HBx function in immune evasion
HBx directly interacts with, and inhibits host MAVS protein by inducing its ubiquitination and targeting it for degradation (Wei et al. 2010 ) Rating=2, (Kumar et al. 2011 ) Rating=2. It therefore plays a role in immune evasion. MAVS is localized to the outer mitochondrial membrane and coordinates many signaling events. It plays a pivotal role in the induction of antiviral and inflammatory pathways and is also involved in the coordination of apoptosis.
Unlike most mammalian viruses, hepatitis A, B or C virus do not directly counteract interferon signaling JAK-STAT pathway, suggesting that hepatocytes must be poorly exposed to IFN upon infection and that no selective pressure would induce the virus to counteract this pathway. This page has been funded in part by Hoffmann-La Roche