Mupapillomavirus (taxid:334202)



Non-enveloped. Small, icosahedral, about 52-55 nm in size. A single molecule of circular dsDNA is contained within the T=7 icosahedral capsid, which is composed of 72 pentamers.



Circular dsDNA, about 8 kb in size, associated with cellular histones.
On rare non-specific recombination, the viral genome can be integrated in host chromosome. This inactivates the integrated virus but can gives the host cell a replicative advantage sometimes leading to malignant tumours.


Only one strand of the genome is transcribed and yield two classes of proteins expressed by alternative splicing :
a) Early Proteins: non-structural regulatory proteins (E1-E7).
b) Late Proteins: the structural proteins L1 and L2.



Replication is divided in two distinct steps that are linked to the differentiation state of the host epithelial cell:

a) The plasmid replication takes place in the basal squamous epithelial cells. It corresponds to viral DNA replication in synchrony with the host cell chromosome in order to ensures an average of one viral genome per basal cell.

  1. Attachment of the viral proteins to host receptors mediates endocytosis into vesicles in the basal squamous epithelial cell.
  2. Transport to the nucleus and uncoating of the viral DNA.
  3. Early-region transcription and translation of the early proteins.
  4. Steady-state viral DNA nuclear replication. Requires the origin of DNA replication in cis and the viral E1 and E2 proteins in trans.

b) The vegetative replication, which occurs in differentiated keratinocytes. In these cells, which no longer undergo cellular DNA synthesis, there is a burst of viral DNA synthesis with active production of virions.

  1. Vegetative viral DNA synthesis.
  2. Transcription of the late region.
  3. Capsid proteins L1 and L2 synthesis.
  4. Nuclear capsid assembly and release of viruses.

Matching UniProtKB/Swiss-Prot entries

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15 entries grouped by strain

8 entries

Human papillomavirus type 63 reference strain

VE1_HPV63 Replication protein E1 (EC (ATP-dependent helicase E1)
VE2_HPV63 Regulatory protein E2
VE6_HPV63 Protein E6
VE7_HPV63 Protein E7
VL2_HPV63 Minor capsid protein L2
VE8E2_HPV63 Protein E8^E2C
VE4_HPV63 Protein E4
VL1_HPV63 Major capsid protein L1

7 entries

Human papillomavirus type 1 (Human papillomavirus type 1a) reference strain

VL2_HPV1 Minor capsid protein L2
VE1_HPV1 Replication protein E1 (EC (ATP-dependent helicase E1)
VE2_HPV1 Regulatory protein E2
VE7_HPV1 Protein E7
VE6_HPV1 Protein E6
VL1_HPV1 Major capsid protein L1
VE4_HPV1 Protein E4
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Human papillomavirus type 1 taxid:10583

Protein ModelArchive
E8 protein ma-jd-viral-49300
Major capsid protein L1 ma-jd-viral-67270
Minor capsid protein L2 ma-jd-viral-44894
Protein E6 ma-jd-viral-00962
Protein E7 ma-jd-viral-13700