Atadenovirus

VIRION

Non-enveloped capsid with a pseudo T=25 icosahedral symmetry. The capsid diameter is about 90 nm. The capsid shell consists of 720 hexon subunits arranged as 240 trimers and 12 vertex penton capsomers each with a fiber protruding from the surface.

GENOME

Non-segmented, linear double-stranded DNA of 30 kb encoding about 30 proteins. The genome has terminally redundant sequences which have inverted terminal repetitions (ITR). The terminal protein (TP) is covalently attached to each end of the genome.

GENE EXPRESSION

Transcription is nuclear, in two phases; early (replication), late (virion assembly). All genes are transcribed by host RNA pol II. Genes transcribed by RNA pol II give rise to multiple mRNA that are produced by alternative splicing and use of different poly(A) sites.

REPLICATION

NUCLEUS

  1. Attachment of the viral fiber glycoproteins to host receptors mediates endocytosis of the virus into the host cell and fiber shedding.
  2. Disruption of the endosome by lytic protein VI releases the viral capsid in the cytosol.
  3. Viral penetration into host nucleus.
  4. Transcription of early genes (E genes) by host RNA pol II, replication of the DNA genome by DNA strand displacement in the nucleus.
  5. Transcription of late genes (L genes) by host RNA pol II, mostly encoding for structural proteins.
  6. Assembly of new virions in the nucleus.
  7. Virions are released by lysis of the cell.

Matching UniProtKB/Swiss-Prot entries

33 entries grouped by strain (browse by keywords)

All proteins are shown (view only 32 complete proteome entries)

3 entries

Ovine adenovirus D serotype 7 (isolate OAV287) (OAdV-7) (Ovine adenovirus 7) reference strain

Select_all Deselect_all  
LH3_ADEO7Hexon-interlacing protein LH3
P32K_ADEO7Structural protein p32K
PRO_ADEO7Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus ...

28 entries

Snake adenovirus serotype 1 (SnAdV-1)

Select_all Deselect_all  
105R_ADES1Protein 105R
22K_ADES1Putative protein 22K
33K_ADES1Putative protein 33K
CAP3_ADES1Pre-hexon-linking protein IIIa (Capsid vertex-specific component IIIa) (CVSC) ...
CAP6_ADES1Pre-protein VI (pVI)
CAP8_ADES1Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII)
CAPSH_ADES1Hexon protein (CP-H) (Protein II)
CAPSP_ADES1Penton protein (CP-P) (Penton base protein) (Protein III)
DNB2_ADES1DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)
DPOL_ADES1DNA polymerase (EC 2.7.7.7)
E41_ADES1Protein E4.1
E42_ADES1Protein E4.2
E43_ADES1Protein E4.3
L2MU_ADES1Late L2 mu core protein (Protein X) (pX) (pMu)
LH1_ADES1Protein LH1
LH2_ADES1Protein LH2
LH3_ADES1Hexon-interlacing protein LH3
NP_ADES1Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII)
ORF1_ADES1Protein ORF1
P32K_ADES1Structural protein p32K
PKG1_ADES1Packaging protein 1 (Packaging protein IVa2)
PKG3_ADES1Packaging protein 3 (L1-52/55 kDa protein) (Packaging protein 52K)
PRO_ADES1Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus ...
RH1_ADES1Protein RH1
SHUT_ADES1Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) ...
SPIKE_ADES1Fiber protein (SPIKE) (Protein IV)
TERM_ADES1Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein)
UXP_ADES1Probable U-exon protein

1 entry

Bovine adenovirus 4 (BAdV-4)


PRO_ADEB4Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus ...

1 entry

Bovine adenovirus 7 (BAdV-7)


PRO_ADEB7Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus ...