Yatapoxvirus (taxid:10282)

VIRION

image

Enveloped, brick-shaped about 300x250x200nm in size. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).

GENOME

Linear, dsDNA genome about 145kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.

GENE EXPRESSION

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core into the host cytoplasm.
  3. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
  4. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
  5. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
  6. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
  7. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
  8. IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).

Host-virus interaction

Adaptive immune response inhibition

The poxviral E3 ubiquitin-protein ligase LAP promotes ubiquitination and subsequent degradation of host MHC-I and CD4 molecules.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

20 entries grouped by strain

11 entries

Yaba monkey tumor virus (strain VR587) (YMTV) reference strain

Select_allDeselect_all
LAP_YMTV5 E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...
A18_YMTV5 Transcript termination protein A18 (EC 3.6.4.-)
PAP1_YMTV5 Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit) (PAP-L)
NTP1_YMTV5 Nucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH ...
ETF1_YMTV5 Early transcription factor 70 kDa subunit (EC 3.6.4.-) (ATP-dependent helicase VETFS) (VETF small ...
A28_YMTV5 Envelope protein A28 homolog (Protein 118)
DUT_YMTV5 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
KITH_YMTV5 Thymidine kinase (EC 2.7.1.21)
ETF2_YMTV5 Early transcription factor 82 kDa subunit (ETF large subunit)
MCES_YMTV5 mRNA-capping enzyme small subunit (mRNA (guanine-N(7))-methyltransferase) (EC 2.1.1.56) (mRNA cap ...
VHR2_YMTV5 Probable host range protein 2

9 entries

Yaba-like disease virus (YLDV)

Select_allDeselect_all
A18_YLDV Transcript termination protein A18 (EC 3.6.4.-)
E3_YLDV Protein E3 homolog (Protein E3L homolog)
PAP1_YLDV Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit) (PAP-L)
RIR2_YLDV Ribonucleoside-diphosphate reductase small chain (EC 1.17.4.1) (Ribonucleotide reductase small ...
LAP_YLDV E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...
A28_YLDV Envelope protein A28 homolog (Protein 118)
RP07_YLDV DNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6)
MP44_YLDV Probable metalloendopeptidase G1-type (EC 3.4.24.-)
VHR2_YLDV Probable host range protein 2
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Yaba monkey tumor virus (strain VR587) taxid:928314

Protein ModelArchive
100L ma-jd-viral-43077
101L ma-jd-viral-60215
102R ma-jd-viral-33161
104L ma-jd-viral-46274
105L ma-jd-viral-56071
106L ma-jd-viral-50927
107L ma-jd-viral-37110
108L ma-jd-viral-22775
109L ma-jd-viral-00066
111L ma-jd-viral-33670
112L ma-jd-viral-00091
113R ma-jd-viral-54845
114R ma-jd-viral-29028
117L ma-jd-viral-35840
11L ma-jd-viral-26198
120L ma-jd-viral-44663
123R ma-jd-viral-16491
124R ma-jd-viral-11889
125R ma-jd-viral-06638
126R ma-jd-viral-60160
127R ma-jd-viral-06628
128L ma-jd-viral-32410
129R ma-jd-viral-60587
12L ma-jd-viral-67093
131R ma-jd-viral-47474
132R ma-jd-viral-31423
137R ma-jd-viral-13515
139R ma-jd-viral-13526
13L ma-jd-viral-11358
141R ma-jd-viral-02251
142R ma-jd-viral-24634
144R ma-jd-viral-05882
145R ma-jd-viral-18474
146R ma-jd-viral-26232
147R ma-jd-viral-26213
148R ma-jd-viral-26212
149R ma-jd-viral-02312
14L ma-jd-viral-16502
150R ma-jd-viral-57455
151R ma-jd-viral-00460
16L ma-jd-viral-01711
19L ma-jd-viral-15737
1L ma-jd-viral-00476
21L ma-jd-viral-50421
22L ma-jd-viral-58269
23.5L ma-jd-viral-36540
24L ma-jd-viral-04077
25 kDa core protein OPG138 ma-jd-viral-61888
26L ma-jd-viral-56875
27L ma-jd-viral-42883
28.5L ma-jd-viral-32263
29L ma-jd-viral-50620
2L ma-jd-viral-17686
31R ma-jd-viral-63876
33L ma-jd-viral-04658
34L ma-jd-viral-49146
39kDa core protein OPG130 ma-jd-viral-60354
41L ma-jd-viral-04621
43L ma-jd-viral-02078
44L ma-jd-viral-39143
46L ma-jd-viral-51116
47L ma-jd-viral-63598
48L ma-jd-viral-06328
4L ma-jd-viral-02606
54R ma-jd-viral-22472
59R ma-jd-viral-23578
60R ma-jd-viral-04070
61R ma-jd-viral-47141
62 kDa protein (Rifampicin resistance protein) ma-jd-viral-18033
62L ma-jd-viral-04853
64R ma-jd-viral-22175
65R ma-jd-viral-34514
6L ma-jd-viral-13513
70L ma-jd-viral-35570
73R ma-jd-viral-38040
74L ma-jd-viral-18661
76R ma-jd-viral-43349
78R ma-jd-viral-00555
7L ma-jd-viral-18480
80L ma-jd-viral-52254
81R ma-jd-viral-01684
83R ma-jd-viral-34241
86R ma-jd-viral-07984
87R ma-jd-viral-07893
93L ma-jd-viral-57768
97L ma-jd-viral-03912
Assembly protein G7 ma-jd-viral-34307
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57) ma-jd-viral-22607
Core protein VP8 ma-jd-viral-55832
DNA packaging protein OPG160 ma-jd-viral-10802
DNA polymerase (EC 2.7.7.7) ma-jd-viral-17218
DNA topoisomerase (EC 5.6.2.1) ma-jd-viral-17648
DNA-directed RNA polymerase (EC 2.7.7.6) ma-jd-viral-35636
DNA-directed RNA polymerase 147 kDa polypeptide (EC 2.7.7.6) ma-jd-viral-39175
DNA-directed RNA polymerase 18 kDa subunit (EC 2.7.7.6) ma-jd-viral-07233
DNA-directed RNA polymerase 19 kDa subunit (EC 2.7.7.6) ma-jd-viral-53653
DNA-directed RNA polymerase 30 kDa polypeptide (EC 2.7.7.6) ma-jd-viral-41197
DNA-directed RNA polymerase 35 kDa subunit (EC 2.7.7.6) ma-jd-viral-13924
DNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6) ma-jd-viral-66510
DNA-directed RNA polymerase subunit (EC 2.7.7.6) ma-jd-viral-01542
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP... ma-jd-viral-45047
E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ubiquitin... ma-jd-viral-16869
Early transcription factor 70 kDa subunit (EC 3.6.4.-) (ATP-dependent helicase VETFS) (VETF small... ma-jd-viral-23095
Early transcription factor 82 kDa subunit (ETF large subunit) ma-jd-viral-40184
Entry-fusion complex protein OPG086 ma-jd-viral-02213
Envelope protein A28 homolog (Protein 118) ma-jd-viral-31663
Glutaredoxin-2 ma-jd-viral-24216
Host range factor p28 (E3 ubiquitin-protein ligase p28) ma-jd-viral-21638
Intermediate transcription factor 3 large subunit ma-jd-viral-00032
Intermediate transcription factor 3 small subunit (VITF-3 32 kDa subunit) (VITF-3 small... ma-jd-viral-47953
Late transcription elongation factor OPG087 ma-jd-viral-66001
Late transcription factor 1 ma-jd-viral-21465
Metalloendopeptidase (EC 3.4.24.-) ma-jd-viral-04448
Nucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH... ma-jd-viral-23050
Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit)... ma-jd-viral-36188
Probable host range protein 2 ma-jd-viral-07839
Protein E6 homolog ma-jd-viral-36836
Protein OPG061 ma-jd-viral-14930
Protein OPG067 (Protein E5) ma-jd-viral-35751
Protein OPG070 ma-jd-viral-64786
Protein OPG079 ma-jd-viral-12918
Protein OPG091 ma-jd-viral-06089
Protein OPG161 ma-jd-viral-03059
Protein OPG181 ma-jd-viral-09731
RNA polymerase-associated transcription-specificity factor RAP94 (Protein H4) (RPO-associated protein of 94... ma-jd-viral-63397
Ribonucleoside-diphosphate reductase small chain (EC 1.17.4.1) (Ribonucleotide reductase small... ma-jd-viral-05461
Serine/threonine-protein kinase (EC 2.7.11.1) ma-jd-viral-24822
Sulfhydryl oxidase (EC 1.8.3.2) ma-jd-viral-34783
Thymidine kinase (EC 2.7.1.21) ma-jd-viral-10710
Transcript termination protein A18 (EC 3.6.4.-) ma-jd-viral-22797
Uracil-DNA glycosylase ma-jd-viral-07779
Viral late gene transcription factor 2 (Trans-activator protein A1) ma-jd-viral-16052
Viral late gene transcription factor 3 ma-jd-viral-52633
Virion core protein 4b ma-jd-viral-62995
mRNA-capping enzyme catalytic subunit (EC 2.1.1.56) (EC 2.7.7.50) (Virus termination factor large subunit) (mRNA-capping enzyme 97 kDa subunit) (mRNA-capping enzyme large... ma-jd-viral-41043
mRNA-capping enzyme small subunit (mRNA (guanine-N(7))-methyltransferase) (EC 2.1.1.56) (mRNA cap... ma-jd-viral-09992
protein-tyrosine-phosphatase (EC 3.1.3.48) ma-jd-viral-06250

Yaba-like disease virus taxid:132475

Protein ModelArchive
100L protein ma-jd-viral-43088
101L protein ma-jd-viral-60221
102R protein ma-jd-viral-33157
104L protein ma-jd-viral-46272
105L protein ma-jd-viral-56077
106L protein ma-jd-viral-50924
107L protein ma-jd-viral-37095
108L protein ma-jd-viral-22761
109L protein ma-jd-viral-00067
10L protein ma-jd-viral-02314
111L protein ma-jd-viral-33672
112L protein ma-jd-viral-00080
113R protein ma-jd-viral-54843
114R protein ma-jd-viral-29014
117L protein ma-jd-viral-35841
11L protein ma-jd-viral-26221
120L protein ma-jd-viral-44658
123R protein ma-jd-viral-16481
124R protein ma-jd-viral-11886
125R protein ma-jd-viral-06637
126R protein ma-jd-viral-63557
127R protein ma-jd-viral-06626
128L protein ma-jd-viral-32412
129R protein ma-jd-viral-60588
12L protein ma-jd-viral-67097
130L protein ma-jd-viral-34190
131R protein ma-jd-viral-47475
132R protein ma-jd-viral-31426
133L protein ma-jd-viral-10538
134R protein ma-jd-viral-57286
137R protein ma-jd-viral-13524
139R protein ma-jd-viral-13521
13L protein ma-jd-viral-11355
140R protein ma-jd-viral-15726
141R protein ma-jd-viral-02250
142R protein ma-jd-viral-24619
144R protein ma-jd-viral-05885
145R protein ma-jd-viral-18476
146R protein ma-jd-viral-26222
147R protein ma-jd-viral-26239
148R protein ma-jd-viral-26184
149R protein ma-jd-viral-02290
14L protein ma-jd-viral-16504
150R protein ma-jd-viral-57456
151R protein (1L protein) ma-jd-viral-00461
151R protein (1L protein) ma-jd-viral-00470
15L protein ma-jd-viral-24549
16L protein ma-jd-viral-01710
18L protein ma-jd-viral-51186
19L protein ma-jd-viral-15724
21L protein ma-jd-viral-50420
22L protein ma-jd-viral-58268
23L protein ma-jd-viral-54293
24L protein ma-jd-viral-04057
25 kDa core protein OPG138 ma-jd-viral-61885
26L protein ma-jd-viral-56877
27L protein ma-jd-viral-42876
28R protein ma-jd-viral-48763
29L protein ma-jd-viral-50611
2L protein ma-jd-viral-17687
31R protein ma-jd-viral-63863
33L protein ma-jd-viral-04647
39kDa core protein OPG130 ma-jd-viral-60359
3L protein ma-jd-viral-02607
41L protein ma-jd-viral-04634
42L protein ma-jd-viral-04692
43L protein ma-jd-viral-02065
44L protein ma-jd-viral-39132
46L protein ma-jd-viral-51132
47L protein ma-jd-viral-63602
48L protein ma-jd-viral-06303
4L protein ma-jd-viral-02614
54R protein ma-jd-viral-22452
59R protein ma-jd-viral-23592
60R protein ma-jd-viral-04083
61R protein ma-jd-viral-47140
62 kDa protein (Rifampicin resistance protein) ma-jd-viral-18045
62L protein ma-jd-viral-04839
64R protein ma-jd-viral-22161
65R protein ma-jd-viral-34499
6L protein ma-jd-viral-13499
70L protein ma-jd-viral-35557
73R protein ma-jd-viral-38033
74L protein ma-jd-viral-18654
76R protein ma-jd-viral-43346
78R protein ma-jd-viral-00563
7L protein ma-jd-viral-18478
80L protein ma-jd-viral-52275
81R protein ma-jd-viral-01683
83R protein ma-jd-viral-34245
86R protein ma-jd-viral-07967
87R protein ma-jd-viral-07890
89L protein ma-jd-viral-09980
8L protein ma-jd-viral-26822
93L protein ma-jd-viral-57767
97L protein ma-jd-viral-03891
Assembly protein G7 ma-jd-viral-34309
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57) ma-jd-viral-22606
Core protein VP8 ma-jd-viral-55846
DNA packaging protein OPG160 ma-jd-viral-10779
DNA polymerase (EC 2.7.7.7) ma-jd-viral-17217
DNA topoisomerase (EC 5.6.2.1) ma-jd-viral-17653
DNA-directed RNA polymerase (EC 2.7.7.6) ma-jd-viral-35640
DNA-directed RNA polymerase 147 kDa polypeptide (EC 2.7.7.6) ma-jd-viral-39194
DNA-directed RNA polymerase 18 kDa subunit (EC 2.7.7.6) ma-jd-viral-07222
DNA-directed RNA polymerase 19 kDa subunit (EC 2.7.7.6) ma-jd-viral-53649
DNA-directed RNA polymerase 30 kDa polypeptide (EC 2.7.7.6) ma-jd-viral-41200
DNA-directed RNA polymerase 35 kDa subunit (EC 2.7.7.6) ma-jd-viral-13927
DNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6) ma-jd-viral-66512
DNA-directed RNA polymerase subunit (EC 2.7.7.6) ma-jd-viral-01529
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) (dUTP... ma-jd-viral-45041
E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ubiquitin transferase... ma-jd-viral-16870
Early protein OPG038 (Protein M2) ma-jd-viral-04101
Early transcription factor 70 kDa subunit (ATP-dependent helicase VETFS) ma-jd-viral-23103
Early transcription factor 82 kDa subunit (ETF large subunit) ma-jd-viral-40200
Entry-fusion complex protein OPG086 ma-jd-viral-02209
Envelope protein A28 homolog (Protein 118) ma-jd-viral-31673
Glutaredoxin-2 ma-jd-viral-24232
Host range factor p28 (E3 ubiquitin-protein ligase p28) ma-jd-viral-21656
Intermediate transcription factor 3 large subunit ma-jd-viral-00023
Intermediate transcription factor 3 small subunit (VITF-3 32 kDa subunit) (VITF-3 small... ma-jd-viral-47951
Late transcription elongation factor OPG087 ma-jd-viral-65996
Late transcription factor 1 ma-jd-viral-21473
Nucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate phosphohydrolase... ma-jd-viral-23024
Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit)... ma-jd-viral-36181
Probable host range protein 2 ma-jd-viral-07838
Probable metalloendopeptidase G1-type (EC 3.4.24.-) ma-jd-viral-04442
Protein E3 homolog (Protein E3L homolog) ma-jd-viral-49137
Protein E6 homolog ma-jd-viral-36841
Protein OPG061 ma-jd-viral-14935
Protein OPG067 (Protein E5) ma-jd-viral-35746
Protein OPG070 ma-jd-viral-64797
Protein OPG079 ma-jd-viral-12933
Protein OPG091 ma-jd-viral-06067
Protein OPG161 ma-jd-viral-03056
Protein OPG181 ma-jd-viral-09723
RNA helicase NPH-II (EC 3.6.4.13) (Nucleoside triphosphatase II) (Nucleoside triphosphate phosphohydrolase... ma-jd-viral-58229
RNA polymerase-associated transcription-specificity factor RAP94 (Protein H4) (RPO-associated protein of 94... ma-jd-viral-63407
Ribonucleoside-diphosphate reductase small chain (EC 1.17.4.1) (Ribonucleotide reductase small... ma-jd-viral-05426
Serine/threonine-protein kinase (EC 2.7.11.1) ma-jd-viral-24803
Soluble interferon alpha/beta receptor OPG204 ma-jd-viral-13838
Sulfhydryl oxidase (EC 1.8.3.2) ma-jd-viral-34813
Thymidine kinase (EC 2.7.1.21) ma-jd-viral-10711
Transcript termination protein A18 (EC 3.6.4.-) ma-jd-viral-22794
Uracil-DNA glycosylase ma-jd-viral-07788
Viral late gene transcription factor 2 (Trans-activator protein A1) ma-jd-viral-16079
Viral late gene transcription factor 3 ma-jd-viral-52651
Virion core protein 4b ma-jd-viral-62988
mRNA-capping enzyme catalytic subunit (EC 2.1.1.56) (EC 2.7.7.50) (Virus termination factor large subunit) (mRNA-capping enzyme 97 kDa subunit) (mRNA-capping enzyme large... ma-jd-viral-41047
protein-tyrosine-phosphatase (EC 3.1.3.48) ma-jd-viral-06259