Polyhedral virions 180 nm in diameter. The capsid displays an icosahedral symmetry T=189-217, with an internal lipid membrane. Virions are either externally enveloped or not depending whether they budded from the cell membrane, or were arranged in paracrystaline array in the host cell cytoplasm and were released by lysis.


Linear, dsDNA genome of about 135 kb. The genome contains terminal and redundant sequences. Encodes for about 126 proteins. The genome is not methylated.




  1. Attachement of the viral proteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the DNA core into the host cytoplasm.
  3. Viral DNA is transported to the cell nucleus where host macromolecular synthesis is rapidly shutdown. Transcription is initiated by virally modified host RNA polymerase II.
  4. Parental DNA is used to produce genome and greater than genome length DNA.
  5. Progeny DNA is transported into cytoplasmic viral factories where large concatamers of viral DNA are formed by recombination. Transcription of very late transcripts may also take place in the cytoplasm.
  6. Assembly of new virions in the cytoplasm.
  7. Virions exit the cell by budding or cell lysis.

Host-virus interaction

Apoptosis modulation

Invertebrate iridescent virus 3 encodes a protein homolog to the Chilo iridescent virus functional inhibitor of apoptosis (IAP) . This ORF may therefore play a role in the modulation of host apoptosis.

Matching UniProtKB/Swiss-Prot entries

126 entries grouped by strain (browse by keywords)

126 entries

Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus) reference strain

Select_all Deselect_all  
002R_IIV3Uncharacterized protein 002R
003L_IIV3Uncharacterized protein 003L
005L_IIV3Uncharacterized protein 005L
007R_IIV3Uncharacterized protein 007R
008L_IIV3Uncharacterized protein 008L
011L_IIV3Uncharacterized protein 011L
013L_IIV3Uncharacterized protein IIV3-013L
022L_IIV3Transmembrane protein 022L
023R_IIV3Uncharacterized protein 023R
025R_IIV3Uncharacterized protein 025R
028R_IIV3Uncharacterized protein 028R
030L_IIV3uncharacterized protein 030L
032R_IIV3Uncharacterized protein 032R
037L_IIV3Uncharacterized protein 037L
040R_IIV3Uncharacterized protein 040R
044L_IIV3Putative serine/threonine-protein kinase 040L (EC 2.7.11.-)
045R_IIV3Uncharacterized protein 045R
049R_IIV3Uncharacterized protein 049R
053L_IIV3Uncharacterized protein 053L
054L_IIV3Uncharacterized protein 054L
057L_IIV3Uncharacterized protein 057L
062L_IIV3Uncharacterized protein 062L
064L_IIV3Uncharacterized protein 064L
072L_IIV3Uncharacterized protein 072L
073R_IIV3Uncharacterized protein 073R
075R_IIV3Uncharacterized protein 075R
077R_IIV3Uncharacterized protein 077R
080R_IIV3Putative hydrolase 080R (EC 3.6.1.-)
081L_IIV3Putative FAS1 domain-containing protein 081L
082L_IIV3Uncharacterized protein 082L
089L_IIV3Uncharacterized protein 089L
092R_IIV3Uncharacterized protein 092R
095L_IIV3Probable matrix metalloproteinase 095L (EC 3.4.24.-)
102R_IIV3Uncharacterized protein 102R
103L_IIV3Uncharacterized protein 103L
108L_IIV3Uncharacterized protein 108L
110R_IIV3Uncharacterized protein 110R
114L_IIV3Uncharacterized protein 114L
116R_IIV3Uncharacterized protein 116R
117L_IIV3Uncharacterized protein 117L
118R_IIV3Uncharacterized protein 118R
119R_IIV3Uncharacterized protein 119R
122R_IIV3Uncharacterized protein 122R
123L_IIV3Uncharacterized protein 123L
124R_IIV3Uncharacterized protein 124R
125R_IIV3Uncharacterized protein 125R
126R_IIV3Uncharacterized protein 126R
DPOL_IIV3DNA polymerase 120R (EC
EX0N_IIV3Putative exonuclease 059L (EC 3.1.11.-)
ICP46_IIV3Immediate-early protein ICP-46 homolog
MCP_IIV3Major capsid protein (MCP)
RIR1_IIV3Ribonucleoside-diphosphate reductase large subunit (EC ...
RIR2_IIV3Probable ribonucleoside-diphosphate reductase small subunit 048L (EC ...
RNC_IIV3Putative ribonuclease 3 (EC
RPB1_IIV3Probable DNA-directed RNA polymerase II subunit RPB1 homolog (EC
RPB2_IIV3Probable DNA-directed RNA polymerase II subunit RPB2 homolog (EC
TOP2_IIV3DNA topoisomerase 2 (EC (DNA topoisomerase II)
VF010_IIV3Uncharacterized protein 043R
VF015_IIV3Uncharacterized protein 015R
VF019_IIV3Putative MSV199 domain-containing protein 093L
VF022_IIV3Putative helicase 087L (EC 3.6.4.-)
VF030_IIV3Uncharacterized protein 106R
VF050_IIV3Uncharacterized protein 094L
VF067_IIV3Uncharacterized protein 004R
VF075_IIV3Uncharacterized protein 088R
VF077_IIV3Putative zinc finger protein 034R
VF098_IIV3Uncharacterized protein 038R
VF115_IIV3Uncharacterized protein 031R
VF117_IIV3Uncharacterized protein 107R
VF118_IIV3Putative myristoylated protein 006R
VF136_IIV3Uncharacterized protein 042R
VF143_IIV3Putative kinase protein 029R (EC 2.7.-.-)
VF145_IIV3Uncharacterized protein 050L
VF155_IIV3Uncharacterized protein 113L
VF157_IIV3Putative RING finger protein 027R
VF161_IIV3Putative helicase 109L (EC 3.6.4.-)
VF170_IIV3Uncharacterized protein 97L
VF179_IIV3Uncharacterized protein 035R
VF184_IIV3Putative helicase 121R (EC 3.6.4.-)
VF193_IIV3Putative apoptosis inhibitor 021L
VF196_IIV3Uncharacterized protein 020R
VF197_IIV3Putative tyrosine phosphatase 067L (EC 3.1.3.-)
VF198_IIV3Uncharacterized protein 069L
VF201_IIV3Putative Bro-N domain-containing protein 019R
VF203_IIV3Uncharacterized protein 085L
VF205_IIV3Putative DNA ligase 052L (EC
VF213_IIV3Uncharacterized protein 051L
VF219_IIV3Uncharacterized protein 036R
VF224_IIV3Probable cysteine proteinase 024R (EC 3.4.-.-)
VF229_IIV3Uncharacterized protein 229L
VF232_IIV3Putative ubiquitin thioesterase 232R (EC
VF244_IIV3Putative phosphoesterase 078R (EC 3.1.-.-)
VF259_IIV3Uncharacterized protein 071L
VF268_IIV3Uncharacterized protein 074L
VF282_IIV3Putative transcription factor 079L
VF287_IIV3Uncharacterized protein 056L
VF295_IIV3Uncharacterized protein 016R
VF302_IIV3Putative zinc finger protein 012R
VF306_IIV3Putative SWIB domain-containing protein 070L
VF307_IIV3Uncharacterized protein 033L
VF309_IIV3Uncharacterized protein 063R
VF329_IIV3Uncharacterized protein 099R
VF335_IIV3Uncharacterized protein 017R
VF337_IIV3Putative membrane protein 047R
VF342_IIV3Uncharacterized protein 115R
VF347_IIV3Putative FAD-linked sulfhydryl oxidase 096R (EC
VF349_IIV3Putative transcription elongation factor S-II-like protein 055R
VF350_IIV3Uncharacterized protein 026R
VF355_IIV3Putative CTD phosphatase-like protein 355R (EC 3.1.3.-)
VF357_IIV3Transmembrane protein 066L
VF358_IIV3Uncharacterized protein 083L
VF359_IIV3Uncharacterized protein 105R
VF369_IIV3Probable RAD2-like endonuclease 076L (EC 3.1.-.-)
VF378_IIV3Uncharacterized protein 100L
VF380_IIV3Probable serine/threonine-protein kinase 010L (EC
VF391_IIV3Uncharacterized protein 058R
VF395_IIV3Uncharacterized protein 001R
VF396_IIV3Uncharacterized protein 091L
VF401_IIV3High mobility group protein homolog 068R
VF414_IIV3Putative hydrolase 111R (EC 3.6.1.-)
VF415_IIV3Uncharacterized protein 018L
VF436_IIV3Uncharacterized protein 060L
VF439_IIV3Probable kinase 098L (EC 2.7.-.-)
VF453_IIV3Putative thioredoxin-like protein 041R
VF466_IIV3Uncharacterized protein 112R
VF467_IIV3Uncharacterized protein 061R