Betafusellovirus

VIRION

Enveloped, pleomorphic in shape, assuming shapes ranging from thin-cigar-like to pear-like, with 3 or 4 slightly curved fibers attached to one pole. The virion is about 60 nm in diameter and 100-250 nm in length.

GENOME

Circular, supercoiled dsDNA genome of 15 to 24 kb, encodes 33 to 38 genes.

GENE EXPRESSION

Genomic DNA is specifically integrated into a tRNA gene of the host chromosome.

REPLICATION

CYTOPLASMIC

  1. Attachment to target cell adhesion receptors
  2. Penetration into host cytoplasm
  3. Viral genome is integrated into a tRNA gene of host chromosome
  4. Transcription and translation of early genes
  5. Replication of genomic DNA
  6. Transcription and translation of late genes
  7. Genomic DNA is packaged in new virions
  8. Mature virions are released from the cell by budding