Gammacoronavirus

VIRION

Enveloped, spherical, about 120 nm in diameter. The RNA genome is associated with the N protein to form the nucleocapsid. see Neuman BW et al. for virion cryo-electron microscopy analysis.

GENOME

Monopartite, linear ssRNA(+) genome of 27-32kb in size (the largest of all RNA virus genomes). Capped, and polyadenylated. The leader RNA (65-89 bp) at the 5’ end of the genome is also present at the end of each subgenomic RNAs.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. Genomic RNA encodes for ORF1a, as for ORF1b, it is translated by ribosomal frameshifting. Resulting proteins pp1a and pp1ab are processed into the viral polymerase (RdRp) and other non-structural proteins involved in RNA synthesis. Structural proteins are expressed as subgenomic RNAs. Each RNA (genomic and subgenomic) is translated to yield only the protein encoded by the 5’-most ORF.

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral S protein (maybe also HE if present) to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the endosomal membrane (probably mediated by S2), ssRNA(+) genome is released into the cytoplasm.
  3. Synthesis and proteolytic cleavage of the replicase polyprotein.
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Synthesis of structural proteins encoded by subgenomic mRNAs.
  7. Assembly and budding at membranes of the endoplasmic reticulum (ER), the intermediate compartments, and/or the Golgi complex.
  8. Release of new virions by exocytosis.

Host-virus interaction

Autophagy modulation

IBV nsp6 proteins induces autophagy to promote virus replication .

Apoptosis modulation

IBV seems to induce apoptosis at late stages of the infection cycle .

Cell-cycle modulation

IBV induces a both S-phase and G(2)/M-phase arrest in infected cells to promote favorable conditions for viral replication .

Matching UniProtKB/Swiss-Prot entries

64 entries grouped by strain (browse by keywords)

All proteins are shown (view only 24 complete proteome entries)

10 entries

Avian infectious bronchitis virus (strain Beaudette) (IBV) reference strain

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NCAP_IBVBNucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS3A_IBVBNon-structural protein 3a (ns3a) (Accessory protein 3a)
NS3B_IBVBNon-structural protein 3b (ns3b) (Accessory protein 3b)
NS5A_IBVBNon-structural protein 5a (ns5a) (Accessory protein 5a)
NS5B_IBVBNon-structural protein 5b (ns5b) (Accessory protein 5b)
R1AB_IBVBReplicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
R1A_IBVBReplicase polyprotein 1a (pp1a) (ORF1a polyprotein)
SPIKE_IBVBSpike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_IBVBEnvelope small membrane protein (E protein) (sM protein) (3c protein)
VME1_IBVBMembrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

10 entries

Avian infectious bronchitis virus (strain M41) (IBV)

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NCAP_IBVMNucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS3A_IBVMNon-structural protein 3a (ns3a) (Accessory protein 3a)
NS3B_IBVMNon-structural protein 3b (ns3b) (Accessory protein 3b)
NS5A_IBVMNon-structural protein 5a (ns5a) (Accessory protein 5a)
NS5B_IBVMNon-structural protein 5b (ns5b) (Accessory protein 5b)
R1AB_IBVMReplicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
R1A_IBVMReplicase polyprotein 1a (pp1a) (ORF1a polyprotein)
SPIKE_IBVMSpike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_IBVMEnvelope small membrane protein (E protein) (sM protein) (3c protein)
VME1_IBVMMembrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

5 entries

Avian infectious bronchitis virus (strain KB8523) (IBV)

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NCAP_IBVKNucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS5B_IBVKNon-structural protein 5b (ns5b) (Accessory protein 5b)
SPIKE_IBVKSpike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_IBVKEnvelope small membrane protein (E protein) (sM protein) (3c protein)
VME1_IBVKMembrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

4 entries

Avian infectious bronchitis virus (strain Beaudette CK) (IBV)

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NCAP_IBVBCNucleoprotein (Nucleocapsid protein) (NC) (Protein N)
R1AB_IBVBCReplicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
R1A_IBVBCReplicase polyprotein 1a (pp1a) (ORF1a polyprotein)
VME1_IBVBCMembrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

3 entries

Avian infectious bronchitis virus (strain Portugal/322/82) (IBV)

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NS3A_IBVP3Non-structural protein 3a (ns3a) (Accessory protein 3a)
NS3B_IBVP3Non-structural protein 3b (ns3b) (Accessory protein 3b)
VEMP_IBVP3Envelope small membrane protein (E protein) (sM protein) (3c protein)

3 entries

Avian infectious bronchitis virus (strain UK/183/66) (IBV)

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NS3A_IBVU5Non-structural protein 3a (ns3a) (Accessory protein 3a)
NS3B_IBVU5Non-structural protein 3b (ns3b) (Accessory protein 3b)
VEMP_IBVU5Envelope small membrane protein (E protein) (sM protein) (3c protein)

3 entries

Avian infectious bronchitis virus (strain UK/68/84) (IBV)

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NS3A_IBVU4Non-structural protein 3a (ns3a) (Accessory protein 3a)
NS3B_IBVU4Non-structural protein 3b (ns3b) (Accessory protein 3b)
VEMP_IBVU4Envelope small membrane protein (E protein) (sM protein) (3c protein)

2 entries

Avian infectious bronchitis virus (strain 6/82) (IBV)

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SPIKE_IBV6Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VME1_IBV6Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

2 entries

Avian infectious bronchitis virus (strain Beaudette US) (IBV)

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NCAP_IBVBUNucleoprotein (Nucleocapsid protein) (NC) (Protein N)
VME1_IBVBUMembrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

2 entries

Avian infectious bronchitis virus (strain D1466) (IBV)

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NCAP_IBVD1Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
VME1_IBVD1Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

2 entries

Avian infectious bronchitis virus (strain DE072) (IBV)

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NCAP_IBVDENucleoprotein (Nucleocapsid protein) (NC) (Protein N)
VME1_IBVDEMembrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

2 entries

Avian infectious bronchitis virus (strain Gray) (IBV)

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NCAP_IBVGNucleoprotein (Nucleocapsid protein) (NC) (Protein N)
VME1_IBVGMembrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

2 entries

Avian infectious bronchitis virus (strain H120) (IBV)

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NCAP_IBVH1Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
VME1_IBVH1Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

2 entries

Avian infectious bronchitis virus (strain H52) (IBV)

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NCAP_IBVH5Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
VME1_IBVH5Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

2 entries

Turkey enteric coronavirus (TCoV) (TCV)

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IORF_CVTKEProtein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in ...
VME1_CVTKEMembrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

1 entry

Avian infectious bronchitis virus (strain Arkansas 99) (IBV)


NCAP_IBVARNucleoprotein (Nucleocapsid protein) (NC) (Protein N)

1 entry

Avian infectious bronchitis virus (strain Beaudette M42) (IBV)


VME1_IBVB2Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

1 entry

Avian infectious bronchitis virus (strain D274) (IBV)


SPIKE_IBVD2Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)

1 entry

Avian infectious bronchitis virus (strain D41) (IBV)


VME1_IBV41Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

1 entry

Avian infectious bronchitis virus (strain SAIB20) (IBV)


NCAP_IBVSANucleoprotein (Nucleocapsid protein) (NC) (Protein N)

1 entry

Avian infectious bronchitis virus (strain V18/91) (IBV)


NCAP_IBVV1Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)

1 entry

Avian infectious bronchitis virus (strain Vic S) (IBV)


NCAP_IBVVINucleoprotein (Nucleocapsid protein) (NC) (Protein N)

1 entry

Turkey coronavirus (strain Indiana) (TCoV) (TCV)


NCAP_CVTINNucleoprotein (Nucleocapsid protein) (NC) (Protein N)

1 entry

Turkey coronavirus (strain Minnesota) (TCoV) (TCV)


NCAP_CVTMINucleoprotein (Nucleocapsid protein) (NC) (Protein N)

1 entry

Turkey coronavirus (strain NC95) (TCoV) (TCV)


NCAP_CVTNCNucleoprotein (Nucleocapsid protein) (NC) (Protein N)