Cytomegalovirus

VIRION

image

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embedded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 200 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' untranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. Certain proteins are downregulated translationaly by a leaky scanning from an upstream ORF.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachement of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Entry into host cell is still unclear and may depend on the host cell type, i.e. endocytosis versus fusion at the plasma membrane.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Adaptive immune response inhibition

Many HCMV proteins are dedicated to interfere with the host adaptive immune system. HCMV US11 reverse the translocation of human class I heavy chains from the host endoplasmic reticulum (ER) back to the cytosol which ultimately results in their degradation by the proteasome. US2 destroys two components of the MHC class II pathway, HLA-DR-alpha and DM-alpha, preventing recognition by CD4+ T cells. US3 prevents forward transport and maturation of all major histocompatibility complex (MHC) class I molecules by trapping them in the ER. HCMV US6 inhibits expression of MHC class I on the cell surface through TAP (specific transporters associated with antigen presentation) by blocking translocation of peptides from the proteasome into the ER for loading onto MHC class I.

Apoptosis modulation

Viral inhibitor of caspase-8-induced apoptosis (from gene UL36) plays a role in the inhibition of apoptosis by interacting with the pro-domain of pro-caspase-8/CASP8 and thus preventing its activation . Another viral protein vMIA inhibits BAX- but not BAK- mediated apoptosis.

Autophagy modulation

The human cytomegalovirus protein TRS1 inhibits host autophagy process via its interaction with Beclin 1 .

Cell-cycle modulation

The conserved UL24 family of human alpha, beta and gamma herpesviruses induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex. HCMV encodes an UL24 homolog that should fullfill this role .

Innate immune response inhibition

HCMV inhibits the cascade leading to production of interferon-beta by targeting host IRF3 protein with the viral pp65 protein .
NK cells are a component of the innate immune system which play an important role in the early control of viral infections and also help to drive subsequent adaptive immunity. Several HCMV proteins are involved in the inhibition of NK-cells cytotoxicity including UL16 or UL142 that retain NKGCD2 ligands inside the cell to prevent their cell surface expression .

Host splicing inhibition

HCMV UL69 modulates the host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing .

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

405 entries grouped by strain (browse by keywords)

190 entries

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Select_allDeselect_all
GB_HCMVA Envelope glycoprotein B (gB)
PP71_HCMVA Protein pp71 (pp71) (71 kDa upper matrix phosphoprotein) (Phosphoprotein UL82) (ppUL82) (Tegument ...
PP150_HCMVA Large structural phosphoprotein (150 kDa matrix phosphoprotein) (150 kDa phosphoprotein) (pp150) ...
US11_HCMVA Unique short US11 glycoprotein (Protein HXLF1) (gpUS11)
SCAF_HCMVA Capsid scaffolding protein (Protease precursor) (pPR) [Cleaved into: Assemblin (EC 3.4.21.97) ...
UL35_HCMVA Protein UL35
VGLI_HCMVA UL37 immediate early glycoprotein
UL97_HCMVA Serine/threonine protein kinase UL97 (EC 2.7.11.1) (Ganciclovir kinase) (HSRF3 protein)
VPAP_HCMVA DNA polymerase processivity factor (Polymerase accessory protein) (PAP) (Protein ICP36)
EP84_HCMVA Early phosphoprotein p84 [Cleaved into: p20; p26; p28]
VIE2_HCMVA Viral transcription factor IE2 (IE2) (Protein UL122)
US28_HCMVA G-protein coupled receptor homolog US28 (HHRF3)
PP65_HCMVA 65 kDa phosphoprotein (pp65) (65 kDa matrix phosphoprotein) (Phosphoprotein UL83) (Tegument protein ...
UL18_HCMVA Glycoprotein UL18
US27_HCMVA G-protein coupled receptor homolog US27 (HHRF2)
US03_HCMVA Membrane glycoprotein US3 (Glycoprotein E) (Protein HQLF1) (gpUS3 IE)
US02_HCMVA Unique short US2 glycoprotein (Protein HQLF2) (gpUS2)
IRS1_HCMVA Protein IRS1 (HQRF1)
US09_HCMVA Unique short US9 glycoprotein (Protein HXLF3) (gpUS9)
GH_HCMVA Envelope glycoprotein H (gH)
CEP3_HCMVA Cytoplasmic envelopment protein 3
VIE1_HCMVA Immediate early protein IE1 (IE1) (55 kDa immediate-early protein 1) (IE1p72) (IE72)
US06_HCMVA Unique short US6 glycoprotein (Protein HXLF6) (gpUS6)
GM_HCMVA Envelope glycoprotein M (gM)
ICP27_HCMVA mRNA export factor ICP27 homolog
NEC2_HCMVA Nuclear egress protein 2
NEC1_HCMVA Nuclear egress protein 1
GN_HCMVA Envelope glycoprotein N
CEP2_HCMVA Cytoplasmic envelopment protein 2
UL116_HCMVA Uncharacterized protein UL116
UL22A_HCMVA Glycoprotein UL22A
UL31_HCMVA Protein UL31
UL33_HCMVA G-protein coupled receptor homolog UL33 (vGPCR UL33)
IL10H_HCMVA Viral interleukin-10 homolog (cmvIL-10) (vIL-10)
DPOL_HCMVA DNA polymerase catalytic subunit (EC 2.7.7.7)
TRS1_HCMVA Protein HHLF1
US10_HCMVA Unique short US10 glycoprotein (Protein HXLF2) (gpUS10)
US08_HCMVA Unique short US8 glycoprotein (Protein HXLF4) (gpUS8)
US07_HCMVA Unique short US7 glycoprotein (Protein HXLF5) (gpUS7)
UL11P_HCMVA Protein UL11
TRM1_HCMVA Tripartite terminase subunit 1
UL76_HCMVA Protein UL76
UL84_HCMVA Protein UL84
UL88_HCMVA Protein UL88
TRM3_HCMVA Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
HELI_HCMVA DNA replication helicase (EC 3.6.4.-)
UL119_HCMVA Viral Fc-gamma receptor-like protein UL119 (gp68)
UL07_HCMVA CEACAM1-like protein UL7
UL08_HCMVA Membrane protein UL8
GO_HCMVA Glycoprotein O (gO)
UL16P_HCMVA Protein UL16
UNG_HCMVA Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
RIR1_HCMVA Ribonucleoside-diphosphate reductase large subunit-like protein
LTP_HCMVA Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
AN_HCMVA Alkaline nuclease (EC 3.1.-.-)
UL52_HCMVA Packaging protein UL32 homolog (Protein HFRF1)
UL42_HCMVA Protein UL42
TEG7_HCMVA Tegument protein UL51 homolog
DUT_HCMVA Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
GL_HCMVA Envelope glycoprotein L (gL)
UL23_HCMVA Tegument protein UL23
DNBI_HCMVA Major DNA-binding protein
PRIM_HCMVA DNA primase (EC 2.7.7.-)
UL41A_HCMVA Protein UL41A
US23_HCMVA Tegument protein US23 (Protein HHLF7)
US17_HCMVA Uncharacterized protein HVLF1
US16_HCMVA Uncharacterized protein HVLF2
US15_HCMVA Uncharacterized protein HVLF3
US14_HCMVA Uncharacterized protein HVLF4
US22_HCMVA Early nuclear protein HWLF1 (Tegument protein US22)
US20_HCMVA Transmembrane protein HWLF3
UL01_HCMVA Glycoprotein UL1
UL06_HCMVA Uncharacterized protein UL6
CVC2_HCMVA Capsid vertex component 2
TRX2_HCMVA Triplex capsid protein 2
MCP_HCMVA Major capsid protein (MCP)
UL87_HCMVA Protein UL87
CEP1_HCMVA Cytoplasmic envelopment protein 1
PORTL_HCMVA Portal protein
UL120_HCMVA Uncharacterized protein UL120
UL121_HCMVA Membrane protein UL121
UL124_HCMVA Uncharacterized protein UL124
UL09_HCMVA Uncharacterized protein UL9
UL79_HCMVA Protein UL79
UL13_HCMVA Uncharacterized protein UL13
UL20_HCMVA Uncharacterized protein UL20
PP85_HCMVA Phosphoprotein 85 (pp85) (Phosphoprotein UL25)
UL26_HCMVA Tegument protein UL26
UL27_HCMVA Protein UL27
UL117_HCMVA Protein UL117
UL130_HCMVA Uncharacterized protein UL130
UL05_HCMVA Protein UL5
UL38_HCMVA Apoptosis inhibitor UL38
UL40_HCMVA Protein UL40
UL43_HCMVA Tegument protein UL43
TRX1_HCMVA Triplex capsid protein 1
ITP_HCMVA Inner tegument protein
UL96_HCMVA Protein UL96
TRM2_HCMVA Tripartite terminase subunit 2
CVC1_HCMVA Capsid vertex component 1
UL95_HCMVA Protein UL95
IR10_HCMVA Protein IRL10 (TRL10)
IR11_HCMVA Viral Fc-gamma receptor-like protein IR11 (gp34)
UL34_HCMVA Transcriptional regulator UL34
HEPA_HCMVA DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
UL128_HCMVA Uncharacterized protein UL128
UL10_HCMVA Uncharacterized protein UL10
UL15A_HCMVA Uncharacterized protein UL15A
UL04_HCMVA Early glycoprotein GP48
TR14_HCMVA Protein TRL14
US19_HCMVA Transmembrane protein HWLF4
UL132_HCMVA Envelope glycoprotein UL132 (L3)
US34A_HCMVA Uncharacterized protein US34A
SCP_HCMVA Small capsomere-interacting protein
UL21A_HCMVA Uncharacterized protein UL21A
IR04_HCMVA Uncharacterized protein IRL4 (TRL4)
US35_HCMVA Uncharacterized protein HHLF2
US33_HCMVA Uncharacterized protein HHLF3
US26_HCMVA Uncharacterized protein HHLF5
US24_HCMVA Tegument protein US24 (Protein HHLF6)
US29_HCMVA Uncharacterized protein HHRF4
US30_HCMVA Uncharacterized protein HHRF5
US31_HCMVA Uncharacterized protein HHRF6
US32_HCMVA Uncharacterized protein HHRF7
US34_HCMVA Protein US34
IR01_HCMVA Uncharacterized protein HKLF1 (IRL1) (TRL1)
J1I_HCMVA Uncharacterized protein HKRFX (J1I)
US01_HCMVA Uncharacterized protein HQLF3
US13_HCMVA Uncharacterized protein HVLF5
US12_HCMVA Uncharacterized protein HVLF6
US21_HCMVA Uncharacterized protein HWLF2
UL17_HCMVA Uncharacterized protein UL17
UL19_HCMVA Uncharacterized protein UL19
UL106_HCMVA Uncharacterized protein UL106
UL109_HCMVA Uncharacterized protein UL109
UL59_HCMVA Uncharacterized protein UL59
UL67_HCMVA Uncharacterized protein UL67
UL68_HCMVA Uncharacterized protein UL68
UL78_HCMVA Uncharacterized protein UL78
UL02_HCMVA Uncharacterized protein UL2
UL14_HCMVA Uncharacterized protein UL14
UL21_HCMVA Uncharacterized protein UL21
VP22_HCMVA Protein UL24
UL29_HCMVA Uncharacterized protein UL29
UL30_HCMVA Uncharacterized protein UL30
UL36_HCMVA Uncharacterized protein UL36
UL127_HCMVA Uncharacterized protein UL127
UL131_HCMVA Uncharacterized protein UL131
UL03_HCMVA Uncharacterized protein UL3
UL12_HCMVA Uncharacterized protein UL12
UL49_HCMVA Uncharacterized protein UL49 (Protein HFLF5)
UL90_HCMVA Uncharacterized protein UL90
UL91_HCMVA Protein UL91
UL92_HCMVA Protein UL92
IR02_HCMVA Uncharacterized protein IRL2 (TRL2)
IR05_HCMVA Uncharacterized protein IRL5 (TRL5)
IR06_HCMVA Uncharacterized protein IRL6 (TRL6)
IR07_HCMVA Uncharacterized protein IRL7 (TRL7)
IR08_HCMVA Uncharacterized protein IRL8 (TRL8)
IR09_HCMVA Uncharacterized protein IRL9 (TRL9)
IR12_HCMVA Uncharacterized protein IRL12 (TRL12)
IR13_HCMVA Uncharacterized protein IRL13 (TRL13)
UL39_HCMVA Uncharacterized protein UL39
UL41_HCMVA Uncharacterized protein UL41
UL58_HCMVA Uncharacterized protein UL58
UL60_HCMVA Uncharacterized protein UL60
UL61_HCMVA Uncharacterized protein UL61
UL62_HCMVA Uncharacterized protein UL62
UL63_HCMVA Uncharacterized protein UL63
UL64_HCMVA Uncharacterized protein UL64
UL66_HCMVA Uncharacterized protein UL66
UL81_HCMVA Uncharacterized protein UL81
UL101_HCMVA Uncharacterized protein UL101
UL107_HCMVA Uncharacterized protein UL107
UL108_HCMVA Uncharacterized protein UL108
UL110_HCMVA Uncharacterized protein UL110
UL125_HCMVA Uncharacterized protein UL125
UL126_HCMVA Uncharacterized protein UL126
UL129_HCMVA Uncharacterized protein UL129
US04_HCMVA Uncharacterized protein US4
US05_HCMVA Uncharacterized protein US5
US36_HCMVA Uncharacterized protein US36
UL28_HCMVA Uncharacterized protein UL28
IR03_HCMVA Uncharacterized protein IRL3 (TRL3)
J1L_HCMVA Uncharacterized protein J1L
J1S_HCMVA Uncharacterized protein J1S
US25_HCMVA Uncharacterized protein US25
UL65_HCMVA Uncharacterized protein UL65
IR14_HCMVA Uncharacterized protein IRL14
US18_HCMVA Transmembrane protein US18

166 entries

Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Select_allDeselect_all
UL141_HCMVM Protein UL141
SCAF_HCMVM Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
GB_HCMVM Envelope glycoprotein B (gB)
GO_HCMVM Envelope glycoprotein O
CEP3_HCMVM Cytoplasmic envelopment protein 3 (28 kDa structural phosphoprotein) (pp28)
EP84_HCMVM Early phosphoprotein p84
GH_HCMVM Envelope glycoprotein H (gH)
VGLI_HCMVM UL37 immediate early glycoprotein
UL33_HCMVM G-protein coupled receptor homolog UL33
UL11P_HCMVM Protein UL11
CEP2_HCMVM Cytoplasmic envelopment protein 2
UL135_HCMVM Protein UL135
US08_HCMVM Membrane glycoprotein US8
PP71_HCMVM Protein pp71
CXCL1_HCMVM Chemokine vCXCL1
US09_HCMVM Membrane glycoprotein US9
TRM1_HCMVM Tripartite terminase subunit 1
VPAP_HCMVM DNA polymerase processivity factor (Polymerase accessory protein) (PAP) (Protein ICP36)
GL_HCMVM Envelope glycoprotein L (gL)
VIE1_HCMVM Immediate early protein IE1 (IE1) (55 kDa immediate-early protein 1) (IE1p72) (IE72)
UL130_HCMVM Envelope glycoprotein UL130
US27_HCMVM Envelope glycoprotein US27
US02_HCMVM Unique short US2 glycoprotein (Protein HQLF2) (gpUS2)
UL35_HCMVM Tegument protein UL35
TEG7_HCMVM Tegument protein UL51 homolog
HELI_HCMVM DNA replication helicase (EC 3.6.4.-)
UL78_HCMVM Protein UL78
U131A_HCMVM Protein UL131A
US03_HCMVM Membrane glycoprotein US3
AN_HCMVM Alkaline nuclease (EC 3.1.-.-)
US28_HCMVM Envelope protein US28
US10_HCMVM Membrane glycoprotein US10
NEC1_HCMVM Nuclear egress protein 1
UL38_HCMVM Apoptosis inhibitor UL38
UL138_HCMVM Protein UL138
UL142_HCMVM Membrane glycoprotein UL142
GN_HCMVM Envelope glycoprotein N
UL42_HCMVM Protein UL42
TRS1_HCMVM Protein TRS1
US11_HCMVM Membrane glycoprotein US11
US06_HCMVM Unique short US6 glycoprotein
IRS1_HCMVM Protein IRS1
VIE2_HCMVM Viral transcription factor IE2 (IE2) (Protein UL122)
GM_HCMVM Envelope glycoprotein M (gM)
UL97_HCMVM Serine/threonine protein kinase UL97 (EC 2.7.11.1)
PP65_HCMVM 65 kDa phosphoprotein (pp65) (65 kDa matrix phosphoprotein) (Phosphoprotein UL83) (Tegument protein ...
UL76_HCMVM Protein UL76
ICP27_HCMVM mRNA export factor ICP27 homolog
DPOL_HCMVM DNA polymerase catalytic subunit (EC 2.7.7.7)
NEC2_HCMVM Nuclear egress protein 2
LTP_HCMVM Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
ITP_HCMVM Inner tegument protein
PP150_HCMVM Tegument protein pp150
UL27_HCMVM Protein UL27
UL07_HCMVM CEACAM1-like protein UL7
UL148_HCMVM Membrane protein UL148
UL96_HCMVM Protein UL96
UL88_HCMVM Protein UL88
VP22_HCMVM Tegument protein UL24
UL09_HCMVM Membrane glycoprotein UL9
UL20_HCMVM Membrane protein UL20
UL147_HCMVM Putative viral CXC chemokine 2 (vCXCL2)
CEP1_HCMVM Cytoplasmic envelopment protein 1
TRX1_HCMVM Triplex capsid protein 1
UL15A_HCMVM Uncharacterized protein UL15A
UL144_HCMVM Membrane glycoprotein UL144 (TNF alpha-like receptor UL144) (UL144 protein)
US19_HCMVM Transmembrane protein US19
VICA_HCMVM Viral inhibitor of caspase-8-induced apoptosis (vICA)
US23_HCMVM Protein US23
UL84_HCMVM Protein UL84
PORTL_HCMVM Portal protein
UL119_HCMVM Viral Fc-gamma receptor-like protein UL119 (gp68)
IL10H_HCMVM Viral interleukin-10 homolog (cmvIL-10) (vIL-10)
TRM3_HCMVM Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
UL121_HCMVM Membrane protein UL121
US14_HCMVM Membrane protein US14
US22_HCMVM Tegument protein US22
US07_HCMVM Membrane glycoprotein US7
UL23_HCMVM Tegument protein UL23
DNBI_HCMVM Major DNA-binding protein
US12_HCMVM Uncharacterized protein US12
SCP_HCMVM Small capsomere-interacting protein
UL136_HCMVM Protein UL136
UL22A_HCMVM Glycoprotein UL22A
UL117_HCMVM Protein UL117 (pUL117)
UL18_HCMVM Membrane glycoprotein UL18
UL41A_HCMVM Protein UL41A
PRIM_HCMVM DNA primase (EC 2.7.7.-)
UL16P_HCMVM Protein UL16
UL26_HCMVM Tegument protein UL26
TRM2_HCMVM Tripartite terminase subunit 2
PP85_HCMVM Phosphoprotein 85 (pp85) (Phosphoprotein UL25)
MCP_HCMVM Major capsid protein (MCP)
UL132_HCMVM Envelope glycoprotein UL132
UL124_HCMVM Uncharacterized protein UL124
IR10_HCMVM Protein IRL10 (TRL10)
UNG_HCMVM Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
HEPA_HCMVM DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
TRX2_HCMVM Triplex capsid protein 2
US34A_HCMVM Uncharacterized protein US34A
US16_HCMVM Protein US16
UL133_HCMVM Protein UL133
UL139_HCMVM Membrane glycoprotein UL139
UL120_HCMVM Membrane protein UL120
UL95_HCMVM Protein UL95
CVC1_HCMVM Capsid vertex component 1
UL87_HCMVM Uncharacterized protein UL87
UL79_HCMVM Protein UL79
CVC2_HCMVM Capsid vertex component 2
DUT_HCMVM Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
UL52_HCMVM Packaging protein UL32 homolog
RIR1_HCMVM Ribonucleoside-diphosphate reductase large subunit-like protein
UL43_HCMVM Tegument protein UL43
UL40_HCMVM Protein UL40
UL31_HCMVM Protein UL31
UL298_HCMVM Protein UL29/28
UL14_HCMVM Uncharacterized protein UL14
UL13_HCMVM Uncharacterized protein UL13
UL10_HCMVM Uncharacterized protein UL10
UL06_HCMVM Uncharacterized protein UL6
UL04_HCMVM Envelope glycoprotein UL4
UL01_HCMVM Glycoprotein UL1
RL13_HCMVM Membrane protein RL13
RL11_HCMVM Membrane glycoprotein RL11
UL74A_HCMVM Uncharacterized protein UL74A
U147A_HCMVM Uncharacterized protein UL147A
US24_HCMVM Tegument protein US24
US26_HCMVM Protein US26
US13_HCMVM Membrane protein US13
US17_HCMVM Protein US17
U148B_HCMVM Protein UL148B
US31_HCMVM Uncharacterized protein US31
UL92_HCMVM Uncharacterized protein UL92
US30_HCMVM Uncharacterized protein US30
UL34_HCMVM Transcriptional regulator UL34
UL140_HCMVM Protein UL140
US32_HCMVM Protein US32
U148C_HCMVM Protein UL148C
US18_HCMVM Transmembrane protein US18
U148A_HCMVM Protein UL148A
US34_HCMVM Protein US34
RL5A_HCMVM Protein RL5A
UL145_HCMVM Protein UL145
US15_HCMVM Membrane protein US15
UL91_HCMVM Protein UL91
US29_HCMVM Uncharacterized protein US29
UL30_HCMVM Uncharacterized protein UL30
US20_HCMVM Membrane protein US20
UL21A_HCMVM Uncharacterized protein UL21A
U148D_HCMVM Protein UL148D
UL17_HCMVM Protein UL17
US21_HCMVM Membrane protein US21
UL19_HCMVM Uncharacterized protein UL19
RL8A_HCMVM Protein RL8A
RL9A_HCMVM Protein RL9A
U150A_HCMVM Uncharacterized protein UL150A
US33A_HCMVM Uncharacterized protein US33A
US01_HCMVM Protein US1
UL150_HCMVM Uncharacterized protein UL150
UL116_HCMVM Uncharacterized protein UL116
UL49_HCMVM Protein UL49
UL05_HCMVM Protein UL5
UL02_HCMVM Uncharacterized protein UL2
RL12_HCMVM Uncharacterized protein RL12
IR06_HCMVM Uncharacterized protein IRL6 (TRL6)
IR01_HCMVM Uncharacterized protein HKLF1 (IRL1) (TRL1)

3 entries

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)

Select_allDeselect_all
UL298_HCMVA Protein UL29/UL28
YHL4_HCMVA Uncharacterized protein HHLF4
YHR1_HCMVA Uncharacterized protein HHRF1

1 entry

Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)

UL128_HCMVM Envelope protein UL128

28 entries

Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Select_allDeselect_all
VIE1_HCMVT Immediate early protein IE1 (IE1) (55 kDa immediate-early protein 1) (IE1p72) (IE72)
GB_HCMVT Envelope glycoprotein B (gB)
US03_HCMVT Membrane glycoprotein US3
UL42_HCMVT Protein UL42
LTP_HCMVT Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
VIE2_HCMVT Viral transcription factor IE2 (IE2) (Protein UL122)
PRIM_HCMVT DNA primase (EC 2.7.7.-)
IE247_HCMVT 45 kDa immediate-early protein 2 (IE2)
GH_HCMVT Envelope glycoprotein H (gH)
PP65_HCMVT 65 kDa phosphoprotein (pp65) (64 kDa matrix phosphoprotein) (pp64) (GP64) (Phosphoprotein UL83) ...
US02_HCMVT Unique short US2 glycoprotein (HQLF2) (gpUS2)
US06_HCMVT Unique short US6 glycoprotein (HXLF6) (gpUS6)
US28_HCMVT G-protein coupled receptor homolog US28 (HHRF3)
UL97_HCMVT Serine/threonine protein kinase UL97 (EC 2.7.11.1) (Ganciclovir kinase)
US11_HCMVT Unique short US11 glycoprotein (HXLF1) (gpUS11)
UL34_HCMVT Transcriptional regulator UL34
UL95_HCMVT Protein UL95
VIE3_HCMVT 30 kDa immediate-early protein 2 (IE2)
UL04_HCMVT Early glycoprotein GP48
UL84_HCMVT UL84 protein
US19_HCMVT Transmembrane protein HWLF4
UL132_HCMVT Envelope glycoprotein UL132 (L3)
US20_HCMVT Transmembrane protein HWLF3
UL135_HCMVT Protein UL135
UL136_HCMVT Protein UL136
UL147_HCMVT Putative viral CXC chemokine 2 (vCXCL2)
UL17_HCMVT Protein UL17
US18_HCMVT Transmembrane protein HWLF5

2 entries

Human cytomegalovirus (strain Toledo) (HHV-5) (Human herpesvirus 5)

Select_allDeselect_all
UL144_HCMVO Membrane glycoprotein UL144 (TNF alpha-like receptor UL144) (UL144 protein)
US05_HCMVO Uncharacterized protein US5

2 entries

Rhesus cytomegalovirus (strain 68-1) (RhCMV)

Select_allDeselect_all
GB_RHCM6 Envelope glycoprotein B (gB)
DPOL_RHCM6 DNA polymerase catalytic subunit (EC 2.7.7.7)

2 entries

Simian cytomegalovirus (strain Colburn)

Select_allDeselect_all
SCAF_SCMVC Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
DNBI_SCMVC Major DNA-binding protein

1 entry

Human cytomegalovirus (HHV-5) (Human herpesvirus 5)

TEGU_HCMV Tegument protein (67 kDa phosphorylated protein)

1 entry

Human cytomegalovirus (strain 1042) (HHV-5) (Human herpesvirus 5)

GL_HCMV2 Envelope glycoprotein L (gL)

1 entry

Human cytomegalovirus (strain 119) (HHV-5) (Human herpesvirus 5)

GL_HCMV1 Envelope glycoprotein L (gL)

1 entry

Human cytomegalovirus (strain 2387) (HHV-5) (Human herpesvirus 5)

GL_HCMV3 Envelope glycoprotein L (gL)

1 entry

Human cytomegalovirus (strain 4654) (HHV-5) (Human herpesvirus 5)

GL_HCMV4 Envelope glycoprotein L (gL)

1 entry

Human cytomegalovirus (strain 5035) (HHV-5) (Human herpesvirus 5)

GL_HCMV5 Envelope glycoprotein L (gL)

1 entry

Human cytomegalovirus (strain 5040) (HHV-5) (Human herpesvirus 5)

GL_HCMV6 Envelope glycoprotein L (gL)

1 entry

Human cytomegalovirus (strain 5160) (HHV-5) (Human herpesvirus 5)

GL_HCMV7 Envelope glycoprotein L (gL)

1 entry

Human cytomegalovirus (strain 5508) (HHV-5) (Human herpesvirus 5)

GL_HCMV8 Envelope glycoprotein L (gL)

1 entry

Human cytomegalovirus (strain Eisenhardt) (HHV-5) (Human herpesvirus 5)

V30K_HCMVE 30 kDa major early protein

1 entry

Human cytomegalovirus (strain PT) (HHV-5) (Human herpesvirus 5)

GL_HCMVP Envelope glycoprotein L (gL)