Metapneumovirus

Molecular biology

VIRION

Enveloped, spherical. Diameter from about 150 nm.

GENOME

Negative-stranded RNA linear genome, about 13 kb in size. Encodes for eight proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through F and G glycoproteins.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. the ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The G protein plays a role in inhibition of RIG-I antiviral signaling

The M2-2 protein plays a role in inhibition of MAVS antiviral signaling

Matching UniProtKB/Swiss-Prot entries

23 entries grouped by strain (browse by keywords)

All proteins are shown (view only 18 complete proteome entries)

9 entries

Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain

Select_all Deselect_all  
FUS_AMPV1Fusion glycoprotein F0 (Protein F)
L_AMPV1RNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
M21_AMPV1Matrix M2-1 (Envelope-associated 22 kDa protein)
M22_AMPV1Matrix M2-2
MTRX_AMPV1Matrix protein
NCAP_AMPV1Nucleoprotein (Protein N) (Nucleocapsid protein)
PHOSP_AMPV1Phosphoprotein
SH_AMPV1Small hydrophobic protein
VGLG_AMPV1Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound ...

9 entries

Human metapneumovirus (strain CAN97-83) (HMPV) reference strain

Select_all Deselect_all  
FUS_HMPVCFusion glycoprotein F0 (Protein F)
L_HMPVCRNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
M21_HMPVCMatrix M2-1 (Envelope-associated 22 kDa protein)
M22_HMPVCMatrix protein M2-2
MTRX_HMPVCMatrix protein
NCAP_HMPVCNucleoprotein (Protein N) (Nucleocapsid protein)
PHOSP_HMPVCPhosphoprotein (Protein P)
SH_HMPVCSmall hydrophobic protein
VGLG_HMPVCMajor surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound ...

5 entries

Turkey rhinotracheitis virus (TRTV)

Select_all Deselect_all  
FUS_TRTVFusion glycoprotein F0
MATRX_TRTVMatrix protein
SH_TRTVSmall hydrophobic protein
VGLG_TRTVMajor surface glycoprotein G (Attachment glycoprotein G)
VMA2_TRTVMatrix M2 (Envelope-associated 22 kDa protein)