Ephemerovirus

VIRION

Enveloped, bullet shaped. 180 nm long and 75 nm wide.

GENOME

Negative-stranded RNA linear genome, about 14.6-14.8 kb in size. Encodes for 5 to 9 proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Attachment of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.

Matching UniProtKB/Swiss-Prot entries

18 entries grouped by strain (browse by keywords)

All proteins are shown (view only 12 complete proteome entries)

12 entries

Bovine ephemeral fever virus (strain BB7721) (BEFV) reference strain

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GLYCO_BEFVBGlycoprotein
L_BEFVBRNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_BEFVBMatrix protein
NCAP_BEFVBNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_BEFVBPhosphoprotein (Protein P) (Protein M1)
VGLN_BEFVBNon-structural glycoprotein GNS
VPA1_BEFVBProtein alpha-1
VPA2_BEFVBProtein alpha-2
VPA3_BEFVBProtein alpha-3
VPB_BEFVBProtein beta
VPG_BEFVBProtein gamma
VPP_BEFVBPutative protein P'

6 entries

Adelaide River virus (ARV)

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GLYCO_ARVGlycoprotein
NCAP_ARVNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
VGLN_ARVNon-structural glycoprotein
VPA1_ARVProtein alpha-1
VPA2_ARVProtein alpha-2
VPB_ARVProtein beta