Polyhedral virions 120-350 nm in diameter. The capsid displays an icosahedral symmetry T=133 or 147, with an internal lipid membrane. Virions are either externally enveloped or not depending whether they budded from the cell membrane, or were arranged in paracrystaline array in the host cell cytoplasm and were released by lysis.


Linear, dsDNA genome of 150-170 kb. The genome contains terminal and redundant sequences. Encodes for about 100 proteins.
Approximately 25% of the cytosine residues of the genome are methylated by a virus encoded DNA methyltransferase. However, there is at least one ranavirus, Singapore grouper iridovirus (SGIV), that lacks the DNA methyltransferase gene and cannot methylate its DNA.




  1. Attachement of the viral proteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the DNA core into the host cytoplasm.
  3. Viral DNA is transported to the cell nucleus where host macromolecular synthesis is rapidly shutdown. Transcription is initiated by virally modified host RNA polymerase II.
  4. Parental DNA is used to produce genome and greater than genome length DNA.
  5. Progeny DNA is transported into cytoplasmic viral factories where large concatamers of viral DNA are formed by recombination. Transcription of very late transcripts may also take place in the cytoplasm.
  6. Assembly of new virions in the cytoplasm.
  7. Virions exit the cell by budding or cell lysis.

Host-virus interaction

Apoptosis modulation

The grouper iridovirus (GIV) contains an antiapoptotic B-cell lymphoma (Bcl)-2-like gene that inhibits host apoptosis.

Matching UniProtKB/Swiss-Prot entries

99 entries grouped by strain (browse by keywords)

All proteins are shown (view only 98 complete proteome entries)

98 entries

Frog virus 3 (isolate Goorha) (FV-3) reference strain

Select_all Deselect_all  
001R_FRG3GPutative transcription factor 001R
002L_FRG3GUncharacterized protein 002L
003R_FRG3GUncharacterized protein 3R
004R_FRG3GUncharacterized protein 004R
005R_FRG3GUncharacterized protein 005R
006R_FRG3GUncharacterized protein 006R
007R_FRG3GUncharacterized protein 007R
009L_FRG3GPutative helicase 009L (EC 3.6.4.-)
010R_FRG3GUncharacterized protein 010R
011R_FRG3GUncharacterized protein 011R
012L_FRG3GUncharacterized protein 012L
013R_FRG3GUncharacterized protein 013R
014R_FRG3GUncharacterized protein 014R
015R_FRG3GUncharacterized protein 015R
017L_FRG3GUncharacterized protein 017L
018L_FRG3GUncharacterized protein 018L
019R_FRG3GPutative serine/threonine-protein kinase 019R (EC
020R_FRG3GUncharacterized protein 020R
021L_FRG3GUncharacterized protein 021L
023R_FRG3GUncharacterized protein 023R
024R_FRG3GUncharacterized protein 024R
027R_FRG3GUncharacterized protein 027R
028R_FRG3GUncharacterized protein 028R
029L_FRG3GUncharacterized protein 029L
030R_FRG3GUncharacterized protein 030R
031R_FRG3GUncharacterized protein 031R
032R_FRG3GUncharacterized protein 032R
033R_FRG3GTransmembrane protein 033R
034R_FRG3GUncharacterized protein 034R
035L_FRG3GUncharacterized protein 035L
036L_FRG3GUncharacterized protein 036L
037R_FRG3Guncharacterized protein 037R
039R_FRG3GUncharacterized protein 039R
040R_FRG3GUncharacterized protein 040R
041R_FRG3GUncharacterized protein 041R
042L_FRG3GUncharacterized protein 042L
043R_FRG3GUncharacterized protein 043R
044R_FRG3GUncharacterized protein 044R
045L_FRG3GUncharacterized protein 045L
046L_FRG3GUncharacterized protein 046L
047L_FRG3GUncharacterized protein 047L
048L_FRG3GUncharacterized protein 048L
049L_FRG3GPutative SAP domain-containing protein 049L
050L_FRG3GUncharacterized protein 050L
051R_FRG3GUncharacterized protein 051R
052L_FRG3GUncharacterized protein 052L
053R_FRG3GPutative myristoylated protein 053R
054L_FRG3GUncharacterized protein 054L
055L_FRG3GPutative helicase 055L (EC 3.6.4.-)
055R_FRG3GUncharacterized protein 055R
056R_FRG3GUncharacterized protein 056R
057R_FRG3GPutative phosphotransferase 057R
058R_FRG3GUncharacterized protein 058R
059L_FRG3GUncharacterized protein 059L
061L_FRG3GUncharacterized protein 061L
064R_FRG3GCaspase recruitment domain-containing protein 064R
065L_FRG3GPutative collagen-like domain-containing protein 065L
066L_FRG3GUncharacterized protein 066L
068R_FRG3GPutative uncharacterized protein 068R
069R_FRG3GTransmembrane protein 069R
070R_FRG3GUncharacterized protein 070R
071R_FRG3GUncharacterized protein 071R
072L_FRG3GUncharacterized protein 072L
073L_FRG3GUncharacterized protein 073L
074L_FRG3GUncharacterized protein 074L
075L_FRG3GUncharacterized protein 075L
076R_FRG3GUncharacterized protein 076R
077L_FRG3GLCDV1 orf2-like protein
078L_FRG3GUncharacterized protein 078L
079R_FRG3GUncharacterized protein 079R
081R_FRG3GPutative transcription elongation factor S-II-like protein 81R
084R_FRG3GUncharacterized protein 084R
086L_FRG3GUncharacterized protein 086L
087L_FRG3GUncharacterized protein 087L
088R_FRG3GPutative FAD-linked sulfhydryl oxidase 088R (EC
089R_FRG3GUncharacterized protein 89R
092R_FRG3GUncharacterized protein 092R
093L_FRG3GUncharacterized protein 093L
094L_FRG3GUncharacterized protein 094L
095R_FRG3GPutative RAD2-like endonuclease 095R (EC 3.1.-.-)
096R_FRG3GUncharacterized protein 096R
097R_FRG3GUncharacterized protein 097R
098R_FRG3GUncharacterized protein 098R
DNK_FRG3GPutative deoxynucleoside kinase (EC 2.7.1.-)
DNMT_FRG3GPutative DNA (cytosine-5)-methyltransferase (EC
DPOL_FRG3GPutative DNA polymerase 060R (EC
DUT_FRG3GPutative deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC ...
ICP18_FRG3GImmediate-early protein ICP-18
ICP46_FRG3GImmediate-early protein ICP-46
MCP_FRG3GMajor capsid protein (MCP) (P50)
O22R_FRG3GPutative helicase 022R (EC 3.6.4.-)
RIR1_FRG3GPutative ribonucleoside-diphosphate reductase large subunit (EC ...
RIR2_FRG3GPutative ribonucleoside-diphosphate reductase small subunit 067L (EC
RNC_FRG3GPutative ribonuclease 3 (EC (Ribonuclease III) (RNase III)
RPB1_FRG3GPutative DNA-directed RNA polymerase 008R (EC
RPB2_FRG3GPutative DNA-directed RNA polymerase II subunit RPB2 homolog (EC
VINT_FRG3GIntegrase homolog
VP31_FRG3GEarly 31 kDa protein (P31K)

1 entry

Rana tigrina ranavirus

MCP_RTRVMajor capsid protein (MCP) (P50)