Anelloviridae

VIRION

Non-enveloped, T=1 icosahedral symmetry, with a diameter of about 30-32nm.

GENOME

Circular ssDNA genome (-) genome of about 3.8 kb.
The genome is replicated through double-stranded intermediates. It may encode for 4 proteins: ORF1 (Rep protein?), ORF2, ORF3 and ORF4.

GENE EXPRESSION

The proteins are expressed by alternative splicing of pre-mRNA.

REPLICATION

NUCLEAR

  1. Virus penetrates into the host cell.
  2. Uncoating, the viral ssDNA genome penetrates into the nucleus.
  3. The ssDNA is converted into dsDNA with the participation of cellular factors. dsDNA transcription gives rise to viral mRNAs.
  4. viral mRNAs are transcribed and translated to produce viral proteins.
  5. Replication may be mediated by a “Rep-like” protein, and would occur by rolling circle producing ssDNA genomes.
  6. These newly synthesized ssDNA can either
    a) be converted to dsDNA and serve as a template for transcription/replication
    b) be encapsidated by capsid protein and form virions released by cell lysis.

Host-virus interaction

NF-kappaB modulation

Torque teno virus ORF2 protein might suppress NF-kappaB pathways via interaction with IkappaB kinases .

Matching UniProtKB/Swiss-Prot entries

56 entries grouped by strain (browse by keywords)

5 entries

Torque teno virus (isolate Human/Finland/Hel32/2002) (TTV) (Torque teno virus genotype 6) reference strain

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CAPSD_TTVV3Capsid protein
ORF11_TTVV3ORF1/1 protein
ORF12_TTVV3ORF1/2 protein
ORF24_TTVV3ORF2/4 protein
ORF2_TTVV3ORF2 protein

4 entries

Torque teno tamarin virus (isolate So-TTV2) reference strain

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CAPSD_TTVE1Capsid protein
ORF2_TTVE1Uncharacterized ORF2 protein
ORF3_TTVE1Uncharacterized ORF3 protein
ORF4_TTVE1Uncharacterized ORF4 protein

3 entries

Torque teno canis virus (isolate Cf-TTV10) reference strain

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CAPSD_TTVT1Capsid protein
ORF2_TTVT1Uncharacterized ORF2 protein
ORF3_TTVT1Uncharacterized ORF2 protein

3 entries

Torque teno douroucouli virus (isolate At-TTV3) reference strain

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CAPSD_TTVZ1Capsid protein
ORF2_TTVZ1Uncharacterized ORF2 protein
ORF3_TTVZ1Uncharacterized ORF3 protein

3 entries

Torque teno felis virus (isolate Fc-TTV4) reference strain

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CAPSD_TTVF1Capsid protein
ORF2_TTVF1Uncharacterized ORF2 protein
ORF3_TTVF1Uncharacterized ORF3 protein

3 entries

Torque teno mini virus 1 (isolate TLMV-CBD279) reference strain

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CAPSD_TTVB1Capsid protein
ORF2_TTVB1Uncharacterized ORF2 protein
ORF3_TTVB1Uncharacterized ORF3 protein

3 entries

Torque teno sus virus 1 (isolate Sd-TTV31) reference strain

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CAPSD_TTVI1Capsid protein
ORF2_TTVI1Uncharacterized ORF2 protein
ORF3_TTVI1Uncharacterized ORF3 protein

3 entries

Torque teno tupaia virus (isolate Tbc-TTV14) reference strain

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CAPSD_TTVD1Capsid protein
ORF2_TTVD1Uncharacterized ORF2 protein
ORF3_TTVD1Uncharacterized ORF3 protein

3 entries

Torque teno virus (isolate Human/China/CT23F/2001) (TTV) reference strain

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CAPSD_TTVV6Capsid protein
ORF23_TTVV6Probable protein VP2 (ORF2/3 protein)
ORF24_TTVV6Uncharacterized ORF2/4 protein

3 entries

Torque teno virus (isolate Human/China/CT39F/2001) (TTV) reference strain

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CAPSD_TTVV7Capsid protein
ORF23_TTVV7Probable protein VP2 (ORF2/3 protein)
ORF24_TTVV7Uncharacterized ORF2/4 protein

3 entries

Torque teno virus (isolate Human/Germany/KAV/2001) (TTV) reference strain

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CAPSD_TTVV4Capsid protein
ORF23_TTVV4Probable protein VP2 (ORF2/3 protein)
ORF24_TTVV4Uncharacterized ORF2/4 protein

3 entries

Torque teno virus (isolate Human/Ghana/GH1/1996) (TTV) reference strain

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CAPSD_TTVVGProbable capsid and replication-associated protein
ORF2_TTVVGUncharacterized ORF2 protein
YORF3_TTVVGUncharacterized ORF3 protein

3 entries

Torque teno virus (isolate Human/Japan/TRM1/1999) (TTV) (Torque teno virus genotype 1a) reference strain

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CAPSD_TTVV2Capsid protein
ORF23_TTVV2Probable protein VP2 (ORF2/3 protein)
ORF24_TTVV2ORF2/4 protein

3 entries

Torque teno virus (isolate Japanese macaque/Japan/Mf-TTV9/2000) (TTV) reference strain

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CAPSD_TTVV9Capsid protein
YORF2_TTVV9Uncharacterized ORF2 protein
YORF3_TTVV9Uncharacterized ORF3 protein

2 entries

Torque teno midi virus 1 (isolate MD1-073) reference strain

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CAPSD_TTVG1Capsid protein
ORF3_TTVG1Uncharacterized ORF3 protein

2 entries

Torque teno virus (isolate Chimpanzee/Japan/Pt-TTV6/2000) (TTV) reference strain

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CAPSD_TTVV8Capsid protein
ORF2_TTVV8Uncharacterized ORF2 protein

2 entries

Torque teno virus (isolate Human/Japan/SANBAN/1999) (TTV) reference strain

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CAPSD_TTVV5Capsid protein
ORF23_TTVV5Probable protein VP2 (ORF2/3 protein)

2 entries

Torque teno virus 1 (isolate TA278) reference strain

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CAPSD_TTVA1Capsid protein
ORF2_TTVA1Uncharacterized ORF2 protein

3 entries

Torque teno virus (strain VT416) (TTV)

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CAPSD_TTVV1Probable capsid and replication-associated protein
ORF23_TTVV1Probable protein VP2 (ORF2/3 protein)
ORF24_TTVV1Uncharacterized ORF2/4 protein