Non enveloped, turreted virion with a T=2 icosahedral symmetry, about 49-50 nm in diameter. The capsid is composed of only a single shell of protein.


Segmented linear dsRNA genome. Contains 9 segments encoding for at least 9 proteins.


The dsRNA genome is never completely uncoated, to prevent activation of antiviral state by the cell in response to dsRNA. The viral polymerase synthesizes a capped mRNA from each dsRNA segment. This capped mRNA is translocated to the cell cytoplasm where it is translated.



  1. Attachement to host receptors probably mediates endocytosis of virus into host cell.
  2. Particles are partially uncoated in endolysosomes, but not entirely, and penetrate in the cytoplasm.
  3. Early transcription of the dsRNA genome by viral polymerase occurs inside this sub-viral particle (naked core), so that dsRNA is never exposed to the cytoplasm.
  4. Full-length plus-strand transcripts from each of the dsRNA segments are synthesized. These plus-strand transcripts are used as templates for translation.
  5. Viral proteins and genomic RNAs aggregates in cytoplasmic viral factories.
  6. (+)RNAs are encapsidated in a sub-viral particle, in which they are transcribed to give RNA (-) molecules with which they become base-paired to produce dsRNA genomes.
  7. The capsid is assembled on the sub-viral particle.
  8. Mature virions are released presumably following cell death and associated breakdown of host plasma membrane.

Matching UniProtKB/Swiss-Prot entries

9 entries grouped by strain (browse by keywords)

9 entries

Aedes pseudoscutellaris reovirus (isolate France) (ApRV) reference strain

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CAPSD_APRVFPutative major capsid protein VP3
RDRP_APRVFRNA-directed RNA polymerase VP2 (EC
VP1_APRVFPutative structural protein VP1
VP4_APRVFPutative non-structural protein 4 (NS4)
VP5_APRVFOuter capsid protein VP5
VP6_APRVFMicrotubule-associated protein VP6
VP7_APRVFUncharacterized protein VP7
VP8_APRVFUncharacterized protein VP8
VP9_APRVFUncharacterized protein VP9