Alloherpesviridae

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers. Glycoproteins complexes are embed in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of 134-248 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5’ leader sequence of 30-300 bp (not translated), a 3’ non-translated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Entry into host cell is still unclear and may depend on the host cell type, i.e. endocytosis versus fusion at the plasma membrane.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes.
  5. Transcription of early viral mRNA by host polymerase II, transport into the cytoplasm and translation into early proteins.
  6. Early proteins are involved in replication of the viral DNA and are transported back into the nucleus.
  7. Synthesis of multiple copies of viral DNA by the viral DNA-dependent DNA polymerase.
  8. Transcription of late mRNAs by host polymerase II, transport into the cytoplasm and translation into late proteins.
  9. Late proteins are structural or core proteins and are transported back into the nucleus.
  10. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Matching UniProtKB/Swiss-Prot entries

76 entries grouped by strain (browse by keywords)

76 entries

Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

Select_all Deselect_all  
DPOL_ICHVADNA polymerase (EC 2.7.7.7)
DUT_ICHVADeoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
HELI_ICHVAProbable ATP-dependent helicase 25 (EC 3.6.4.-)
KITH_ICHVAThymidine kinase (EC 2.7.1.21)
KR14_ICHVAProtein kinase ORF14 (EC 2.7.11.1)
KR15_ICHVAProtein kinase ORF15 (EC 2.7.11.1)
KR16_ICHVAProtein kinase ORF16 (EC 2.7.11.1)
KR73_ICHVAProtein kinase ORF73 (EC 2.7.11.1)
KR74_ICHVAProtein kinase ORF74 (EC 2.7.11.1)
VG01_ICHVAUncharacterized protein ORF1
VG02_ICHVAUncharacterized protein ORF2
VG03_ICHVAUncharacterized protein ORF3
VG04_ICHVAUncharacterized protein ORF4
VG06_ICHVAPutative membrane protein ORF6
VG07_ICHVAPutative membrane protein ORF7
VG08_ICHVAPutative membrane protein ORF8
VG09_ICHVAPutative zinc-binding protein ORF9
VG10_ICHVAPutative membrane protein ORF10
VG11_ICHVAPutative zinc-binding protein ORF11
VG12_ICHVAPutative zinc-binding protein ORF12
VG13_ICHVAUncharacterized protein ORF13
VG17_ICHVAUncharacterized protein ORF17
VG18_ICHVAUncharacterized protein ORF18
VG19_ICHVAPutative membrane protein ORF19
VG20_ICHVAUncharacterized protein ORF20
VG21_ICHVAUncharacterized protein ORF21
VG22_ICHVAUncharacterized protein ORF22
VG23_ICHVAUncharacterized protein ORF23
VG24_ICHVAUncharacterized protein ORF24
VG26_ICHVAUncharacterized protein ORF26
VG27_ICHVAUncharacterized protein ORF27
VG28_ICHVAUncharacterized protein ORF28
VG29_ICHVAUncharacterized protein ORF29
VG30_ICHVAUncharacterized protein ORF30
VG31_ICHVAUncharacterized protein ORF31
VG32_ICHVAUncharacterized protein ORF32
VG33_ICHVAUncharacterized protein ORF33
VG34_ICHVAUncharacterized protein ORF34
VG35_ICHVAUncharacterized protein ORF35
VG36_ICHVAUncharacterized protein ORF36
VG37_ICHVAUncharacterized protein ORF37
VG38_ICHVAUncharacterized protein ORF38
VG39_ICHVAUncharacterized protein ORF39
VG40_ICHVAUncharacterized protein ORF40
VG41_ICHVAUncharacterized protein ORF41
VG42_ICHVAUncharacterized protein ORF42
VG43_ICHVAUncharacterized protein ORF43
VG44_ICHVAUncharacterized protein ORF44
VG45_ICHVAUncharacterized protein ORF45
VG46_ICHVAProbable major glycoprotein
VG47_ICHVASubtilisin-like protease (EC 3.4.21.-)
VG48_ICHVAUncharacterized protein ORF48
VG50_ICHVAUncharacterized protein ORF50
VG51_ICHVAPutative membrane protein ORF51
VG52_ICHVAUncharacterized protein ORF52
VG53_ICHVAUncharacterized protein ORF53
VG54_ICHVAUncharacterized protein ORF54
VG55_ICHVAUncharacterized protein ORF55
VG56_ICHVAUncharacterized protein ORF56
VG59_ICHVAPutative membrane protein ORF59
VG60_ICHVAUncharacterized protein ORF60
VG61_ICHVAUncharacterized protein ORF61
VG63_ICHVAUncharacterized protein ORF63
VG64_ICHVAUncharacterized protein ORF64
VG65_ICHVAUncharacterized protein ORF65
VG66_ICHVAUncharacterized protein ORF66
VG67_ICHVAUncharacterized protein ORF67
VG68_ICHVAUncharacterized protein ORF68
VG70_ICHVAUncharacterized protein ORF70
VG72_ICHVAUncharacterized protein ORF72
VG75_ICHVAUncharacterized protein ORF75
VG76_ICHVAUncharacterized protein ORF76
VG77_ICHVAUncharacterized protein ORF77
VG78_ICHVAPutative zinc-binding protein ORF78
VG79_ICHVAUncharacterized protein ORF79
VTER_ICHVAProbable DNA-packaging protein (Terminase)