Tymoviridae

VIRION

Non-enveloped, isometric capsid with T=3 icosahedral symmetry, about 30 nm in diameter.

GENOME

Monopartite, linear, C-rich, ssRNA(+) genome of 6-7.5 kb. The 3’-terminus may have a tRNA-like structure or a polyA tract, depending upon the virus.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. The virion RNA is infectious and serves as both the genome and viral messenger RNA. The ORF1 encodes a polyprotein whichis expressed by leaky scanning. The capsid protein is translated from a subgenomic RNA.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. The viral RNA is translated to produce the protein necessary for RNA synthesis (replication and transcription).
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. The RdRp recognizes an internal subgenomic promoter on the negative-sense RNA to transcribe the 3’co-terminal subgenomic RNA that will generate the capsid protein.
  7. Assembly of new virus particles.

Host-virus interaction

Modulation of host ubiquitin pathway by virus

Turnip yellow mosaic virus 98K replication protein counteracts degradation of its RNA-dependent RNA polymerase (RdRp) by the host ubiquitin-proteasome system. The viral 98K replication protein mediates deubiquitylation of RdRp leading to its stabilization .

Matching UniProtKB/Swiss-Prot entries

28 entries grouped by strain (browse by keywords)

All proteins are shown (view only 18 complete proteome entries)

4 entries

Grapevine fleck virus (isolate Italy/MT48) (GFkV) reference strain

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CAPSD_GFKVMCapsid protein (CP) (Coat protein)
ORF3_GFKVMUncharacterized protein ORF3
ORF4_GFKVMUncharacterized protein ORF4
RDRP_GFKVMRNA replication protein

3 entries

Turnip yellow mosaic virus reference strain

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COAT_TYMVCoat protein (Virion protein)
P69_TYMV69 kDa protein (p69)
POLR_TYMVRNA replicase polyprotein (206 kDa polyprotein)

2 entries

Maize rayado fino virus (isolate Costa Rica/Guapiles) (MRFV) reference strain

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MOVP_MRFVCPutative movement protein
POLG_MRFVCGenome polyprotein

3 entries

Eggplant mosaic virus

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COAT_EPMVCoat protein (Virion protein)
P69_EPMV70 kDa protein
POLR_EPMVRNA replicase polyprotein (EC 2.7.7.48)

3 entries

Erysimum latent virus (ELV)

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COAT_ELVCoat protein (Virion protein)
POLR_ELVRNA replicase polyprotein (EC 2.7.7.48)
Y48K_ELVUncharacterized 48 kDa protein

3 entries

Ononis yellow mosaic virus

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COAT_OYMVCoat protein (Virion protein)
P69_OYMV66 kDa protein
POLR_OYMVRNA replicase polyprotein (EC 2.7.7.48)

3 entries

Turnip yellow mosaic virus (isolate Australia)

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COAT_TYMVACoat protein (Virion protein)
P69_TYMVA69 kDa protein (p69)
POLR_TYMVARNA replicase polyprotein (EC 2.7.7.48)

2 entries

Kennedya yellow mosaic virus (strain Jervis bay) (KYMV)

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COAT_KYMVJCoat protein (Virion protein)
POLR_KYMVJRNA replicase polyprotein (EC 2.7.7.48)

2 entries

Turnip yellow mosaic virus (isolate TYMC)

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P69_TYMVC69 kDa protein (p69)
POLR_TYMVCRNA replicase polyprotein (EC 2.7.7.48)

1 entry

Belladonna mottle virus (BMDV)


COAT_BMDVCoat protein (Virion protein)

1 entry

Cacao yellow mosaic virus


COAT_CAYMVCoat protein (Virion protein)

1 entry

Physalis mottle virus (PhMV) (Belladonna mottle virus-Iowa)


COAT_PHMVCoat protein (Virion protein)