Alpharetrovirus

Molecular biology

VIRION

Enveloped, spherical to pleomorphic in shape, 80-100 nm in diameter.

GENOME

Monopartite, linear, dimeric, ssRNA(+) genome of about 7.2 kb, with a 5’-cap and a 3’poly-A tail. There are two long terminal repeats (LTRs) of about 600nt long at the 5’ and 3’ ends. The LTRs contain the U3, R, and U5 regions. There are also a primer binding site (PBS) at the 5’end and a polypurine tract (PPT) at the 3’end.

GENE EXPRESSION

The integrated provirus utilizes the promoter elements in the 5’ LTR to drive transcription. This gives rise to the unspliced full length mRNA that will serve as genomic RNA to be packaged into virions or used as a template for translation of gag(pro) and gag(pro)-pol (1 ribosomal frameshift) polyproteins. The spliced mRNA encodes env that is cleaved into SU and TM envelope proteins. There are no additional genes other than gag, pro, pol and env.

REPLICATION

NUCLEAR

  1. Virus attaches to host receptors through the SU glycoprotein. TM glycoprotein mediates fusion with cell membrane.
  2. Internalization and partial uncoating.
  3. ssRNA(+) genome is copied into a linear dsDNA molecule by the reverse transcriptase.
  4. Nuclear entry of the viral dsDNA when the nuclear membrane is disassembled at mitosis.
  5. Viral dsDNA is covalently and randomly integrated into the cell’s genome by the viral integrase (=provirus).
  6. Transcription of provirus by Pol II produces viral spliced and unspliced RNAs.
  7. Nuclear export of the incompletely spliced RNAs.
  8. Translation of unspliced viral RNAs produces Env, Gag and Gag-Pol polyproteins.
  9. Assembly of the virion at the host cellular membrane and packaging of the viral RNA genome.
  10. Budding through the plasma membrane and release of the virions.
  11. Proteolytic processing of the precursors polyproteins by viral protease and maturation of the virions.

Matching UniProtKB/Swiss-Prot entries

47 entries grouped by strain (browse by keywords)

All proteins are shown (view only 8 complete proteome entries)

5 entries

Avian leukosis virus RSA (RSV-SRA) (Rous sarcoma virus (strain Schmidt-Ruppin A)) reference strain

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ENV_RSVSAEnvelope glycoprotein gp95 (Env polyprotein)
GAG_RSVSAGag-Pro polyprotein
POL_RSVSAGag-Pro-Pol polyprotein
VP14_RSVSAPutative trans-acting factor
SRC_RSVSATyrosine-protein kinase transforming protein Src (EC 2.7.10.2) (pp60v-src) ...

4 entries

Rous sarcoma virus (strain Prague C) (RSV-PrC)

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ENV_RSVPEnvelope glycoprotein gp95 (Env polyprotein)
GAG_RSVPGag-Pro polyprotein
POL_RSVPGag-Pro-Pol polyprotein
SRC_RSVPTyrosine-protein kinase transforming protein Src (EC 2.7.10.2) (pp60v-src) ...

2 entries

Avian leukosis virus (ALV)

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ERBB_ALVTyrosine-protein kinase transforming protein erbB (EC 2.7.10.1)
POL_ALVPol polyprotein

2 entries

Avian myelocytomatosis virus MC29

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GAG_AVIMCGag polyprotein
MYC_AVIMCViral myc transforming protein (v-Myc)

2 entries

Avian retrovirus MH2

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MIL_AVIMHSerine/threonine-protein kinase-transforming protein mil (EC 2.7.11.1)
MYC_AVIMHViral myc transforming protein (v-Myc)

2 entries

Fujinami sarcoma virus

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FPS_FUJSVTyrosine-protein kinase transforming protein Fps (EC 2.7.10.2)
GAG_FUJSVGag polyprotein

2 entries

Rous sarcoma virus (strain Schmidt-Ruppin B) (RSV-SRB)

Select_all Deselect_all  
GAG_RSVSBGag-Pro polyprotein
POL_RSVSBGag-Pro-Pol polyprotein

2 entries

UR2 sarcoma virus (UR2SV) (Avian sarcoma virus (strain UR2))

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GAG_AVISUCore protein p19 (Gag protein p19)
ROS_AVISUTyrosine-protein kinase transforming protein ros (EC 2.7.10.1)

1 entry

Avian erythroblastosis virus (strain ES4)


ERBB_AVIERTyrosine-protein kinase transforming protein erbB (EC 2.7.10.1)

1 entry

Avian erythroblastosis virus (strain S13)


SEA_AVIETTyrosine-protein kinase transforming protein SEA (EC 2.7.10.2)

1 entry

Avian erythroblastosis virus (strain Sloan-Kettering)


SKI_AVIESTransforming protein Ski

1 entry

Avian erythroblastosis virus (strain ts167)


ERBB_AVIEUTyrosine-protein kinase transforming protein erbB (EC 2.7.10.1)

1 entry

Avian musculoaponeurotic fibrosarcoma virus AS42


MAF_AVIS4Transforming protein Maf

1 entry

Avian myeloblastosis associated virus (MAV)


GAG_AVIMAProteinase p15 (EC 3.4.23.-)

1 entry

Avian myeloblastosis virus


MYB_AVIMBTransforming protein Myb

1 entry

Avian myelocytomatosis virus CMII


MYC_AVIM2Viral myc transforming protein (v-Myc)

1 entry

Avian retrovirus IC10


RMIL_AVII1Serine/threonine-protein kinase-transforming protein Rmil (EC 2.7.11.1)

1 entry

Avian retrovirus MH2E21


MYC_AVIMEViral myc transforming protein (v-Myc)

1 entry

Avian retrovirus NK24


FOS_AVINKp55-v-Fos-transforming protein

1 entry

Avian retrovirus OK10


MYC_AVIOKViral myc transforming protein (v-Myc)

1 entry

Avian retrovirus RPL30


RYK_AVIR3Tyrosine-protein kinase transforming protein RYK (EC 2.7.10.1)

1 entry

Avian rous-associated virus type 1


RMIL_AVEVRSerine/threonine-protein kinase-transforming protein Rmil (EC 2.7.11.1)

1 entry

Avian sarcoma virus (strain 17)


JUN_AVIS1Viral jun-transforming protein (v-Jun)

1 entry

Avian sarcoma virus (strain 31) (ASV31)


QIN_AVIS3Transforming protein Qin (Oncogene Qin)

1 entry

Avian sarcoma virus (strain CT10)


GAGC_AVISCP47(GAG-CRK) protein

1 entry

Avian sarcoma virus (strain PR2257)


SRC_AVIS2Tyrosine-protein kinase transforming protein Src (EC 2.7.10.2) (pp60v-src) ...

1 entry

Avian sarcoma virus (strain PRCII)


FPS_AVISPTyrosine-protein kinase transforming protein Fps (EC 2.7.10.2)

1 entry

Avian sarcoma virus (strain S1)


SRC_AVISSTyrosine-protein kinase transforming protein Src (EC 2.7.10.2) (pp60v-src) ...

1 entry

Avian sarcoma virus (strain S2)


SRC_AVISTTyrosine-protein kinase transforming protein Src (EC 2.7.10.2) (pp60v-src) ...

1 entry

Avian sarcoma virus (strain Y73)


GAG_AVISYGag polyprotein

1 entry

Avian sarcoma virus (strain rASV1441)


SRC_AVISRTyrosine-protein kinase transforming protein Src (EC 2.7.10.2) (pp60v-src) ...

1 entry

Rous sarcoma virus (strain H-19)


SRC_RSVH1Tyrosine-protein kinase transforming protein Src (EC 2.7.10.2) (pp60v-src) ...

1 entry

Rous sarcoma virus (strain PA101T)


SRC_RSVPATyrosine-protein kinase transforming protein Src (EC 2.7.10.2) (pp60v-src) ...

1 entry

Rous sarcoma virus (strain Schmidt-Ruppin E) (RSV-SR-E)


SRC_RSVSETyrosine-protein kinase transforming protein Src (EC 2.7.10.2) (pp60v-src) ...