Polyhedral virions 185 nm in diameter. The capsid displays an icosahedral symmetry T=147, with an internal lipid membrane. Virions are either externally enveloped or not depending whether they budded from the cell membrane, or were arranged in paracrystaline array in the host cell cytoplasm and were released by lysis.


Linear, dsDNA genome of 140 to 213 kb. The genome contains terminal and redundant sequences and is circularly permuted. According to a recent estimation, IIV-6 genome might encode about 211 proteins. The genome is not methylated.


there are classical or slightly modified canonical promoters and termination signals upstream and downstream of the start and stop codons of most ORFs.



  1. Attachement of the viral proteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the DNA core into the host cytoplasm.
  3. Viral DNA is transported to the cell nucleus where host macromolecular synthesis is rapidly shutdown. Transcription is initiated by virally modified host RNA polymerase II.
  4. Parental DNA is used to produce genome and greater than genome length DNA.
  5. Progeny DNA is transported into cytoplasmic viral factories where large concatamers of viral DNA are formed by recombination. Transcription of very late transcripts may also take place in the cytoplasm.
  6. Assembly of new virions in the cytoplasm.
  7. Virions exit the cell by budding or cell lysis.

Host-virus interaction

Apoptosis modulation

Chilo iridescent virus encodes a functional inhibitor of apoptosis (IAP) . The grouper iridovirus (GIV) contains an antiapoptotic B-cell lymphoma (Bcl)-2-like gene that also inhibits host apoptosis.

Matching UniProtKB/Swiss-Prot entries

221 entries grouped by strain (browse by keywords)

All proteins are shown (view only 215 complete proteome entries)

215 entries

Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) reference strain

Select_all Deselect_all  
006L_IIV6Putative KilA-N domain-containing protein 006L
009R_IIV6Uncharacterized protein 009R
026R_IIV6Uncharacterized protein 026R
029R_IIV6Uncharacterized protein 029R
032R_IIV6Uncharacterized protein 032R
034R_IIV6Uncharacterized protein 034R
041L_IIV6Uncharacterized protein 041L
042R_IIV6Uncharacterized protein 042R
043L_IIV6Uncharacterized protein 043L
044R_IIV6Uncharacterized protein 044R
049L_IIV6Transmembrane protein 049L
056R_IIV6Uncharacterized protein 056R
060L_IIV6Uncharacterized protein 060L
061R_IIV6Uncharacterized protein 061R
062L_IIV6Uncharacterized protein 062L
065R_IIV6Uncharacterized protein 065R
069L_IIV6Putative Bro-N domain-containing protein 069L
071L_IIV6Uncharacterized protein 071L
082L_IIV6Uncharacterized protein 082L
083L_IIV6Uncharacterized protein 083L
084L_IIV6Uncharacterized protein 084L
094L_IIV6Uncharacterized protein 094L
095L_IIV6Putative RING finger protein 095L
096L_IIV6Putative FAS1 domain-containing protein 096L
101L_IIV6Uncharacterized protein 101L
104L_IIV6Uncharacterized protein 104L
106L_IIV6Uncharacterized protein 106L
107L_IIV6Uncharacterized protein 107L
110R_IIV6Uncharacterized protein 110R
111R_IIV6Uncharacterized protein 111R
113L_IIV6Uncharacterized protein 113L
116L_IIV6Uncharacterized protein 116L
120L_IIV6Uncharacterized protein 120L
121R_IIV6Putative RING finger protein 121R
122R_IIV6Uncharacterized protein 122R
123R_IIV6Putative tyrosine phosphatase 123R (EC 3.1.3.-)
126R_IIV6Uncharacterized protein 126R
127L_IIV6Uncharacterized protein 127L
130R_IIV6Uncharacterized protein 130R
132L_IIV6Putative zinc finger protein 132L
135R_IIV6Uncharacterized protein 135R
137R_IIV6Uncharacterized protein 137R
138R_IIV6Uncharacterized protein 138R
139L_IIV6Uncharacterized protein 139L
140L_IIV6Uncharacterized protein 140L
141R_IIV6Uncharacterized protein 141R
146R_IIV6Putative MSV199 domain-containing protein 146R
148R_IIV6Putative MSV199 domain-containing protein 148R
149L_IIV6Uncharacterized protein 149L
156R_IIV6Uncharacterized protein 156R
159L_IIV6Uncharacterized protein 159L
160L_IIV6Uncharacterized protein 160L
162R_IIV6Uncharacterized protein 162R
165R_IIV6Putative metalloproteinase 165R (EC 3.4.24.-)
169L_IIV6Uncharacterized protein 169L
172L_IIV6Putative helicase 172L (EC 3.6.4.-)
175R_IIV6Putative RING finger protein 175R
192R_IIV6Uncharacterized protein 192R
195L_IIV6Uncharacterized protein 195L
200R_IIV6Putative MSV199 domain-containing protein 200R
206L_IIV6Uncharacterized protein 206L
209R_IIV6Uncharacterized protein 209R
211L_IIV6Putative MSV199 domain-containing protein 211L
212L_IIV6Putative MSV199 domain-containing protein 212L
216R_IIV6Uncharacterized protein 216R
218R_IIV6Uncharacterized protein 218R
221L_IIV6Uncharacterized protein 221L
226R_IIV6Uncharacterized protein 226R
227L_IIV6Uncharacterized protein 227L
228L_IIV6Uncharacterized protein 228L
234R_IIV6Uncharacterized protein 234R
235L_IIV6Putative methyltransferase 235L (EC 2.1.1.-)
236L_IIV6Uncharacterized protein 236L
238R_IIV6Putative MSV199 domain-containing protein 238R
240R_IIV6Uncharacterized protein 240R
241L_IIV6Cysteine-rich uncharacterized protein 241L
242L_IIV6Putative GIY-YIG domain-containing protein 242L
246L_IIV6Uncharacterized protein 246L
247L_IIV6Uncharacterized protein 247L
249R_IIV6Uncharacterized protein 249R
250L_IIV6Uncharacterized protein 250L
253L_IIV6Uncharacterized protein 253L
254L_IIV6Uncharacterized protein 254L
255L_IIV6Uncharacterized protein 255L
261R_IIV6Uncharacterized protein 261R
272L_IIV6Uncharacterized protein 272L
273R_IIV6Uncharacterized protein 273R
284R_IIV6Uncharacterized protein 284R
285L_IIV6Uncharacterized protein 285L
287R_IIV6Uncharacterized protein 287R
289L_IIV6Putative Bro-N domain-containing protein 289L
293R_IIV6Uncharacterized protein 293R
300R_IIV6Transmembrane protein 300R
301L_IIV6Uncharacterized protein 301L
308L_IIV6Uncharacterized protein 308L
312R_IIV6Uncharacterized protein 312R
313L_IIV6Putative KilA-N domain-containing protein 313L
315L_IIV6Putative KilA-N domain-containing protein 315L
317L_IIV6Uncharacterized protein 317L
322R_IIV6Uncharacterized protein 322R
325L_IIV6Uncharacterized protein 325L
332L_IIV6Uncharacterized RING finger protein 332L
340R_IIV6DRBM domain-containing protein 340R
343L_IIV6Probable DNA-directed RNA polymerase subunit 343L (EC
346R_IIV6Uncharacterized protein 346R
348R_IIV6Uncharacterized protein 348R
361L_IIV6Probable cysteine proteinase 361L (EC 3.4.-.-)
366R_IIV6Uncharacterized protein 366R
368R_IIV6Uncharacterized protein 368R
373L_IIV6Uncharacterized protein 373L
374R_IIV6Uncharacterized protein 374R
375R_IIV6Uncharacterized protein 375R
384L_IIV6Uncharacterized protein 384L
385L_IIV6Uncharacterized protein 385L
388R_IIV6Putative MSV199 domain-containing protein 388R
389L_IIV6Probable serine/threonine-protein kinase 389L (EC
400R_IIV6Uncharacterized protein 400R
404L_IIV6Uncharacterized protein 404L
411L_IIV6Uncharacterized protein 411L
413R_IIV6Putative RING finger protein 413R
420R_IIV6Putative MSV199 domain-containing protein 420R
422L_IIV6Uncharacterized protein 422L
423L_IIV6Uncharacterized protein 423L
426R_IIV6Uncharacterized protein 426R
437L_IIV6Uncharacterized protein 437L
438L_IIV6Probable deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC ...
441R_IIV6Uncharacterized protein 441R
443R_IIV6Uncharacterized protein 443R
451L_IIV6Uncharacterized protein 451L
454R_IIV6Putative DNA-directed RNA polymerase subunit 454R
457L_IIV6Uncharacterized protein 457L
458R_IIV6Putative myristoylated membrane protein 458R
460R_IIV6Uncharacterized protein 460R
463L_IIV6Probable lipid hydrolase 463L (EC 3.1.1.-)
468L_IIV6Putative MSV199 domain-containing protein 468L
DPOL_IIV6DNA polymerase 037L (EC
EXON_IIV6Putative exonuclease 012L (EC 3.1.11.-)
HMGH_IIV6High mobility group protein homolog
ICP46_IIV6Immediate-early protein ICP-46 homolog
KTHY_IIV6Putative thymidylate kinase 251L (EC (dTMP kinase)
MCP_IIV6Major capsid protein (MCP) (P50)
PARP_IIV6Putative poly
RIR1_IIV6Ribonucleoside-diphosphate reductase large subunit (EC ...
RIR2_IIV6Probable ribonucleoside-diphosphate reductase small subunit 376L (EC ...
RNC_IIV6Putative ribonuclease 3 (EC (Ribonuclease III) (RNase III)
RPB1_IIV6Probable DNA-directed RNA polymerase II subunit RPB1 homolog (EC
RPB2_IIV6Probable DNA-directed RNA polymerase II subunit RPB2 homolog (EC
TOP2_IIV6DNA topoisomerase 2 (EC (DNA topoisomerase II)
TYSY_IIV6Probable thymidylate synthase 225R (EC
VF010_IIV6Transmembrane protein 010R
VF019_IIV6Uncharacterized protein 019R
VF022_IIV6Putative helicase 022L (EC 3.6.4.-)
VF030_IIV6Uncharacterized protein 030L
VF050_IIV6Uncharacterized protein 050L
VF067_IIV6Uncharacterized protein 067R
VF075_IIV6Uncharacterized protein 075L
VF077_IIV6Putative zinc finger protein 077L
VF098_IIV6Uncharacterized protein 098R
VF115_IIV6Uncharacterized protein 115R
VF117_IIV6Uncharacterized protein 117L
VF118_IIV6Putative myristoylated protein 118L
VF136_IIV6Uncharacterized protein 136R
VF143_IIV6Putative kinase protein 143R (EC 2.7.-.-)
VF145_IIV6Uncharacterized protein 145L
VF155_IIV6Uncharacterized protein 155L
VF157_IIV6Putative RING finger protein 157L
VF161_IIV6Putative helicase 161L (EC 3.6.4.-)
VF170_IIV6Uncharacterized protein 170L
VF179_IIV6Uncharacterized protein 179R
VF184_IIV6Putative helicase 184R (EC 3.6.4.-)
VF193_IIV6Apoptosis inhibitor 193R
VF196_IIV6Uncharacterized protein 196R
VF197_IIV6Putative tyrosine phosphatase 197R (EC 3.1.3.-)
VF198_IIV6Uncharacterized protein 198R
VF201_IIV6Putative Bro-N domain-containing protein 201R
VF203_IIV6Uncharacterized protein 203L
VF205_IIV6Putative DNA ligase 205R (EC
VF213_IIV6Transmembrane protein 213R
VF219_IIV6Uncharacterized protein 219L
VF224_IIV6Probable cysteine proteinase 224L (EC 3.4.-.-)
VF229_IIV6Uncharacterized protein 229L
VF232_IIV6Putative ubiquitin thioesterase 232R (EC
VF244_IIV6Putative phosphoesterase 244L (EC 3.1.-.-)
VF259_IIV6Uncharacterized protein 259R
VF268_IIV6Uncharacterized protein 268L
VF282_IIV6Putative transcription factor 282R
VF295_IIV6Uncharacterized protein 295L
VF302_IIV6Putative zinc finger protein 302L
VF306_IIV6Putative SWIB domain-containing protein 306R
VF307_IIV6Uncharacterized protein 307L
VF309_IIV6Uncharacterized protein 309L
VF329_IIV6Uncharacterized protein 329R
VF335_IIV6Uncharacterized protein 335L
VF337_IIV6Putative membrane protein 337L
VF342_IIV6Uncharacterized protein 342R
VF347_IIV6Putative FAD-linked sulfhydryl oxidase 347L (EC
VF349_IIV6Putative transcription elongation factor S-II-like protein 349L
VF350_IIV6Uncharacterized protein 350L
VF355_IIV6Putative CTD phosphatase-like protein 355R (EC 3.1.3.-)
VF357_IIV6Uncharacterized protein 357R
VF358_IIV6Uncharacterized protein 358L
VF359_IIV6Uncharacterized protein 359L
VF369_IIV6Probable RAD2-like endonuclease 369L (EC 3.1.-.-)
VF378_IIV6Uncharacterized protein 378R
VF380_IIV6Probable serine/threonine-protein kinase 380R (EC
VF391_IIV6Uncharacterized protein 391R
VF395_IIV6Uncharacterized protein 395R
VF396_IIV6Uncharacterized protein 396L
VF414_IIV6Putative hydrolase 414L (EC 3.6.1.-)
VF415_IIV6Uncharacterized protein 415R
VF436_IIV6Uncharacterized protein 436R
VF439_IIV6Probable kinase 439L (EC 2.7.-.-)
VF453_IIV6Putative thioredoxin-like protein 453L
VF466_IIV6Uncharacterized protein 466R
VF467_IIV6Uncharacterized protein 467R

2 entries

Simulium iridescent virus (IIV-22) (Insect iridescent virus type 22)

Select_all Deselect_all  
MCP_IRV22Major capsid protein (MCP) (P50)
VF015_IRV22Uncharacterized 15.9 kDa protein in MSP 5'region

2 entries

Tipula iridescent virus (TIV) (Insect iridescent virus type 1)

Select_all Deselect_all  
MCP_IRV1Major capsid protein (MCP) (P50)
VL96_IRV1Putative ubiquitin thioesterase L96 (EC

1 entry

Costelytra zealandica iridescent virus (CzIV) (Insect iridescent virus type 16)

MCP_IRV16Major capsid protein (MCP) (P50)

1 entry

Wiseana iridescent virus (WIV) (Insect iridescent virus type 9)

MCP_IRV9Major capsid protein (MCP) (P50)