Aquareovirus

VIRION

Non enveloped, icosahedral virion with a double capsid structure, about 75 nm in diameter. Pentameric turrets sit on the outside of the innermost capsid. The outer capsid has a T=13 icosahedral symmetry, the inner capsid a T=2 icosahedral symmetry.

GENOME

Segmented linear dsRNA genome. Contains 11 segments coding for 12 proteins. Segments size range from 0.8 to 4.0 kb. Genome total size range from 18.2 to 30.5 kb.

GENE EXPRESSION

The dsRNA genome is never completely uncoated, to prevent activation of antiviral state by the cell in response of dsRNA. Viral polymerase synthesizes mRNA from each dsRNA segment which are translocated to the cell cytoplasm where they are translated.

REPLICATION

CYTOPLASMIC

  1. Attachement to host receptors probably mediates endocytosis of virus into host cell.
  2. Particles are partially uncoated in endolysosomes, but not entirely, and penetrate in the cytoplasm.
  3. Early transcription of the dsRNA genome by viral polymerase occurs inside this sub-viral particle (naked core), so that dsRNA is never exposed to the cytoplasm.
  4. Full-length plus-strand transcripts from each of the dsRNA segments are synthesized. These plus-strand transcripts are used as templates for translation.
  5. Viral proteins and genomic RNAs aggregates in cytoplasmic viral factories.
  6. (+)RNAs are encapsidated in a sub-viral particle, in which they are transcribed to give RNA (-) molecules with which they become base-paired to produce dsRNA genomes.
  7. The capsid is assembled on the sub-viral particle.
  8. Mature virions are released presumably following cell death and associated breakdown of host plasma membrane.

Matching UniProtKB/Swiss-Prot entries

27 entries grouped by strain (browse by keywords)

All proteins are shown (view only 24 complete proteome entries)

12 entries

Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain

Select_all Deselect_all  
CAPSD_AQRVCMajor inner capsid protein VP3 (EC 3.6.4.13) (ATP-dependent DNA helicase VP3)
RDRP_AQRVCRNA-directed RNA polymerase VP2 (EC 2.7.7.48)
VNS1_AQRVCNon-structural protein 1 (NS1)
VNS2_AQRVCNon-structural protein 2 (NS2)
VNS3_AQRVCNon-structural protein 3 (NS3)
VNS4_AQRVCNon-structural protein 4 (NS4)
VNS5_AQRVCNon-structural protein 5 (NS5)
VP1_AQRVCOuter capsid protein VP1
VP4_AQRVCOuter capsid protein VP4
VP5_AQRVCMicrotubule-associated protein VP5
VP6_AQRVCClamp protein VP6
VP7_AQRVCOuter capsid protein VP7

12 entries

Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain

Select_all Deselect_all  
CAPSD_AQRVGMajor inner capsid protein VP3 (EC 3.6.4.13) (ATP-dependent DNA helicase VP3)
RDRP_AQRVGRNA-directed RNA polymerase VP2 (EC 2.7.7.48)
VNS1_AQRVGNon-structural protein 1 (NS1) (NS73)
VNS2_AQRVGNon-structural protein 2 (NS2)
VNS3_AQRVGNon-structural 3 (NS3) (NS26)
VNS4_AQRVGNon-structural protein 4 (NS4) (NS31)
VNS5_AQRVGNon-structural protein 5 (NS5) (NS16)
VP1_AQRVGOuter capsid protein VP1
VP4_AQRVGOuter capsid protein VP4
VP5_AQRVGMicrotubule-associated protein VP5
VP6_AQRVGClamp protein VP6
VP7_AQRVGOuter capsid protein VP7

3 entries

Aquareovirus A (isolate Chum salmon/Japan/CSRV/1981) (AQRV-A)

Select_all Deselect_all  
CAPSD_AQRVAMajor inner capsid protein VP3 (EC 3.6.4.13) (ATP-dependent DNA helicase VP3)
RDRP_AQRVARNA-directed RNA polymerase VP2 (EC 2.7.7.48)
VP1_AQRVAOuter capsid protein VP1