Enveloped, brick-shaped or ovoid virion, 70-250x350nm in size. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).


Linear, dsDNA genome of 250-380kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.




  1. Attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core into the host cytoplasm.
  3. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
  4. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
  5. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
  6. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
  7. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
  8. IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).
  9. Mature virion can be occluded in spheroids comprised of spheroidin protein.

Host-virus interaction

Apoptosis modulation

The Amsacta moorei entomopoxvirus encodes AMV p33, a functional homolog of the baculovirus apoptosis inhibitor p35 . P33 is a direct inhibitor of caspases.

Matching UniProtKB/Swiss-Prot entries

24 entries grouped by strain (browse by keywords)

All proteins are shown (view only 16 complete proteome entries)

11 entries

Amsacta moorei entomopoxvirus (AmEPV) reference strain

PTPH_AMEPV Putative tyrosine-protein phosphatase AMV078 (EC
NTP1_AMEPV Nucleoside triphosphatase I (EC (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH ...
NMT_AMEPV Putative glycylpeptide N-tetradecanoyltransferase (EC (Myristoyl-CoA:protein ...
SPHR_AMEPV Spheroidin
V183_AMEPV Uncharacterized protein AMV183/G2R
V185_AMEPV Uncharacterized protein AMV185/G3L
YO17_AMEPV Uncharacterized protein AMV017/Q1
Y014_AMEPV Uncharacterized leucine-rich repeat-containing protein AMV014/Q3
A28_AMEPV Envelope protein A28 homolog (Protein G4R)
KITH_AMEPV Thymidine kinase (EC
I7_AMEPV Core protease I7 homolog (EC 3.4.22.-)

5 entries

Melanoplus sanguinipes entomopoxvirus (MsEPV) reference strain

NMT_MSEPV Putative glycylpeptide N-tetradecanoyltransferase (EC (Myristoyl-CoA:protein ...
NPH2_MSEPV RNA helicase NPH-II (EC (Nucleoside triphosphatase II) (NTPase II) (Nucleoside ...
NTP1_MSEPV Nucleoside triphosphatase I (EC (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH ...
ETF1_MSEPV Early transcription factor 70 kDa subunit (EC 3.6.4.-) (ATP-dependent helicase VETFS) (ETF small ...
ETF2_MSEPV Early transcription factor 82 kDa subunit (ETF large subunit)

4 entries

Choristoneura biennis entomopoxvirus (CbEPV)

NTP1_CBEPV Nucleoside triphosphatase I (EC (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH ...
SPIN_CBEPV Spindolin (Spheroidin) (p50)
DPOL_CBEPV DNA polymerase (EC
KITH_CBEPV Thymidine kinase (EC

2 entries

Choristoneura fumiferana entomopoxvirus (CfEPV)

NTP1_CFEPV Nucleoside triphosphatase I (EC (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH ...
KITH_CFEPV Thymidine kinase (EC

2 entries

Heliothis armigera entomopoxvirus (HaEPV)

NTP1_HAEPV Nucleoside triphosphatase I (EC (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH ...
SPIN_HAEPV Spindolin (Fusolin) (p50)