Entomopoxvirinae (taxid:10284)



Enveloped, brick-shaped or ovoid virion, 70-250x350nm in size. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).


Linear, dsDNA genome of 250-380kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.





  1. Attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core into the host cytoplasm.
  3. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
  4. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
  5. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
  6. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
  7. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
  8. IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).
  9. Mature virion can be occluded in spheroids comprised of spheroidin protein.

Host-virus interaction

Apoptosis modulation

The Amsacta moorei entomopoxvirus encodes AMV p33, a functional homolog of the baculovirus apoptosis inhibitor p35 . P33 is a direct inhibitor of caspases.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

24 entries grouped by strain

11 entries

Amsacta moorei entomopoxvirus (AmEPV) reference strain

NTP1_AMEPV Nucleoside triphosphatase I (EC (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH ...
SPHR_AMEPV Spheroidin
KITH_AMEPV Thymidine kinase (EC
A28_AMEPV Envelope protein A28 homolog (Protein G4R)
I7_AMEPV Core protease I7 homolog (EC 3.4.22.-)
NMT_AMEPV Putative glycylpeptide N-tetradecanoyltransferase (EC (Myristoyl-CoA:protein ...
PTPH_AMEPV Putative tyrosine-protein phosphatase AMV078 (EC
YO17_AMEPV Uncharacterized protein AMV017/Q1
Y014_AMEPV Uncharacterized leucine-rich repeat-containing protein AMV014/Q3
V183_AMEPV Uncharacterized protein AMV183/G2R
V185_AMEPV Uncharacterized protein AMV185/G3L

5 entries

Melanoplus sanguinipes entomopoxvirus (MsEPV) reference strain

ETF1_MSEPV Early transcription factor 70 kDa subunit (EC 3.6.4.-) (ATP-dependent helicase VETFS) (ETF small ...
NPH2_MSEPV RNA helicase NPH-II (EC (Nucleoside triphosphatase II) (NTPase II) (Nucleoside ...
NTP1_MSEPV Nucleoside triphosphatase I (EC (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH ...
NMT_MSEPV Putative glycylpeptide N-tetradecanoyltransferase (EC (Myristoyl-CoA:protein ...
ETF2_MSEPV Early transcription factor 82 kDa subunit (ETF large subunit)

4 entries

Choristoneura biennis entomopoxvirus (CbEPV)

SPIN_CBEPV Spindolin (Spheroidin) (p50)
NTP1_CBEPV Nucleoside triphosphatase I (EC (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH ...
DPOL_CBEPV DNA polymerase (EC
KITH_CBEPV Thymidine kinase (EC

2 entries

Choristoneura fumiferana entomopoxvirus (CfEPV)

NTP1_CFEPV Nucleoside triphosphatase I (EC (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH ...
KITH_CFEPV Thymidine kinase (EC

2 entries

Heliothis armigera entomopoxvirus (HaEPV)

NTP1_HAEPV Nucleoside triphosphatase I (EC (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH ...
SPIN_HAEPV Spindolin (Fusolin) (p50)