Luteovirus

VIRION

Non-enveloped, spherical virion about 25-30 nm in diameter with T=3 icosahedral symmetry composed of 180 CP proteins.

GENOME

Monopartite, linear, ssRNA(+) genome of 5.3-5.7 kb in size. Poleroviruses and enamoviruses have a VPg bound at the 5’ end. There is no poly(A) tail or tRNA-like structure at the 3’ end.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. The only proteins translated directly from genomic RNA are the polymerase (ORF2), which is expressed as a fusion protein by a -1 ribosomal frameshifting at the end of ORF1, and ORF1 protein. All other ORFs are translated from subgenomic RNAs (sgRNAs).

The movement protein is expressed by leaky scanning of the subgenomic mRNA. Suppression of termination of the CP stop codon produces CP-RTD (CP extended), the capsid subunit essential for aphid transmission.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. The viral RNA ORF1 and ORF2 are translated to produce the RdRp fusion protein.
  4. Replication takes place in cytoplasmic viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Expression of the 3’ coterminal sgRNAs. Traduction of these sgRNAs yields the capsid, CP-RTD and movement proteins.
  7. Virus assembly.
  8. Viral movement protein probably mediates virion cell-to-cell transfer.

Host-virus interaction

Suppression of RNA silencing

Barley yellow dwarf virus protein P6 acts as a suppressor of RNA silencing

Matching UniProtKB/Swiss-Prot entries

17 entries grouped by strain (browse by keywords)

All proteins are shown (view only 6 complete proteome entries)

6 entries

Barley yellow dwarf virus (isolate PAV) (BYDV) reference strain

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CAPSD_BYDVPMajor capsid protein (Coat protein) (CP)
MCAPS_BYDVPMinor capsid protein (P74) (Readthrough protein) (RT protein)
MVP_BYDVPMovement protein (MP) (17 kDa protein)
ORF6_BYDVPUncharacterized protein ORF6
ORF7_BYDVPUncharacterized protein ORF7
RDRP_BYDVPPutative RNA-directed RNA polymerase (EC 2.7.7.48)

3 entries

Barley yellow dwarf virus (isolate MAV-PS1) (BYDV)

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CAPSD_BYDV1Major capsid protein (Coat protein) (CP)
MVP_BYDV1Movement protein (MP) (17 kDa protein)
RDRP_BYDV1Putative RNA-directed RNA polymerase (EC 2.7.7.48)

3 entries

Barley yellow dwarf virus (isolate P-PAV) (BYDV)

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CAPSD_BYDVRMajor capsid protein (Coat protein) (CP)
MVP_BYDVRMovement protein (MP) (17 kDa protein)
RDRP_BYDVRPutative RNA-directed RNA polymerase (EC 2.7.7.48)

2 entries

Barley yellow dwarf virus (isolate NY-RPV) (BYDV)

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CAPSD_BYDVNMajor capsid protein (Coat protein) (CP)
MVP_BYDVNMovement protein (MP) (17 kDa protein)

2 entries

Bean leafroll virus (BLRV)

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CAPSD_BLRVMajor capsid protein (Coat protein) (CP)
MVP_BLRVMovement protein (MP) (16 kDa protein)

1 entry

Barley yellow dwarf virus (isolate MAV) (BYDV)


CAPSD_BYDVMMajor capsid protein (Coat protein) (CP)