Parapoxvirus (taxid:10257)

VIRION

image

Enveloped, ovoid virion, 220-300nm long and 140-170nm wide. The surface membrane displays surface filaments. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).

GENOME

Linear, dsDNA genome of 130-150kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.
_Bovine papular stomatitis virus strain BV-AR02_genome at Poxvirus Bioinformatics Ressource center

GENE EXPRESSION

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core into the host cytoplasm.
  3. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
  4. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
  5. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
  6. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
  7. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
  8. IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).

Host-virus interaction

Apoptosis modulation

The orf virus encodes a viral bcl-2 protein (v-Bcl2) that prevents host apoptosis .

NF-kappa-B modulation

Orf virus ORFV121 physically interacts with NF-kappaB-p65 in the cell cytoplasm and thereby inhibits host NF-kappaB signaling pathway .

Cell cycle modulation

The poxvirus anaphase promoting complex regulator (PACR) promotes viral replication by manipulating the anaphase promoting complex/cyclosome (APC/C), thus promoting the host differentiated G0 cells to enter G1 .

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

7 entries grouped by protein

1 entry

DNA polymerase (EC 2.7.7.7)

DPOL_ORFN2
Orf virus (strain NZ2) (OV NZ-2)

1 entry

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)

DUT_ORFN2
Orf virus (strain NZ2) (OV NZ-2)

1 entry

Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit) (PAP-L)

PAP1_ORFN2
Orf virus (strain NZ2) (OV NZ-2)

1 entry

Protein ORFV073

V073_ORFSA
Orf virus (strain Goat/Texas/SA00/2000) (OV-SA00) (Orf virus-San Angelo 2000) reference strain

2 entries

Vascular endothelial growth factor homolog

Select_allDeselect_all
VEGFH_ORFN2
Orf virus (strain NZ2) (OV NZ-2)
VEGFH_ORFN7
Orf virus (strain NZ7) (OV NZ-7)

1 entry

10 kDa fusion protein

VFUS_ORFN2
Orf virus (strain NZ2) (OV NZ-2)
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Orf virus taxid:10258

Protein ModelArchive
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57) ma-jd-viral-22623
DNA packaging protein OPG160 ma-jd-viral-10803
DNA topoisomerase (EC 5.6.2.1) ma-jd-viral-17672
DNA-directed RNA polymerase 147 kDa polypeptide (EC 2.7.7.6) ma-jd-viral-39183
DNA-directed RNA polymerase 19 kDa subunit (EC 2.7.7.6) ma-jd-viral-53639
DNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6) ma-jd-viral-66509
EEV glycoprotein ma-jd-viral-16494
Early transcription factor 70 kDa subunit (ATP-dependent helicase VETFS) ma-jd-viral-23098
Entry-fusion complex protein OPG086 ma-jd-viral-02211
Glutaredoxin-2 ma-jd-viral-24231
Holliday junction resolvase (PP243) (Resolvase (EC 3.1.-.-)) ma-jd-viral-29040
IMV membrane protein ma-jd-viral-00093
IMV membrane protein (Putative IMV membrane protein) (Putative virulence factor, IMV) (Virion membrane protein... ma-jd-viral-50915
Late transcription factor 1 ma-jd-viral-21470
Metalloendopeptidase (EC 3.4.24.-) ma-jd-viral-04433
PP46 (Virion membrane protein) ma-jd-viral-66658
Protein I2 ma-jd-viral-39148
Protein L5 (Putative membrane protein) ma-jd-viral-22155
Protein OPG070 ma-jd-viral-64789
Protein OPG091 ma-jd-viral-06078
Putative phosphorylated IMV membrane protein ma-jd-viral-00072
Sulfhydryl oxidase (EC 1.8.3.2) ma-jd-viral-34802
Telomere-binding protein ma-jd-viral-63597
Thioredoxin-like protein ma-jd-viral-57754
Uncharacterized protein ma-jd-viral-47555
Viral late gene transcription factor 2 (Trans-activator protein A1) ma-jd-viral-16065
Viral late gene transcription factor 3 ma-jd-viral-52653
Virion core protein P4a ma-jd-viral-60216
Virion formation ma-jd-viral-33159
Virion protein ma-jd-viral-52255
Zn-finger protein ma-jd-viral-33655

Orf virus (strain Goat/Texas/SA00/2000) taxid:647330

Protein ModelArchive
25 kDa core protein OPG138 ma-jd-viral-61892
62 kDa protein (Rifampicin resistance protein) ma-jd-viral-18040
Apoptosis inhibitor ma-jd-viral-58385
Assembly protein G7 ma-jd-viral-34305
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57) ma-jd-viral-22623
Core protein VP8 ma-jd-viral-55851
DNA packaging protein OPG160 ma-jd-viral-10803
DNA polymerase (EC 2.7.7.7) ma-jd-viral-17211
DNA topoisomerase (EC 5.6.2.1) ma-jd-viral-17672
DNA-binding protein ma-jd-viral-04676
DNA-directed RNA polymerase (EC 2.7.7.6) ma-jd-viral-35649
DNA-directed RNA polymerase 147 kDa polypeptide (EC 2.7.7.6) ma-jd-viral-39183
DNA-directed RNA polymerase 18 kDa subunit (EC 2.7.7.6) ma-jd-viral-07236
DNA-directed RNA polymerase 19 kDa subunit (EC 2.7.7.6) ma-jd-viral-53639
DNA-directed RNA polymerase 30 kDa polypeptide (EC 2.7.7.6) ma-jd-viral-41201
DNA-directed RNA polymerase 35 kDa subunit (EC 2.7.7.6) ma-jd-viral-13917
DNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6) ma-jd-viral-66509
DNA-directed RNA polymerase subunit (EC 2.7.7.6) ma-jd-viral-01540
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) (dUTP... ma-jd-viral-04301
Early transcription factor 70 kDa subunit (ATP-dependent helicase VETFS) ma-jd-viral-23098
Early transcription factor 82 kDa subunit (ETF large subunit) ma-jd-viral-40191
Entry-fusion complex protein OPG086 ma-jd-viral-02211
FEN1-like nuclease ma-jd-viral-22456
Glutaredoxin-2 ma-jd-viral-24231
IMV membrane protein ma-jd-viral-00093
IMV membrane protein ma-jd-viral-39148
IMV membrane protein ma-jd-viral-55748
IMV surface protein ma-jd-viral-31652
Intermediate transcription factor 3 large subunit ma-jd-viral-00008
Intermediate transcription factor 3 small subunit (VITF-3 32 kDa subunit) (VITF-3 small... ma-jd-viral-47954
Late transcription elongation factor OPG087 ma-jd-viral-65999
Late transcription factor 1 ma-jd-viral-21470
Metalloendopeptidase (EC 3.4.24.-) ma-jd-viral-04433
NF-kB inhibitor ma-jd-viral-53802
NF-kappa pathway inhibitor ma-jd-viral-52754
NF-kappa-p65 acetylation inhibitor ma-jd-viral-62579
ORF008 ankyrin repeat protein ma-jd-viral-26673
ORF010 putative EEV maturation protein ma-jd-viral-56876
ORF011 putative EEV envelope phospholipase ma-jd-viral-42894
ORF014 modified RING finger protein ma-jd-viral-62183
ORF017 DNA-binding phosphoprotein ma-jd-viral-34607
ORF020 dsRNA-binding PKR inhibitor ma-jd-viral-49133
ORF027 virion core protein ma-jd-viral-04626
ORF030 DNA-binding virion protein ma-jd-viral-02067
ORF033 putative IMV membrane protein ma-jd-viral-53469
ORF035 virion core protease ma-jd-viral-06309
ORF046 putative myristylated protein ma-jd-viral-23579
ORF047 putative myristylated IMV envelope protein ma-jd-viral-04067
ORF051 putative membrane protein ma-jd-viral-22155
ORF052 putative IMV membrane protein ma-jd-viral-34504
ORF055 late membrane protein ma-jd-viral-35576
ORF059 putative IMV protein VP55 ma-jd-viral-18655
ORF061 late transcription factor VLTF-4 ma-jd-viral-34360
ORF065 virion protein ma-jd-viral-52255
ORF066 virion protein ma-jd-viral-44721
ORF068 NTPase ma-jd-viral-34254
ORF074 mRNA capping enzyme small subunit ma-jd-viral-09995
ORF078 thioredoxin-like protein ma-jd-viral-57754
ORF080 virion core protein ma-jd-viral-41071
ORF085 late virion membrane protein ma-jd-viral-43072
ORF086 virion core protein P4a ma-jd-viral-60216
ORF089 virion membrane protein ma-jd-viral-66658
ORF090 putative IMV phosphorylated membrane protein ma-jd-viral-56072
ORF091 putative IMV membrane protein ma-jd-viral-50915
ORF093 predicted myristylated protein ma-jd-viral-22758
ORF094 putative phosphorylated IMV membrane protein ma-jd-viral-00072
ORF097 DNA polymerase processivity factor ma-jd-viral-54851
ORF099 Holliday junction resolvase ma-jd-viral-29040
ORF102 A type inclusion protein ma-jd-viral-04545
ORF103 A type inclusion protein ma-jd-viral-04549
ORF104 fusion protein ma-jd-viral-49290
ORF107 virion morphogenesis ma-jd-viral-39944
ORF110 EEV glycoprotein ma-jd-viral-16494
ORF112 putative chemokine-binding protein ma-jd-viral-04157
ORF117 GM-CSF/IL-2 inhibition factor-like protein ma-jd-viral-04159
ORF123 ankyrin repeat protein ma-jd-viral-26671
ORF126 ankyrin repeat protein ma-jd-viral-26668
ORF128 ankyrin repeat protein ma-jd-viral-26667
ORF129 ankyrin repeat protein ma-jd-viral-26666
ORF131 putative membrane protein ma-jd-viral-04043
ORF132 vascular endothelial growth factor-like protein ma-jd-viral-66635
Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large... ma-jd-viral-36195
Poxvirus F5/Telomere-binding protein I6 domain-containing protein ma-jd-viral-63597
Protein A51 ma-jd-viral-09717
Protein A6 ma-jd-viral-03896
Protein E6 homolog ma-jd-viral-36830
Protein OPG061 ma-jd-viral-14921
Protein OPG070 ma-jd-viral-64789
Protein OPG079 ma-jd-viral-12932
Protein OPG091 ma-jd-viral-06078
Protein OPG161 ma-jd-viral-03066
Protein ORFV073 ma-jd-viral-62249
RNA polymerase-associated transcription-specificity factor RAP94 (Protein H4) (RPO-associated protein of 94... ma-jd-viral-63399
RhoA inhibitor ma-jd-viral-22106
Secreted protein ma-jd-viral-37265
Serine/threonine-protein kinase (EC 2.7.11.1) ma-jd-viral-24808
Sulfhydryl oxidase (EC 1.8.3.2) ma-jd-viral-34802
Transcript termination protein A18 ma-jd-viral-22791
Uncharacterized protein ma-jd-viral-00549
Uncharacterized protein ma-jd-viral-01241
Uncharacterized protein ma-jd-viral-04870
Uncharacterized protein ma-jd-viral-04652
Uncharacterized protein ma-jd-viral-06644
Uncharacterized protein ma-jd-viral-11879
Uncharacterized protein ma-jd-viral-16505
Uncharacterized protein ma-jd-viral-16506
Uncharacterized protein ma-jd-viral-34416
Uncharacterized protein ma-jd-viral-31815
Uncharacterized protein ma-jd-viral-35399
Uncharacterized protein ma-jd-viral-33787
Uncharacterized protein ma-jd-viral-47555
Uncharacterized protein ma-jd-viral-51481
Uncharacterized protein ma-jd-viral-45732
Uncharacterized protein ma-jd-viral-44462
Uncharacterized protein ma-jd-viral-44699
Uncharacterized protein ma-jd-viral-38521
Uncharacterized protein ma-jd-viral-39048
Uncharacterized protein ma-jd-viral-66809
Uracil-DNA glycosylase ma-jd-viral-07773
Viral interleukin-10 homolog ma-jd-viral-13431
Viral late gene transcription factor 2 (Trans-activator protein A1) ma-jd-viral-16065
Viral late gene transcription factor 3 ma-jd-viral-52653
Virion core protein 4b ma-jd-viral-62985
Virion formation protein ma-jd-viral-33159
Zn-finger protein ma-jd-viral-33655
mRNA-capping enzyme catalytic subunit (EC 2.1.1.56) (EC 2.7.7.50) (Virus termination factor large subunit) (mRNA-capping enzyme 97 kDa subunit) (mRNA-capping enzyme large... ma-jd-viral-41028
protein-tyrosine-phosphatase (EC 3.1.3.48) ma-jd-viral-06241

Parapoxvirus red deer/HL953 taxid:1579460

Protein ModelArchive
25 kDa core protein OPG138 ma-jd-viral-61883
62 kDa protein (Rifampicin resistance protein) ma-jd-viral-18016
Apoptosis inhibitor ma-jd-viral-58384
Assembly protein G7 ma-jd-viral-34310
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57) ma-jd-viral-22605
Chemokine binding protein ma-jd-viral-04156
Chemokine binding protein ma-jd-viral-04158
Core protein VP8 ma-jd-viral-55845
Crescent membrane and immature virion formation protein ma-jd-viral-44701
Cullin family profile domain-containing protein ma-jd-viral-01242
DNA packaging protein OPG160 ma-jd-viral-10786
DNA topoisomerase (EC 5.6.2.1) ma-jd-viral-17676
DNA-binding protein ma-jd-viral-04688
DNA-directed RNA polymerase 18 kDa subunit (EC 2.7.7.6) ma-jd-viral-07220
DNA-directed RNA polymerase 19 kDa subunit (EC 2.7.7.6) ma-jd-viral-53633
DNA-directed RNA polymerase 30 kDa polypeptide (EC 2.7.7.6) ma-jd-viral-41199
DNA-directed RNA polymerase 35 kDa subunit (EC 2.7.7.6) ma-jd-viral-13925
DNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6) ma-jd-viral-66502
DNA-directed RNA polymerase subunit (EC 2.7.7.6) ma-jd-viral-01523
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) (dUTP... ma-jd-viral-36215
Early transcription factor 82 kDa subunit (ETF large subunit) ma-jd-viral-40174
Entry-fusion complex protein OPG086 ma-jd-viral-02203
Glutaredoxin-2 ma-jd-viral-24226
IMV membrane protein ma-jd-viral-00088
IMV membrane protein ma-jd-viral-53430
IMV membrane protein ma-jd-viral-38013
IMV membrane protein ma-jd-viral-39125
Intermediate transcription factor 3 large subunit ma-jd-viral-00017
Intermediate transcription factor 3 small subunit (VITF-3 32 kDa subunit) (VITF-3 small... ma-jd-viral-47967
Internal virion protein ma-jd-viral-04871
Late transcription elongation factor OPG087 ma-jd-viral-66000
Late transcription factor 1 ma-jd-viral-21454
Metalloendopeptidase (EC 3.4.24.-) ma-jd-viral-04450
NF-kB inhibitor ma-jd-viral-35596
NF-kappa pathway inhibitor ma-jd-viral-52753
Nucleoside triphosphatase I (EC 3.6.1.15) (Nucleoside triphosphate phosphohydrolase... ma-jd-viral-23028
Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large... ma-jd-viral-36202
Poxvirus F5/Telomere-binding protein I6 domain-containing protein ma-jd-viral-63610
Protein E6 homolog ma-jd-viral-36840
Protein F16 ma-jd-viral-14920
Protein OPG070 ma-jd-viral-64798
Protein OPG079 ma-jd-viral-12919
Protein OPG091 ma-jd-viral-06094
Protein OPG161 ma-jd-viral-03065
Protein OPG181 ma-jd-viral-09718
Putative A type inclusion protein ma-jd-viral-04544
Putative A type inclusion protein ma-jd-viral-04548
Putative DNA polymerase processivity factor ma-jd-viral-54856
Putative DNA-binding phosphoprotein ma-jd-viral-34608
Putative DNA-binding virion protein ma-jd-viral-02073
Putative EEV glycoprotein ma-jd-viral-16493
Putative EEV maturation protein ma-jd-viral-56879
Putative EEV phospholipase ma-jd-viral-42872
Putative FEN-1 like endonuclease ma-jd-viral-22468
Putative GM-CSF ma-jd-viral-04154
Putative Holliday junction resolvase ma-jd-viral-29019
Putative IMV membrane protein ma-jd-viral-34503
Putative IMV membrane protein ma-jd-viral-50930
Putative IMV membrane protein ma-jd-viral-53470
Putative IMV phosphorylated membrane protein ma-jd-viral-56081
Putative IMV protein VP55 ma-jd-viral-18664
Putative IMV surface protein ma-jd-viral-31668
Putative NPH-PPH downregulator ma-jd-viral-07878
Putative NTPase ma-jd-viral-34227
Putative Zn-finger protein ma-jd-viral-33651
Putative ankyrin repeat protein ma-jd-viral-26663
Putative ankyrin repeat protein ma-jd-viral-26664
Putative ankyrin repeat protein ma-jd-viral-26665
Putative ankyrin repeat protein ma-jd-viral-26669
Putative ankyrin repeat protein ma-jd-viral-26670
Putative ankyrin repeat protein ma-jd-viral-26672
Putative ankyrin repeat protein ma-jd-viral-26674
Putative chemokine-binding protein ma-jd-viral-04155
Putative dsRNA-binding PKR inhibitor ma-jd-viral-49134
Putative early transcription factor VETF ma-jd-viral-23076
Putative fusion protein ma-jd-viral-49289
Putative late membrane protein ma-jd-viral-35556
Putative late transcription factor VLTF-4 ma-jd-viral-34361
Putative late virion membrane protein ma-jd-viral-63165
Putative mRNA capping enzyme small subunit ma-jd-viral-09990
Putative membrane protein ma-jd-viral-04039
Putative membrane protein ma-jd-viral-22177
Putative modified RING finger protein ma-jd-viral-62180
Putative myristylated IMV envelope protein ma-jd-viral-04052
Putative myristylated protein ma-jd-viral-23583
Putative myristylated protein ma-jd-viral-22746
Putative phosphorylated IMV membrane protein ma-jd-viral-00060
Putative thioredoxin-like protein ma-jd-viral-57748
Putative vascular endothelial growth factor-like protein ma-jd-viral-66636
Putative virion core protease ma-jd-viral-06302
Putative virion core protein ma-jd-viral-04632
Putative virion core protein ma-jd-viral-41072
Putative virion core protein P4a ma-jd-viral-60211
Putative virion membrane protein ma-jd-viral-66660
Putative virion morphogenesis ma-jd-viral-39946
Putative virion protein ma-jd-viral-52271
Putative virion protein ma-jd-viral-44720
RNA helicase NPH-II (EC 3.6.4.13) (Nucleoside triphosphatase II) (Nucleoside triphosphate phosphohydrolase... ma-jd-viral-58237
RNA polymerase-associated transcription-specificity factor RAP94 (Protein H4) (RPO-associated protein of 94... ma-jd-viral-63402
RhoA inhibitor ma-jd-viral-22107
Serine/threonine-protein kinase 2 (EC 2.7.11.1) ma-jd-viral-24813
Sulfhydryl oxidase (EC 1.8.3.2) ma-jd-viral-34793
Transcript termination protein A18 ma-jd-viral-22816
Uncharacterized protein ma-jd-viral-00551
Uncharacterized protein ma-jd-viral-04656
Uncharacterized protein ma-jd-viral-06232
Uncharacterized protein ma-jd-viral-06643
Uncharacterized protein ma-jd-viral-11882
Uncharacterized protein ma-jd-viral-32455
Uncharacterized protein ma-jd-viral-35400
Uncharacterized protein ma-jd-viral-48611
Uncharacterized protein ma-jd-viral-45733
Uncharacterized protein ma-jd-viral-37264
Uncharacterized protein ma-jd-viral-45029
Uncharacterized protein ma-jd-viral-66810
Uncharacterized protein ma-jd-viral-66811
Uncharacterized protein ma-jd-viral-62248
Uncharacterized protein ma-jd-viral-60062
Uracil-DNA glycosylase ma-jd-viral-07797
Viral interleukin-10 homolog ma-jd-viral-13435
Viral late gene transcription factor 2 (Trans-activator protein A1) ma-jd-viral-16072
Viral late gene transcription factor 3 ma-jd-viral-52639
Virion core protein ma-jd-viral-47556
Virion core protein 4b ma-jd-viral-62994
Virion formation protein ma-jd-viral-33165
Virion morphogenesis core protein ma-jd-viral-03894
mRNA-capping enzyme catalytic subunit (EC 2.1.1.56) (EC 2.7.7.50) (Virus termination factor large subunit) (mRNA-capping enzyme 97 kDa subunit) (mRNA-capping enzyme large... ma-jd-viral-41044