Circoviridae (taxid:39724)

VIRION

image

Non-enveloped, round, T=1 icosahedral symmetry, about 20 nm in diameter. The capsid consists of 12 pentagonal trumpet-shaped pentamers.
image

GENOME

Monopartite, circular, ssDNA genome of about 1.8 to 3.8 kb.
The genome is replicated through double-stranded intermediates. The replication (Rep) protein initiates rolling circle replication.

GENE EXPRESSION

One or two mRNAs encode for the Rep, capsid, and possibly others proteins. Some mRNA can undergo alternative splicing.

ENZYMES

REPLICATION

NUCLEAR

  1. Virus penetrates into the host cell.
  2. Uncoating, the viral ssDNA genome penetrates into the nucleus.
  3. Viral ssDNA is converted into dsDNA with the participation of cellular factors. dsDNA transcription gives rise to viral mRNAs.
  4. Viral mRNAs are translated to produce viral proteins.
  5. Replication may be mediated by a Rep protein, and would occur by rolling circle replication producing ssDNA genomes.
  6. These newly synthesized ssDNA can either
    a) be converted to dsDNA and serve as a template for transcription/replication
    b) be encapsidated by capsid protein and form virions released by cell lysis.

Host-virus interaction

Autophagy modulation

Cap protein of PCV2 induces activation of host autophagy in order to enhance its own replication .

Apoptosis modulation

PCV2 ORF3-encoded protein induces apoptosis by activating caspase-8 and caspase-3 pathways . This protein may be a candidate for PML bodies inhibition which is essential for nuclear virus replication in mammals.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

27 entries grouped by strain

7 entries

Beak and feather disease virus (BFDV) reference strain

Select_allDeselect_all
REP_BFDV Replication-associated protein (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase Rep) ...
CAPSD_BFDV Capsid protein
ORF4_BFDV Uncharacterized protein ORF4
ORF7_BFDV Uncharacterized protein ORF7
ORF6_BFDV Uncharacterized protein ORF6
ORF5_BFDV Uncharacterized protein ORF5
ORF3_BFDV Uncharacterized protein ORF3

3 entries

Porcine circovirus 2 (PCV2) reference strain

Select_allDeselect_all
CAPSD_PCV2 Capsid protein
REP_PCV2 Replication-associated protein (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase Rep) ...
NS0_PCV2 Protein NS0

4 entries

Goose circovirus (GoCV) reference strain

Select_allDeselect_all
REP_GOCV Replication-associated protein (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase Rep) ...
CAPSD_GOCV Probable capsid protein
ORFC2_GOCV Uncharacterized protein ORFC2
ORFV2_GOCV Uncharacterized protein ORFV2

2 entries

Canary circovirus (CaCV) reference strain

Select_allDeselect_all
REP_CACV Replication-associated protein (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase Rep) ...
CAPSD_CACV Probable capsid protein

2 entries

Human associated cyclovirus 1 (isolate Homo sapiens/Pakistan/PK5510/2007) (HuCyV-1) (Cyclovirus PK5510) reference strain

Select_allDeselect_all
REP_HCYV5 Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase ...
CAPSD_HCYV5 Capsid protein

2 entries

Porcine circovirus 1 (PCV1) reference strain

Select_allDeselect_all
REP_PCV1 Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase ...
CAPSD_PCV1 Capsid protein

5 entries

Pigeon circovirus (PiCV) (Columbid circovirus)

Select_allDeselect_all
REP_PICV Replication-associated protein (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase Rep) ...
CAPSD_PICV Probable capsid protein
ORFC3_PICV Uncharacterized protein ORFC3
ORFC4_PICV Uncharacterized protein ORFC4
ORFC2_PICV Uncharacterized protein ORFC2

2 entries

Porcine circovirus 2 (PCV2)

Select_allDeselect_all
ORF3_PCV2 Protein ORF3
ORF4_PCV2 Anti-apoptotic ORF4 protein
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Acartia tonsa copepod circovirus taxid:1168547

Protein ModelArchive
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20901
Uncharacterized protein ma-jd-viral-49947

Aiptasia sp. sea anemone associated circular virus taxid:1692242

Protein ModelArchive
Putative capsid protein ma-jd-viral-27282
Putative replication initiation protein ma-jd-viral-17086

Anguilla anguilla circovirus taxid:1420600

Protein ModelArchive
Putative capsid protein ma-jd-viral-63316
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20702

Artemia melana sponge associated circular genome taxid:1692243

Protein ModelArchive
Putative spliced replication initiation protein ma-jd-viral-20872

Avon-Heathcote Estuary associated circular virus 1 taxid:1618232

Protein ModelArchive
Putative capsid protein ma-jd-viral-28633
Replication-associated protein ma-jd-viral-20932

Avon-Heathcote Estuary associated circular virus 11 taxid:1618234

Protein ModelArchive
Putative capsid protein ma-jd-viral-39165
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20965

Avon-Heathcote Estuary associated circular virus 12 taxid:1618235

Protein ModelArchive
Putative capsid protein ma-jd-viral-41440
Replication-associated protein ma-jd-viral-20744

Avon-Heathcote Estuary associated circular virus 14 taxid:1618237

Protein ModelArchive
Putative capsid protein ma-jd-viral-28507
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20863

Avon-Heathcote Estuary associated circular virus 15 taxid:1618238

Protein ModelArchive
Putative capsid protein ma-jd-viral-27868
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20138

Avon-Heathcote Estuary associated circular virus 17 taxid:1618240

Protein ModelArchive
Putative capsid protein ma-jd-viral-28020
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20859

Avon-Heathcote Estuary associated circular virus 19 taxid:1618242

Protein ModelArchive
Putative capsid protein ma-jd-viral-54884
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20818

Avon-Heathcote Estuary associated circular virus 2 taxid:1618243

Protein ModelArchive
Putative capsid protein ma-jd-viral-46335
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20675
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20675

Avon-Heathcote Estuary associated circular virus 20 taxid:1618244

Protein ModelArchive
Putative capsid protein ma-jd-viral-30800
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20745

Avon-Heathcote Estuary associated circular virus 21 taxid:1618245

Protein ModelArchive
Putative capsid protein ma-jd-viral-28848
Replication-associated protein ma-jd-viral-20856

Avon-Heathcote Estuary associated circular virus 22 taxid:1618246

Protein ModelArchive
Putative capsid protein ma-jd-viral-48218
Replication-associated protein ma-jd-viral-50674

Avon-Heathcote Estuary associated circular virus 23 taxid:1618247

Protein ModelArchive
Putative capsid protein ma-jd-viral-28653
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20755

Avon-Heathcote Estuary associated circular virus 24 taxid:1618248

Protein ModelArchive
Putative capsid protein ma-jd-viral-27286
Replication-associated protein ma-jd-viral-17097

Avon-Heathcote Estuary associated circular virus 26 taxid:1618250

Protein ModelArchive
Putative capsid protein ma-jd-viral-63939
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20735

Avon-Heathcote Estuary associated circular virus 27 taxid:1618251

Protein ModelArchive
Putative capsid protein ma-jd-viral-27804
Replication-associated protein ma-jd-viral-17095

Avon-Heathcote Estuary associated circular virus 28 taxid:1618252

Protein ModelArchive
Putative capsid protein ma-jd-viral-41560
Replication-associated protein ma-jd-viral-41439

Avon-Heathcote Estuary associated circular virus 29 taxid:1618253

Protein ModelArchive
Putative capsid protein ma-jd-viral-56953
Replication-associated protein ma-jd-viral-50691

Avon-Heathcote Estuary associated circular virus 3 taxid:1618254

Protein ModelArchive
Putative capsid protein ma-jd-viral-08419
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20726

Avon-Heathcote Estuary associated circular virus 4 taxid:1618255

Protein ModelArchive
Putative capsid protein ma-jd-viral-44218
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20760

Avon-Heathcote Estuary associated circular virus 5 taxid:1618256

Protein ModelArchive
Putative capsid protein ma-jd-viral-27558
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20682

Avon-Heathcote Estuary associated circular virus 6 taxid:1618257

Protein ModelArchive
Putative capsid protein ma-jd-viral-53457
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20795

Avon-Heathcote Estuary associated circular virus 7 taxid:1618258

Protein ModelArchive
Putative capsid protein ma-jd-viral-55034
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20767

Avon-Heathcote Estuary associated circular virus 8 taxid:1618259

Protein ModelArchive
Putative capsid protein ma-jd-viral-53120
Replication-associated protein ma-jd-viral-50675

Barbel circovirus taxid:759938

Protein ModelArchive
Putative capsid protein ma-jd-viral-27842
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20903

Bat circovirus POA/2012/VI taxid:1572239

Protein ModelArchive
Capsid ma-jd-viral-27483
Replicase ma-jd-viral-17138

Calanoida sp. copepod associated circular virus taxid:1692244

Protein ModelArchive
Putative capsid protein ma-jd-viral-08414
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20881

Callinectes ornatus blue crab associated circular virus taxid:1692245

Protein ModelArchive
Putative capsid protein ma-jd-viral-38877
Putative replication initiation protein ma-jd-viral-17109

Callinectes sapidus associated circular virus taxid:1692246

Protein ModelArchive
Putative capsid protein ma-jd-viral-60604
Replication-associated protein ma-jd-viral-20691

Canary circovirus taxid:142661

Protein ModelArchive
Probable capsid protein ma-jd-viral-28754
Replication-associated protein (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase Rep)... ma-jd-viral-20927

Canine circovirus taxid:1194757

Protein ModelArchive
Putative capsid protein ma-jd-viral-27432
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20747

Chimpanzee faeces associated circular DNA virus 1 taxid:1676184

Protein ModelArchive
Capsid protein ma-jd-viral-50905
Putative CP ma-jd-viral-55732
Replication-associated protein ma-jd-viral-33283

Cyclovirus NGchicken15/NGA/2009 taxid:942037

Protein ModelArchive
Cap protein ma-jd-viral-27174
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20740

Cyclovirus PKgoat11/PAK/2009 taxid:942034

Protein ModelArchive
Cap protein ma-jd-viral-27181
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20828

Cyclovirus PKgoat21/PAK/2009 taxid:942033

Protein ModelArchive
Cap protein ma-jd-viral-27171
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20716

Cyclovirus TsCyV-1_JP-NUBS-2014 taxid:1592764

Protein ModelArchive
Capsid protein ma-jd-viral-27192
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20807

Cyclovirus ZM36a taxid:1506568

Protein ModelArchive
Capsid protein ma-jd-viral-27187
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20672

Cyclovirus bat/USA/2009 taxid:942035

Protein ModelArchive
Cap protein ma-jd-viral-27184
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20851

Didemnum sp. Sea Squirt associated virus taxid:1692247

Protein ModelArchive
Putative capsid protein ma-jd-viral-28003
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20719

Dragonfly associated cyclovirus 1 taxid:1234879

Protein ModelArchive
Capsid protein ma-jd-viral-27188
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20940

Dragonfly associated cyclovirus 3 taxid:1234881

Protein ModelArchive
Putative capsid protein ma-jd-viral-27170
Replication-associated protein ma-jd-viral-20785
Spliced replication-associated protein ma-jd-viral-20936

Dragonfly associated cyclovirus 5 taxid:1234883

Protein ModelArchive
Putative capsid protein ma-jd-viral-27165
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20817

Dragonfly cyclovirus 2 taxid:1234880

Protein ModelArchive
Putative capsid protein ma-jd-viral-28875
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20804

Duck circovirus taxid:324685

Protein ModelArchive
Capsid protein ma-jd-viral-28851
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20938
Uncharacterized protein ma-jd-viral-57969
Uncharacterized protein ORFC2 ma-jd-viral-42269

Farfantepenaeus duorarum pink shrimp associated circular virus taxid:1692248

Protein ModelArchive
Putative capsid protein ma-jd-viral-27280
Putative replication initiation protein ma-jd-viral-20945

Feline cyclovirus taxid:1530454

Protein ModelArchive
Capsid protein ma-jd-viral-28014
Replication-associated protein ma-jd-viral-20853

Fiddler Crab associated circular virus taxid:1692249

Protein ModelArchive
Putative capsid protein ma-jd-viral-28652
Putative replication initiation protein ma-jd-viral-17115

Finch circovirus taxid:400122

Protein ModelArchive
Capsid protein ma-jd-viral-28761
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20866
Uncharacterized protein ma-jd-viral-58828

Fur seal faeces associated circular DNA virus taxid:1353241

Protein ModelArchive
Capsid protein ma-jd-viral-27905
Replication-associated protein ma-jd-viral-20968

Gammarus sp. amphipod associated circular virus taxid:1692250

Protein ModelArchive
Putative capsid protein ma-jd-viral-28018
Putative replication initiation protein ma-jd-viral-17096

Goose circovirus taxid:146032

Protein ModelArchive
Probable capsid protein ma-jd-viral-28852
Replication-associated protein (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase Rep)... ma-jd-viral-20920
Uncharacterized protein ORFC2 ma-jd-viral-44063
Uncharacterized protein ORFV2 ma-jd-viral-34052

Gull circovirus taxid:400121

Protein ModelArchive
Capsid protein ma-jd-viral-28760
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20763
Uncharacterized protein ma-jd-viral-29081

Hermit crab associated circular genome taxid:1692251

Protein ModelArchive
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20673

Hermit crab associated circular virus taxid:1692252

Protein ModelArchive
Putative capsid protein ma-jd-viral-27964
Putative replication initiation protein ma-jd-viral-17087

Human circovirus VS6600022 taxid:1525173

Protein ModelArchive
Capsid protein ma-jd-viral-27904
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20967
Uncharacterized protein ma-jd-viral-53306
Uncharacterized protein ma-jd-viral-42295

Human cyclovirus taxid:1455626

Protein ModelArchive
Capsid protein ma-jd-viral-28874
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20835

Human cyclovirus VS5700009 taxid:1345637

Protein ModelArchive
Capsid protein ma-jd-viral-27190
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20890

Indian encephalitis associated cyclovirus taxid:1755290

Protein ModelArchive
Capsid protein ma-jd-viral-27182
Replication-associated protein ma-jd-viral-20704

Labidocera aestiva circovirus taxid:1173709

Protein ModelArchive
Putative structural protein ma-jd-viral-43922
Putative viral replication protein ma-jd-viral-20727

Littorina sp. associated circular virus taxid:1692253

Protein ModelArchive
Putative capsid protein ma-jd-viral-48878
Putative replication initiation protein ma-jd-viral-17125

Lytechinus variegatus variable sea urchin associated circular virus taxid:1692254

Protein ModelArchive
Putative capsid protein ma-jd-viral-28769
Putative replication initiation protein ma-jd-viral-17051

Marine snail associated circular virus taxid:1692255

Protein ModelArchive
Putative capsid protein ma-jd-viral-27963
Putative replication initiation protein ma-jd-viral-17134

Mink circovirus taxid:1475143

Protein ModelArchive
Cap protein (Capsid protein) ma-jd-viral-27514
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20734

Mosquito circovirus taxid:1611039

Protein ModelArchive
Capsid ma-jd-viral-64631
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20752

Mytilus sp. clam associated circular virus taxid:1692256

Protein ModelArchive
Putative capsid protein ma-jd-viral-27281
Putative replication initiation protein ma-jd-viral-17060

Palaemonetes intermedius brackish grass shrimp associated circular virus taxid:1692257

Protein ModelArchive
Putative capsid protein ma-jd-viral-27962
Putative replication initiation protein ma-jd-viral-17126

Palaemonetes kadiakensis Mississippi grass shrimp associated circular virus taxid:1692258

Protein ModelArchive
Putative capsid protein ma-jd-viral-36122
Replication-associated protein ma-jd-viral-20769

Palaemonetes sp. common grass shrimp associated circular virus taxid:1692259

Protein ModelArchive
Putative capsid protein ma-jd-viral-53458
Putative replication initiation protein ma-jd-viral-17089

Paramuricea placomus associated circular virus taxid:1692260

Protein ModelArchive
Putative capsid protein ma-jd-viral-56688
Putative replication initiation protein ma-jd-viral-16981

Penaeus monodon circovirus VN11 taxid:1419711

Protein ModelArchive
Nonstructural protein 2 ma-jd-viral-33106
Replication-associated protein ma-jd-viral-20894
Structural protein VP ma-jd-viral-28530

Petrochirus diogenes giant hermit crab associated circular virus taxid:1692261

Protein ModelArchive
Putative capsid protein ma-jd-viral-33198
Putative replication initiation protein ma-jd-viral-20826

Pigeon circovirus taxid:126070

Protein ModelArchive
Probable capsid protein ma-jd-viral-28758
Replication-associated protein (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase Rep)... ma-jd-viral-20736
Uncharacterized protein ORFC2 ma-jd-viral-29716
Uncharacterized protein ORFC3 ma-jd-viral-63445
Uncharacterized protein ORFC4 ma-jd-viral-29225

Po-Circo-like virus 21 taxid:1105383

Protein ModelArchive
Capsid protein ma-jd-viral-27894
Capsid protein ma-jd-viral-51698
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20898
Secreted protein ma-jd-viral-39752
Uncharacterized protein ma-jd-viral-35097

Po-Circo-like virus 41 taxid:1105385

Protein ModelArchive
Capsid protein ma-jd-viral-32841
Capsid protein ma-jd-viral-27893
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20773

Po-Circo-like virus 51 taxid:1105386

Protein ModelArchive
Capsid protein ma-jd-viral-32019
Capsid protein ma-jd-viral-27892
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20497

Porcine circovirus 3 taxid:1868221

Protein ModelArchive
Cap ma-jd-viral-27790
Cap (Capsid) ma-jd-viral-27790

Porcine circovirus type 1/2a taxid:720569

Protein ModelArchive
Capsid ma-jd-viral-27508
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20701

Porcine stool-associated circular virus 4 taxid:1475062

Protein ModelArchive
Cap protein ma-jd-viral-27902
Replication-associated protein ma-jd-viral-20966

Porcine stool-associated circular virus 5 taxid:1475063

Protein ModelArchive
Cap protein ma-jd-viral-57412
Replication-associated protein ma-jd-viral-20885

Primnoa pacifica coral associated circular virus taxid:1692262

Protein ModelArchive
Putative capsid protein ma-jd-viral-34280
Replication-associated protein ma-jd-viral-20137

Raven circovirus taxid:345250

Protein ModelArchive
Capsid protein ma-jd-viral-28759
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20758

Sicyonia brevirostris associated circular virus taxid:1692263

Protein ModelArchive
Putative capsid protein ma-jd-viral-27882
Putative replication initiation protein ma-jd-viral-38092

Starling circovirus taxid:349370

Protein ModelArchive
Putative capsid protein ma-jd-viral-28753
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20809
Uncharacterized protein ma-jd-viral-39523

Swan circovirus taxid:459957

Protein ModelArchive
Putative capsid protein ma-jd-viral-28850
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20771

Zebra finch circovirus taxid:1642515

Protein ModelArchive
Capsid protein ma-jd-viral-28756
ORFC2 ma-jd-viral-29717
ORFV2 ma-jd-viral-42535
Replication-associated protein (ATP-dependent helicase Rep) (RepP) ma-jd-viral-20778