Alphahypovirus (taxid:2946791)

VIRION

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Capsidless virus: These viruses don't produce virions, and cannot be assigned to the Baltimore classification in the strict sense. The polymerase shows homologies to dsRNA Durnavirales, but experimental data suggest that they can be considered ssRNA viruses "with dsRNA lifestyle".

GENOME

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Linear dsRNA genome of 9-13kb, encodes one or two ORFs (ORFB, and eventually ORFA). The 3'end is polyadenylated. The genome only encodes non-structural proteins.
May also contain additional satellite dsRNAs.

GENE EXPRESSION

ORFB (and if present, ORFA) encodes a polyprotein that is proteolytically processed.
Translation is initiated on a unique internal ribosome entry site internal ribosome entry site (IRES) element situated at the 5'-UTR.

ENZYMES

REPLICATION

CYTOPLASMIC

Poorly understood. The virus never buds out of its host and probably replicates in lipid pleomorphic vesicles like positive ssRNA virus replication viral manner. Transmission depends on cell-to-cell cytoplasmic exchange and hyphal anastomosis.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

4 entries grouped by strain

2 entries

Cryphonectria hypovirus 1 (strain EP713) (CHV-1/EP713) (Chestnut blight fungus hypovirulence-associated virus) reference strain

Select_allDeselect_all
POLA_CHPVE Polyprotein p69 (ORFA polyprotein) [Cleaved into: Papain-like protease p29 (EC 3.4.22.-); p40 ...
POLB_CHPVE ORFB polyprotein [Cleaved into: Papain-like protease p48 (EC 3.4.22.-); Putative RNA-directed RNA ...

2 entries

Cryphonectria hypovirus 1 (strain Euro7) (CHV-1/Euro7) (Chestnut blight fungus hypovirulence-associated virus)

Select_allDeselect_all
POLB_CHPVU ORFB polyprotein [Cleaved into: Papain-like protease p48 (EC 3.4.22.-); Putative RNA-directed RNA ...
POLA_CHPVU Polyprotein p69 (ORFA polyprotein) [Cleaved into: Papain-like protease p29 (EC 3.4.22.-); p40 ...
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Cryphonectria hypovirus 1 (strain EP713) taxid:12478

Protein ModelArchive
Polyprotein p69 (ORFA polyprotein) ma-jd-viral-32818

Fusarium graminearum hypovirus 1 taxid:1284208

Protein ModelArchive
RNAse III-like virus domain-containing protein ma-jd-viral-29979