Novirhabdovirus

Molecular biology

VIRION

Enveloped, bullet shaped. 180 nm long and 75 nm wide.

GENOME

Negative-stranded RNA linear genome, about 11kb in size. Encodes for six proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription , viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.

Host-virus interaction

Inhibition of host apoptosis

The NV protein of VHSV has an antiapoptotic function at the early stage of the virus infection

Matching UniProtKB/Swiss-Prot entries

30 entries grouped by strain (browse by keywords)

All proteins are shown (view only 24 complete proteome entries)

6 entries

Infectious hematopoietic necrosis virus (strain WRAC) (IHNV) reference strain

Select_all Deselect_all  
L_IHNVWRNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_IHNVWMatrix protein (Protein M2)
NCAP_IHNVWNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
NV_IHNVWNon-virion protein
PHOSP_IHNVWPhosphoprotein (Protein P) (Protein M1)
VGLG_IHNVWGlycoprotein G (Spike glycoprotein)

6 entries

Hirame rhabdovirus (strain Korea/CA 9703/1997) (HIRRV)

Select_all Deselect_all  
L_HIRRVRNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_HIRRVMatrix protein
NCAP_HIRRVNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
NV_HIRRVNon-virion protein
PHOSP_HIRRVPhosphoprotein (Protein P) (Protein M1)
VGLG_HIRRVGlycoprotein G

6 entries

Infectious hematopoietic necrosis virus (strain Oregon69) (IHNV)

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L_IHNVORNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_IHNVOMatrix protein (Protein M2)
NCAP_IHNVONucleoprotein (NP) (Nucleocapsid protein) (Protein N)
NV_IHNVONon-virion protein
PHOSP_IHNVOPhosphoprotein (Protein P) (Protein M1)
VGLG_IHNVOGlycoprotein G (Spike glycoprotein)

6 entries

Snakehead rhabdovirus (SHRV)

Select_all Deselect_all  
L_SHRVRNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_SHRVMatrix protein
NCAP_SHRVNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
NV_SHRVNon-virion protein
PHOSP_SHRVPhosphoprotein (Protein P) (Protein M1)
VGLG_SHRVGlycoprotein G

3 entries

Infectious hematopoietic necrosis virus (strain Round Butte) (IHNV)

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NCAP_IHNVRNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
NV_IHNVRNon-virion protein
VGLG_IHNVRGlycoprotein G (Spike glycoprotein)

2 entries

Viral hemorrhagic septicemia virus (strain 07-71) (VHSV)

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NCAP_VHSV0Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
VGLG_VHSV0Spike glycoprotein

1 entry

Viral hemorrhagic septicemia virus (strain Makah) (VHSV)


NCAP_VHSVMNucleoprotein (NP) (Nucleocapsid protein) (Protein N)