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Autographiviridae (taxid:2731643)

VIRION

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Non-enveloped, head-tail structure with Podo-type morphology. Head is about 60 nm in diameter. The tail is non-contractile, has 6 short subterminal fibers. The capsid is icosahedral with a T=7 symmetry.
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GENOME

Linear, dsDNA genome of about 40-42 kb encoding for 55 genes.

GENE EXPRESSION

ENZYMES

REPLICATION

CYTOPLASMIC

  1. The phage attaches to target cell adhesion receptors through its tail fibers.
  2. Ejection by short tail system: viral DNA is injected in host cell periplasm.
  3. Transcription of class I genes by host RNA polymerase before the viral genome completely exits out of capsid.
  4. Transcription of class II genes by T7 RNA polymerase.
  5. Bacterial genome degradation
  6. Replication of genomic DNA by T7 DNA polymerase, formation of viral genome concatemers.
  7. Transcription of class III genes by T7 RNA polymerase.
  8. Assembly of empty procapsids and viral genome packaging.
  9. Mature virions are released from the cell by lysis.
DB LINKS image image

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TAXONOMY Group I: dsDNA viruses
Realm: Duplodnaviria
Kingdom: Heunggongvirae
Phylum: Uroviricota
Class: Caudoviricetes
Order: Autographivirales
Family: Autographiviridae
Subfamily:
Genus: 133 genera, including:
Teseptimavirus
Zindervirus
Phikmvvirus
VIRUS
REFERENCE STRAINS Enterobacteria phage T7
Sequence | Genome assembly | Proteome Enterobacteria phage SP6
Sequence | Genome assembly | Proteome Enterobacteria phage phiKMV
Sequence | Genome assembly | Proteome

Host

NATURAL HOSTS Bacteria

Ecology and disease

GEOGRAPHY Worldwide
TRANSMISSION Passive diffusion through medium
ANTIVIRAL DRUGS

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

141 entries grouped by strain

57 entries

Escherichia phage T7 (Bacteriophage T7) reference strain

Select_allDeselect_all
RPOL_BPT7 T7 RNA polymerase (DNA-directed RNA polymerase) (EC 2.7.7.6)

pdb 1ARO; 1CEZ; 1H38; 1MSW; 1QLN; 1S0V; 1S76; 1S77; 2PI4; 2PI5; 3E2E; 3E3J; 4RNP; 8DH0; 8DH1; 8DH2; 8DH3; 8DH4; 8DH5

DPOL_BPT7 DNA-directed DNA polymerase (EC 2.7.7.7) (EC 3.1.11.-) (Gene product 5) (Gp5)

pdb 1SKR; 1SKS; 1SKW; 1SL0; 1SL1; 1SL2; 1T7P; 1T8E; 1TK0; 1TK5; 1TK8; 1TKD; 1X9M; 1X9S; 1X9W; 1ZYQ; 2AJQ; 5IKN; 6N7W; 6N9U; 6N9V; 6N9W; 6N9X; 6P7E

ENLYS_BPT7 Endolysin (EC 3.5.1.28) (N-acetylmuramoyl-L-alanine amidase) (T7 endolysin)

pdb 1ARO; 1LBA

HELIC_BPT7 DNA helicase/primase (EC 2.7.7.-) (EC 3.6.4.12) (Gene product 4) (Gp4)

pdb 1CR0; 1CR1; 1CR2; 1CR4; 1E0J; 1E0K; 1NUI; 1Q57; 5IKN; 6N7I; 6N7N; 6N7S; 6N7T; 6N7V; 6N9U; 6N9V; 6N9W; 6N9X

EXLYS_BPT7 Peptidoglycan transglycosylase gp16 (EC 4.2.2.n1) (Internal core protein gp16)

pdb 6YT5; 7EYB; 7K5C; 9JYY

DNLI_BPT7 DNA ligase (EC 6.5.1.1) (DNA ligase gp1.3) (Gene product 1.3) (Gp1.3)

pdb 1A0I

TERL_BPT7 Terminase, large subunit (DNA-packaging protein) (Gene product 19) (Gp19) [Includes: ATPase (EC ...

pdb 4BIJ; 4BIL

FIBER_BPT7 Tail fiber protein (Gene product 17) (Gp17) (Tail fiber protein gp17)

pdb 4A0T; 4A0U; 7BOZ; 7EY7; 7EY9; 8DSP; 8E4G; 9JYZ; 9JZ0

CAPSA_BPT7 Major capsid protein (Gene product 10A) (Gp10A) (Major head protein)

pdb 2XVR; 3IZG; 3J7V; 3J7W; 3J7X

PK_BPT7 Protein kinase 0.7 (EC 2.7.11.1) (Gene product 0.7) (Gp0.7) (Protein kinase gp0.7)
ENDO_BPT7 Endonuclease I (EC 3.1.21.2) (Gene product 3) (Gp3) (Junction-resolving enzyme gp3)

pdb 1FZR; 1M0D; 1M0I; 2PFJ; 3CAE

SSB_BPT7 Single-stranded DNA-binding protein (SSB protein) (2.5 protein) (Gene product 2.5) (gp2.5)

pdb 1JE5

GP15_BPT7 Internal virion protein gp15 (Gene product 15) (Gp15)

pdb 6YSZ; 6YT5; 7EYB; 7K5C; 8E4G; 9JYY

PORTL_BPT7 Portal protein (Gene product 8) (Gp8) (Head-to-tail connector)

pdb 3J4A; 6QWP; 6QX5; 6QXM; 6R21; 6TJP; 7BOU; 7BP0; 7EY6; 7EY8; 8E4G; 9JYZ; 9JZ0

OCR_BPT7 Protein Ocr (Gene product 0.3) (Gp0.3) (Overcome classical restriction) (Ocr)

pdb 1S7Z; 2Y7C; 6R9B; 6R9G; 7BST; 7BTP; 7EEW; 8Q56; 8V45; 8ZEK; 9EX7

NUCK_BPT7 Nucleotide kinase gp1.7 (Gene product 1.7) (Gp1.7) (EC 2.7.4.-)
CAPSB_BPT7 Minor capsid protein (Gene product 10B) (Gp10B) (Minor head protein)
EXRN_BPT7 Exonuclease (Exonuclease gp6) (Gene product 6) (Gp6) (EC 3.1.11.3)
TERS_BPT7 Terminase, small subunit gp18 (DNA-packaging protein A) (Gene product 18) (Gp18)
VRPI_BPT7 Bacterial RNA polymerase inhibitor (Gene product 2) (Gp2)

pdb 2LMC; 2WNM; 4LK0; 4LLG

SCAF_BPT7 Capsid assembly scaffolding protein (Gene product 9) (Gp9) (Head morphogenesis protein) (Scaffold ...
GP14_BPT7 Internal virion protein gp14 (Gene product 14) (Gp14)

pdb 7EY7; 7EYB; 8E4G; 9JYY; 9JZ0

TUBE1_BPT7 Tail tubular protein gp11 (Gene product 11) (Gp11)

pdb 3J4B; 6R21; 7BOX; 7EY7; 7EY9; 8E4G; 9JYZ; 9JZ0

TUBE2_BPT7 Tail tubular protein gp12 (Gene product 12) (Gp12)

pdb 6R21; 7BOY; 7EY7; 7EY9; 8E4G; 9JYZ; 9JZ0

GP73_BPT7 Protein 7.3 (Gene product 7.3) (Gp7.3)

pdb 9JYZ

GP04_BPT7 Gene 0.4 protein (Gene product 0.4) (Gp0.4)
Y06_BPT7 Protein 0.6B [Cleaved into: Protein 0.6A]
GP12_BPT7 Inhibitor of dGTPase (Gene product 1.2) (Gp1.2) (Inhibitor of dGTPase gp1.2)

pdb 2MDP; 7U65; 7U66; 7U67

ITAS_BPT7 Inhibitor of toxin/antitoxin system (Gene product 4.5) (Gp4.5)
SPAN2_BPT7 Spanin, outer lipoprotein subunit (o-spanin) (Gene product 18.7) (Gp18.7) (Protein 18.7)
GP67_BPT7 Protein 6.7 (Gene product 6.7) (Gp6.7)

pdb 9JYY; 9JYZ; 9JZ0

HOLIN_BPT7 Holin (Gene product 17.5) (Gp17.5)
SPAN1_BPT7 Spanin, inner membrane subunit (i-spanin) (Gene product 18.5) (Gp18.5)
SGS_BPT7 Protein suppressor of silencing (Gene product 5.5)
GP59_BPT7 Probable RecBCD inhibitor gp5.9 (Gene product 5.9) (Gp5.9)

pdb 8B1R

GP13_BPT7 Probable scaffold protein gp13 (Gene product 13) (Gp13)
Y7_BPT7 Protein 7 (Gene product 7) (Gp7)
Y05_BPT7 Protein 0.5 (Gene product 0.5) (Gp0.5)
Y11_BPT7 Uncharacterized protein 1.1 (Gene product 1.1) (Gp1.1)
Y41_BPT7 Protein 4.1 (Gene product 4.1) (Gp4.1)
Y42_BPT7 Protein 4.2 (Gene product 4.2) (Gp4.2)
Y43_BPT7 Protein 4.3 (Gene product 4.3) (Gp4.3)
Y47_BPT7 Protein 4.7 (Gene product 4.7) (Gp4.7)
V5557_BPT7 Fusion protein 5.5/5.7

pdb 5LGM

Y192_BPT7 Protein 19.2 (Gene product 19.2) (Gp19.2)
Y193_BPT7 Protein 19.3 (Gene product 19.3) (Gp19.2)
Y14_BPT7 Protein 1.4 (Gene product 1.4) (Gp1.4)
Y15_BPT7 Protein 1.5 (Gene product 1.5) (Gp1.5)
Y16_BPT7 Protein 1.6 (Gene product 1.6) (Gp1.6)
Y18_BPT7 Protein 1.8 (Gene product 1.8) (Gp1.8)
Y28_BPT7 Protein 2.8 (Gene product 2.8) (Gp2.8)
Y77_BPT7 Protein 7.7 (Gene product 7.7) (Gp7.7)
Y38_BPT7 Protein 3.8 (Gene product 3.8) (Gp3.8)
Y53_BPT7 Protein 5.3 (Gene product 5.3) (Gp5.3)
Y63_BPT7 Protein 6.3 (Gene product 6.3) (Gp6.3)
Y65_BPT7 Protein 6.5 (Gene product 6.5) (Gp6.5)
Y195_BPT7 Protein 19.5 (Gene product 19.5) (Gp19.5)

1 entry

Enterobacteria phage T3 (Bacteriophage T3) reference strain

ADOM_BPT3 S-Adenosylmethionine lyase (ADOMetase) (Adenosylmethionine lyase) (SAMase) (EC 4.4.1.42)

pdb 7OCK; 8BB1

8 entries

Pseudomonas phage phiKMV reference strain

Select_allDeselect_all
ENLYS_BPKMV SAR-endolysin (EC 3.2.1.17) (Endolysin) (Gene product 45) (gp45) (KMV45) (Lysis protein) (Lysozyme) ...
HOLIN_BPKMV Holin (KMV44) (Pinholin)
EXLYS_BPKMV Peptidoglycan hydrolase gp36 (EC 3.2.1.17) (Gene product 36) (Gp36)
RPOL_BPKMV DNA-directed RNA polymerase (EC 2.7.7.6)
SPAN2_BPKMV Probable spanin, outer lipoprotein subunit
SPAN1_BPKMV Probable spanin, inner membrane subunit (i-spanin)
CAPSD_BPKMV Major capsid protein (Gene product 32) (gp32) (Major head protein)
PORTL_BPKMV Portal protein (Head-to-tail connector)

4 entries

Klebsiella phage KP32 (Bacteriophage KP32) reference strain

Select_allDeselect_all
DPOL2_BPK32 Depolymerase 2, capsule K21-specific (Gene product 38) (gp38) (KP32gp38) (Probable tail spike ...

pdb 6TKU

DPOL1_BPK32 Depolymerase 1, capsule K3-specific (Gene product 37) (gp37) (KP32gp37) (Probable tail spike ...
ENLYS_BPK32 Endolysin (EC 3.5.1.28) (Gene product 15) (gp15) (N-acetylmuramoyl-L-alanine amidase)
TUBE1_BPK32 Tail tubular protein A (TTPA) (Depolymerase) (EC 3.2.1.-) (Gene product 31) (gp31)

pdb 5MU4

2 entries

Enterobacteria phage SP6 (Bacteriophage SP6) reference strain

Select_allDeselect_all
EXLYS_BPSP6 Peptidoglycan hydrolase gp36 (Gene product 36) (Gp36)
PORTL_BPSP6 Portal protein (Head-to-tail connector)

3 entries

Klebsiella phage KP34 (Bacteriophage KP34) reference strain

Select_allDeselect_all
TUBE1_BPK34 Tail tubular protein A (TTPA) (Depolymerase) (EC 3.2.1.28) (Gene product 44) (gp44)
DEPOL_BPK34 Depolymerase, capsule K63-specific (DepoKP34) (Gene product 57) (gp57) (KP34gp57) (Probable tail ...

pdb 8BKE

ANCHR_BPK34 Anchor protein (Gene product 49) (gp49) (KP34gp49)

2 entries

Klebsiella phage K5-2 (Bacteriophage K5-2) reference strain

Select_allDeselect_all
DPOL1_BPK52 Depolymerase 1, capsule K30/K69-specific (Gene product 37) (gp37) (K30/K69 depolymerase) (Probable ...
DPOL2_BPK52 Depolymerase 2, capsule K5-specific (Gene product 38) (gp38) (K5 depolymerase) (Probable tail spike ...

2 entries

Klebsiella phage KN3-1 (Bacteriophage KN3-1) reference strain

Select_allDeselect_all
DPOL1_BPK31 Depolymerase 1, capsule KN3-specific (KN3dep) (Probable tail spike protein)
DPOL2_BPK31 Depolymerase 2, capsule K56-specific (K56dep) (Probable tail spike protein)

2 entries

Klebsiella phage NTUH-K2044-K1-1 (Bacteriophage NTUH-K2044-K1-1) reference strain

Select_allDeselect_all
DEPOL_BPKNT Depolymerase, capsule K1-specific (EC 4.-.-.-) (Gene product 34) (gp34) (K1-ORF34 protein) (Probable ...

pdb 7W1C; 7W1D; 7W1E

ANCHR_BPKNT Anchor protein (Gene product 28) (gp28)

2 entries

Klebsiella phage vB_KpnP_IME205 (Bacteriophage vB_KpnP_IME205) reference strain

Select_allDeselect_all
DPOL2_BPKIM Depolymerase 1, capsule K47-specific (Dpo43) (Gene product 43) (gp43) (Probable tail spike protein)
DPOL1_BPKIM Depolymerase 1, capsule K47-specific (Dpo42) (Gene product 42) (gp42) (Probable tail spike protein)

1 entry

Escherichia phage K1E (Bacteriophage K1E) reference strain

FIBER_BPK1E Tail spike protein (TSP) (Endo-N-acetylneuraminidase) (Endo-N) (Endo-alpha-sialidase) (EC 3.2.1.129) ...

1 entry

Escherichia phage K1F (Bacteriophage K1F) reference strain

FIBER_BPK1F Tail spike protein (TSP) (Endo-N-acetylneuraminidase) (Endo-N) (Endo-alpha-sialidase) (EC 3.2.1.129) ...

pdb 1V0E; 1V0F; 3GVJ; 3GVK; 3GVL; 3GW6; 3JU4

1 entry

Escherichia phage phiKT reference strain

DISRP_BPPKT Disruptin gp28

1 entry

Klebsiella phage KN4-1 (Bacteriophage KN4-1) reference strain

DEPOL_BPK41 Depolymerase, capsule KN4-specific (KN4dep) (Probable tail spike protein)

1 entry

Klebsiella phage P510 (Bacteriophage P510) reference strain

DEPOL_BPK51 Depolymerase, capsule KL64-specific (Gene product 38) (gp38) (P510dep) (Probable tail spike protein)

1 entry

Klebsiella phage P560 (Bacteriophage P560) reference strain

DEPOL_BPK56 Depolymerase, capsule KL47-specific (P560Dep) (Probable tail spike protein)

42 entries

Enterobacteria phage T3 (Bacteriophage T3)

Select_allDeselect_all
TERL_BPT3 Terminase, large subunit (DNA-packaging protein) (Gene product 19) (gp19) [Includes: ATPase (EC ...
HELIC_BPT3 DNA helicase/primase (EC 2.7.7.-) (EC 3.6.4.12) (Gene product 4) (Gp4)
ENLYS_BPT3 Endolysin (EC 3.5.1.28) (N-acetylmuramoyl-L-alanine amidase) (T3 lysozyme)
RPOL_BPT3 DNA-directed RNA polymerase (EC 2.7.7.6)
DNLI_BPT3 DNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP])
CAPSB_BPT3 Minor capsid protein (Gene product 10B) (Gp10B) (Minor head protein)
DPOL_BPT3 DNA-directed DNA polymerase (EC 2.7.7.7) (EC 3.1.11.-) (Gene product 5) (Gp5)
SPAN2_BPT3 Spanin, outer lipoprotein subunit (o-spanin) (Gene product 18.7) (Gp18.7) (Protein 18.7)
SPAN1_BPT3 Spanin, inner membrane subunit (i-spanin) (Gene product 18.5) (Gp18.5)
HOLIN_BPT3 Holin (Lysis protein)
FIBER_BPT3 Tail fiber protein (Gene product 17) (Gp17) (Tail fiber protein gp17)
VDMA_BPT3 DNA maturase A (DNA-packaging protein A) (GP18)
CAPSA_BPT3 Major capsid protein (Gene product 10A) (Gp10A) (Major head protein)
SSB_BPT3 Single-stranded DNA-binding protein (SSB protein) (Helix-destabilizing protein)
ENRN_BPT3 Endodeoxyribonuclease 1 (EC 3.1.21.2) (Endodeoxyribonuclease I) (Endonuclease)
EXRN_BPT3 Exodeoxyribonuclease (Exonuclease) (EC 3.1.11.3)
GP73_BPT3 Protein 7.3 (Gene product 7.3) (Gp7.3) (Host specificity protein B)
PORTL_BPT3 Portal protein (Gene product 8) (Gp8) (Head-to-tail connector)
SCAF_BPT3 Capsid assembly scaffolding protein (Capsid assembly protein) (Gene product 9) (Gp9) (Head ...
V11_BPT3 Gene 1.1 protein
Y105_BPT3 Uncharacterized gene 1.05 protein
V12_BPT3 Gene 1.2 protein
Y16_BPT3 Uncharacterized gene 1.6 protein
V17_BPT3 Gene 1.7 protein
V192_BPT3 Gene 19.2 protein
V193_BPT3 Gene 19.3 protein
Y195_BPT3 Uncharacterized gene 19.5 protein
Y18_BPT3 Uncharacterized gene 1.8 protein
V42_BPT3 Gene 4.2 protein
V43_BPT3 Gene 4.3 protein
V45_BPT3 Gene 4.5 protein
V55_BPT3 Gene 5.5 protein
V57_BPT3 Gene 5.7 protein
Y37_BPT3 Uncharacterized gene 3.7 protein
Y51_BPT3 Uncharacterized gene 5.1 protein
Y53_BPT3 Uncharacterized gene 5.3 protein
Y63_BPT3 Uncharacterized gene 6.3 protein
Y65_BPT3 Uncharacterized gene 6.5 protein
Y67_BPT3 Uncharacterized gene 6.7 protein
V59_BPT3 Gene 5.9 protein
Y15_BPT3 Uncharacterized gene 1.5 protein
VRPI_BPT3 Bacterial RNA polymerase inhibitor (Gene product 2) (Gp2)

1 entry

Enterobacteria phage SP6 (Bacteriophage SP6)

RPOL_BPSP6 DNA-directed RNA polymerase (EC 2.7.7.6)

2 entries

Enterobacteria phage K11 (Bacteriophage K11)

Select_allDeselect_all
RPOL_BPK11 DNA-directed RNA polymerase (EC 2.7.7.6)
ENLYS_BPK11 Endolysin (EC 3.5.1.28) (Gene product 3.5) (gp3.5) (N-acetylmuramoyl-L-alanine amidase)

2 entries

Klebsiella phage K5-4 (Bacteriophage K5-4)

Select_allDeselect_all
DPOL2_BPK54 Depolymerase 2, capsule K5-specific (Gene product 38) (gp38) (K5 depolymerase) (Probable tail spike ...
DPOL1_BPK54 Depolymerase 1, capsule K8-specific (Gene product 37) (gp37) (Probable tail spike protein)

1 entry

Escherichia virus K5 (Bacteriophage K5)

FIBER_BPK5 Tail spike protein (Depolymerase, capsule K5-specific) (EC 4.-.-.-) [Cleaved into: Mature tail spike ...

pdb 2X3H

1 entry

Klebsiella phage KN1-1 (Bacteriophage KN1-1)

DEPOL_BPKN1 Depolymerase, capsule KN1-specific (KN1dep) (Probable tail spike protein)

1 entry

Klebsiella phage KpV71 (Bacteriophage KpV71)

DEPOL_BPK71 Depolymerase, capsule K1-specific (EC 4.-.-.-) (Dep_kpv71) (Gene product 52) (gp52) (Probable tail ...

1 entry

Klebsiella phage SH-KP152226 (Bacteriophage SH-KP152226)

DEPOL_BPK15 Depolymerase, capsule K47-specific (Dep42) (Gene product 42) (gp42) (Probable tail spike protein)

1 entry

Klebsiella phage vB_KpnP_KpV74 (Bacteriophage vB_KpnP_KpV74)

DEPOL_BPK74 Depolymerase, capsule K2-specific (Dep_kpv74) (Gene product 56) (gp56) (Probable tail spike protein)