Lolavirus

VIRION

Non-enveloped, flexuous, filamentous, about 640 nm long and 13 nm in diameter.

GENOME

Linear ssRNA(+) genome of 7.6 kb in size. The 3’ terminus is polyadenylated. Encodes 6 proteins.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. RNA-dependent RNA polymerase (RdRp) is translated directly from the genomic RNA. The other ORFS, are transcribed presumably as monocistronic subgenomic mRNAs (sgRNAs).

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. The viral RNA is translated as a monocistronic mRNA to produce the RdRp (encoded by the 5’-proximal ORF).
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Internal subgenomic promoters are used to transcribe the sgRNAs. Traduction of these sgRNAs yields the capsid and movement proteins.
  7. Assembly of new virus particles.
  8. Triple gene block proteins (TGBp) allow cell-to-cell and long-distance movement.

Matching UniProtKB/Swiss-Prot entries

6 entries grouped by strain (browse by keywords)

6 entries

Lolium latent virus (isolate Lolium/USA/US1/-) (LoLV) reference strain

Select_all Deselect_all  
CAPSD_LOLVCapsid protein (CP) (Coat protein)
ORF6_LOLVUncharacterized ORF6 protein
RDRP_LOLVRNA-directed RNA polymerase (EC 2.7.7.48)
TGB1_LOLVMovement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor ...
TGB2_LOLVMovement protein TGB2 (14 kDa protein) (Triple gene block 2 protein) (TGBp2)
TGB3_LOLVMovement protein TGBp3 (Triple gene block 3 protein) (TGBp3)