Autographivirinae

Molecular biology

VIRION

Nonenveloped, head-tail structure. Head is about 60 nm in diameter. The tail is non-contractile, has 6 short subterminal fibers. The capsid is icosahedral with a T=7 symmetry.

GENOME

Linear, dsDNA genome of about 40-42 kb encoding for 55 genes.

GENE EXPRESSION

REPLICATION

CYTOPLASMIC

  1. Adsorption: the phage attaches to target cell through its tail fibers.
  2. Injection: viral DNA is injected in host cell periplasm
  3. Transcription and traduction of early genes
  4. Replication of genomic DNA
  5. Transcription and traduction of late genes
  6. Assembly of new virions in host cell cytoplasm
  7. Mature virions are released from the cell by lysis
DB LINKS Nucleotide DB: NCBI
Protein DB: UniProtKB
TAXONOMY Group I: dsDNA viruses
Order: Caudovirales
Family: Podoviridae
Subfamily: Autograpivirinae
Genus: T7-like viruses
SP6-like viruses
phiKMV-like viruses
SPECIES
Type: Enterobacteria phage T7
Enterobacteria phage P22
Bacillus phage phi29
Enterobacteria phage N4
REFERENCE STRAINS Enterobacteria phage T7
Sequence | Genome | Proteome Enterobacteria phage SP6
Sequence | Genome | Proteome Enterobacteria phage phiKMV
Sequence | Genome | Proteome
HOST Bacteria

Epidemiology

GEOGRAPHY Worldwide
TRANSMISSION Passive diffusion through medium
ANTIVIRAL DRUGS

Matching UniProtKB/Swiss-Prot entries

102 entries grouped by strain

All proteins are shown (view only 57 complete proteome entries)

56 entries

Enterobacteria phage T7 (Bacteriophage T7) reference strain

Select_all Deselect_all  
DNLI_BPT7DNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase

pdb 1A0I 

DPOL_BPT7DNA polymerase (EC 2.7.7.7) (T7 DNA polymerase)

pdb 1SKR  1SKS  1SKW  1SL0  1SL1  1SL2  1T7P  1T8E  1TK0  1TK5  1TK8  1TKD  1X9M  1X9S  1X9W  1ZYQ  2AJQ 

ENPP_BPT7Probable endopeptidase (EC 3.4.-.-)
ENRN_BPT7Endodeoxyribonuclease 1 (EC 3.1.21.2) (Endodeoxyribonuclease I) (Endonuclease)

pdb 1FZR  1M0D  1M0I  2PFJ  3CAE 

EXRN_BPT7Exodeoxyribonuclease (Exonuclease) (EC 3.1.11.3)
KIPA_BPT7Protein kinase (EC 2.7.11.1)
NAAA_BPT7N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) (T7 lysozyme)

pdb 1ARO  1LBA 

PRIM_BPT7DNA primase/helicase (EC 2.7.7.-) (EC 3.6.4.12)

pdb 1CR0  1CR1  1CR2  1CR4  1E0J  1E0K  1NUI  1Q57 

RPOL_BPT7DNA-directed RNA polymerase (EC 2.7.7.6)

pdb 1ARO  1CEZ  1H38  1MSW  1QLN  1S0V  1S76  1S77  2PI4  2PI5  3E2E  3E3J  4RNP 

V03_BPT7Gene 0.3 protein

pdb 1S7Z  2Y7C 

V04_BPT7Gene 0.4 protein
V05_BPT7Gene 0.5 protein
V06_BPT7Protein 0.6B
V11_BPT7Gene 1.1 protein
V12_BPT7Gene 1.2 protein
V17_BPT7Gene 1.7 protein
V187_BPT7Gene 18.7 protein
V192_BPT7Gene 19.2 protein
V193_BPT7Gene 19.3 protein
V42_BPT7Gene 4.2 protein
V43_BPT7Gene 4.3 protein
V45_BPT7Gene 4.5 protein
V47_BPT7Gene 4.7 protein
V55_BPT7Gene 5.5/5.7 fusion protein
V59_BPT7Gene 5.9 protein
VC10A_BPT7Major capsid protein 10A

pdb 2XVR  3IZG 

VC10B_BPT7Minor capsid protein 10B
VCAP_BPT7Capsid assembly protein (Scaffolding protein)
VDMA_BPT7DNA maturase A (DNA-packaging protein A) (GP18)
VDMB_BPT7DNA maturase B (DNA-packaging protein B) (GP19)
VHED_BPT7Helix-destabilizing protein (Single-stranded DNA-binding protein) (SSB protein)

pdb 1JE5 

VHSA_BPT7Host specificity protein A
VHSB_BPT7Host specificity protein B
VHTJ_BPT7Head-to-tail joining protein
VIVA_BPT7Internal virion protein A
VIVB_BPT7Internal virion protein B
VIVC_BPT7Internal virion protein C
VIVD_BPT7Internal virion protein D
VLYS_BPT7Lysis protein
VRPI_BPT7Bacterial RNA polymerase inhibitor

pdb 2WNM 

VTFP_BPT7Tail fiber protein
VTTA_BPT7Tail tubular protein A
VTTB_BPT7Tail tubular protein B
Y14_BPT7Uncharacterized gene 1.4 protein
Y15_BPT7Uncharacterized gene 1.5 protein
Y16_BPT7Uncharacterized gene 1.6 protein
Y18_BPT7Uncharacterized gene 1.8 protein
Y195_BPT7Uncharacterized gene 19.5 protein
Y28_BPT7Uncharacterized gene 2.8 protein
Y38_BPT7Uncharacterized gene 3.8 protein
Y41_BPT7Uncharacterized gene 4.1 protein
Y53_BPT7Uncharacterized gene 5.3 protein
Y63_BPT7Uncharacterized gene 6.3 protein
Y65_BPT7Uncharacterized gene 6.5 protein
Y67_BPT7Uncharacterized gene 6.7 protein
Y77_BPT7Uncharacterized gene 7.7 protein

1 entry

Enterobacteria phage SP6 (Bacteriophage SP6) reference strain


RPOL_BPSP6DNA-directed RNA polymerase (EC 2.7.7.6)

43 entries

Enterobacteria phage T3 (Bacteriophage T3)

Select_all Deselect_all  
ADOM_BPT3S-adenosyl-L-methionine hydrolase (ADOMetase) (Adenosylmethionine hydrolase) ...
DNLI_BPT3DNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase
DPOL_BPT3DNA polymerase (EC 2.7.7.7)
ENPP_BPT3Probable endopeptidase (EC 3.4.-.-)
ENRN_BPT3Endodeoxyribonuclease 1 (EC 3.1.21.2) (Endodeoxyribonuclease I) (Endonuclease)
EXRN_BPT3Exodeoxyribonuclease (Exonuclease) (EC 3.1.11.3)
NAAA_BPT3N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) (T3 lysozyme)
PRIM_BPT3DNA primase/helicase (EC 2.7.7.-) (EC 3.6.4.12)
RPOL_BPT3DNA-directed RNA polymerase (EC 2.7.7.6)
V11_BPT3Gene 1.1 protein
V12_BPT3Gene 1.2 protein
V17_BPT3Gene 1.7 protein
V187_BPT3Gene 18.7 protein
V192_BPT3Gene 19.2 protein
V193_BPT3Gene 19.3 protein
V42_BPT3Gene 4.2 protein
V43_BPT3Gene 4.3 protein
V45_BPT3Gene 4.5 protein
V55_BPT3Gene 5.5 protein
V57_BPT3Gene 5.7 protein
V59_BPT3Gene 5.9 protein
VC10A_BPT3Major capsid protein 10A
VC10B_BPT3Minor capsid protein 10B
VCAP_BPT3Capsid assembly protein (Scaffolding protein)
VDMA_BPT3DNA maturase A (DNA-packaging protein A) (GP18)
VDMB_BPT3DNA maturase B (DNA-packaging protein B) (GP19)
VHED_BPT3Helix-destabilizing protein (Single-stranded DNA-binding protein) (SSB protein)
VHSB_BPT3Host specificity protein B
VHTJ_BPT3Head-to-tail joining protein
VLYS_BPT3Lysis protein
VRPI_BPT3Bacterial RNA polymerase inhibitor
VTFP_BPT3Tail fiber protein
Y105_BPT3Uncharacterized gene 1.05 protein
Y15_BPT3Uncharacterized gene 1.5 protein
Y16_BPT3Uncharacterized gene 1.6 protein
Y18_BPT3Uncharacterized gene 1.8 protein
Y195_BPT3Uncharacterized gene 19.5 protein
Y37_BPT3Uncharacterized gene 3.7 protein
Y51_BPT3Uncharacterized gene 5.1 protein
Y53_BPT3Uncharacterized gene 5.3 protein
Y63_BPT3Uncharacterized gene 6.3 protein
Y65_BPT3Uncharacterized gene 6.5 protein
Y67_BPT3Uncharacterized gene 6.7 protein

1 entry

Enterobacteria phage K1E (Bacteriophage K1E)


ENAN_BPK1EEndo-N-acetylneuraminidase (Endo-N) (EC 3.2.1.129) (Endosialidase)

1 entry

Enterobacteria phage K1F (Bacteriophage K1F)


ENAN_BPK1FEndo-N-acetylneuraminidase (Endo-N) (EC 3.2.1.129) (Endosialidase) (G102)

pdb 1V0E  1V0F  3GVJ  3GVK  3GVL  3GW6  3JU4 

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