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Non-enveloped, spherical, about 32-34 nm in diameter. The RNA genome is enclosed within a capsid that is composed of 60 capsid proteins, assembled into a T=1 icosahedral particle.


Monopartite, linear, ssRNA(+) genome of 7.2 kb. The 5’ end is capped and the 3’ terminus is polyadenylated. Their is no VPg at the 5’-terminus of the genome. The genome consists of three partially overlapping ORFs.


The virion RNA is infectious and serves as both the genome and viral messenger RNA. ORF 1 encodes the nonstructural proteins, it is not clear whether this polyprotein is cleaved or not; ORF 2 encodes the capsid protein; ORF 3 encodes a small immunogenic protein. ORF2 is translated by leaky scanning from the bicistronic ORF3-2 subgenomic RNA.


  1. Attachement of the virus to host receptors mediates internalization into the host cell by clathrin-mediated endocytosis.
  2. RNA genome is released into the cytoplasm.
  3. The positive-sense genomic ssRNA is translated into a processed ORF1 polyprotein to yield the mature non-structural proteins involved in RNA transcription.
  4. Replication takes place in cytoplasmic viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Expression of two other messenger RNAs, a 3.7 kb subgenomic one and a 2.0 kb coterminal one.
  7. Virus assembly and release.

Host-virus interaction

Innate immune response inhibition

HEV ORF3 protein suppresses host interferon-α signaling by inhibiting STAT1 phosphorylation .

Matching UniProtKB/Swiss-Prot entries

30 entries grouped by strain (browse by keywords)

3 entries

Hepatitis E virus genotype 1 (isolate Human/China/HeBei/1987) (HEV) reference strain

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CAPSD_HEVCHCapsid protein (Protein ORF2) (pORF2)
ORF3_HEVCHProtein ORF3 (pORF3)
POLN_HEVCHNon-structural polyprotein pORF1

3 entries

Avian hepatitis E virus (isolate Chicken/California/Meng) (AHEV)

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CAPSD_AHEVCapsid protein (Protein ORF2) (pORF2)
ORF3_AHEVProtein ORF3 (pORF3)
POLN_AHEVNon-structural polyprotein pORF1

3 entries

Hepatitis E virus genotype 1 (isolate Human/Burma) (HEV-1)

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CAPSD_HEVBUCapsid protein (Protein ORF2) (pORF2)
ORF3_HEVBUProtein ORF3 (pORF3)
POLN_HEVBUNon-structural polyprotein pORF1

3 entries

Hepatitis E virus genotype 1 (isolate Human/India/Hyderabad) (HEV-1)

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CAPSD_HEVHYCapsid protein (Protein ORF2) (pORF2)
ORF3_HEVHYProtein ORF3 (pORF3)
POLN_HEVHYNon-structural polyprotein pORF1

3 entries

Hepatitis E virus genotype 1 (isolate Human/Myanmar/HEVNE8L) (HEV-1)

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CAPSD_HEVMYCapsid protein (Protein ORF2) (pORF2)
ORF3_HEVMYProtein ORF3 (pORF3)
POLN_HEVMYNon-structural polyprotein pORF1

3 entries

Hepatitis E virus genotype 1 (isolate Human/Pakistan/Sar-55) (HEV-1)

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CAPSD_HEVPACapsid protein (Protein ORF2) (pORF2)
ORF3_HEVPAProtein ORF3 (pORF3)
POLN_HEVPANon-structural polyprotein pORF1

3 entries

Hepatitis E virus genotype 2 (isolate Human/Mexico) (HEV-2)

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CAPSD_HEVMECapsid protein (Protein ORF2) (pORF2)
ORF3_HEVMEProtein ORF3 (pORF3)
POLN_HEVMENon-structural polyprotein pORF1

3 entries

Hepatitis E virus genotype 3 (isolate Human/United States/US2) (HEV-3)

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CAPSD_HEVUSCapsid protein (Protein ORF2) (pORF2)
ORF3_HEVUSProtein ORF3 (pORF3)
POLN_HEVUSNon-structural polyprotein pORF1

3 entries

Hepatitis E virus genotype 3 (isolate Swine/United States/swUS1) (HEV-3) (Hepatitis E virus genotype 3 (isolate Swine/United States/Meng))

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CAPSD_HEVMGCapsid protein (Protein ORF2) (pORF2)
ORF3_HEVMGProtein ORF3 (pORF3)
POLN_HEVMGNon-structural polyprotein pORF1

3 entries

Hepatitis E virus genotype 4 (isolate Human/China/T1) (HEV-4) (Hepatitis E virus genotype 4 (isolate Human/China/Ct1))

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CAPSD_HEVCTCapsid protein (Protein ORF2) (pORF2)
ORF3_HEVCTProtein ORF3 (pORF3)
POLN_HEVCTNon-structural polyprotein pORF1