Aviadenovirus

VIRION

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Non-enveloped capsid with a pseudo T=25 icosahedral symmetry. The capsid diameter is about 90 nm. The capsid shell consists of 720 hexon subunits arranged as 240 trimers and 12 vertex penton capsomers each with a fiber protruding from the surface.

GENOME

Non-segmented, linear double-stranded DNA of 35-36kb encoding about 40 proteins. The genome has terminally redundant sequences which have inverted terminal repetitions (ITR). The terminal protein (TP) is covalently attached to each end of the genome.

GENE EXPRESSION

Transcription is nuclear, in two phases; early (replication), late (virion assembly). All genes are transcribed by host RNA pol II except virus-associated (VA) gene(s) of some fowl adenoviruses transcribed by RNA pol III. Genes transcribed by RNA pol II give rise to multiple mRNA that are produced by alternative splicing and use of different poly(A) sites.

REPLICATION

NUCLEUS

  1. Attachment of the viral fiber glycoproteins to host receptors mediates endocytosis of the virus into the host cell and fiber shedding.
  2. Disruption of the endosome by lytic protein VI releases the viral capsid in the cytosol.
  3. Viral penetration into host nucleus.
  4. Transcription of early genes (E genes) by host RNA pol II, replication of the DNA genome by DNA strand displacement in the nucleus.
  5. Transcription of late genes (L genes) by host RNA pol II, mostly encoding for structural proteins.
  6. Assembly of new virions in the nucleus.
  7. Virions are released by lysis of the cell.

Matching UniProtKB/Swiss-Prot entries

42 entries grouped by strain (browse by keywords)

38 entries

Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

Select_allDeselect_all
YO4_ADEG1 Uncharacterized protein ORF4
YO10_ADEG1 Putative Ig-like domain-containing protein ORF10
YO2_ADEG1 Uncharacterized protein ORF2
YO5_ADEG1 Uncharacterized protein ORF5
YO20_ADEG1 Uncharacterized protein ORF20
CAPSP_ADEG1 Penton protein (CP-P) (Penton base protein) (Protein III)
YO12_ADEG1 Uncharacterized protein ORF12
YO15_ADEG1 Uncharacterized protein ORF15
PKG1_ADEG1 Packaging protein 1 (Packaging protein IVa2)
SPIK1_ADEG1 Fiber protein 1
YO16_ADEG1 Uncharacterized protein ORF16
YO14_ADEG1 Uncharacterized protein ORF14
PRO_ADEG1 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
SHUT_ADEG1 Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)
TERM_ADEG1 Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein) [Cleaved into: Intermediate ...
PKG3_ADEG1 Packaging protein 3 (L1-52/55 kDa protein) (Packaging protein 52K)
YO17_ADEG1 Uncharacterized protein ORF17
YO21_ADEG1 Uncharacterized protein ORF21
YO7_ADEG1 Uncharacterized protein ORF7
YO19_ADEG1 Uncharacterized protein ORF19
YO22_ADEG1 Uncharacterized protein ORF22
YO11_ADEG1 Uncharacterized protein ORF11
SPIK2_ADEG1 Fiber protein 2
YO18_ADEG1 Uncharacterized protein ORF18
YO3_ADEG1 Uncharacterized protein ORF3
YO13_ADEG1 Uncharacterized protein ORF13
YO6_ADEG1 Uncharacterized protein ORF6
YO9_ADEG1 Uncharacterized protein ORF9
DUT_ADEG1 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
DNB2_ADEG1 DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)
GAM1_ADEG1 Protein GAM-1 (Gallus-anti morte protein) (Gam1)
DPOL_ADEG1 DNA polymerase (EC 2.7.7.7)
CAPSH_ADEG1 Hexon protein (CP-H) (Protein II)
CAP6_ADEG1 Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]
CAP3_ADEG1 Pre-hexon-linking protein IIIa (Capsid vertex-specific component IIIa) (CVSC) (Protein IIIa) (pIIIa) ...
CAP8_ADEG1 Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
NP_ADEG1 Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like ...
L2MU_ADEG1 Late L2 mu core protein (Protein X) (pX) (pMu)

2 entries

Avian adenovirus 8 (strain ATCC A-2A) (FAdV-8) (Fowl adenovirus 8)

Select_allDeselect_all
PRO_ADEG8 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
DUT_ADEG8 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)

2 entries

Fowl adenovirus C serotype 10 (strain SA2) (FAdV-10) (Fowl adenovirus 10)

Select_allDeselect_all
SHUT_ADEGX Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)
CAPSP_ADEGX Penton protein (CP-P) (Penton base protein) (Protein III)