplex capsid protein 2
UL24_ALHV1Protein UL24 homolog
UL32_ALHV1Packaging protein UL32 homolog
UL49_ALHV1Uncharacterized gene 66 protein
UL79_ALHV1Gene 18 protein
UL87_ALHV1Uncharacterized gene 24 protein
UL91_ALHV1Uncharacterized gene 30 protein
UL92_ALHV1Gene 31 protein
UL95_ALHV1Gene 34 protein
UL96_ALHV1Gene 35 protein
UNG_ALHV1Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
VG10_ALHV1Uncharacterized gene 10 protein
VG11_ALHV1Uncharacterized gene 11 protein
VG23_ALHV1Uncharacterized gene 23 protein
VG27_ALHV1Uncharacterized gene 27 protein
VG36_ALHV1Putative tyrosine kinase 36 (EC 2.7.10.2)
VG40_ALHV1Uncharacterized gene 40 protein
VG41_ALHV1Uncharacterized gene 41 protein
VG45_ALHV1Uncharacterized gene 45 protein
VG48_ALHV1Uncharacterized gene 48 protein
VG52_ALHV1Uncharacterized gene 52 protein
VG58_ALHV1Gene 58 protein
VG59_ALHV1DNA polymerase processivity factor
VG73_ALHV1Uncharacterized gene 73 protein
VGA10_ALHV1Uncharacterized gene A10 protein
VGA1_ALHV1Uncharacterized gene A1 protein
VGA2_ALHV1Uncharacterized protein A2
VGA4_ALHV1Uncharacterized gene A4 protein
VGA5_ALHV1G-protein coupled receptor A5
VGA6_ALHV1Uncharacterized gene A6 protein
VGA7_ALHV1Putative C-type lectin protein A7
VGA8_ALHV1Uncharacterized gene A8 protein
VGA9_ALHV1Putative apoptosis regulator A9
VP03_ALHV1Probable tegument protein antigen 3
VP75_ALHV1Probable membrane antigen 75 (Tegument protein)

1 entry

Alcelaphine herpesvirus 1 (strain WC11) (AlHV-1) (Malignant catarrhal fever virus)


KITH_AHV1WThymidine kinase (EC 2.7.1.21)