Cytomegalovirus

VIRION

image

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embedded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 200 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' untranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. Certain proteins are downregulated translationaly by a leaky scanning from an upstream ORF.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachement of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Entry into host cell is still unclear and may depend on the host cell type, i.e. endocytosis versus fusion at the plasma membrane.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Adaptive immune response inhibition

Many HCMV proteins are dedicated to interfere with the host adaptive immune system. HCMV US11 reverse the translocation of human class I heavy chains from the host endoplasmic reticulum (ER) back to the cytosol which ultimately results in their degradation by the proteasome. US2 destroys two components of the MHC class II pathway, HLA-DR-alpha and DM-alpha, preventing recognition by CD4+ T cells. US3 prevents forward transport and maturation of all major histocompatibility complex (MHC) class I molecules by trapping them in the ER. HCMV US6 inhibits expression of MHC class I on the cell surface through TAP (specific transporters associated with antigen presentation) by blocking translocation of peptides from the proteasome into the ER for loading onto MHC class I.

Apoptosis modulation

Viral inhibitor of caspase-8-induced apoptosis (from gene UL36) plays a role in the inhibition of apoptosis by interacting with the pro-domain of pro-caspase-8/CASP8 and thus preventing its activation . Another viral protein vMIA inhibits BAX- but not BAK- mediated apoptosis.

Autophagy modulation

The human cytomegalovirus protein TRS1 inhibits host autophagy process via its interaction with Beclin 1 .

Cell-cycle modulation

The conserved UL24 family of human alpha, beta and gamma herpesviruses induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex. HCMV encodes an UL24 homolog that should fullfill this role .

Innate immune response inhibition

HCMV inhibits the cascade leading to production of interferon-beta by targeting host IRF3 protein with the viral pp65 protein .
NK cells are a component of the innate immune system which play an important role in the early control of viral infections and also help to drive subsequent adaptive immunity. Several HCMV proteins are involved in the inhibition of NK-cells cytotoxicity including UL16 or UL142 that retain NKGCD2 ligands inside the cell to prevent their cell surface expression .

Host splicing inhibition

HCMV UL69 modulates the host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing .

Matching UniProtKB/Swiss-Prot entries

405 entries grouped by strain (browse by keywords)

190 entries

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Select_allDeselect_all
SCAF_HCMVA Capsid scaffolding protein (Protease precursor) (pPR) [Cleaved into: Assemblin (EC 3.4.21.97) ...
UL17_HCMVA Uncharacterized protein UL17
UL06_HCMVA Uncharacterized protein UL6
UL101_HCMVA Uncharacterized protein UL101
TRM2_HCMVA Tripartite terminase subunit 2
TRX2_HCMVA Triplex capsid protein 2
US22_HCMVA Early nuclear protein HWLF1 (Tegument protein US22)
TRM1_HCMVA Tripartite terminase subunit 1
UL12_HCMVA Uncharacterized protein UL12
US32_HCMVA Uncharacterized protein HHRF7
UL08_HCMVA Membrane protein UL8
UL116_HCMVA Uncharacterized protein UL116
UL28_HCMVA Uncharacterized protein UL28
UL09_HCMVA Uncharacterized protein UL9
US27_HCMVA G-protein coupled receptor homolog US27 (HHRF2)
US34A_HCMVA Uncharacterized protein US34A
UL02_HCMVA Uncharacterized protein UL2
SCP_HCMVA Small capsomere-interacting protein
UL61_HCMVA Uncharacterized protein UL61
PRIM_HCMVA DNA primase (EC 2.7.7.-)
UL96_HCMVA Protein UL96
VP22_HCMVA Protein UL24
UL76_HCMVA Protein UL76
UL110_HCMVA Uncharacterized protein UL110
UL11P_HCMVA Protein UL11
UL91_HCMVA Protein UL91
UL34_HCMVA Transcriptional regulator UL34
UL124_HCMVA Uncharacterized protein UL124
US03_HCMVA Membrane glycoprotein US3 (Glycoprotein E) (Protein HQLF1) (gpUS3 IE)
UL125_HCMVA Uncharacterized protein UL125
US18_HCMVA Transmembrane protein US18
IR02_HCMVA Uncharacterized protein IRL2 (TRL2)
IRS1_HCMVA Protein IRS1 (HQRF1)
NEC1_HCMVA Nuclear egress protein 1
PP65_HCMVA 65 kDa phosphoprotein (pp65) (65 kDa matrix phosphoprotein) (Phosphoprotein UL83) (Tegument protein ...
UL65_HCMVA Uncharacterized protein UL65
US36_HCMVA Uncharacterized protein US36
US13_HCMVA Uncharacterized protein HVLF5
UL21A_HCMVA Uncharacterized protein UL21A
US29_HCMVA Uncharacterized protein HHRF4
UL131_HCMVA Uncharacterized protein UL131
US30_HCMVA Uncharacterized protein HHRF5
US35_HCMVA Uncharacterized protein HHLF2
UL127_HCMVA Uncharacterized protein UL127
UL43_HCMVA Tegument protein UL43
UL42_HCMVA Protein UL42
UL81_HCMVA Uncharacterized protein UL81
US12_HCMVA Uncharacterized protein HVLF6
US09_HCMVA Unique short US9 glycoprotein (Protein HXLF3) (gpUS9)
UL59_HCMVA Uncharacterized protein UL59
UL29_HCMVA Uncharacterized protein UL29
UL52_HCMVA Packaging protein UL32 homolog (Protein HFRF1)
UL35_HCMVA Protein UL35
US16_HCMVA Uncharacterized protein HVLF2
US07_HCMVA Unique short US7 glycoprotein (Protein HXLF5) (gpUS7)
UL13_HCMVA Uncharacterized protein UL13
UL66_HCMVA Uncharacterized protein UL66
UL23_HCMVA Tegument protein UL23
US05_HCMVA Uncharacterized protein US5
UNG_HCMVA Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
NEC2_HCMVA Nuclear egress protein 2
PP85_HCMVA Phosphoprotein 85 (pp85) (Phosphoprotein UL25)
UL19_HCMVA Uncharacterized protein UL19
UL27_HCMVA Protein UL27
UL78_HCMVA Uncharacterized protein UL78
US01_HCMVA Uncharacterized protein HQLF3
US02_HCMVA Unique short US2 glycoprotein (Protein HQLF2) (gpUS2)
UL62_HCMVA Uncharacterized protein UL62
UL03_HCMVA Uncharacterized protein UL3
US33_HCMVA Uncharacterized protein HHLF3
UL106_HCMVA Uncharacterized protein UL106
VPAP_HCMVA DNA polymerase processivity factor (Polymerase accessory protein) (PAP) (Protein ICP36)
UL49_HCMVA Uncharacterized protein UL49 (Protein HFLF5)
UL108_HCMVA Uncharacterized protein UL108
UL01_HCMVA Glycoprotein UL1
US06_HCMVA Unique short US6 glycoprotein (Protein HXLF6) (gpUS6)
TRX1_HCMVA Triplex capsid protein 1
UL92_HCMVA Protein UL92
GB_HCMVA Envelope glycoprotein B (gB)
AN_HCMVA Alkaline nuclease (EC 3.1.-.-)
GL_HCMVA Envelope glycoprotein L (gL)
EP84_HCMVA Early phosphoprotein p84 [Cleaved into: p20; p26; p28]
DPOL_HCMVA DNA polymerase catalytic subunit (EC 2.7.7.7)
CEP2_HCMVA Cytoplasmic envelopment protein 2
DNBI_HCMVA Major DNA-binding protein
GO_HCMVA Glycoprotein O (gO)
J1I_HCMVA Uncharacterized protein HKRFX (J1I)
IR01_HCMVA Uncharacterized protein HKLF1 (IRL1) (TRL1)
DUT_HCMVA Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
CVC1_HCMVA Capsid vertex component 1
CEP1_HCMVA Cytoplasmic envelopment protein 1
CEP3_HCMVA Cytoplasmic envelopment protein 3
IR12_HCMVA Uncharacterized protein IRL12 (TRL12)
IR14_HCMVA Uncharacterized protein IRL14
IR06_HCMVA Uncharacterized protein IRL6 (TRL6)
GH_HCMVA Envelope glycoprotein H (gH)
MCP_HCMVA Major capsid protein (MCP)
ICP27_HCMVA mRNA export factor ICP27 homolog
IR11_HCMVA Viral Fc-gamma receptor-like protein IR11 (gp34)
CVC2_HCMVA Capsid vertex component 2
IR08_HCMVA Uncharacterized protein IRL8 (TRL8)
IR05_HCMVA Uncharacterized protein IRL5 (TRL5)
IR07_HCMVA Uncharacterized protein IRL7 (TRL7)
J1L_HCMVA Uncharacterized protein J1L
J1S_HCMVA Uncharacterized protein J1S
ITP_HCMVA Inner tegument protein
HEPA_HCMVA DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
IR10_HCMVA Protein IRL10 (TRL10)
IR09_HCMVA Uncharacterized protein IRL9 (TRL9)
IR03_HCMVA Uncharacterized protein IRL3 (TRL3)
IR04_HCMVA Uncharacterized protein IRL4 (TRL4)
LTP_HCMVA Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
HELI_HCMVA DNA replication helicase (EC 3.6.4.-)
GM_HCMVA Envelope glycoprotein M (gM)
PORTL_HCMVA Portal protein
IL10H_HCMVA Viral interleukin-10 homolog (cmvIL-10) (vIL-10)
UL119_HCMVA Viral Fc-gamma receptor-like protein UL119 (gp68)
UL20_HCMVA Uncharacterized protein UL20
UL107_HCMVA Uncharacterized protein UL107
UL30_HCMVA Uncharacterized protein UL30
UL16P_HCMVA Protein UL16
UL68_HCMVA Uncharacterized protein UL68
US11_HCMVA Unique short US11 glycoprotein (Protein HXLF1) (gpUS11)
TEG7_HCMVA Tegument protein UL51 homolog
TRM3_HCMVA Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
UL64_HCMVA Uncharacterized protein UL64
UL126_HCMVA Uncharacterized protein UL126
UL10_HCMVA Uncharacterized protein UL10
UL31_HCMVA Protein UL31
US24_HCMVA Tegument protein US24 (Protein HHLF6)
US21_HCMVA Uncharacterized protein HWLF2
UL121_HCMVA Membrane protein UL121
US15_HCMVA Uncharacterized protein HVLF3
UL128_HCMVA Uncharacterized protein UL128
US25_HCMVA Uncharacterized protein US25
UL38_HCMVA Apoptosis inhibitor UL38
US26_HCMVA Uncharacterized protein HHLF5
UL22A_HCMVA Glycoprotein UL22A
UL84_HCMVA Protein UL84
US20_HCMVA Transmembrane protein HWLF3
UL63_HCMVA Uncharacterized protein UL63
US31_HCMVA Uncharacterized protein HHRF6
UL129_HCMVA Uncharacterized protein UL129
UL97_HCMVA Serine/threonine protein kinase UL97 (EC 2.7.11.1) (Ganciclovir kinase) (HSRF3 protein)
UL15A_HCMVA Uncharacterized protein UL15A
UL07_HCMVA CEACAM1-like protein UL7
UL21_HCMVA Uncharacterized protein UL21
TRS1_HCMVA Protein HHLF1
UL36_HCMVA Uncharacterized protein UL36
US28_HCMVA G-protein coupled receptor homolog US28 (HHRF3)
IR13_HCMVA Uncharacterized protein IRL13 (TRL13)
US23_HCMVA Tegument protein US23 (Protein HHLF7)
UL120_HCMVA Uncharacterized protein UL120
US14_HCMVA Uncharacterized protein HVLF4
UL26_HCMVA Tegument protein UL26
US19_HCMVA Transmembrane protein HWLF4
UL05_HCMVA Protein UL5
UL109_HCMVA Uncharacterized protein UL109
UL33_HCMVA G-protein coupled receptor homolog UL33 (vGPCR UL33)
UL58_HCMVA Uncharacterized protein UL58
UL90_HCMVA Uncharacterized protein UL90
US10_HCMVA Unique short US10 glycoprotein (Protein HXLF2) (gpUS10)
UL67_HCMVA Uncharacterized protein UL67
UL41_HCMVA Uncharacterized protein UL41
UL88_HCMVA Protein UL88
UL14_HCMVA Uncharacterized protein UL14
UL39_HCMVA Uncharacterized protein UL39
UL40_HCMVA Protein UL40
UL79_HCMVA Protein UL79
VIE2_HCMVA Viral transcription factor IE2 (IE2) (Protein UL122)
US04_HCMVA Uncharacterized protein US4
UL95_HCMVA Protein UL95
VIE1_HCMVA Immediate early protein IE1 (IE1) (55 kDa immediate-early protein 1) (IE1p72) (IE72)
UL132_HCMVA Envelope glycoprotein UL132 (L3)
US08_HCMVA Unique short US8 glycoprotein (Protein HXLF4) (gpUS8)
PP71_HCMVA Protein pp71 (pp71) (71 kDa upper matrix phosphoprotein) (Phosphoprotein UL82) (ppUL82) (Tegument ...
PP150_HCMVA Large structural phosphoprotein (150 kDa matrix phosphoprotein) (150 kDa phosphoprotein) (pp150) ...
RIR1_HCMVA Ribonucleoside-diphosphate reductase large subunit-like protein
US17_HCMVA Uncharacterized protein HVLF1
VGLI_HCMVA UL37 immediate early glycoprotein
UL87_HCMVA Protein UL87
TR14_HCMVA Protein TRL14
UL130_HCMVA Uncharacterized protein UL130
UL18_HCMVA Glycoprotein UL18
US34_HCMVA Protein US34
UL60_HCMVA Uncharacterized protein UL60
UL41A_HCMVA Protein UL41A
UL117_HCMVA Protein UL117
UL04_HCMVA Early glycoprotein GP48
GN_HCMVA Envelope glycoprotein N

166 entries

Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Select_allDeselect_all
RIR1_HCMVM Ribonucleoside-diphosphate reductase large subunit-like protein
TRM2_HCMVM Tripartite terminase subunit 2
TRM1_HCMVM Tripartite terminase subunit 1
U148C_HCMVM Protein UL148C
RL9A_HCMVM Protein RL9A
SCAF_HCMVM Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
UL145_HCMVM Protein UL145
US32_HCMVM Protein US32
RL8A_HCMVM Protein RL8A
UL14_HCMVM Uncharacterized protein UL14
US21_HCMVM Membrane protein US21
US14_HCMVM Membrane protein US14
UL10_HCMVM Uncharacterized protein UL10
UL33_HCMVM G-protein coupled receptor homolog UL33
US27_HCMVM Envelope glycoprotein US27
US20_HCMVM Membrane protein US20
UL92_HCMVM Uncharacterized protein UL92
UL18_HCMVM Membrane glycoprotein UL18
UL04_HCMVM Envelope glycoprotein UL4
UL120_HCMVM Membrane protein UL120
RL5A_HCMVM Protein RL5A
UL91_HCMVM Protein UL91
US12_HCMVM Uncharacterized protein US12
US33A_HCMVM Uncharacterized protein US33A
PP65_HCMVM 65 kDa phosphoprotein (pp65) (65 kDa matrix phosphoprotein) (Phosphoprotein UL83) (Tegument protein ...
PP85_HCMVM Phosphoprotein 85 (pp85) (Phosphoprotein UL25)
NEC1_HCMVM Nuclear egress protein 1
RL11_HCMVM Membrane glycoprotein RL11
PP71_HCMVM Protein pp71
UL130_HCMVM Envelope glycoprotein UL130
UL79_HCMVM Protein UL79
UL135_HCMVM Protein UL135
UL139_HCMVM Membrane glycoprotein UL139
US19_HCMVM Transmembrane protein US19
UL87_HCMVM Uncharacterized protein UL87
US24_HCMVM Tegument protein US24
RL12_HCMVM Uncharacterized protein RL12
UL95_HCMVM Protein UL95
TRS1_HCMVM Protein TRS1
UL49_HCMVM Protein UL49
UL140_HCMVM Protein UL140
UL147_HCMVM Putative viral CXC chemokine 2 (vCXCL2)
UL52_HCMVM Packaging protein UL32 homolog
UL35_HCMVM Tegument protein UL35
VIE2_HCMVM Viral transcription factor IE2 (IE2) (Protein UL122)
US08_HCMVM Membrane glycoprotein US8
UL09_HCMVM Membrane glycoprotein UL9
UL144_HCMVM Membrane glycoprotein UL144 (TNF alpha-like receptor UL144) (UL144 protein)
UL88_HCMVM Protein UL88
US30_HCMVM Uncharacterized protein US30
VGLI_HCMVM UL37 immediate early glycoprotein
UL34_HCMVM Transcriptional regulator UL34
UL30_HCMVM Uncharacterized protein UL30
US22_HCMVM Tegument protein US22
UL19_HCMVM Uncharacterized protein UL19
US02_HCMVM Unique short US2 glycoprotein (Protein HQLF2) (gpUS2)
VPAP_HCMVM DNA polymerase processivity factor (Polymerase accessory protein) (PAP) (Protein ICP36)
US07_HCMVM Membrane glycoprotein US7
US01_HCMVM Protein US1
UL84_HCMVM Protein UL84
UL121_HCMVM Membrane protein UL121
UNG_HCMVM Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
US09_HCMVM Membrane glycoprotein US9
US34_HCMVM Protein US34
UL26_HCMVM Tegument protein UL26
US28_HCMVM Envelope protein US28
US16_HCMVM Protein US16
US15_HCMVM Membrane protein US15
RL13_HCMVM Membrane protein RL13
UL141_HCMVM Protein UL141
UL06_HCMVM Uncharacterized protein UL6
UL76_HCMVM Protein UL76
US23_HCMVM Protein US23
TRX1_HCMVM Triplex capsid protein 1
SCP_HCMVM Small capsomere-interacting protein
PP150_HCMVM Tegument protein pp150
DNBI_HCMVM Major DNA-binding protein
IR10_HCMVM Protein IRL10 (TRL10)
IR01_HCMVM Uncharacterized protein HKLF1 (IRL1) (TRL1)
IR06_HCMVM Uncharacterized protein IRL6 (TRL6)
DPOL_HCMVM DNA polymerase catalytic subunit (EC 2.7.7.7)
EP84_HCMVM Early phosphoprotein p84
CEP2_HCMVM Cytoplasmic envelopment protein 2
CVC2_HCMVM Capsid vertex component 2
AN_HCMVM Alkaline nuclease (EC 3.1.-.-)
CEP3_HCMVM Cytoplasmic envelopment protein 3 (28 kDa structural phosphoprotein) (pp28)
CVC1_HCMVM Capsid vertex component 1
ITP_HCMVM Inner tegument protein
HEPA_HCMVM DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
GB_HCMVM Envelope glycoprotein B (gB)
GM_HCMVM Envelope glycoprotein M (gM)
CXCL1_HCMVM Chemokine vCXCL1
DUT_HCMVM Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
GH_HCMVM Envelope glycoprotein H (gH)
CEP1_HCMVM Cytoplasmic envelopment protein 1
IRS1_HCMVM Protein IRS1
GO_HCMVM Envelope glycoprotein O
GL_HCMVM Envelope glycoprotein L (gL)
IL10H_HCMVM Viral interleukin-10 homolog (cmvIL-10) (vIL-10)
MCP_HCMVM Major capsid protein (MCP)
PORTL_HCMVM Portal protein
HELI_HCMVM DNA replication helicase (EC 3.6.4.-)
ICP27_HCMVM mRNA export factor ICP27 homolog
NEC2_HCMVM Nuclear egress protein 2
LTP_HCMVM Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
UL17_HCMVM Protein UL17
US10_HCMVM Membrane glycoprotein US10
UL150_HCMVM Uncharacterized protein UL150
UL78_HCMVM Protein UL78
VICA_HCMVM Viral inhibitor of caspase-8-induced apoptosis (vICA)
UL74A_HCMVM Uncharacterized protein UL74A
UL132_HCMVM Envelope glycoprotein UL132
UL11P_HCMVM Protein UL11
U131A_HCMVM Protein UL131A
UL02_HCMVM Uncharacterized protein UL2
TRM3_HCMVM Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
US34A_HCMVM Uncharacterized protein US34A
US29_HCMVM Uncharacterized protein US29
UL40_HCMVM Protein UL40
US11_HCMVM Membrane glycoprotein US11
U148B_HCMVM Protein UL148B
UL07_HCMVM CEACAM1-like protein UL7
US17_HCMVM Protein US17
UL43_HCMVM Tegument protein UL43
UL41A_HCMVM Protein UL41A
U148D_HCMVM Protein UL148D
UL133_HCMVM Protein UL133
UL117_HCMVM Protein UL117 (pUL117)
UL119_HCMVM Viral Fc-gamma receptor-like protein UL119 (gp68)
UL116_HCMVM Uncharacterized protein UL116
UL05_HCMVM Protein UL5
UL01_HCMVM Glycoprotein UL1
UL20_HCMVM Membrane protein UL20
US13_HCMVM Membrane protein US13
US26_HCMVM Protein US26
UL22A_HCMVM Glycoprotein UL22A
UL42_HCMVM Protein UL42
U150A_HCMVM Uncharacterized protein UL150A
U147A_HCMVM Uncharacterized protein UL147A
UL124_HCMVM Uncharacterized protein UL124
VP22_HCMVM Tegument protein UL24
UL148_HCMVM Membrane protein UL148
UL16P_HCMVM Protein UL16
U148A_HCMVM Protein UL148A
UL97_HCMVM Serine/threonine protein kinase UL97 (EC 2.7.11.1)
UL142_HCMVM Membrane glycoprotein UL142
US18_HCMVM Transmembrane protein US18
UL23_HCMVM Tegument protein UL23
US06_HCMVM Unique short US6 glycoprotein
UL27_HCMVM Protein UL27
PRIM_HCMVM DNA primase (EC 2.7.7.-)
TEG7_HCMVM Tegument protein UL51 homolog
UL13_HCMVM Uncharacterized protein UL13
UL15A_HCMVM Uncharacterized protein UL15A
UL136_HCMVM Protein UL136
VIE1_HCMVM Immediate early protein IE1 (IE1) (55 kDa immediate-early protein 1) (IE1p72) (IE72)
UL31_HCMVM Protein UL31
UL21A_HCMVM Uncharacterized protein UL21A
US03_HCMVM Membrane glycoprotein US3
UL298_HCMVM Protein UL29/28
UL96_HCMVM Protein UL96
TRX2_HCMVM Triplex capsid protein 2
US31_HCMVM Uncharacterized protein US31
UL38_HCMVM Apoptosis inhibitor UL38
UL138_HCMVM Protein UL138
GN_HCMVM Envelope glycoprotein N

3 entries

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)

Select_allDeselect_all
YHR1_HCMVA Uncharacterized protein HHRF1
UL298_HCMVA Protein UL29/UL28
YHL4_HCMVA Uncharacterized protein HHLF4

1 entry

Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)

UL128_HCMVM Envelope protein UL128

28 entries

Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Select_allDeselect_all
UL147_HCMVT Putative viral CXC chemokine 2 (vCXCL2)
PRIM_HCMVT DNA primase (EC 2.7.7.-)
UL136_HCMVT Protein UL136
UL97_HCMVT Serine/threonine protein kinase UL97 (EC 2.7.11.1) (Ganciclovir kinase)
UL135_HCMVT Protein UL135
VIE3_HCMVT 30 kDa immediate-early protein 2 (IE2)
US20_HCMVT Transmembrane protein HWLF3
PP65_HCMVT 65 kDa phosphoprotein (pp65) (64 kDa matrix phosphoprotein) (pp64) (GP64) (Phosphoprotein UL83) ...
GB_HCMVT Envelope glycoprotein B (gB)
GH_HCMVT Envelope glycoprotein H (gH)
IE247_HCMVT 45 kDa immediate-early protein 2 (IE2)
UL04_HCMVT Early glycoprotein GP48
UL34_HCMVT Transcriptional regulator UL34
US11_HCMVT Unique short US11 glycoprotein (HXLF1) (gpUS11)
UL95_HCMVT Protein UL95
VIE2_HCMVT Viral transcription factor IE2 (IE2) (Protein UL122)
UL42_HCMVT Protein UL42
US03_HCMVT Membrane glycoprotein US3
US18_HCMVT Transmembrane protein HWLF5
US28_HCMVT G-protein coupled receptor homolog US28 (HHRF3)
UL132_HCMVT Envelope glycoprotein UL132 (L3)
US19_HCMVT Transmembrane protein HWLF4
LTP_HCMVT Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
UL17_HCMVT Protein UL17
VIE1_HCMVT Immediate early protein IE1 (IE1) (55 kDa immediate-early protein 1) (IE1p72) (IE72)
US02_HCMVT Unique short US2 glycoprotein (HQLF2) (gpUS2)
UL84_HCMVT UL84 protein
US06_HCMVT Unique short US6 glycoprotein (HXLF6) (gpUS6)

2 entries

Human cytomegalovirus (strain Toledo) (HHV-5) (Human herpesvirus 5)

Select_allDeselect_all
US05_HCMVO Uncharacterized protein US5
UL144_HCMVO Membrane glycoprotein UL144 (TNF alpha-like receptor UL144) (UL144 protein)

2 entries

Rhesus cytomegalovirus (strain 68-1) (RhCMV)

Select_allDeselect_all
GB_RHCM6 Envelope glycoprotein B (gB)
DPOL_RHCM6 DNA polymerase catalytic subunit (EC 2.7.7.7)

2 entries

Simian cytomegalovirus (strain Colburn)

Select_allDeselect_all
SCAF_SCMVC Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
DNBI_SCMVC Major DNA-binding protein

1 entry

Human cytomegalovirus (HHV-5) (Human herpesvirus 5)

TEGU_HCMV Tegument protein (67 kDa phosphorylated protein)

1 entry

Human cytomegalovirus (strain 1042) (HHV-5) (Human herpesvirus 5)

GL_HCMV2 Envelope glycoprotein L (gL)

1 entry

Human cytomegalovirus (strain 119) (HHV-5) (Human herpesvirus 5)

GL_HCMV1 Envelope glycoprotein L (gL)

1 entry

Human cytomegalovirus (strain 2387) (HHV-5) (Human herpesvirus 5)

GL_HCMV3 Envelope glycoprotein L (gL)

1 entry

Human cytomegalovirus (strain 4654) (HHV-5) (Human herpesvirus 5)

GL_HCMV4 Envelope glycoprotein L (gL)

1 entry

Human cytomegalovirus (strain 5035) (HHV-5) (Human herpesvirus 5)

GL_HCMV5 Envelope glycoprotein L (gL)

1 entry

Human cytomegalovirus (strain 5040) (HHV-5) (Human herpesvirus 5)

GL_HCMV6 Envelope glycoprotein L (gL)

1 entry

Human cytomegalovirus (strain 5160) (HHV-5) (Human herpesvirus 5)

GL_HCMV7 Envelope glycoprotein L (gL)

1 entry

Human cytomegalovirus (strain 5508) (HHV-5) (Human herpesvirus 5)

GL_HCMV8 Envelope glycoprotein L (gL)

1 entry

Human cytomegalovirus (strain Eisenhardt) (HHV-5) (Human herpesvirus 5)

V30K_HCMVE 30 kDa major early protein

1 entry

Human cytomegalovirus (strain PT) (HHV-5) (Human herpesvirus 5)

GL_HCMVP Envelope glycoprotein L (gL)